Category: 39959-51-8

Reference of 39959-51-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 39959-51-8 name is (2-Iodophenyl)methanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: 2-/3-/4-Iodobenzyl chloride (1a-c) was dissolved in chloroform containing 1.1 equivalents of triethylamine. A solution of substituted benzoyl chloride (2a-g) in chloroform was added dropwise with stirring over 15min. The precipitate that formed was removed by filtration and the resulting filtrate was washed sequentially with water, 1N hydrochloric acid, 5% sodium carbonate and brine. The organic phase was dried over magnesium sulfate (anhyd.), filtered, evaporated to dryness and the resultant 2-/3/-4-substituted-N-(2/3/4-iodo)- benzylbenzamide 3a-i was recrystallized from alcohol. To obtain the corresponding 2-/4-iodo-N-substituted benzyl benzamide derivatives, the same procedure was followed, except that the 2-/4-iodobenzoyl chlorides 2h,2i and isomeric 2-/4-methoxybenzylamines 1d,1e were used. All new compounds 3a-i and 4a-d were characterized by 1H, 13C NMR spectrometry, and elemental analysis or LC-MS.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (2-Iodophenyl)methanamine, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 39959-51-8, name is (2-Iodophenyl)methanamine, A new synthetic method of this compound is introduced below., SDS of cas: 39959-51-8

Example 14 N4-[(trans-4-aminocyclohexyl)methyl]-N2-{2-[(2-aminophenyl)thio]benzyl}-5-nitropyrimidine-2,4-diamine To a solution of {4-[(2-chloro-5-nitro-pyrimidin-4-ylamino)-methyl]-cyclohexyl}-carbamic acid tert-butyl ester (100 mg, 0.26 mmol) in a mixture of CH2Cl2 (2 mL) and DMF (1 mL) were added 2-iodobenzylamine (192 mg, 0.82 mmol) and DIPEA (135 muL, 1.04 mmol). The reaction mixture was stirred at room temperature for 16 h and concentrated in vacuo. The resulting residue was diluted with EtOAc and washed with water (*3) and then with brine. The organic phase was dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by silica gel preparative TLC using 98:2 CH2Cl2:MeOH as an eluent to afford 97 mg (64%) of (4-{[2-(2-iodo-benzylamino)-5-nitro-pyrimidin-4-ylamino]-methyl}-cyclohexyl)-carbamic acid tert-butyl ester.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Boehringer Ingelheim Pharmaceuticals, Inc.; US2006/25433; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com