These common heterocyclic compound, 41070-12-6, name is 3-(3-Iodophenyl)acrylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 3-(3-Iodophenyl)acrylic acid
EXAMPLE 5(a) 3-Iodo-N-ethylcinnamamide Trans m-iodocinnamoyl chloride was prepared from trans m-iodocinnamic acid according to the standard procedure exemplified in Example 1. The acid chloride (6.6g) in dry toluene (200ml) was added with stirring to a solution of ethylamine (3.0g) in dry ether (300ml) at room temperature. The reaction mixture was heated at reflux for 1 hour and then worked up according to Example 2 to yield trans m-iodo-N-ethylcinnamamide (6.4g, 93% of theoretical), m.p. 116-117 C. as a white, crystalline material. NMR, IR and elemental analysis were consistent with this structure.
The synthetic route of 3-(3-Iodophenyl)acrylic acid has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Burroughs Wellcome Co.; US4041071; (1977); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com