Category: 39115-95-2

Haristos, Demetrius A. published the artcileStudy of the hydrolysis of halo-substituted benzoic acid hydrazides, SDS of cas: 39115-95-2, the publication is Chimika Chronika (1981), 10(2), 163-74, database is CAplus.

Alk. hydrolysis kinetics of RC₆H₄CONHNH₂ (R = o-, m-, or p-F, Cl, Br, I) were spectrally determined at 40-60°. The reaction involves successive enolization and hydrolysis with rate constants ∼10³ s^-1 and ∼10⁵ mol L s^-1, resp. The enolization kinetics are slightly affected by temperature and substituents. The substituent, its position, and the temperature have a large effect on the hydrolysis.

Chimika Chronika published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, SDS of cas: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zorzi, Rodrigo Rocha published the artcileExploring 5-nitrofuran derivatives against nosocomial pathogens: synthesis, antimicrobial activity and chemometric analysis, Name: 4-Iodobenzohydrazide, the publication is Bioorganic & Medicinal Chemistry (2014), 22(10), 2844-2854, database is CAplus and MEDLINE.

The burden of nosocomial or health care-associated infection (HCAI) is increasing worldwide. According to the World Health Organization (WHO), it is severalfold higher in low- and middle-income countries. Considering multidrug-resistant infections, the development of new and more effective drugs is crucial. Here, two series (I and II) of 5-nitrofuran derivatives were designed, synthesized and assayed against microorganisms, including Gram-pos. and -neg. bacteria, and fungi. Sets I and II were composed by substituted-[N’-(5-nitrofuran-2-yl)methylene]benzhydrazide and 3-acetyl-5-(substituted-phenyl)-2-(5-nitro-furan-2-yl)-2,3-dihydro-1,3,4-oxadiazole compounds, resp. The selection of the substituent groups was based upon physicochem. properties, such as hydrophobicity and electronic effect. The compounds exhibited good activity against Staphylococcus aureus, Escherichia coli, and Enterococcus faecalis. It is noteworthy that the compound 4-butyl-[N’-(5-nitrofuran-2-yl)methylene]benzhydrazide had a similar MIC value to vancomycin, which is the reference drug for multidrug-resistant S. aureus infections.

Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C10H14O, Name: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palace-Berl, Fanny published the artcile5-Nitro-2-furfuriliden derivatives as potential anti-Trypanosoma cruzi agents: Design, synthesis, bioactivity evaluation, cytotoxicity and exploratory data analysis, Product Details of C7H7IN2O, the publication is Bioorganic & Medicinal Chemistry (2013), 21(17), 5395-5406, database is CAplus and MEDLINE.

The anti-Trypanosoma cruzi activity of 5-nitro-2-furfuriliden derivatives as well as the cytotoxicity of these compounds on J774 macrophages cell line and FN1 human fibroblast cells were investigated in this study. The most active compounds of series I and II were 4-butyl-[N’-(5-nitrofuran-2-yl) methylene] benzidrazide (3g; IC₅₀ = 1.05 μM ± 0.07) and 3-acetyl-5-(4-butylphenyl)-2-(5-nitrofuran-2-yl)-2,3-dihydro,1,3,4-oxadiazole (4g; IC₅₀ = 8.27 μM ± 0.42), resp. Also, compound 3g was more active than the standard drugs, benznidazole (IC₅₀ = 22.69 μM ± 1.96) and nifurtimox (IC₅₀ = 3.78 μM ± 0.10). Regarding the cytotoxicity assay, the 3g compound presented IC₅₀ value of 28.05 μM (SI = 26.71) against J774 cells. For the FN1 fibroblast assay, 3g showed IC₅₀ value of 98 μM (SI = 93.33). On the other hand, compound 4g presented a cytotoxicity value on J774 cells higher than 400 μM (SI >48), and for the FN1 cells its IC₅₀ value was 186 μM (SI = 22.49). Moreover, an exploratory data anal., which comprises hierarchical cluster (HCA) and principal component anal. (PCA), was carried out and the findings were complementary. The mol. properties that most influenced the compounds’ grouping were C log P and total dipole moment, pointing out the need of a lipophilic/hydrophilic balance in the designing of novel potential anti-T. cruzi mols.

Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Product Details of C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ishii, Marina published the artcileSynthesis, molecular modeling and preliminary biological evaluation of a set of 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazole as potential antibacterial, anti-Trypanosoma cruzi and antifungal agents, Recommanded Product: 4-Iodobenzohydrazide, the publication is Bioorganic & Medicinal Chemistry (2011), 19(21), 6292-6301, database is CAplus and MEDLINE.

A series of 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazole derivatives was synthesized and their activity screened in vitro against Staphylococcus aureus, Trypanosoma cruzi, and Candida albicans. The bioactivity was expressed as min. inhibitory concentration (MIC) for S. aureus strains, and as IC₅₀ of parasite population growth for T. cruzi. A mol. modeling approach was performed to establish qual. relationships regarding the biol. data and the compounds’ physicochem. properties. Oxadiazole derivatives I [R = OBu, OAc] were the most active compounds for S. aureus ATCC 25923 (MIC = 1.95 -1.25 μg/mL) and T. cruzi (IC₅₀ = 7.91 μM), resp. Also, a preliminary evaluation against C. albicans involving some compounds was performed and I [R = CF₃] was the most active compound (MIC = 3.28-2.95 μg/mL). In this preliminary study, all synthesized 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazole derivatives were active against all microorganisms tested.

Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Recommanded Product: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com