Category: 3930-83-4

Related Products of 3930-83-4,Some common heterocyclic compound, 3930-83-4, name is 2-Iodobenzamide, molecular formula is C7H6INO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

At room temperature,A reaction tube equipped with a stirring magnet was charged with 0.2 mmol of the compound represented by the formula (I-2)0.005 mmol catalyst Dichloro (p-cymene) ruthenium dimer ([RuCl2 (cymene)] 2),0.24 mmol cesium acetate,Then purged with nitrogen,Under nitrogen protection was added 1mL isopropanol,Stirring heated to 100 ,And reacted at this temperature for 20h.After the reaction,The reaction solution was cooled to room temperature,Filtration with a layer of silica gel funnel,Then, the solvent was distilled off under reduced pressure,The residue was purified by flash column chromatography (petroleum ether / ethyl acetate,Both volume ratio of 1: 1) purification,Thus, the target dehalogenation product represented by formula (III-2) was obtained.Calculated,The yield is 98%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Iodobenzamide, its application will become more common.

Reference:
Patent; Wenzhou University; Xia Yuanzhi; You Tingjie; (11 pag.)CN106588687; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 3930-83-4, name is 2-Iodobenzamide, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3930-83-4, Recommanded Product: 3930-83-4

General procedure: To a solution of 2-iodobenzamide (3) or 2-bromonicotinamide (6) (2.0 mmol) in DMSO (3 mL), was added aldehyde (2.2 mmol), NaN3 (260 mg, 4.0 mmol), CuBr (29 mg, 0.2 mmol), and l-proline (46 mg, 0.4 mmol). The reaction mixture was stirred at 80 C under air. After disappearance of the reactant (monitored by TLC), water (30 mL) was added to the mixture, and then extracted with ethyl acetate (15 mL) for three times. The extraction was washed with saturated NaCl solution, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel using petroleum ether/ethyl acetate (10:1 to 3:1) as the eluent to give the desired products 5 or 7.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Li, Ting; Chen, Minglu; Yang, Lei; Xiong, Zhengxin; Wang, Yongwei; Li, Fei; Chen, Dongyin; Tetrahedron; vol. 72; 6; (2016); p. 868 – 874;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

3930-83-4, name is 2-Iodobenzamide, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 2-Iodobenzamide

General procedure: 2-Iodobenzamide 1a (1.0 equiv.), 2-aminoisovaleric acid 2a (3.0 equiv.), Cs2CO3 (3.0 equiv.) and GO/Fe3O4-CuI (Cu+ 0.03 equiv.) were added to DMSO/ethylene glycol (60:1, v/v) in a round bottom flask. The reaction was monitored by TLC. The product was purified by column chromatography with petroleum ether/ethyl acetate (3:1, v/v) to give pure white solid 3a.

The synthetic route of 3930-83-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kong, Lu-Lu; Fan, Li-Yan; Chinese Chemical Letters; vol. 27; 6; (2016); p. 827 – 831;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 3930-83-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3930-83-4, name is 2-Iodobenzamide, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a 10 mL reaction tube were added MCM-41-L-Proline-CuBr(135 mg, 0.1 mmol), 2-halobenzamide 1 (1.0 mmol), benzylamine derivative 2 (2.0 mmol), K2CO3 (3.0 mmol), and DMSO (3 mL). The reaction mixture was stirred at 110 or 120 C under air for 6-12 h.After being cooled to room temperature, the reaction mixture was diluted with 20 mL of EtOAc, and filtered. The MCM-41-L-Proline-CuBr complex was washed with distilled water (2 5 mL) and ethanol (2 5 mL), and reused in the next run. The filtrate was washed with water (2 10 mL) and dried over MgSO4. After being concentrated in vacuo, the residue was purified by flash column chromatography on silica gel (petroleum ether/EtOAc 3:1 to 2:1)to afford the target product 3.

The chemical industry reduces the impact on the environment during synthesis 2-Iodobenzamide. I believe this compound will play a more active role in future production and life.

Reference:
Article; Yan, Nan; You, Chongren; Cai, Mingzhong; Journal of Organometallic Chemistry; vol. 897; (2019); p. 161 – 169;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 3930-83-4, The chemical industry reduces the impact on the environment during synthesis 3930-83-4, name is 2-Iodobenzamide, I believe this compound will play a more active role in future production and life.

General procedure: To a solution of 2-iodobenzamide (3) or 2-bromonicotinamide (6) (2.0 mmol) in DMSO (3 mL), was added aldehyde (2.2 mmol), NaN3 (260 mg, 4.0 mmol), CuBr (29 mg, 0.2 mmol), and l-proline (46 mg, 0.4 mmol). The reaction mixture was stirred at 80 C under air. After disappearance of the reactant (monitored by TLC), water (30 mL) was added to the mixture, and then extracted with ethyl acetate (15 mL) for three times. The extraction was washed with saturated NaCl solution, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel using petroleum ether/ethyl acetate (10:1 to 3:1) as the eluent to give the desired products 5 or 7.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodobenzamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Li, Ting; Chen, Minglu; Yang, Lei; Xiong, Zhengxin; Wang, Yongwei; Li, Fei; Chen, Dongyin; Tetrahedron; vol. 72; 6; (2016); p. 868 – 874;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 3930-83-4, A common heterocyclic compound, 3930-83-4, name is 2-Iodobenzamide, molecular formula is C7H6INO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 2-iodobenzamide (3a) (2.0 mmol) in DMSO(3 mL), was added NaN3 (260 mg, 4.0 mmol) and CuBr (29 mg,0.2 mmol). The reaction mixture was stirred at 50 C under air for4 h. Water (30 mL) was added to the mixture, and then extractedwith ethyl acetate (15 mL) for three times. The extraction waswashed with saturated NaCl solution, dried over anhydrous Na2SO4and concentrated under reduced pressure. The residuewas purifiedby column chromatography on silica gel using petroleum ether/ethyl acetate (8:1) as the eluent to give 8 as a light brown solid(269 mg, 83% yield).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Li, Ting; Chen, Minglu; Yang, Lei; Xiong, Zhengxin; Wang, Yongwei; Li, Fei; Chen, Dongyin; Tetrahedron; vol. 72; 6; (2016); p. 868 – 874;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 3930-83-4,Some common heterocyclic compound, 3930-83-4, name is 2-Iodobenzamide, molecular formula is C7H6INO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Substrate diversity:In the following reaction formulas, the substances shown in Table 6 were used as substrates (Substrates), and the yield of cyclic compounds was examined. The yields are also shown in Table 6. The amount of terephthalaldehyde used is 0.25 mmoL.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Iodobenzamide, its application will become more common.

Reference:
Patent; Machine: Enui?kemukyatto Co ., Ltd .; Kadoguchi Tai; Hattori Rin Hiroshi; Ueda Shun; Sawa Kan Yoshinari; Saji Ki Hiroshi Nao; (23 pag.)JP2018/24631; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3930-83-4, name is 2-Iodobenzamide belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 2-Iodobenzamide

General procedure: 2-iodobenzamide 1a (0.261 g, 1 mmol), 1,3-indanedione 2a (0.161 g, 1.1 mmol), cesium carbonate (0.39 g, 1.2 mmol) and copper sulfate pentahydrate (1.25 mg, 5 mumol) in a 100 mL high pressure tube, add 5 mL of water, and then seal the tube.The mixture was rapidly stirred in an oil bath previously heated to 130 C, and it was checked by a TLC sheet whether or not the reaction was completed. After the reaction was completed, the mixture was returned to room temperature, centrifuged, washed with water, and the tube was dried in an oven to obtain a pure product compound (1). Weighing 214 mg, the yield was 82%.

The synthetic route of 3930-83-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Yao Qingfa; (40 pag.)CN109748870; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 3930-83-4, name is 2-Iodobenzamide, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3930-83-4, Recommanded Product: 2-Iodobenzamide

General procedure: To a solution of 2-iodobenzamide (3) or 2-bromonicotinamide (6) (2.0 mmol) in DMSO (3 mL), was added aldehyde (2.2 mmol), NaN3 (260 mg, 4.0 mmol), CuBr (29 mg, 0.2 mmol), and l-proline (46 mg, 0.4 mmol). The reaction mixture was stirred at 80 C under air. After disappearance of the reactant (monitored by TLC), water (30 mL) was added to the mixture, and then extracted with ethyl acetate (15 mL) for three times. The extraction was washed with saturated NaCl solution, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel using petroleum ether/ethyl acetate (10:1 to 3:1) as the eluent to give the desired products 5 or 7.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Li, Ting; Chen, Minglu; Yang, Lei; Xiong, Zhengxin; Wang, Yongwei; Li, Fei; Chen, Dongyin; Tetrahedron; vol. 72; 6; (2016); p. 868 – 874;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 3930-83-4, name is 2-Iodobenzamide, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3930-83-4, Application In Synthesis of 2-Iodobenzamide

0.5 mmol (123.5 mg) of o-iodobenzamide, 0.05 mmol (8.0 mg) of copper sulfate, 0.1 mmol (19.8 mg) of 1,10-phenanthroline, sodium hydroxide 1 mmol (40 mg), phenylacetylene 0.6 mmol (61.2 mg), tetrabutylammonium bromide 0.1 mmol (32.2 mg), and water 2 mL were added to the reaction vessel. The reaction was carried out in an oil bath at 100 C for 24 hours, cooled to room temperature, the product was extracted with ethyl acetate and concentrated under reduced pressure. The product was purified by column chromatography to give a white solid product in 90% yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodobenzamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nanyang Normal College; Yu, Lintao; Wang, Huifang; Wang, Zhen; Zhang, Xu; Li, Ting; Yang, Yanbin; Chen, Shaohui; (10 pag.)CN106588767; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com