Category: 3718-88-5

Adding a certain compound to certain chemical reactions, such as: 3718-88-5, name is 3-Iodobenzylamine hydrochloride, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3718-88-5, COA of Formula: C7H9ClIN

A suspension of 3-iodobenzylamine hydrochloride (4.95g, 18.4mmol) in dichloromethane (100ml) was treated with triethylamine (3.1ml, 22mmol) and di-t-butyl dicarbonate (4.40g, 20mmol) and the resulting solution left to stir at room temperature under a nitrogen atmosphere for 1.5 hours. The reaction mixture was washed with 2M hydrochloric acid (30ml), water (30ml), dried (sodium sulfate), and the solvent removed in vacua to give the title compound as a colourless solid (6.43g).1HNMR (400MHz, CDCI3) 5 :7.63 (s, 1H), 7.60 (d, 1H), 7.25 (d, 1H), 7.06 (dd, 1H), 4.79-4.89 (bs, 1H), 4.21-4.30 (m, 2H), 1.46 (s, 9H) ppm.MS (electrospray) m/z 332 [M-H]’, 356 [M+Na]”1″

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Iodobenzylamine hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/108676; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3718-88-5, name is 3-Iodobenzylamine hydrochloride, A new synthetic method of this compound is introduced below., Recommanded Product: 3718-88-5

Resin 1 (obtained from previous synthesis) (100 mg, 0.077 mmol) was swelled in DCM (2 mL) for 1 h anddrained. A solution of 3-iodobenzylamane hydrochloride 2 (83.0 mg, 0.308 mmol) and Et3N (250 mL, 1.80 mmol) in DMF(1.5 mL) was purged with a stream of N2 bubbles for two minutes and added to the resin. After mixing for 5 min,PdCl2(PPh3)2 (11.0 mg, 0.016 mmol) and CuI (7.0 mg, 0.037 mmol) were added and the mixture shaken for 36 h. Theresin was drained, washed with DMF (4 3 2 mL), DCM (4 3 2 mL) and cleaved with 10% TFA/DCM (1.5 mL) for 20min. The solution was collected and the resin was rinsed with additional 10% TFA/DCM (1.5 mL). The cleavage fractionswere combined, treated with neat TFA (3.0 mL), stirred for 1 h at rt and concentrated by rotary evaporation to give acrude brown residue. Purification by RP-HPLC (C18 column, CH3CN gradient 5-65%, 0.1% TFA, UV analysis 300 nm,28 min) and lyophilization of the collected fractions afforded 4.3 mg (14%) of (2S,3R)-4-[4-(3-aminomethyl-phenyl)-buta-1,3-diynyl]-N-(2-hydroxy-1-hydroxycarbamoyl-propyl)-benzamide as a white solid. LRMS (ES+) m/z 392.0 (C22H21N3O4+ H requires 392.15); RP-HPLC (300 nm, 28 min run) 10.0 min.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; The University of Washington; Novartis Vaccines and Diagnostics, Inc.; Andersen, Niels H.; Bowman, Jason; Erwin, Alice; Harwood, Eric; Kline, Toni; Mdluli, Khisimuzi; Ng, Simon; Pfister, Keith B.; Shawar, Ribhi; Wagman, Allan; Yabannavar, Asha; EP2295402; (2015); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 3718-88-5, The chemical industry reduces the impact on the environment during synthesis 3718-88-5, name is 3-Iodobenzylamine hydrochloride, I believe this compound will play a more active role in future production and life.

Dissolve 2,6-dichloro-9-cyclopentylpurine (620 mg, crude), 3-iodobenzylamine hydrochloride (810 mg, 3.00 mmol) and triethylamine (835 muL, 6.00 mmol) in dry ethanol (20 mL). Heat at reflux for 15 hours, cool, and filter the solid to give the title compound as a white solid (680 mg).1H-NMR (Me2SO-d6 + D2O, delta): 8.27 (s, 1H, purine H-8), 7.74 (s, 1H), 7.61 (d, 1H), 7.39 (d, 1H), 7.16 (t, 1H), 4.78 (m, 1H), 4.62 (bs, 2H), 2.15 (m, 2H), 1.90 (m, 4H), 1.70 (m, 2H); CIMS (NH3) 454 (MH+), 328.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Iodobenzylamine hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Aventis Pharmaceuticals Inc.; EP1056745; (2004); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 3718-88-5, name is 3-Iodobenzylamine hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 3718-88-5

Example 41 This example describes the synthesis of N6 -(3-iodobenzyl)-9-[beta-D-ribofuranosyl]-adenine. A mixture of 6-chloropurine riboside (Aldrich Chemical Co., 100 mg, 0.35 mmol), triethylamine (0.146 ml, 1.05 mmol), and 3-iodobenzylamine hydrochloride (103 mg, 0.38 mmol) in ethanol (2 ml) was heated for 18 h at 85 C. in a sealed bottle. After the reaction mixture was concentrated to dryness, the residue was purified on a silica gel column chromatography (CHCl3 –MeOH, 10:1) to yield N6 -(3-iodobenzyl)-9-[beta-D-ribofuranosyl]-adenine (148 mg, 88%) as a colorless solid: m.p. 172 C.; 1 H NMR (DMSO-d6) d 3.54 (m, 1H, H-5’a), 3.67 (m, 1H, H-5’b), 3.96 (d, J=3.3 Hz, 1H, H-4′), 4.14 (m, 1H, H-3′), 4.60 (m, 1H, H-2′), 4.66 (br s, 2H, CH2), 5.16 (d, J=4.4 Hz, 1H, exchangeable with D2 O, 3′-OH), 5.34 (br s, 1H, exchangeable with D2 O, 5′-OH), 5.43 (d, J=6.1 Hz, 1H, exchangeable with D2 O, 2′-OH), 5.89 (d, J=6.0 Hz, 1H, H-1′), 7.11 (pseudo t, J=8.0 and 7.8 Hz, 1H, H-5″), 7.36 (d, J=7.6 Hz, 1H, H-4″ or -6″), 7.58 (d, J=7.8 Hz, 1H, H-4″ or -6″), 7.72 (s, 1H, H-2″), 8.21 (s, 1H, H-2 or 8), 8.40 (s, 1H, H-2 or 8), 8.48 (br s, 1H, exchangeable with D2 O, N6 H,).

The synthetic route of 3-Iodobenzylamine hydrochloride has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The United States of America as represented by the Department of Health and Human Services; US5773423; (1998); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 3718-88-5, name is 3-Iodobenzylamine hydrochloride, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3718-88-5, Recommanded Product: 3718-88-5

1.5 mL of ethanol were added to 80 mg (0.17 mmol) of benzoic acid (3aS,4R,6S,6aR)-6-(2,6-dichloropurin-9-yl)-2,2-dimethyltetrahydrothieno[3,4-d][1,3]dioxol-4-yl methyl ester, 60 mg (0.22 mmol) of 3-iodobenzylamine hydrochloride, and 0.07 mL (0.49 mmol) of triethylamine, which was stirred at ambient temperature for 3 days. The reaction mixture was distilled under reduced pressure, and the concentrate was purified by silica gel column chromatography using the eluant (hexane:ethyl acetate=1:1) to obtain 102 mg (yield: 90%) of benzoic acid (3aS,4R,6S,6aR)-6-(2-chloro-6-(3-iodobenzylamino)purin-9-yl)-2,2-dimethyltetrahydrothieno[3,4-d][1,3]dioxol-4-yl methyl ester as white foam. 1H-NMR(CDCl3) delta: 1.23 (s, 3H), 1.28 (s, 3H), 3.89 (t, 1H), 3.94 (dd, 1H), 4.08 (dd, 1H), 4.65 (d, 2H), 5.01 (m, 2H), 5.81 (d, 1H), 6.91-7.75 (m, 9H), 8.83 (s. 1H) UV (methanol): lambdamax 282 nm (pH 7).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Government of the United States of America, repres ented by The Secretary, Department of Health and; Ewha Womans University; US2005/256143; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3718-88-5, name is 3-Iodobenzylamine hydrochloride, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H9ClIN

Example 54 This example describes the synthesis of 2-chloro-N6 -(3-iodobenzyl)adenine. A solution of 2,6-dichloropurine (Aldrich Chemical Co., 1 g, 5.3 mmol), 3-iodobenzylamine hydrochloride (1.7 g, 5.8 mmol), and triethylamine (2.2 ml, 15.35 mmol) in ethanol (10 ml) was stirred for 5 days at room temperature. The colorless solid formed was collected by suction, washed with small amount of cold ethanol, and dried to yield 2-chloro-N6 -(3-iodobenzyl)adenine (1.16 g, 60%): m.p. 222-224 C.; mass (EI) 385: 1 H NMR (DMSO-d6 d 4.59 (br s, 2H, –CH2), 7.13 (pseudo t, J=8.2 and 7.5 Hz, 1H, Bn), 7.36 (d, J=7.5 Hz, 1H, Bn), 7.61 (d, J=7.5 Hz, 1H, Bn), 7.74 (s, 1H, Bn), 8.14 (s, 1H, H-8), 8.76 (br s, 1H, exchangeable with D2 O, NH), 13.14 (br s, 1H, exchangeable with D2 O, NH). UV (MeOH) 1max 281.7, 257.5, 232.5 nm.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3718-88-5.

Reference:
Patent; The United States of America as represented by the Department of Health and Human Services; US5773423; (1998); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 3718-88-5, These common heterocyclic compound, 3718-88-5, name is 3-Iodobenzylamine hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The intermediate compound prepared in Step 1 (204 mg, 0.32 mmol) and3-iodo-benzylamine hydrochloride (113 mg, 0.41mmol) toIn absolute ethanol (5 mL) under nitrogen gas streamTriethylamine (0.13 mL, 0.96 mmol) was dissolved by stirring at room temperature for 24 hours.Remove the completed residue obtained by concentrated under reduced pressure, the reaction solution after confirming the reaction by column chromatography to intermediate compound (2R, 3S, 4S, 5R) -2- (benzoyloxy-methyl) -5- (2-chloro-6 (3-iodo-benzyl-amino) -9H- purin-9-yl) tetrahydrofuran-3,4-di yl benzoate (230 mg, to obtain a 86.14%).

Statistics shows that 3-Iodobenzylamine hydrochloride is playing an increasingly important role. we look forward to future research findings about 3718-88-5.

Reference:
Patent; Korea University Industry-Academic Cooperation Agency; Kim, Won Gi; Choe, Yong Suk; (44 pag.)KR2015/10195; (2015); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 3718-88-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3718-88-5, name is 3-Iodobenzylamine hydrochloride belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A suspension of 3-iodobenzylamine hydrochloride (4.95 g, 18.4 mrnol) in dichloromethane (100 mL) was treated with trieihylamine (3.1 mL, 22 mmol) and di-tert-butyl dicarbonate (4.40 g, 20 mmol) artid the resulting solution stirred at room temperature for 1.5 hours. The reaction fixture was then washed with 2M hydrochloric acid (30 mL), water (30 mL), cried over sodium sulfate and concentrated in vacuo to afford the title compound as a colourless solid in quantitative yield, 6.43 g. HNMR (400MHz, CDCI3) 8 : 1.46 (9H, s), 4.21-4. SO (2H, m), 4. 79-4. 89 (1 H, bs), 7.06 (1H, dd), 7.25 (1H, d), 7.60 (1H, d), 7.63 (1H, s); LRMS ESl m/z 332 [M-H]-

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Iodobenzylamine hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/92840; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 3718-88-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3718-88-5 name is 3-Iodobenzylamine hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Recrystallization from H2 O-EtOH provided m-iodobenzylguanidine sulfate as colorless crystals: mp 166-167 C.; HPLC [THF/0.1M NaH2 PO4 12/88, 3.0 ml/min] showed only one peak tR= 8.6 min; IR (nujol) 3340 (NH), 3160 (NH), 1660 and 1630 (C=N), 1090 (S=0), 780 and 695 cm (1,3-disubstituted benzene); PMR (CD3 OD) delta4.36 (S,2,CH2), 6.96-7.73 [m(7 peaks), 4,arom]; the aromatic peak pattern was identical to that observed for m-iodobenzylamine hydrochloride in CD3 OD. Anal. Calcd for C8 H10 IN3.O.5H2 SO4: C,29.64; H, 3.42. Found C,29.55,H, 3.40.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Iodobenzylamine hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; Wieland; Donald M.; Brown; Lawrence E.; Beierwaltes; William H.; Wu; Jiann-long; US4584187; (1986); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 3718-88-5, name is 3-Iodobenzylamine hydrochloride, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3718-88-5, COA of Formula: C7H9ClIN

Example 150: Synthesis of 4-Chloro-6-[3-(3-dimethylamino-propylamino)- benzylamino]-2//-phthalazin-l-one hydroformate; (3-Iodo-benzyl)-carbamic acid tert-butyl ester; A mixture of 3-iodobenzylamine hydrochloride (3g, 11.131 mmol), CH2Cl2(6OmL) and triethylamine (3.ImL, 22.263 mmol) was stirred at room temperature. Boc- anhydride (2.6Og, 11.913 mmol) was added and the reaction stirred at room temperature for Ih. The reaction was poured onto water, extracted with CH2Cl2 and dried (Na2SO4). Preparatory HPLC afforded (3-iodo-benzyl)-carbamic acid tert-butyl ester (3.494g) as a white solid, m/z (M+l) 333.84.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; FOREST LABORATORIES HOLDINGS LIMITED; WO2008/61108; (2008); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com