Category: 39115-95-2

Yokoyama, Takuya published the artcileIdentification of candidate molecular targets of the novel antineoplastic antimitotic NP-10, SDS of cas: 39115-95-2, the publication is Scientific Reports (2019), 9(1), 1-13, database is CAplus and MEDLINE.

We previously reported the identification of a novel antimitotic agent with carbazole and benzohydrazide structures: N’-[(9-ethyl-9H-carbazol-3-yl)methylene]-2-iodobenzohydrazide (code number NP-10). However, the mechanism(s) underlying the cancer cell-selective inhibition of mitotic progression by NP-10 remains unclear. Here, we identified NP-10-interacting proteins by affinity purification from HeLa cell lysates using NP-10-immobilized beads followed by mass spectrometry. The results showed that several mitosis-associated factors specifically bind to active NP-10, but not to an inactive NP-10 derivative Among them, NUP155 and importin β may be involved in NP-10-mediated mitotic arrest. Because NP-10 did not show antitumor activity in vivo in a previous study, we synthesized 19 NP-10 derivatives to identify more effective NP-10-related compounds HMI83-2, an NP-10-related compound with a Cl moiety, inhibited HCT116 cell tumor formation in nude mice without significant loss of body weight, suggesting that HMI83-2 is a promising lead compound for the development of novel antimitotic agents.

Scientific Reports published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C4H6O3, SDS of cas: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Zheng published the artcileMicrowave-accelerated solvent-free synthesis of 1,3,4-oxadiazoles using polymer supported dehydration reagent, Related Products of iodides-buliding-blocks, the publication is Synthetic Communications (2004), 34(16), 2981-2986, database is CAplus.

2-Aryl-5-(coumarin-3′-yl)-1,3,4-oxadiazoles are efficiently synthesized by microwave accelerated solvent-free procedure in high yield via the condensation of coumarin-3-carboxylic acid with (un)substituted benzoic acid hydrazides using poly(ethylene glycol) (PEG) supported dichlorophosphate as dehydration reagent.

Synthetic Communications published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liu, Congrong published the artcilePalladium/Copper Cocatalyzed Coupling Reaction of Aroyl Hydrazides with Indoles, SDS of cas: 39115-95-2, the publication is Chinese Journal of Chemistry (2016), 34(12), 1213-1217, database is CAplus.

An unprecedented palladium/copper cocatalyzed coupling reaction of indoles with simple aroyl hydrazides has been developed under aerobic conditions. A range of aroyl hydrazides underwent palladium/copper cocatalyzed oxidative arylation with indoles open to air in a 1:1 mixture of DMSO and nitromethane to give structurally diverse 2-arylindoles or 3-arylindoles in moderate to good yields. The reaction well tolerates a wide variety of functional groups such as alkoxy, halo, ester.

Chinese Journal of Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, SDS of cas: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yuan, Chen published the artcileDiscovery of [1,2,4]triazole derivatives as new metallo-β-lactamase inhibitors, Quality Control of 39115-95-2, the publication is Molecules (2020), 25(1), 56, database is CAplus and MEDLINE.

The emergence and spread of metallo-β-lactamase (MBL)-mediated resistance to β-lactam antibacterials has already threatened the global public health. A clin. useful MBL inhibitor that can reverse β-lactam resistance has not been established yet. We here report a series of [1,2,4]triazole derivatives and analogs, which displayed inhibition to the clin. relevant subclass B1 (Verona integron-encoded MBL-2) VIM-2. 3-(4-Bromophenyl)-6,7-dihydro-5H-[1,2,4]triazolo [3,4-b][1,3]thiazine (5l) manifested the most potent inhibition with an IC50 (half-maximal inhibitory concentration) value of 38.36μM. Investigations of 5l against other B1 MBLs and the serine β-lactamases (SBLs) revealed the selectivity to VIM-2. Mol. docking analyses suggested that 5l bound to the VIM-2 active site via the triazole involving zinc coordination and made hydrophobic interactions with the residues Phe61 and Tyr67 on the flexible L1 loop. This work provided new triazole-based MBL inhibitors and may aid efforts to develop new types of inhibitors combating MBL-mediated resistance.

Molecules published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C9H7N5O, Quality Control of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Han, Jie published the artcileSynthesis, liquid crystalline and photoluminescent properties of 1,3,4-oxadiazole derivatives: From calamitic monomers, H-Shaped dimers to calix[4]arene-based tetramers, Quality Control of 39115-95-2, the publication is Dyes and Pigments (2018), 234-241, database is CAplus.

A new class of calamitic 1,3,4-oxadiazole monomers H-shaped dimers , and calix [4]arene-based tetramer have been synthesized and characterized fully by means of ¹H NMR (proton NMR), ¹³C-NMR, high resolution mass spectroscopy (HRMS) and elemental anal., and the thermal properties and photoluminescent behaviors have been investigated systemically. All of the monomers display stable liquid crystalline properties with smectic and/or nematic mesophases determined by the electronic and steric nature of the terminal groups. In contrast, both the H-shaped dimers and the calix [4]arene based tetramer are not mesogenic, while they show specific recognition for Cu²⁺ through the fluorescent emission intensity quenching. The relationship between the mol. structures and properties has been discussed according to the mol. shapes.

Dyes and Pigments published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Quality Control of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Xu, F. Z. published the artcileDesign, synthesis, insecticidal activity and 3D-QSR study for novel trifluoromethyl pyridine derivatives containing an 1,3,4-oxadiazole moiety, SDS of cas: 39115-95-2, the publication is RSC Advances (2018), 8(12), 6306-6314, database is CAplus and MEDLINE.

A series of trifluoromethyl pyridine derivatives containing 1,3,4-oxadiazole moiety I (R = H, 3-Cl-4-CH₃, 3-CH₃, etc.) was designed, synthesized and bio-assayed for their insecticidal activity. The result of bio-assays indicated the synthesized compounds exhibited good insecticidal activity against Mythimna separata and Plutella xylostella, most of the title compounds show 100% insecticidal activity at 500 mg L^-1 and >80% activity at 250 mg L^-1 against the two pests. Compounds I (R = 2-CF₃) and 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5-(4-fluorobenzyl)-1,3,4-oxadiazole showed LC₅₀ values of 38.5 and 30.8 mg L^-1 against Mythimna separata, resp., which were close to that of avermectin (29.6 mg L^-1). Compounds I (R = 3,5-Cl₂, 4-C₂H₅, 2-Cl-5-Br, 4-I, 3,4-Cl₂, 2-I, 3-N(CH₃)₂) and 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5-(4-fluorobenzyl)-1,3,4-oxadiazole showed 100% activity at 250 mg L^-1, which were better than chlorpyrifos (87%). CoMFA and CoMSIA models with good predictability were proposed, which revealed the electron-withdrawing groups with an appropriate bulk at 2- and 4-positions of benzene ring could enhance insecticidal activity.

RSC Advances published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C17H20ClN3, SDS of cas: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mokhtar, Hassan M. published the artcileSynthesis of nitrogenous compounds from δ-unsaturated 1,3-dicarbonyl esters: trisubstituted pyrazoles of possible antimicrobial and hypoglycemic activities and hydrazones with antituberculosis activity, Recommanded Product: 4-Iodobenzohydrazide, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1985), 24B(2), 188-92, database is CAplus.

R¹CH:CRCOCH₂COCO₂Et (I, R = H, Me, Ph; R¹ = 3-methylbenzofuran-2-yl, 2-phenyl-2H-1,2,3-triazol-4-yl) were prepared by condensing R¹CH:CRCOMe (II) with Et oxalate in dry ether. Treating I with hydrazine and arylhydrazines caused cyclization to the corresponding Et substituted pyrazole-3-carboxylates, e.g., III, which were hydrolyzed to acids or converted into acid hydrazides. Condensing I with acylhydrazines gave hydrazones which were cyclized to the corresponding N-acylpyrazoles. Treating I with HONH₂ gave 3,5-disubstituted isoxazoles, e.g., IV, whereas using o-phenylenediamine gave hydroxyquinoxalines. Reaction of II with arylhydrazines gave the corresponding hydrazones, which on boiling with EtOH-HCl cyclized to pyrazolines. Treating the latter compounds with excess bromine-water gave the brominated pyrazoles. Condensing II with acylhydrazines gave the corresponding acylhydrazones.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Recommanded Product: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nakagawa, Yoshiaki published the artcile3-D QSAR analysis of inhibition of murine soluble epoxide hydrolase (MsEH) by benzoylureas, arylureas, and their analogues. [Erratum to document cited in CA134:174695], SDS of cas: 39115-95-2, the publication is Bioorganic & Medicinal Chemistry (2001), 9(7), 1941, database is CAplus.

The term “log P” was omitted from three sentences in the manuscript. On page 2663, line 16 of the Abstract should read, “The addition of the mol. hydrophobicity, log P, to CoMFA did not improve the correlation significantly.”. On page 2665, line 6 of the right column should read, “The hydrophobic effects were examined using either HINT terms or log P values as an addnl. independent variable.”. On page 2665, line 10 of the right column should read, “The correlations of the biol. activity index with the lattice variables and log P were analyzed by the partial least squares (PLS) method with a column filtering setting of 2 kcal mol^-1.”.

Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, SDS of cas: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nakagawa, Yoshiaki published the artcile3-D QSAR analysis of inhibition of murine soluble epoxide hydrolase (MsEH) by benzoylureas, arylureas, and their analogues, Category: iodides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry (2000), 8(11), 2663-2673, database is CAplus and MEDLINE.

Two hundred and seventy-one compounds including benzoylureas, arylureas and related compounds were assayed using recombinant murine soluble epoxide hydrolase (MsEH) produced from a baculovirus expression system. Among all the insect growth regulators assayed, 18 benzoylphenylurea congeners showed weak activity against MsEH. Newly synthesized cyclohexylphenylurea, 1-benzyl-3-phenylurea, and 1,3-dibenzylurea analogs were rather potent. The introduction of a Me group at the para-position of the Ph ring of cyclohexylphenylurea enhanced the activity 6-fold, though similar substituent effects were not seen for any of the benzoylphenylureas. The activities of these compounds, including several previously reported compounds, such as dicyclohexylurea, diphenylurea, and their related analogs, were quant. analyzed using comparative mol. field anal. (CoMFA), a three-dimensional quant. structure-activity relationship (3-D QSAR) method. Both steric and electrostatic factors contributing to variations in the activity were visualized using CoMFA. CoMFA results showed that one side of the cyclohexylurea moiety having a trans-amide conformation (A-ring moiety) is surrounded by large sterically unfavorable fields, while the other side of A-ring moiety and the other cyclohexyl group (B-ring moiety) is encompassed by sterically favored fields. Electrostatically neg. fields were scattered around the entire mol., and a pos. field surrounds the carbon of the carbonyl group. Hydrophobic fields were visualized using Kellogg’s hydropathic interaction (HINT) in conjunction with CoMFA. Hydrophobically favorable fields appeared beside the 4- and 4′-carbon atoms of the cyclohexyl groups, and hydrophobically unfavorable fields surrounded the urea bridge. The addition of the mol. hydrophobicity, it> /it>, to CoMFA did not improve the correlation significantly. The ligand-binding interactions shown by x-ray crystallog. data were rationalized using the results of the CoMFA and HINT analyses, and the essential physicochem. parameters for the design of new MsEH inhibitors were disclosed.

Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kadesch, Richard G. published the artcileThe steric inhibition of resonance in aromatic carbonyl compounds, Name: 4-Iodobenzohydrazide, the publication is Journal of the American Chemical Society (1941), 1310-14, database is CAplus.

The d., ns and dielec. constants were measured of benzene solutions of acetophenone, acetylmesitylene, acetyldurene, BzH, mesitylaldehyde, BzCl, 2,4,6-Me₃C₆H₂COCl and benzophenone. From these data it is shown by the method of Birtles and Hampson (cf. C. A. 31, 2198.9) that the resonance of compounds of the type PhCOR involving quinoid structures may be inhibited by 2 o-Me groups. This inhibition of resonance is purely a steric effect in which the o-Me groups block the attainment of the completely coplanar configuration necessary in the quinonoid structure. The steric effect depends on the size of the COR group, being absent in the small CHO group while COMe and COCl lead to readily observable effects.

Journal of the American Chemical Society published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Name: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com