Category: 4387-36-4

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4387-36-4, name is 2-Iodobenzonitrile, A new synthetic method of this compound is introduced below., name: 2-Iodobenzonitrile

S1:100 mmol of the compound of the above formula (1), 150 mmol of the compound of the above formula (2), 0.8 mmol of palladium acetate, 100 mmol of tetra-n-butylammonium bromide were added to an appropriate amount of the organic solvent N,N-dimethylacetamide (DMA) at room temperature. And 225 mmol of sodium carbonate, and then the temperature was raised to 95 ° C with stirring, and the reaction was stirred at this temperature for 25 hours;After the reaction was completed, the reaction mixture was poured into a sufficient amount of ethyl acetate, and then washed with saturated brine, and the organic layer and aqueous layer were separated, and the aqueous layer was extracted with ethyl acetate. The organic layer and the organic layer obtained by ethyl acetate extraction were dried over anhydrous Na 2 SO 4 and evaporated under reduced pressure. The elution is carried out, the eluent is collected and the eluent is removed by evaporation.The compound of the above formula (3) is thus a white solid, the yield is 87.6percent;

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4387-36-4, name is 2-Iodobenzonitrile, A new synthetic method of this compound is introduced below., Formula: C7H4IN

Example 19 3-[2-({4-[(2,4-difluorophenoxy)methyl]phenyl}sulfonyl)plienyl]-4/r-l,2,4-triazole Step 1: 2-JOdO-JV -4H- l,2,4-triazol-4-ylbenzenecarboximidamide; 4H-l,2,4-Triazol-4-amine (5.0 g, 0.06 mol) and 2-iodobenzonitrile (13.6 g, 0.06 mol) were added to sodium ethoxide (21percent in ethanol, 0.06 mol) and heated to 78 0C for 5 h. The cooled reaction mixture was poured into water and the resulting precipitate filtered off and azeotroped with toluene to give the title compound as a solid (15.6 g, 81percent). 1H NMR (400 MHz, DMSO): delta 8.40 (2 H, s), 7.92 (1 H, d, J 7.6 Hz), 7.51-7.43 (3 H, m), 7.37 (1 H, d, J 4.3 Hz), 7.25-7.19 (1 H, m).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4387-36-4, name is 2-Iodobenzonitrile, A new synthetic method of this compound is introduced below., Product Details of 4387-36-4

Weigh 0.02 mM halogenated aromatic hydrocarbon in a reaction flask, add 1 mL of solvent, and fill the reaction flask with nitrogen.Deoxygenation was performed for 10 minutes and 15 yL of triethylamine was added during the deoxygenation.After that, the reaction vessel was sealed, placed over a light-emitting diode (LED) with a wavelength of 400 nm and a power of 0.5 W, and the reaction was stirred at room temperature for 12 hours.After that, the dehalogenation reaction yield was characterized by gas chromatography-mass spectrometry.The yield of o-phenylacetonitrile was 80.7percent, and the characterization results of the gas chromatography and mass spectrometry were shown in Figure 2. The halogenated aromatic hydrocarbon waso-Iodobenzeneacetonitrile, the solvent is tetrahydrofuran.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 4387-36-4,Some common heterocyclic compound, 4387-36-4, name is 2-Iodobenzonitrile, molecular formula is C7H4IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

S1: The reaction formula of this step is as follows. The specific reaction operation is: at room temperature,Adding 100 mmol of the compound of the above formula (III) to an appropriate amount of the organic solvent N,N-dimethylacetamide (DMA),200 mmol of the compound of the above formula (IV), 0.4 mmol of palladium acetate,150 mmol of tetra-n-butylammonium bromide and 150 mmol of sodium carbonate,Then, the temperature was stirred to 120 ¡ã C, and the reaction was stirred at this temperature for 15 hours;After the reaction was completed, the reaction mixture was poured into a sufficient amount of ethyl acetate and then washed with saturated brine.The organic layer and the aqueous layer were separated, and the aqueous layer was sufficiently extracted with ethyl acetate.The organic layers are combined (ie, the organic layer washed with saturated brine and the organic layer obtained by ethyl acetate extraction).Dry with anhydrous Na2SO4 and distill under reduced pressure.The residue was eluted by flash column chromatography (a mixture of petroleum ether and ethyl acetate in a volume ratio of 8:1).The eluent was collected and evaporated to remove the eluent.The compound of the above formula (II) was obtained as a white solid in a yield of 87.8percent

The synthetic route of 4387-36-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Wenzhou Medical University Affiliated The Second Hospital ? Wenzhou Medical University Affiliated Yuying Child Hospital; Wenzhou Medical University; Wang Zhiyi; Weng Jie; Chen Chan; Wang Zhibin; Zhou Zhiliang; Ma Jianshe; Xu Tong; (18 pag.)CN108250162; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 4387-36-4, A common heterocyclic compound, 4387-36-4, name is 2-Iodobenzonitrile, molecular formula is C7H4IN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The specific reaction operation is:At room temperature,Add 100 mmol of the compound of the above formula (II), 200 mmol of the compound of the above formula (III), 0.4 mmol of palladium acetate, to an appropriate amount of the organic solvent N,N-dimethylacetamide (DMA).150 mmol of tetra-n-butylammonium bromide and 150 mmol of sodium carbonate,Then stir to raise the temperature to 120 ¡ã C,And stirring the reaction at this temperature for 15 hours;After the reaction was completed, the reaction mixture was poured into a sufficient amount of ethyl acetate.After washing with saturated brine, the organic layer and the aqueous layer were separated.After the aqueous layer is sufficiently extracted with ethyl acetate,The combined organic layers (i.e., the organic layer washed with saturated brine and organic layer extracted from ethyl acetate) were dried over anhydrous Na2SO?The residue was eluted by flash column chromatography (a mixture of petroleum ether and ethyl acetate in a ratio of 8:1 as eluent).The eluent was collected and evaporated to remove the eluent.Thereby obtaining a compound of the above formula (I) as a white solid,The yield was 87.8percent.

The synthetic route of 4387-36-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Wenzhou Medical University Affiliated The Second Hospital ? Wenzhou Medical University Affiliated Yuying Child Hospital; Wenzhou Medical University; Wang Zhiyi; Pan Chenwei; Chen Chan; Weng Jie; Wang Xianqin; Xu Tong; Wu He; (10 pag.)CN108250103; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

4387-36-4, name is 2-Iodobenzonitrile, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C7H4IN

S1: The reaction formula of this step is as follows.The specific reaction operation is: at room temperature,Adding 100 mmol of the compound of the above formula (III) to an appropriate amount of the organic solvent N,N-dimethylacetamide (DMA),175 mmol of the above compound of formula (IV), 0.6 mmol of palladium acetate,125 mmol of tetra-n-butylammonium bromide and 175 mmol of sodium carbonate, and then the temperature was raised to 110 C with stirring.And stirring the reaction at this temperature for 20 hours;After the reaction was completed, the reaction mixture was poured into a sufficient amount of ethyl acetate.After washing with saturated brine, the organic layer and the aqueous layer were separated.After the aqueous layer is sufficiently extracted with ethyl acetate,The organic layers are combined (ie, the organic layer washed with saturated brine and the organic layer obtained by ethyl acetate extraction).Dry with anhydrous Na2SO4 and distill under reduced pressure.The residue was eluted by flash column chromatography (a mixture of petroleum ether and ethyl acetate in a volume ratio of 8:1).The eluent was collected and evaporated to remove the eluent.Thus obtaining a compound of the above formula (II) as a white solid in a yield of 88.2%

The synthetic route of 4387-36-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Wenzhou Medical University Affiliated The Second Hospital ? Wenzhou Medical University Affiliated Yuying Child Hospital; Wenzhou Medical University; Wang Zhiyi; Weng Jie; Chen Chan; Wang Zhibin; Zhou Zhiliang; Ma Jianshe; Xu Tong; (18 pag.)CN108250162; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 4387-36-4, name is 2-Iodobenzonitrile, molecular formula is C7H4IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 2-Iodobenzonitrile

Example VI; tert.butyl[[1-(2-cyano-phenyl)-1H-indol-5-yl]-(3,5-dichloro-phenylsulphonyl)-amino]-acetate; 300 mg tert.butyl[(3,5-dichloro-phenylsulphonyl)-(1H-indol-5-yl)-amino]-acetate, 12 mg copper iodide and 307 mg potassium phosphate are placed in a flask. It is evacuated twice and filled with argon. Then 1 ml of toluene and 166 mg 2-iodo-benzonitrile are added. After the addition of 21 mul N,N’-dimethyl-trans-cyclohexanediamine the mixture is heated to 110¡ã C. for 8 hours. Then it is divided between water and ethyl acetate. The aqueous phase is extracted with ethyl acetate and the combined organic phases are dried on magnesium sulphate. The solvents are eliminated in vacuo and the residue is chromatographed on silica gel (cyclohexane/ethyl acetate 10:1 to 1:2).Yield: 266 mg (73percent of theory)Mass spectrum (ESI+): m/z=573 [M+NH4]+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4387-36-4, its application will become more common.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2010/93703; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 4387-36-4,Some common heterocyclic compound, 4387-36-4, name is 2-Iodobenzonitrile, molecular formula is C7H4IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Weigh 2.28 g of o-iodobenzonitrile and 1.13 g of phenylacetylene. Bis-triphenylphosphine palladium dichloride 140mg, 19 mg of cuprous iodide is dissolved in 250 mL of triethylamine. The reaction was carried out under nitrogen at 60 C for 12 h. Thin chromatography was used to detect the reaction process. After the reaction is completed, it is filtered with diatomaceous earth. Rotating off the solvent triethylamine, dry loading by column chromatography to obtain a pale yellow solid 1.86 g (yield 91%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Iodobenzonitrile, its application will become more common.

Reference:
Patent; Zhengzhou University; Chen Xiaolan; Sun Kai; Yu Bing; Qu Lingbo; Sun Yuanqiang; (8 pag.)CN108689892; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com