Category: 368435-46-5

Synthesis of polynorbornene with pendant moiety bearing azide and terminal alkyne groups was written by Zhang, Ze;Peng, Zhi Wei;Fan, Kun Zeng. And the article was included in Chinese Chemical Letters in 2011.Recommanded Product: 368435-46-5 The following contents are mentioned in the article:

A powerful approach to the synthesis of an unprecedented polynorbornene with pendant moiety bearing azide and terminal alkyne groups is developed. Two key intermediates, namely, 3-azido-5-(2-(trimethylsilyl)ethynyl) benzyl alc. and 4-(4-aza-tricyclo [5.2.1.0^2.6]dec-8-en-4-yl) benzoic acid, were optimally synthesized for convergent synthesis of the corresponding monomer. This study involved multiple reactions and reactants, such as (3-Amino-5-iodophenyl)methanol (cas: 368435-46-5Recommanded Product: 368435-46-5).

(3-Amino-5-iodophenyl)methanol (cas: 368435-46-5) belongs to iodide derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Recommanded Product: 368435-46-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

[¹²⁵I]-N-[(3-Azido-5-iodo)benzyl]dantrolene and [¹²⁵I]-N-{[3-Iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)]benzyl}dantrolene: photoaffinity probes specific for the physiological Ca²⁺ release from sarcoplasmic reticulum of skeletal muscle was written by Hosoya, Takamitsu;Aoyama, Hiroshi;Ikemoto, Takaaki;Hiramatsu, Toshiyuki;Kihara, Yasutaka;Endo, Makoto;Suzuki, Masaaki. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2002.SDS of cas: 368435-46-5 The following contents are mentioned in the article:

To capture and identify key mols. that regulate the release of Ca²⁺ from the sarcoplasmic reticulum (SR) of skeletal muscle, we designed specific photoaffinity probes based on the structural modification of dantrolene. Thus, GIF-0082 and GIF-0276 possessing azido- and trifluoromethyldiazirinyl-benzyl groups, resp., at the hydantoin moiety were found to have a highly selective inhibitory effect on physiol. Ca²⁺ release (PCR) without affecting Ca²⁺-induced Ca²⁺ release (CICR). Successful realization of the sharp discrimination between PCR and CICR has led to the creation of [¹²⁵I]GIF-0082 and [¹²⁵I]GIF-0276, which were synthesized by substituting a stannyl group with ¹²⁵I in the corresponding phenylstannane precursors. This study involved multiple reactions and reactants, such as (3-Amino-5-iodophenyl)methanol (cas: 368435-46-5SDS of cas: 368435-46-5).

(3-Amino-5-iodophenyl)methanol (cas: 368435-46-5) belongs to iodide derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.SDS of cas: 368435-46-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis of ring- and side-chain-substituted m-iodobenzylguanidine analogues was written by Vaidyanathan, Ganesan;Shankar, Sriram;Zalutsky, Michael R.. And the article was included in Bioconjugate Chemistry in 2001.Electric Literature of C7H8INO The following contents are mentioned in the article:

With the goal of developing m-iodobenzylguanidine (MIBG) analogs with improved targeting properties especially for oncol. applications, several radioiodinated ring- and side-chain-substituted MIBG analogs were synthesized. Except for 3-[¹³¹I]iodo-4-nitrobenzylguanidine (I) and N-hydroxy-3-[¹³¹I]iodobenzylguanidine (II), the radioiodinated analogs were prepared at no-carrier-added levels from their resp. tin precursors. The radiochem. yields generally were in the range of 70-90% except for 3-amino-5-[¹³¹I]iodobenzylguanidine for which a radiochem. yield of about 40% was obtained. While the silicon precursor N¹,N²-bis(tert-butyloxycarbonyl)-N¹-(4-nitro-3-trimethylsilylbenzyl)guanidine did not yield 3-[¹³¹I]iodo-4-nitrobenzylguanidine, its deprotected derivative, N¹-(4-nitro-3-trimethylsilylbenzyl)guanidine was radioiodinated in a modest yield of 20% providing 3-[¹³¹I]iodo-4-nitrobenzylguanidine. Exchange radioiodination of 3-iodo-4-nitrobenzylguanidine gave 3-[¹³¹I]iodo-4-nitrobenzylguanidine in 80% radiochem. yield. No-carrier-added [¹³¹I]NHIBG (III) was prepared from its silicon precursor N¹-hydroxy-N³-(3-trimethylsilylbenzyl)guanidine in 85% radiochem. yield. The paired-label tissue uptake of ¹²⁵I and ¹³¹I activity after injection of [¹²⁵I]MIBG, I, II, and III is provided. This study involved multiple reactions and reactants, such as (3-Amino-5-iodophenyl)methanol (cas: 368435-46-5Electric Literature of C7H8INO).

(3-Amino-5-iodophenyl)methanol (cas: 368435-46-5) belongs to iodide derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Electric Literature of C7H8INO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis of diverse 3-Azido-5-(azidomethyl)benzene derivatives via formal C-H azidation and functional group-selective transformations was written by Nishiyama, Yoshitake;Misawa, Yoshihiro;Hazama, Yuki;Oya, Kazuhiro;Yoshida, Suguru;Hosoya, Takamitsu. And the article was included in Heterocycles in 2019.Quality Control of (3-Amino-5-iodophenyl)methanol The following contents are mentioned in the article:

3-Azido-5-(azidomethyl)benzene derivatives are useful compounds for preparing diverse bistriazole compounds and photoaffinity probes for target identification of bioactive compounds To more easily synthesize a diverse range of diazido compounds, a facile method for synthesizing diazido compounds bearing a transformable functional group, such as iodo, bromo, methoxycarbonyl, or cyano group, was developed. This method is based on formal C-H azidation of 1,3-disubstituted benzenes via regioselective borylation followed by deborylative azidation with subsequent transformations, such as that of a one-carbon unit on the benzene ring to an azidomethyl group. The functional groups of the diazido compounds were efficiently transformed to various connecting groups, including carboxy, (succinimidyloxy)carbonyl, hydroxymethyl, formyl, bromomethyl, tosylthiomethyl, ethynyl, diazoacetyl, bromoacetyl, boryl, hydroxy, aminocarbonyl, amino, and isothiocyanato groups, leaving the azido groups untouched. Several diazido building blocks were used to prepare diazido compounds by forming amide, thiourea, and sulfide bonds via conjugation at the connecting groups. These results show that the method described here would facilitate diazido probe syntheses and bistriazole library construction. This study involved multiple reactions and reactants, such as (3-Amino-5-iodophenyl)methanol (cas: 368435-46-5Quality Control of (3-Amino-5-iodophenyl)methanol).

(3-Amino-5-iodophenyl)methanol (cas: 368435-46-5) belongs to iodide derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Quality Control of (3-Amino-5-iodophenyl)methanol

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com