Category: 41252-95-3

Bakherad, Mohammad; Bahramian, Bahram; Nasr-Isfahani, Hossein; Keivanloo, Ali; Doostmohammadi, Nesa published an article on January 31 ,2009. The article was titled 《Polystyrene-supported palladium(II) ethylenediamine complex: a highly active and recyclable catalyst for the synthesis of 2-benzylimidazo[2,1-b]pyridines through heteroannulation of acetylenic compounds》, and you may find the article in Journal of Heterocyclic Chemistry.HPLC of Formula: 41252-95-3 The information in the text is summarized as follows:

The polymer-supported palladium(II) ethylenediamine [PS-en-Pd(II)] complex is a highly active catalyst for the heterocyclization that takes place during the Sonogashira reaction between an aryl iodide and 2-amino-1-(2-propynyl)pyridinium bromide. This heterogeneous palladium catalyst can readily be recovered from the reaction medium by simple filtration and reused without a significant loss in its activity. In the experiment, the researchers used 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3HPLC of Formula: 41252-95-3)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.HPLC of Formula: 41252-95-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ivachtchenko, Alexandre; Golovina, Elena; Kadieva, Madina; Mitkin, Oleg; Tkachenko, Sergei; Okun, Ilya published their research in Bioorganic & Medicinal Chemistry on August 1 ,2013. The article was titled 《Synthesis of substituted diphenyl sulfones and their structure-activity relationship with the antagonism of 5-HT6 receptors》.Quality Control of 1-Chloro-4-iodo-2-nitrobenzene The article contains the following contents:

Substituted di-Ph sulfones were synthesized, and the structures were confirmed by NMR, LC-MS and X-ray crystallog. Their antagonistic activities towards 5-HT6 receptor were assessed in a cell-based functional assay. Di-Ph sulfone, in spite of being the smallest and simplest known sulfonyl-containing 5-HT6R antagonist, showed a strong potency (Ki = 1.6 μM). Its derivative with a methylamine substituent, [N-methyl-2-(phenylsulfonyl)aniline], was ∼66-times as active as di-Ph sulfone (Ki = 24.3 nM). Addition of a piperazinyl moiety in the para-position relative to the sulfonyl group in N-methyl-2-(phenylsulfonyl)-5-piperazin-1-ylaniline led to a further 150-fold increase in potency (Ki = 0.16 nM) to block the serotonin-induced response of HEK-293 cells that were stably transfected with the human recombinant 5-HT6 receptor. In the experimental materials used by the author, we found 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Quality Control of 1-Chloro-4-iodo-2-nitrobenzene)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Quality Control of 1-Chloro-4-iodo-2-nitrobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Simple method for determining of the isokinetic temperature value for the SNAr reactions in solution》 were Vlasov, Vladislav M.. And the article was published in Journal of Physical Organic Chemistry in 2018. Recommanded Product: 1-Chloro-4-iodo-2-nitrobenzene The author mentioned the following in the article:

The changes of the free energy of activation δΔG≠exp and the activation entropy δΔS≠ in the framework of the isokinetic relationship δΔG≠exp vs. (Tiso – Texp) δΔS≠ were explored quant. to predict the isokinetic temperature Tiso for the aromatic nucleophilic substitution reactions in solution The experimental process involved the reaction of 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Recommanded Product: 1-Chloro-4-iodo-2-nitrobenzene)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Recommanded Product: 1-Chloro-4-iodo-2-nitrobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Synthesis of novel 6-(substituted benzyl)imidazo[2,1-b][1,3]thiazole catalyzed by polystyrene-supported palladium(II) ethylenediamine complex》 was published in Journal of the Brazilian Chemical Society in 2009. These research results belong to Bakherad, Mohammad; Keivanloo, Ali; Bahramian, Bahram; Kamali, Taghi A.. Computed Properties of C6H3ClINO2 The article mentions the following:

Sonogashira coupling reaction of 2-amino-3-(2-propynyl)-1,3-thiazolium bromide with various aryl iodides RI (R = 2-O2NC6H4, 4-Cl-2-O2NC6H4, etc.) catalyzed by polymer-supported palladium(II) ethylenediamine complex, [PS-en-Pd(II)] gave the title compounds I. This heterogeneous palladium catalyst is efficient, stable, and recyclable. In the experiment, the researchers used 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Computed Properties of C6H3ClINO2)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Computed Properties of C6H3ClINO2Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Iodination and iodo compounds. IV. Effect of substituents and solvent composition on the rate of aromatic iodination by the triiodine cation》 were Arotsky, Judah; Darby, A. Carl; Hamilton, John B. A.. And the article was published in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1973. Application of 41252-95-3 The author mentioned the following in the article:

The rate and products of the reaction of deactivated substituted benzenes (e.g., 4-ClC6H4CO2h) and I3+ in H2SO4 were studied. The rate constants were correlated by the electrophilic substituent constants σ+ to give the reaction constant ρ = -6.4. The kinetic isotope effect for the iodination of benzoic acid was kH/kD = 2. The rate of iodination increased as the proportion of H2O in the solvent increased. The results came from multiple reactions, including the reaction of 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Application of 41252-95-3)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Application of 41252-95-3 Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2017,Chemical Communications (Cambridge, United Kingdom) included an article by Yang, Xinglin; Shan, Gang; Yang, Zimo; Huang, Guiyi; Dong, Guoqiang; Sheng, Chunquan; Rao, Yu. Related Products of 41252-95-3. The article was titled 《One-pot synthesis of quaternary carbon centered cyclobutanes via Pd(II)-catalyzed cascade C(sp3)-H activations》. The information in the text is summarized as follows:

A novel approach toward quaternary carbon centered cyclobutanes through Pd(II)-catalyzed sequential intramol. methylene C-H alkylation and intermol. methine C-H bond arylation, alkenylation, alkylation, alkynylation, allylation, benzylation or alkoxylation is described. These quaternary carbon centered cyclobutanes could be further diversified through Pd(II)-catalyzed γ-C(sp3)-H bond activations. The synthetic utility of this novel approach was exemplified by its application to the synthesis of a bioactive small mol. Thus, e.g., cascade intramol. C-H alkylation/C-H arylation of 6-bromohexanamide containing the 8-aminoquinoline directing group (I) with 4-iodoacetophenone in presence of Pd(OAc)2/Ag2CO3 afforded cyclobutane II (75% isolated). In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Related Products of 41252-95-3)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Related Products of 41252-95-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Pd-Catalyzed Heterocyclization During Sonogashira Coupling: Synthesis of 3-Aryl-substituted Imidazo[2,1-b]thiazoles》 were Bakherad, Mohammad; Keivanloo, Ali; Nasr-Isfahani, Hossein; Raeissi, Mersad. And the article was published in Phosphorus, Sulfur and Silicon and the Related Elements in 2011. Reference of 1-Chloro-4-iodo-2-nitrobenzene The author mentioned the following in the article:

The reaction of 4,5-diphenyl-2-propargylmercaptoimidazole with various aryl iodides catalyzed by Pd-Cu in the presence of triethylamine as base in DMF leads to the formation of 3-aryl-substituted imidazo[2,1-b]thiazoles, e.g, I. In the experiment, the researchers used 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Reference of 1-Chloro-4-iodo-2-nitrobenzene)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Reference of 1-Chloro-4-iodo-2-nitrobenzene Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 1-Chloro-4-iodo-2-nitrobenzeneOn October 31, 2016 ,《Pd-catalyzed coupling reaction of 6-hydroxy-2-(prop-2-yn-1-ylsulfanyl)pyrimidin-4(1H)-one with aryl iodides: efficient syntheses of new 3-benzylthiazolo[3,2-a]pyrimidinones》 appeared in Chemistry of Heterocyclic Compounds (New York, NY, United States). The author of the article were Keivanloo, Ali; Bakherad, Mohammad; Shahani, Taraneh; Amin, Amir Hossein. The article conveys some information:

An efficient synthetic protocol was developed for the preparation of 3-benzyl-7(5)-hydroxy-5(7)H-[1,3]thiazolo[3,2-a]pyrimidin-5(7)-ones from 6-hydroxy-2-(prop-2-yn-1-ylthio)pyrimidin-4(1H)-one and aryl iodides in the presence of Pd-Cu complex catalyst. This one-pot process provides a simple and direct method for the synthesis of new thiazolo[3,2-a]pyrimidinones in good to high yields. In the experiment, the researchers used 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Reference of 1-Chloro-4-iodo-2-nitrobenzene)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Reference of 1-Chloro-4-iodo-2-nitrobenzene Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Quantum-chemical description of nucleophilic substitution reactions in the series of benzene derivatives in a localization approximation》 was written by Pankratov, A. N.. Application In Synthesis of 1-Chloro-4-iodo-2-nitrobenzene And the article was included in Journal of Structural Chemistry (Translation of Zhurnal Strukturnoi Khimii) on August 31 ,2001. The article conveys some information:

The energies of anion localization for reactions of 1-chloro-2-nitro-4-substituted benzenes with the methoxide ion -OCH3 were calculated The correlations between these energies and the relative rate of the nucleophilic substitution were established. The compounds studied were 1-Cl-2-NO2C6H3X, where X = H, CH3, CF3, CN, CHO, COCH3, COC6H5, CONH2, CON(CH3)2, COOCH3, N=NC6H5, N=NOC6H5, NO=NC6H5, N3, NO2, SCH3, SO2CH3, SO2C6H11, SO2C6H5, SO2N(CH3)C6H5, F, Cl, Br, and I. PM3 quantum-chem. calculations were performed using the MOPAC programs with full geometry optimization. Linear dependences of Inν on Λ- [Λ- = ΔΔHf, ΔΔGf (Gibbs energies)]. The correlation coefficients were rather high, especially when the exptl. data for the reaction in the polar medium were compared with the gas-phase reactivity index. For the reaction at 0°, the linear model is even more adequate if the exptl. and calculated data for 1-chloro-2-nitro-4-X-benzenes with X = N=NOC6H5, NO=NC6H5, N3, and F are excluded from consideration. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Application In Synthesis of 1-Chloro-4-iodo-2-nitrobenzene)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides.Application In Synthesis of 1-Chloro-4-iodo-2-nitrobenzene The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com