Category: 444-29-1

These common heterocyclic compound, 444-29-1, name is 1-Iodo-2-(trifluoromethyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1-Iodo-2-(trifluoromethyl)benzene

General procedure: 9-[2-(4-Nitrophenoxy)naphthalene-1-yl]-11,12-dihydro-10H-indeno[6,5,4-kl]xanthene (3a): A mixture of 1a (73.6 mg, 189 mumol, 1.00 equiv.), 2 (67.1 mg, 198 mumol, 1.05 equiv.), Pd(OAc)2 (4.22 mg, 18.8 mumol, 0.10 equiv.), PPh3 (24.7 mg, 94.0 mumol, 0.50 equiv.) and (nBu)4NOAc (341 mg, 1.13 mmol, 6.00 equiv.) in degassed DMF (5 mL) was stirred at 100 ¡ãC for 21 h. The reaction mixturewas filtered through SiO2, flushed with EtOAc and the solvent of the filtrate was removed in vacuo.Column chromatography (SiO2, n-pentane/EtOAc 20:1) yielded 3

The synthetic route of 1-Iodo-2-(trifluoromethyl)benzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Tietze, Lutz F.; Eichhorst, Christoph; Heterocycles; vol. 90; 2; (2015); p. 919 – 927;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 444-29-1, name is 1-Iodo-2-(trifluoromethyl)benzene, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-Iodo-2-(trifluoromethyl)benzene

General procedure: A mixture of aryl iodide (2 mmol), CuI (0.10 mmol), ligand(1.1 mmol), and S8 (1.1 mmol) were added to an oven-driedreaction tube equipped with a septum. The reaction tube wasevacuated and back-filled with argon. Under a counterflowof argon, EIPA (0.258 g, 2 mmol) and DMSO (2 mL) wereadded, and the mixture stirred at r.t. for 8 h. After completedisappearance of aryl iodide (monitored by TLC), H2O (5mL) was added, and the mixture was extracted with CH2Cl2(3 ¡Á 5 mL). The combined organic phases were dried (onMgSO4) and filtered before evaporation of the solvent. Theresidue was purified on silica gel, eluting with PE?EtOAc(20:1), to give product 2. Analytical and spectroscopic datafor all derivatives, except 2g?i have been reported previously.19

The synthetic route of 444-29-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yavari, Issa; Ghazanfarpour-Darjani, Majid; Solgi, Yazdan; Synlett; vol. 25; 8; (2014); p. 1121 – 1123;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

444-29-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 444-29-1, name is 1-Iodo-2-(trifluoromethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of [9-((1R,2R,4R,5R)-4-ethynyl-7,7-dimethyl-3,6,8-trioxabicyclo[3.3.0]oct-2-yl)purin-6-yl]cyclopentylamine (40 mg, 0.12 mmol), a compound of formula (5), in tetrahydrofuran (4 ml) under nitrogen was added catalytic amounts (3 mg) of dichlorobis(triphenylphosphine)palladium(II) and copper(II)iodide, followed by 1-iodo-2-trifluoromethylbenzene (0.25 ml, 0.3 mmol). Triethylamine (0.4 ml) was then added, and the mixture stirred for 15 minutes at room temperature. The solvent was removed under reduced pressure, and the residue was purified by preparative TLC, eluding with methanol:methylene chloride (6.5:1), to yield [9-((1R,2R,4R,5R)-7,7-dimethyl-4-{2-[2-(trifluoromethyl)-phenyl]ethynyl}-3,6,8-trioxabicyclo[3.3.0]oct-2-yl)purin-6-yl]cyclopentylamine, a compound of formula (6).

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Reference:
Patent; Zablocki, Jeff; Palle, Venkata; Elzein, Elfatih; Li, Xiaofen; US2004/43960; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com