Category: 371764-70-4

Regioselective syntheses of 1-aryl-substituted-5H-[1,3]thiazolo[3,2-a]quinazoline-5-ones during Sonogashira coupling was written by Bakherad, Mohammad;Keivanloo, Ali;Kalantar, Zahra;Keley, Vahid. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2011.Category: iodides-buliding-blocks The following contents are mentioned in the article:

Reaction of 2-mercaptopropargyl quinazolin-4-one (I) with various aryl iodides catalyzed by Pd-Cu leads to the regioselective formation of 1-aryl substituted-5H-[1,3]thiazolo-[3,2-a]quinazoline-5-ones, e.g., II. This study involved multiple reactions and reactants, such as 2-Chloro-4-iodobenzonitrile (cas: 371764-70-4Category: iodides-buliding-blocks).

2-Chloro-4-iodobenzonitrile (cas: 371764-70-4) belongs to iodide derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A convenient alumination of functionalized aromatics by using the frustrated Lewis pair Et₃Al and TMPMgCl-LiCl was written by Unsinn, Andreas;Wunderlich, Stefan H.;Jana, Anukul;Karaghiosoff, Konstantin;Knochel, Paul. And the article was included in Chemistry – A European Journal in 2013.Recommanded Product: 371764-70-4 The following contents are mentioned in the article:

A straightforward and efficient alumination of functionalized arenes, in particular, halogenated electron-rich aromatic compounds, with Et₃Al and stoichiometric amounts of frustrated Lewis pair TMPMgCl-LiCl (TMP = 2,2,6,6-tetramethylpiperidyl) as a co-reactant, has been developed. In particular, halogenated electron-rich aromatics can be smoothly functionalized by using the frustrated Lewis pair Et₃Al and TMPMgCl-LiCl. Compared with previously described alumination methods, this procedure avoids extensive cooling and the need for an excess of base. This in situ procedure has proven to be most practical and allows for regio- and chemoselective metalation of a wide range of aromatics with sensitive functional groups (CONEt₂, CO₂Me, CN, OCONMe₂) or halogens (F, Cl, Br, I). The resulting aromatic aluminates, which were characterized by using NMR spectroscopy, were subjected to allylations, acylations, and palladium-catalyzed cross-coupling reactions after transmetalation to zinc. It was shown that the nature of the Zn salt used for transmetalation is crucial. Thus, compared with ZnCl₂ (2 equiv), the use of Zn(OPiv)₂ (2 equiv; OPiv=pivalate) allows the subsequent quenching reactions to be performed with only a slight excess of electrophile (1.2 equiv) and provides interesting functionalized aromatics in good yields. This study involved multiple reactions and reactants, such as 2-Chloro-4-iodobenzonitrile (cas: 371764-70-4Recommanded Product: 371764-70-4).

2-Chloro-4-iodobenzonitrile (cas: 371764-70-4) belongs to iodide derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Recommanded Product: 371764-70-4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Metabolically stable diphenylamine derivatives suppress androgen receptor and BET protein in prostate cancer was written by Yu, Jiang;Zhou, Peiting;Du, Wu;Xu, Ruixue;Yan, Guoyi;Deng, Yufang;Li, Xinghai;Chen, Yuanwei. And the article was included in Biochemical Pharmacology (Amsterdam, Netherlands) in 2020.Application In Synthesis of 2-Chloro-4-iodobenzonitrile The following contents are mentioned in the article:

Androgen receptor (AR) is a crucial driver of prostate cancer (PC). AR-relevant resistance remains a major challenge in castration-resistant prostate cancer (CRPC). Bromodomain and extra-terminal domain (BET) family are critical AR coregulators. Here, we developed several diphenylamine derivatives and identified compound 7d that disrupted the functions of AR and BET family in prostate cancer and exhibited favorable metabolic stability in vitro and high drug exposure in vivo. We showed 7d not only bound to AR, suppressed transactivation of wild-type AR (wt-AR) and the mutant that mediates Enzalutamide resistance, but also reduced c-Myc protein expression through BET inhibition. In addition, 7d inhibited the proliferation of AR-pos. PC cells with favorable selectivity and suppressed AR-V7-expressing VCaP and 22Rv1 xenografts growth in vivo. Collectively, these results indicate the potential of lead compound 7d as an orally available AR and BET inhibitor to treat CRPC and overcome antiandrogen resistance. This study involved multiple reactions and reactants, such as 2-Chloro-4-iodobenzonitrile (cas: 371764-70-4Application In Synthesis of 2-Chloro-4-iodobenzonitrile).

2-Chloro-4-iodobenzonitrile (cas: 371764-70-4) belongs to iodide derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Application In Synthesis of 2-Chloro-4-iodobenzonitrile

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Catalyst free hydrazone ligation for protein labeling and modification using electron-deficient benzaldehyde reagents was written by Xu, Yang;Wang, Yu;Liu, Peiyuan;Chu, Guo-Chao;Xu, Huajian;Li, Yi-Ming;Wang, Jun;Shi, Jing. And the article was included in Organic & Biomolecular Chemistry in 2018.Product Details of 371764-70-4 The following contents are mentioned in the article:

Bioorthogonal reactions have emerged as valuable tools for site-specific protein labeling and modification in vitro and in vivo. Hydrazone and oxime ligation has recently attracted considerable attention for wide applications in the conjugation of biomols. However, this kind of reaction has suffered from slow kinetics under physiol. conditions and toxicity or complications of the reaction system due to catalysts. The authors have developed an electron-deficient benzaldehyde reagent, which can be easily equipped with various types of bio-functional mols. for catalyst-free hydrazone ligation. The reagent can be equipped with not only small mols. such as fluorescence dyes or drugs, but also macromols. like PEG. These can be precisely ligated to the C-terminus of proteins by an efficient hydrazone reaction at neutral pH and room temperature The new reagent based catalyst-free hydrazone ligation provides a practical approach for the site specific modification of proteins. This study involved multiple reactions and reactants, such as 2-Chloro-4-iodobenzonitrile (cas: 371764-70-4Product Details of 371764-70-4).

2-Chloro-4-iodobenzonitrile (cas: 371764-70-4) belongs to iodide derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Product Details of 371764-70-4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Identification of a Novel Aminotetralin Class of HDAC6 and HDAC8 Selective Inhibitors was written by Tang, Guozhi;Wong, Jason C.;Zhang, Weixing;Wang, Zhanguo;Zhang, Nan;Peng, Zhenghong;Zhang, Zhenshan;Rong, Yiping;Li, Shijie;Zhang, Meifang;Yu, Lingjie;Feng, Teng;Zhang, Xiongwen;Wu, Xihan;Wu, Jim Z.;Chen, Li. And the article was included in Journal of Medicinal Chemistry in 2014.Electric Literature of C7H3ClIN The following contents are mentioned in the article:

Herein we report the identification of a novel class of HDAC6 and HDAC8 selective inhibitors through a unique chem. and phenotypic screening strategy. Tetrahydroisoquinoline 12 was identified as a potent HDAC6 and HDAC8 dual inhibitor from a focused library through cellular tubulin acetylation and p21 induction screening assays. Scaffold hopping from 12 led to the discovery of an aminotetralin class of HDAC inhibitors. In particular, the 3-R stereoisomer 32 showed highly potent inhibition against HDAC6 and HDAC8 with IC₅₀ values of 50 and 80 nM, resp. Treatment of neuroblastoma BE(2)C cells with 32 resulted in elevated levels of acetylated tubulin, TrkA, and neurite outgrowth with only marginal effects on p21 induction and histone H3 acetylation. Consistent with its weak enzymic inhibition of HDAC1, 32 showed significantly less cytotoxicity than SAHA and moderately inhibited the growth of myeloma NCI-H929 and OPM-2 cells. This study involved multiple reactions and reactants, such as 2-Chloro-4-iodobenzonitrile (cas: 371764-70-4Electric Literature of C7H3ClIN).

2-Chloro-4-iodobenzonitrile (cas: 371764-70-4) belongs to iodide derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Electric Literature of C7H3ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A convenient alumination of functionalized aromatics by using the frustrated Lewis pair Et₃Al and TMPMgCl-LiCl was written by Unsinn, Andreas;Wunderlich, Stefan H.;Jana, Anukul;Karaghiosoff, Konstantin;Knochel, Paul. And the article was included in Chemistry – A European Journal in 2013.Recommanded Product: 371764-70-4 The following contents are mentioned in the article:

A straightforward and efficient alumination of functionalized arenes, in particular, halogenated electron-rich aromatic compounds, with Et₃Al and stoichiometric amounts of frustrated Lewis pair TMPMgCl-LiCl (TMP = 2,2,6,6-tetramethylpiperidyl) as a co-reactant, has been developed. In particular, halogenated electron-rich aromatics can be smoothly functionalized by using the frustrated Lewis pair Et₃Al and TMPMgCl-LiCl. Compared with previously described alumination methods, this procedure avoids extensive cooling and the need for an excess of base. This in situ procedure has proven to be most practical and allows for regio- and chemoselective metalation of a wide range of aromatics with sensitive functional groups (CONEt₂, CO₂Me, CN, OCONMe₂) or halogens (F, Cl, Br, I). The resulting aromatic aluminates, which were characterized by using NMR spectroscopy, were subjected to allylations, acylations, and palladium-catalyzed cross-coupling reactions after transmetalation to zinc. It was shown that the nature of the Zn salt used for transmetalation is crucial. Thus, compared with ZnCl₂ (2 equiv), the use of Zn(OPiv)₂ (2 equiv; OPiv=pivalate) allows the subsequent quenching reactions to be performed with only a slight excess of electrophile (1.2 equiv) and provides interesting functionalized aromatics in good yields. This study involved multiple reactions and reactants, such as 2-Chloro-4-iodobenzonitrile (cas: 371764-70-4Recommanded Product: 371764-70-4).

2-Chloro-4-iodobenzonitrile (cas: 371764-70-4) belongs to iodide derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Recommanded Product: 371764-70-4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Discovery and biological evaluation of novel androgen receptor antagonist for castration-resistant prostate cancer was written by Yu, Jiang;Zhang, Lanxi;Yan, Guoyi;Zhou, Peiting;Cao, Chaoguo;Zhou, Fei;Li, Xinghai;Chen, Yuanwei. And the article was included in European Journal of Medicinal Chemistry in 2019.Quality Control of 2-Chloro-4-iodobenzonitrile The following contents are mentioned in the article:

Prostate cancer (PC) is the second most common malignancy in men worldwide. Among current therapies, two antiandrogens, Abiraterone Acetate and Enzalutamide (Enza) have become the standard of care for patients with metastatic castration-resistant prostate cancer (mCRPC). Here, the authors designed and synthesized a new series of nonsteroidal compounds deriving from the hybridization of Abiraterone (Abi) and Enzalutamide, among which compound I featuring the diphenylamine scaffold was identified as a potent and cell selective androgen receptor (AR) antagonist. In cell proliferation assays, compound I exhibited better antiproliferative activities than Enzalutamide against AR-overexpressing VCaP cells and 22Rv1 cells bearing H874Y-mutated AR. In addition, I suppressed the activity of AR-F876L mutant that confers resistance to Enzalutamide and efficiently blocked R1881-induced PSA and FKBP5 gene expression. In competitive binding assay, compound I displayed higher binding affinity to AR than Enzalutamide. These results suggest compound I as a potential candidate to treat Enza-resistant CRPC. This study involved multiple reactions and reactants, such as 2-Chloro-4-iodobenzonitrile (cas: 371764-70-4Quality Control of 2-Chloro-4-iodobenzonitrile).

2-Chloro-4-iodobenzonitrile (cas: 371764-70-4) belongs to iodide derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Quality Control of 2-Chloro-4-iodobenzonitrile

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com