Category: 39115-95-2

Jorge, Salomao Doria published the artcileLigand-based design, synthesis, and experimental evaluation of novel benzofuroxan derivatives as anti-Trypanosoma cruzi agents, Computed Properties of 39115-95-2, the publication is European Journal of Medicinal Chemistry (2013), 200-214, database is CAplus and MEDLINE.

A set of substituted [N’-(benzofuroxan-5-yl)methylene]benzohydrazides (I; R¹ = H, Me, NH₂, CF₃, etc.; R² = H, Cl, CF₃; R³ = H, Cl), previously designed and synthesized, was exptl. assayed against Trypanosoma cruzi, the etiol. agent of Chagas’ disease, one of the most neglected tropical diseases. Exploratory data anal., Hansch approach and VolSurf formalism were applied to aid the ligand-based design of novel anti-T. cruzi agents. The best 2D-QSAR model showed suitable statistical measures [n = 18; s = 0.11; F = 42.19; R² = 0.90 and Q² = 0.77 (SDEP = 0.15)], and according to the optimum 3D-QSAR model [R² = 0.98, Q² = 0.93 (SDEP = 0.08)], three latent variables explained 62% of the total variance from original data. Steric and hydrophobic properties were pointed out as the key for biol. activity. Based upon the findings, six novel benzofuroxan derivatives I (R¹ = Pr, Me₂CH, Me₃C, Bu, OPr, OBu; R² = R³ H) were designed, synthesized, and in vitro assayed to perform the QSAR external prediction. Then, the predictability for the both models, 2D-QSAR (R_pred² = 0.91) and 3D-QSAR (R_pred² = 0.77), was exptl. validated, and compound I (R¹ = Pr; R² = R³ = H) was identified as the most active anti-T. cruzi hit (IC₅₀ = 3.04 μM).

European Journal of Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Computed Properties of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Watanabe, Hiroyuki published the artcileSynthesis and biological evaluation of radioiodinated 2,5-diphenyl-1,3,4-oxadiazoles for detecting β-amyloid plaques in the brain, Recommanded Product: 4-Iodobenzohydrazide, the publication is Bioorganic & Medicinal Chemistry (2009), 17(17), 6402-6406, database is CAplus and MEDLINE.

This paper describes the synthesis and biol. evaluation of a new series of 2,5-diphenyl-1,3,4-oxadiazole (1,3,4-DPOD) derivatives for detecting β-amyloid plaques in Alzheimer’s brains. The affinity for β-amyloid plaques was assessed by an in vitro binding assay using pre-formed synthetic Aβ42 aggregates. The new series of 1,3,4-DPOD derivatives showed affinity for Aβ42 aggregates with K _i values ranging from 20 to 349 nM. The 1,3,4-DPOD derivatives clearly stained β-amyloid plaques in an animal model of Alzheimer’s disease, reflecting the affinity for Aβ42 aggregates in vitro. Compared to 3,5-diphenyl-1,2,4-oxadiazole (1,2,4-DPOD) derivatives, they displayed good penetration of and fast washout from the brain in biodistribution experiments using normal mice. The novel radioiodinated 1,3,4-DPOD derivatives may be useful probes for detecting β-amyloid plaques in the Alzheimer’s brain.

Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C28H41N7O4, Recommanded Product: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

El Ashry, El Sayed H. published the artcileHeterocycles from carbohydrates precursors. Part XXIII. (2-Quinoxalinon-3-yl)glyoxal derivatives from L-ascorbic acid, Safety of 4-Iodobenzohydrazide, the publication is Carbohydrate Research (1980), 83(1), 79-84, database is CAplus.

Reaction of dehydro-L-ascorbic acid with o-phenylenediamine, followed by aroylhydrazines, gave 3-[1-(aroylhydrazono)-L–threo-2,3,4-trihydroxybutyl]-2-quinoxalinones (I; R = Ph, substituted Ph, 4-pyridyl) which, upon periodate oxidation, gave 3-[1-(aroylhydrazono)glyoxal-1-yl]-2-quinoxalinones. Reaction of 3-[1-(benzoylhydrazono)glyoxal-1-yl]-2-quinoxalinone with benzoylhydrazine gave 3-[1,2-bis(benzoylhydrazono)glyoxal-1-yl]-2-quinoxalinone, and its reduction gave 3-[1-(benzoylhydrazono)-2-hydroxyethyl]-2-quinoxalinone.

Carbohydrate Research published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Safety of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

El Ashry, E. S. H. published the artcileScope of reactions of hydrazines and hydrazones. Part X. Bis(aroylhydrazones) and phenylacetylhydrazones of vic-dicarbonyl compounds and their oxidation to 1,2,3-triazoles, Application In Synthesis of 39115-95-2, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1980), 19B(7), 612-15, database is CAplus.

Treating acenaphthenequinone with hydrazines gave 40-70% monohydrazones I (Z = O, R = Ph, o-, m-, p-MeC₆H₄ m-, p-ClC₆H₄, p-IC₆H₄, p-MeOC₆H₄, p-O₂NC₆H₄, 3-, 4-pyridyl). Oxidative cyclization of I (R = Ph, Z = NNHBz) by Pb(OAc)₄ gave triazole II. The (phenylacetyl)hydrazones of benzil and phenylglyoxal were similarly prepared and cyclized to the triazoles.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Application In Synthesis of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Khan, Madiha Sahar published the artcileSynthesis of novel indenoquinoxaline derivatives as potent α-glucosidase inhibitors, Application of 4-Iodobenzohydrazide, the publication is Bioorganic & Medicinal Chemistry (2014), 22(3), 1195-1200, database is CAplus and MEDLINE.

A series of new N-(11H-Indeno[1,2-b]quinoxalin-11-ylidene)benzohydrazide derivatives were synthesized and evaluated for their α-glucosidase inhibitory activity. Some of the synthesized compounds showed significant α-glucosidase inhibitory activity as compared to acrabose, a standard drug used to treat type II diabetes. Structures of the synthesized compounds were determined by using FT-IR, ¹H NMR, ¹³C NMR, mass spectrometry and elemental anal. techniques.

Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Application of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nisa, Mehr-un published the artcileSynthesis of novel 5-(aroylhydrazinocarbonyl)escitalopram as cholinesterase inhibitors, Quality Control of 39115-95-2, the publication is European Journal of Medicinal Chemistry (2017), 396-406, database is CAplus and MEDLINE.

A novel series of 5-(aroylhydrazinocarbonyl)escitalopram were designed, synthesized and tested for their inhibitory potential against cholinesterases. N’-(3-Chlorobenzoyl)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbohydrazide is the most potent compound of this series having IC₅₀ 1.80 ± 0.11 μM for acetylcholinesterase (AChE) inhibition. For the butyrylcholinesterase (BChE) inhibition, N’-(2-Bromobenzoyl)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbohydrazide was the most active compound of the series with IC₅₀ 2.11 ± 0.31 μM. Structure-activity relation illustrated that mild electron donating groups enhanced enzyme inhibition while electron withdrawing groups reduced the inhibition except o-NO₂. However, size and position of the substituents affected enzyme inhibitions. In docking study of AChE, the ligands N’-(3-Chlorobenzoyl)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbohydrazide, N’-(4-Chlorobenzoyl)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbohydrazide and N’-(2-Bromobenzoyl)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbohydrazide showed the scores of 5874, 5756 and 5666 and ACE of -64.92,-203.25 and -140.29 kcal/mol, resp. In case of BChE, ligands 71, 76 and 81 depicted high scores 6016, 6150 and 5994 with ACE values -170.91, -256.84 and -235.97 kcal/mol, resp.

European Journal of Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Quality Control of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mehr-un-Nisa published the artcileSynthesis of novel triazoles and a tetrazole of escitalopram as cholinesterase inhibitors, Application In Synthesis of 39115-95-2, the publication is Bioorganic & Medicinal Chemistry (2015), 23(17), 6014-6024, database is CAplus and MEDLINE.

A novel series of escitalopram triazoles I and a tetrazole II have been synthesized and subjected to a study to establish the inhibitory potential of these compounds toward acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Some selectivity in inhibition has been observed The compound I (R = 4-Cl, IC₅₀, 6.71 ± 0.25 μM) and I (R = 2-Me, 70, IC₅₀, 9.52 ± 0.23 μM) escitalopram triazole derivatives depicted high AChE inhibition, while compound I (R = 2-F, IC₅₀ = 4.52 ± 0.17 μM) and I (r = 4-F, IC₅₀ = 5.31 ± 0.43 μM) have found to be excellent BChE inhibitors. It has also been observed that ortho, meta and para substituted electron donating groups increase the inhibition, while electron withdrawing groups reduce the inhibition. Docking analyses of inhibitors with AChE have depicted the binding energies for I (R = 2-Me, 4-Cl) as ΔG_bind -6.42 and -6.93 kcal/mol, resp., while ligands I (R = 2-F, 4-F) have shown the binding affinity ΔG_bind -9.04 and -8.51 kcal/mol, resp., for BChE.

Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Application In Synthesis of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Haristos, Demetrius A. published the artcileKinetic study of the oxidation of benzoic acid hydrazide by mercury(II) acetate, SDS of cas: 39115-95-2, the publication is Chimika Chronika (1982), 11(3), 193-200, database is CAplus.

The oxidation kinetics of RC₆H₄CONHNH₂ (I; R = H, p-F, m-Cl, p-Cl, m-Br, p-Br, p-iodo, m-MeO, p-MeO, m-NO₂) by Hg(OAc)₂ are not dependent on inductive or resonance effects. Two possible mechanisms can explain the kinetics. In one of these, the NH₂ group N atom is involved as an electron donor in a complex with Hg²⁺. This electron transfer reaction leads to the C-N bond cleavage which gives RC₆H₄C⁺(O) and •NHNH₂. The alternative mechanism involves a 4-electron transfer in which RC₆H₄CON:NH is an intermediate.

Chimika Chronika published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, SDS of cas: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Gupta, Jeetendra Kumar published the artcileAntimicrobial screening of some newly synthesized triazoles, Category: iodides-buliding-blocks, the publication is Journal of Pure & Applied Microbiology (2017), 11(2), 1067-1077, database is CAplus.

4-Iodobenzoic acid was taken as initial reactant material which was converted into Me ester then to hydrazide and finally into triazole via dithiocarbazate salt. This triazole was treated with chloroacetyl chloride and further with secondary amines which yielded amine linked triazoles I [R = pyrrolidin-1-yl, 2-methyl-piperidin-1-yl, 4-benzyl-1-piperazinyl, etc.]. The synthesized compounds were screened for their antibacterial and antifungal activities. The study was carried out against four bacteria and three fungi by disk diffusion method using ciprofloxacin and fluconazole as reference drug for antibacterial and antifungal activities resp. Among the synthesized compounds, compounds I [R = 4-methyl-1-piperazinyl, 4-benzyl-1-piperazinyl] showed highest antibacterial and antifungal activities.

Journal of Pure & Applied Microbiology published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Upadhyay, Prabhat K. published the artcileSynthesis and antimicrobial screening of some 1,3,4-oxadiazoles and their molecular properties prediction through ‘rule of five’, SDS of cas: 39115-95-2, the publication is Pakistan Journal of Pharmaceutical Sciences (2019), 32(3), 1025-1032, database is CAplus and MEDLINE.

In the current study, a series of 5-(4-substituted phenyl)-1,3,4-oxadiazole-2-thiols I (R = F, Cl, Br, I, Me, OMe, OH, OEt) were prepared from 4-substituted benzoic acid hydrazides 4-RC₆H₄C(O)NHNH₂. All these synthesized compounds I were investigated for their antibacterial activities against bacterial strains i.e. Staphylococcus aureus, Bacillus substilis, Escherichia coli and Pseudomonas aeruginosa. The strains, Aspergillus niger and Candida albicans were also examined for antifungal screening. The zone of inhibition was measured and percentage inhibition was calculated by comparing with standard drug. The min. inhibitory concentrations (MICs) of potent synthesized compounds I were determined Then, all the synthesized compounds I were computed to assess the drug-like properties through Lipinski’s rule of five. The results of in-vitro assay showed that the compounds I (R = F, Cl, I) possess significant antibacterial activity, whereas compounds I (R = F, OMe, OEt) possess significant antifungal activity. The predicted drug likeness score of all these compounds I were also meritorious among 1,3,4-oxadiazoles. The results recommended that these compounds I might be used in future to generate derivatives for emergent antimicrobial agents with improved pharmacokinetic profile.

Pakistan Journal of Pharmaceutical Sciences published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C18H28B2O4, SDS of cas: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com