Category: 36748-88-6

Tertiary Amines Acting as Alkyl Radical Equivalents Enabled by a P/N Heteroleptic Cu(I) Photosensitizer was written by Zheng, Limeng;Jiang, Qinfang;Bao, Hanyang;Zhou, Bingwei;Luo, Shu-Ping;Jin, Hongwei;Wu, Huayue;Liu, Yunkui. And the article was included in Organic Letters in 2020.SDS of cas: 36748-88-6 This article mentions the following:

An unprecedented exploration of tertiary amines as alkyl radical equivalent for cross-coupling with aromatic alkynes to access allylarenes has been achieved by a P/N heteroleptic Cu(I)-based photosensitizer under photoredox catalysis conditions. Mechanistic studies reveal that the reaction might undergo radical addition of in situ-generated 浼?amino radical intermediates to alkynes followed by 1,5-hydrogen transfer, C-N bond cleavage, and concomitant isomerization of the resulting allyl radical species. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6SDS of cas: 36748-88-6).

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.SDS of cas: 36748-88-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Iodine/palladium approaches to the synthesis of polyheterocyclic compounds was written by Mehta, Saurabh;Larock, Richard C.. And the article was included in Journal of Organic Chemistry in 2010.Application In Synthesis of 3-Iodobenzo[b]thiophene This article mentions the following:

A simple, straightforward strategy for the synthesis of polyheterocyclic compounds (PHCs) is reported, which involves iterative cycles of palladium-catalyzed Sonogashira coupling, followed by iodocyclization using I₂ or ICl. A variety of heterocyclic units, including benzofurans, benzothiophenes, indoles, and isocoumarins, can be efficiently incorporated under mild reaction conditions. In addition, variations of this strategy afford a variety of linked and fused PHCs. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6Application In Synthesis of 3-Iodobenzo[b]thiophene).

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons鑱砈mith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Application In Synthesis of 3-Iodobenzo[b]thiophene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Carbonylation of aryl halides and vinyl bromides mediated by tetracarbonylcobalt anion was written by Miura, Masahiro;Akase, Fumiaki;Shinohara, Masato;Nomura, Masakatsu. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1987.Recommanded Product: 36748-88-6 This article mentions the following:

The reaction of aryl halides with octacarbonyldicobalt in the presence of Me iodide and sodium hydroxide under phase-transfer conditions gave a mixture of aryl Me ketones and aromatic carboxylic acids. For example, 1-bromonaphthalene gave 54% 1-acetonaphthone and 20% 1-naphthoic acid. From vinyl bromides the corresponding carboxylic acids were obtained exclusively. Thus, Ph₂C:CHBr gave 80% Ph₂C:CHCO₂H. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6Recommanded Product: 36748-88-6).

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Recommanded Product: 36748-88-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bromination, iodination, and phenylation of thianaphthenes was written by Gaertner, Russell. And the article was included in Journal of the American Chemical Society in 1952.Product Details of 36748-88-6 This article mentions the following:

2-Bromo-3-methylthianaphthene (12.4 g.), 9.7 g. N-bromosuccinimide, and 0.4 g. (BzO)₂ in 130 cc. CCl₄ refluxed 90 min., cooled, filtered, and the CCl₄ replaced by petr. ether (70-90鎺? yielded 14.4 g. 2-bromo-3-(bromomethyl)thianaphthene (I), m. 97.6-8.6, b_0.5 148-51鎺?(decomposition). I (19.3 g.) converted in the cyclic reactor, treated with ClCO₂Et, and the product hydrolyzed (alkali) yielded a polymer, m. 200-40鎺?(decomposition); the neutral material yielded 1.2 g. 1,2-bis(2-bromo-3-thianaphthenyl)ethane, m. 195-6鎺? Conversion of 21.3 g. I and treatment with HCHO yielded a taffylike polymer. Thianaphthene (II) (44.4 g.) in 70 cc. C₆H₆ at 55-65鎺?treated during 1 hr. with 54 g. yellow HgO and 76 g. iodine, the mixture filtered, and the C₆H₆ removed in vacuo gave 15.7 g. II and 39.6 g. liquid which on chromatography on C and Al₂O₃ yielded 3-iodothianaphthene (III), b_1.6 120-1鎺? d₂₀ 1.898, n²⁰_D > 1.7. Attempted chloromethylation of III at 90 in the presence of ZnCl₂ gave III and a trace of higher-boiling material. III reacted normally with Mg. Carbonation yielded 7.4 g. 3-thianaphthenecarboxylic acid, m. 176-7.5鎺? and 1.4 g. crude material, m. 150-65鎺? II (67 g.) was converted to the Li derivative, the solution added dropwise to 252 g. iodine and 100 cc. Et₂O in an ice-salt bath, the mixture let warm to room temperature, diluted with water, the excess iodine removed, and 48.2 g. crude II recovered, leaving 37.4 g. 2-iodothianaphthene (IV), b_1.6 119-20鎺? m. 59-62鎺? Attempted chloromethylation failed. Conversion of 13 g. IV to the Grignard reagent and carbonation yielded 1.02 g. 2-thianaphthenecarboxylic acid, m. 242-3鎺? AcN(NO)Ph (25 g.) dissolved in 25 g. molten II at 32鎺?(the mixture reacted violently and about half was lost through foaming) and the unchanged II removed by distillation in vacuo yielded 10.5 g. liquid, b_0.3 150-5鎺? which on recrystallization gave 1.63 g. 2-phenylthianaphthene (V), m. 174.2-5.2鎺? V (1.00 g.) and 12 g. Raney Ni in 70 cc. EtOH heated 3 hrs. yielded 0.81 g. bibenzyl, m. 49-51鎺? The mother liquors yielded 2.5 g. of the picrate of II. Attempted preparation of the 1,1-dioxide yielded a gummy polymer. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6Product Details of 36748-88-6).

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Product Details of 36748-88-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Metal-Free, Oxidant-Free, and Controllable Graphene Oxide Catalyzed Direct Iodination of Arenes and Ketones was written by Zhang, Jingyu;Li, Shiguang;Deng, Guo-Jun;Gong, Hang. And the article was included in ChemCatChem in 2018.Electric Literature of C8H5IS This article mentions the following:

A direct, metal-free, and oxidant-free method for the graphene oxide (GO)-catalyzed iodination of arenes and ketones with iodine in a neutral medium was explored. This iodination protocol was performed by using a simple technique to avoid the use of external metal catalysts and oxidants and harsh acidic/basic reaction conditions. In addition, by this method the degree of iodination could be controlled, and the reaction was scalable and compatible with air. This strategy opens a new field for GO-catalyzed chem. and provides an avenue for the convenient direct iodination of arenes and ketones. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6Electric Literature of C8H5IS).

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Electric Literature of C8H5IS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Metal-Free, Oxidant-Free, and Controllable Graphene Oxide Catalyzed Direct Iodination of Arenes and Ketones was written by Zhang, Jingyu;Li, Shiguang;Deng, Guo-Jun;Gong, Hang. And the article was included in ChemCatChem in 2018.Electric Literature of C8H5IS This article mentions the following:

A direct, metal-free, and oxidant-free method for the graphene oxide (GO)-catalyzed iodination of arenes and ketones with iodine in a neutral medium was explored. This iodination protocol was performed by using a simple technique to avoid the use of external metal catalysts and oxidants and harsh acidic/basic reaction conditions. In addition, by this method the degree of iodination could be controlled, and the reaction was scalable and compatible with air. This strategy opens a new field for GO-catalyzed chem. and provides an avenue for the convenient direct iodination of arenes and ketones. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6Electric Literature of C8H5IS).

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Electric Literature of C8H5IS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Transition-metal-free decarboxylative iodination: New routes for decarboxylative oxidative cross-couplings was written by Perry, Gregory J. P.;Quibell, Jacob M.;Panigrahi, Adyasha;Larrosa, Igor. And the article was included in Journal of the American Chemical Society in 2017.Product Details of 36748-88-6 This article mentions the following:

Constructing products of high synthetic value from inexpensive and abundant starting materials is of great importance. Aryl iodides are essential building blocks for the synthesis of functional mols., and efficient methods for their synthesis from chem. feedstocks are highly sought after. Here we report a low-cost decarboxylative iodination that occurs simply from readily available benzoic acids and I₂. The reaction is scalable and the scope and robustness of the reaction is thoroughly examined Mechanistic studies suggest that this reaction does not proceed via a radical mechanism, which is in contrast to classical Hunsdiecker-type decarboxylative halogenations. In addition, DFT studies allow comparisons to be made between our procedure and current transition-metal-catalyzed decarboxylations. The utility of this procedure is demonstrated in its application to oxidative cross-couplings of aromatics via decarboxylative/C-H or double decarboxylative activations that use I₂ as the terminal oxidant. This strategy allows the preparation of biaryls previously inaccessible via decarboxylative methods and holds other advantages over existing decarboxylative oxidative couplings, as stoichiometric transition metals are avoided. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6Product Details of 36748-88-6).

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Product Details of 36748-88-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis, Photophysical Properties, and Biological Profiling of Benzothieno-Fused 7-Deazapurine Ribonucleosides was written by Yang, Chao;Pohl, Radek;Tichy, Michal;Gurska, Sona;Pavlis, Petr;Dzubak, Petr;Hajduch, Marian;Hocek, Michal. And the article was included in Journal of Organic Chemistry in 2020.Product Details of 36748-88-6 This article mentions the following:

Two isomeric series of benzothieno-fused 7-deazapurine (benzo[4′,5′]thieno[3′,2′:4,5]- and benzo[4′,5′]thieno[2′,3′:4,5]pyrrolo[2,3-d]pyrimidine) ribonucleosides were designed and synthesized. Key steps of the synthesis included the Negishi coupling of zincated dichloropyrimidine with 2- or 3-iodobenzothiophene followed by azidation, thermal or photochem. cyclization, glycosylation, and final functionalization at position 6 through cross-couplings or nucleophilic substitutions. Deprotection gave the final nucleosides, some of which showed moderate cytotoxic and antiviral activity. Most of the free nucleosides showed moderate to strong fluorescence with emission maxima of 362-554 nm. 2′-Deoxyribonucleoside and its 5′-O-triphosphate were also prepared from benzothieno-fused 7-deazaadenine derivative, and the triphosphate was a good substrate for KOD XL DNA polymerase in primer extension synthesis of modified DNA which exerted a weak fluorescence which was slightly enhanced in double-stranded DNA as compared to single-stranded oligonucleotides. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6Product Details of 36748-88-6).

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Product Details of 36748-88-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com