Category: 39115-95-2

Zhang, Ziyi published the artcileSynthesis and anticancer activity of N-carbamoyl-N’-(1-oxy-2,2,5,5-tetramethylpyrrolin-3-yl)urea compounds, Recommanded Product: 4-Iodobenzohydrazide, the publication is Gaodeng Xuexiao Huaxue Xuebao (1989), 10(12), 1202-7, database is CAplus.

By the addition of 1-oxy-2,2,5,5-tetramethylpyrroline-3-isocyanate, synthesized by seven steps, to substituted hydrazides with biol. activity, nineteen title compounds were synthesized. The characteristics of ESR, IR and mass spectra of some were discussed. The preliminary experiment showed that these compounds possess an inhibiting activity on L7712-leukemia cell and ascitic hepatoma.

Gaodeng Xuexiao Huaxue Xuebao published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C14H28BNO4, Recommanded Product: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Su, Bo published the artcileDiversity-Oriented Synthesis through Rh-Catalyzed Selective Transformations of a Novel Multirole Directing Group, Product Details of C7H7IN2O, the publication is ChemCatChem (2015), 7(18), 2986-2990, database is CAplus.

In the context of transition-metal-catalyzed C-H functionalization, directing-group strategy was developed for the improvement of chem. reactivity and selectivity. Recently, to avoid the inherent limitations of traditional mono-role directing groups, a dual-role oxidizing-directing-group strategy was developed, in which the directing group acts both as directing group and oxidant. Herein, the authors report a multirole directing group, which possesses multiple reactive sites, exhibits unique reactivity and selectivity, and leads to four different types of products from a single starting material through rhodium-catalyzed C-H activation/alkyne annulation reactions. The excellent product diversity and regio- and redox selectivity were well controlled by the tuning of solvents and oxidants.

ChemCatChem published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C4H5F3N2O3S, Product Details of C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Xiao, Yufeng published the artcileDiscovery of histone deacetylase 3 (HDAC3)-specific PROTACs, Synthetic Route of 39115-95-2, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(68), 9866-9869, database is CAplus and MEDLINE.

Histone deacetylases (HDACs) are validated drug targets for cancer treatment. Increased HDAC isoenzyme selectivity and novel strategies to inhibit HDAC activity could lead to safer and more effective drug candidates. Nonetheless, it is quite challenging to develop isoenzyme-specific HDACi due to the highly conserved catalytic domain. We discovered XZ9002, a first-in-class HDAC3-specific PROTAC that potently degraded HDAC3. Importantly, XZ9002 is more effective to inhibit cancer cell proliferation than its proteolysis-inactive counterpart, suggesting HDAC3 degradation is a novel and promising anticancer approach.

Chemical Communications (Cambridge, United Kingdom) published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C4H3Cl2N3, Synthetic Route of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bagrov, F. V. published the artcile2-Diphenylphosphinoyloxybenzaldehyde 4-Nitrophenyl-, 4-Phenyl-1-phthalazinyl-, and Aroylhydrazones and Thiosemicarbazone, Application In Synthesis of 39115-95-2, the publication is Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) (2002), 38(9), 1309-1313, database is CAplus.

Condensation of aryl- and aroylhydrazines and thiosemicarbazide with 2-diphenylphosphinoyloxybenzaldehyde results in formation of the corresponding hydrazones and thiosemicarbazone. The products give rise to conformational equilibrium between rotational and Z,E isomers, which is strongly displaced toward the E,E’,Z” isomer and is determined by the nature of substituent in the hydrazine fragment.

Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Application In Synthesis of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Charistos, D. A. published the artcileSynthesis and UV and IR spectral study of some 2-aryl-Δ²-1,3,4-oxadiazoline-5-thiones, Formula: C7H7IN2O, the publication is Journal of Heterocyclic Chemistry (1994), 31(6), 1593-8, database is CAplus.

Twenty four 2-aryl-Δ²-1,3,4-oxadizoline-5-thiones (2) were synthesized and their UV and IR spectra were studied. Correlation between σ-Hammett constants of the aryl substituents and the differences in absorption maxima (Δν = ν₁-ν₂ in kK) of the electronic spectra of the deprotonated species were also evaluated. A new method for the synthesis of 2 (aryl = o-, m-, or p-aminophenyl) is also reported.

Journal of Heterocyclic Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Formula: C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Xanthopoulos, C. E. published the artcileStructural properties and potential reactivity of substituted 3-aroyldithiocarbazates, Formula: C7H7IN2O, the publication is Structural Chemistry (1994), 5(3), 147-54, database is CAplus.

The substituted 3-aroyldithiocarbazates I (X = H, halo, nitro, alkyl, etc.) were prepared The corresponding acid dissociation constants were determined potentiometrically. Semiempirical PM3 MO calculations suggest the existence of several tautomeric forms of the compounds Geometrical parameters, proton affinities, and static reactivity indexes have been examined Structural properties and protonation sites are well described by calculations The strong correlations between the pK_a values and the Hammett σ constants as well as the N(3) calculated proton affinities indicate that the N(3) atom is the most probable protonation site. The thermodn. of the protonation process are mainly controlled by HOMO-LUMO rather than electrostatic interactions. According to PM3 results, 3-aroyldithiocarbazic acid should be quite stable in the gas phase, while a mechanism for its decomposition in solution is proposed.

Structural Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C5H6BNO2, Formula: C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Valente, Sergio published the artcile1,3,4-Oxadiazole-Containing Histone Deacetylase Inhibitors: Anticancer Activities in Cancer Cells, Application of 4-Iodobenzohydrazide, the publication is Journal of Medicinal Chemistry (2014), 57(14), 6259-6265, database is CAplus and MEDLINE.

We describe 1,3,4-oxadiazole-containing hydroxamates and 2-aminoanilides as histone deacetylase inhibitors. Among them, N-hydroxy-3-(4-((5-(1-naphthylmethyl)-1,3,4-oxadiazol-2-yl)methyl)phenyl) acrylamide (1), N-hydroxy-4-((5-(1-naphthylmethyl)-1,3,4-oxadiazol-2-yl)methyl)benzamide (2), and N-(2-aminophenyl)-4-((5-(1-naphthylmethyl)-1,3,4-oxadiazol-2-yl)methyl)benzamide (3) were the most potent and selective against HDAC1. In U937 leukemia cells, (1) was more potent than vorinostat (SAHA) in inducing apoptosis, and (3) displayed cell differentiation with a potency similar to MS-275. In several acute myeloid leukemia (AML) cell lines, as well as in U937 cells in combination with doxorubicin, (3) showed higher antiproliferative effects than SAHA.

Journal of Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C14H10N2O, Application of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

dos Santos Filho, Jose Mauricio published the artcileStereoselective, solvent free, highly efficient synthesis of aldo- and keto-N-acylhydrazones applying grindstone chemistry, Name: 4-Iodobenzohydrazide, the publication is Green Chemistry (2017), 19(9), 2212-2224, database is CAplus.

A mild and efficient synthesis of N-acylhydrazones, e.g., I has been developed by applying a simple grindstone procedure leading to a library of 51 examples exhibiting a broad variety of structural features, 21 of them described for the first time in this paper. This methodol. works without any organic solvent under the catalysis of acetic acid at room temperature, promotes the formation of essentially pure crude products, and avoids tedious work-up and the use of harmful solvents, as well as energy consumption. In addition, it leads to the stereoselective formation of N-acylhydrazones, as supported by NMR anal.

Green Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Name: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Milovanovic, Vesna M. published the artcileGreen synthesis of benzamide-dioxoisoindoline derivatives and assessment of their radical scavenging activity – Experimental and theoretical approach, Application of 4-Iodobenzohydrazide, the publication is Tetrahedron (2020), 76(38), 131456, database is CAplus.

A series of benzamide-dioxoisoindoline derivatives I (Ar = Ph, 4-HOC₆H₄, 4-IC₆H₄, etc.) was obtained, starting from phthalic anhydride and different benzoyl hydrazides, by ultrasound irradiation in water as solvent and without any catalyst. Five obtained compounds have been reported in this study for the first time and crystal structure of compound I (3,4,5-MeOC₆H₂) was determined All compounds were subjected to exptl. determination of their antioxidative potential. DPPH test revealed that newly synthesized phenolic compounds I (Ar = 2,3-HOC₆H₃, 3,4-HOC₆H₃, 3,4,5-HOC₆H₂) are the best antioxidants. Addnl., probable radical scavenging pathway was analyzed for reactions of the most active compounds and some radicals that can be found in living cells.

Tetrahedron published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Application of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Milovanovic, Vesna published the artcileStructural characterization of benzoyl-1H-pyrazole derivatives obtained in lemon juice medium: Experimental and theoretical approach, HPLC of Formula: 39115-95-2, the publication is Journal of Molecular Structure (2019), 85-94, database is CAplus.

Simple, one-pot and low-cost reactions of acetylacetone with a variety of substituted benzoyl hydrazides in lemon juice, as eco-friendly medium, were performed. In reactions of benzoyl hydrazides with electron-donating groups on Ph ring, the 1-benzoyl-1H-pyrazole derivatives were obtained in short reaction time and in good to high yields. On the other hand, benzoyl hydrazides with electron-withdrawing groups reacted slower, yielding the mixture of 1-benzoyl-5-hydroxy-4,5-dihydro-1H-pyrazole and benzoyl-1H-pyrazole derivatives It is worth pointing out that two products, (2-chlorophenyl)(4,5-dihydro-5-hydroxy-3,5-dimethylpyrazol-1-yl)methanone and (4-iodophenyl)(3,5-dimethyl-1H-pyrazol-1-yl)methanone were reported for the first time. All obtained compounds were characterized using IR, UV-Vis and NMR, exptl. and theor., as well as with m.ps. Good agreement between exptl. and simulated IR, UV-Vis, ¹H and ¹³C NMR spectra was achieved. In addition, crystal structures and Hirshfeld surfaces anal. of (4,5-dihydro-5-hydroxy-3,5-dimethylpyrazol-1-yl)(4-iodophenyl)methanone were reported.

Journal of Molecular Structure published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, HPLC of Formula: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com