Category: 39115-95-2

Upadhyay, Prabhat Kumar published the artcileMicrowave assisted synthesis and evaluation of some substituted 1,3,4-oxadiazoles as free radical scavenger, Category: iodides-buliding-blocks, the publication is Journal of the Indian Chemical Society (2018), 95(6), 661-666, database is CAplus.

A series of 5-(4-substituted phenyl)-1,3,4-oxadiazoles I [R = Me, Br, OH, etc.] was synthesized from 4-substituted benzoic acid hydrazides and carbon disulfide. Structures of the synthesized compounds were confirmed on the basis of IR, ¹³C NMR, mass spectral methods and elemental anal. The compounds were screened for antioxidant activities using hydrogen peroxide scavenging method comparing with ascorbic acid as standard antioxidant. The results revealed that the compounds possess significant free radical scavenging activities, among them compound I [R = OH] showed highest scavenging activity.

Journal of the Indian Chemical Society published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C12H25Br, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Qu-xiang published the artcileSynthesis and characterization of acylthiosemicarbazides containing D-acetylglucosamine, Quality Control of 39115-95-2, the publication is Huaxue Shiji (2015), 37(2), 117-121, database is CAplus.

2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl isothiocyanat, e. g., I, was synthesized through following steps, acylation, chlorination and isothiocyanate with D-glucosamine hydrochloride as starting material. The reaction of 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl isothiocyanate with various hydrazides obtained 12 novel title compounds The structures were confirmed by IR, ¹HNMR and ESI-MS, and all glycosyl derivatives kept the original β-configuration.

Huaxue Shiji published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Quality Control of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Xi-cun published the artcileSynthesis of 2-aryl-5-[5′-(4”-chlorophenyl)-2′-furyl]-1,3,4-oxadiazoles under microwave irradiation, Synthetic Route of 39115-95-2, the publication is Xibei Shifan Daxue Xuebao, Ziran Kexueban (2004), 40(4), 49-51, database is CAplus.

2-Aryl-5-[5′-(4”-chlorophenyl)-2′-furyl]-1,3,4-oxadiazoles is synthesized by cyclization of 5-(4′-chlorophenyl)-2-furancarboxylic acid and aroyl hydrazines in the presence of phosphorus oxychloride under the condition of microwave irradiation This synthetic strategy compared with traditional method has advantages of high yield, elevating reaction rate and simple work-up procedure.

Xibei Shifan Daxue Xuebao, Ziran Kexueban published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C3H5BN2O2, Synthetic Route of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Xicun published the artcileSynthesis of substituted 1,3,4-oxadiazoles under microwave irradiation, COA of Formula: C7H7IN2O, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (2006), 181(3), 627-630, database is CAplus.

A series of substituted 1,3,4-oxadiazoles were synthesized by the cyclization of 2,6-pyridine dicarboxylic acid, 5-(4′-carboxyl-phenyl)-2-furanylcarboxylic acid, or p-phthalic acid, and aryl hydrazines in the presence of phosphorus oxychloride under the condition of microwave irradiation

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C6H4ClNO2, COA of Formula: C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Xicun published the artcileAn expeditious and solvent-free approach to substituted bis-thioureas and bis-thiosemicarbazides, COA of Formula: C7H7IN2O, the publication is Journal of Chemical Research (2005), 791-792, database is CAplus.

An expeditious, high-yield and green approach to substituted bis-thioureas and bis-thiosemicarbazides by grinding the mixture of pyridine-2,6-dicarbonyl dichloride with ammonium thiocyanate and aryl amines or aroyl hydrazines at room temperature under solvent-free condition via one-pot procedure is described.

Journal of Chemical Research published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C4H10O2, COA of Formula: C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liu, Wei-wei published the artcileSynthesis, characterization, and biological evaluation of some novel glycosyl 1,3,4-thiadiazole derivatives as acetylcholinesterase inhibitors, Formula: C7H7IN2O, the publication is Heterocycles (2015), 91(2), 275-286, database is CAplus.

The corresponding 4-substituted glycosyl thiosemicarbazide derivatives were obtained by the reaction of glycosyl isothiocyanate with various hydrazides. Further cyclization with the system of p-TsCl/TEA led to the formation of N-glycosyl-5-substituted 1,3,4-thiadiazole-2-amine. Subsequent removal of the acetyl groups were conducted using the system of NaOMe/MeOH. The chem. structures of all new products were confirmed by IR, 1H NMR and ESI-HRMS. The acetylcholinesterase (AChE) inhibitory activities of those compounds were tested by Ellman’s method. Among them, the compound I possessed the best acetylcholinesterase-inhibition activity with IC₅0 of 18.38 ± 0.89 μM.

Heterocycles published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Formula: C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liu, Weiwei published the artcileSynthesis of novel glycosyl 1,3,4-oxadiazole derivatives, Quality Control of 39115-95-2, the publication is Heterocyclic Communications (2014), 20(6), 333-338, database is CAplus.

A convenient and practical protocol was developed to synthesize glycosyl 1,3,4-oxadiazoles from D-glucosamine with good to excellent yields. The key step involved p-TsCl/pyridine-mediated cyclization under mild conditions. Subsequent removal of the acetyl groups in the last step, conducted using the system of NaOMe/MeOH, gave the desired N-acetyl-D-glucosamine 1,3,4-oxadiazole derivatives

Heterocyclic Communications published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Quality Control of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

El Ashry, E. S. H. published the artcileThe scope of the reactions of hydrazines and hydrazones. Part VI. Reaction of hydrazines with dimedone, Computed Properties of 39115-95-2, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1978), 16B(10), 871-5, database is CAplus.

The reactions of dimedone (I) with hydrazines were studied. I and p-tolylhydrazine gave II (R = NHNHC₆H₄Me-p), which was deprotonated to give II (R = N:NC₆H₄Me-p). With excess p-tolylhydrazine, I gave III (Z¹ = Z³ = NNHC₆H₄Me-p, Z² = O) which was identified as its 2-p-nitrobenzoylhydrazone and III (Z¹-Z³ = NNHC₆H₄Me-p). Reactions of I and II (R = NHNHR¹, N:NR¹; R¹ = Ph, C₆H₄Me-p) with R²C₆H₄CONHNH₂ (R² = H, Me, OMe, Cl, Br, I, OH, NO₂) gave the corresponding hydrazones. Reaction of I with semicarbazide, thiosemicarbazide and gluconylhydrazines gave the monohydrazones.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Computed Properties of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Makane, Vitthal B. published the artcileNovel 1,3,4-oxadiazoles as antitubercular agents with limited activity against drug-resistant tuberculosis, Safety of 4-Iodobenzohydrazide, the publication is Future Medicinal Chemistry (2019), 11(6), 499-510, database is CAplus and MEDLINE.

In recent times, heterocyclic chemotypes are being explored for the development of new antimycobacterials that target the drug-resistant tuberculosis. Here, we are disclosing the 5-substitued 2-mercapto-1,3,4-oxadiazoles I (R₁ = Ph, 2-BrC₆H₄, 4-OHC₆H₄, etc.) as potent antitubercular agents. A small library of 2-mercapto-1,3,4-oxadiazoles I was synthesized using various acids. The compounds were evaluated for antituberculosis activity against M. tuberculosis H37Rv. Compound I (R₁ = 4-OHC₆H₄) was identified as antitubercular lead with MIC of 0.6μg/mL against M. tuberculosis H37Rv. This compound was nontoxic to CHO-K1 cells and showed selectivity index of 39. Of note, I (R₁ = 4-OHC₆H₄) showed antitubercular activity against pre-extensively drug-resistant clin. isolate of Mycobacterium with MIC of 2μg/mL. This study provides potent antitubercular agent which can be further optimized to discover novel antibiotics.

Future Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Safety of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kratky, Martin published the artcileIodinated 1,2-diacylhydrazines, benzohydrazide-hydrazones and their analogues as dual antimicrobial and cytotoxic agents, Category: iodides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry (2021), 116209, database is CAplus and MEDLINE.

Here in, authors synthesized and screened twenty-two iodinated hydrazide-hydrazones I (R¹ = H, Me, t-Bu, etc.; R² = 2-OH, 4-OH), ten 1,2-diacylhydrazines II (R = H, t-Bu, CF₃, etc.)and their three reduced analogs for their antibacterial, antifungal, and cytotoxic properties. Hydrazide-hydrazones were prepared by condensation of 4-substituted benzohydrazides with 2-/4-hydroxy-3,5-diiodobenzaldehydes, diacylhydrazines from identical benzohydrazides and 3,5-diiodosalicylic acid via its chloride. These compounds were investigated in vitro against eight bacterial and eight fungal strains. The derivatives were found potent antibacterial agents against Gram-pos. cocci including methicillin-resistant Staphylococcus aureus with the lowest values of min. inhibitory concentrations (MIC) of 7.81μM. Four compounds inhibited also human pathogenic fungi (MIC of ≥ 1.95μM). The derivatives had different degrees of cytotoxicity for HepG2 and HK-2 cell lines (IC₅₀ values from 11.72 and 26.80μM, resp.) and normal human cells exhibited lower sensitivity. The apoptotic effect was also investigated. In general, the presence of 3,5-diiodosalicylidene scaffold in compd I (R² = 2-OH) is translated into enhanced both antimicrobial and cytotoxic properties whereas its 4-hydroxy isomers I (R² = 4-OH) share a low biol. activity. Compounds II have a non-homogeneous activity profile. Focusing on 4-substituted benzohydrazide part, the presence of an electron-withdrawing group (F, Cl, CF₃, NO₂) was found to be beneficial.

Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com