Electric Literature of 41253-01-4, These common heterocyclic compound, 41253-01-4, name is 3-Nitro-5-iodobenzotrifluoride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Into a 50 mL round bottom flask was placed the 1-iodo- 3-nitro-5- (trifluoromethyl)benzene (1 g, 3.15 mmol) , N- methylpiperazine (0.379g, 3.78 mmol), bis(dibenzylideneacetone)palladium(0.029 g, 0.0315 mmol), sodium tert-butoxide (0.424 g, 4.416 mmol), 2-dicyclohexyl- 2′- (N,N-dimethylamino)biphenyl (0.037 g, 0.094 mmol) , and toluene (25 mL) . Reaction was heated to 800C with stirring for 20 hours. Reaction was cooled to room temperature and water (1 mL) and ethyl acetate (10 mL) were added. The organic layer is separated, concentrated under reduced pressure and purified via silica column eluting with 0 to 20% methanol in dichloromethane. The title compound was obtained as an orange oil.
The synthetic route of 41253-01-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMGEN INC.; WO2006/44823; (2006); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com