364-75-0 Archives - Iodides-buliding-blocks

Introduction of a new synthetic route about C6H3FINO2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Fluoro-4-iodo-2-nitrobenzene, its application will become more common.

Application of 364-75-0,Some common heterocyclic compound, 364-75-0, name is 1-Fluoro-4-iodo-2-nitrobenzene, molecular formula is C6H3FINO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 3-45-4 Preparation of 4-iodo-N-(1-(3-methoxy-4-((6-methoxypyridin-3-yl)methoxy)phenyl)ethyl)-2-nitroaniline To a stirred solution of 1-(3-methoxy-4-((6-methoxypyridin-3-yl)methoxy)phenyl)ethan-1-amine (1.93 g, 6.68 mmol) and potassium carbonate (3.70 g, 26.75 mmol) in acetonitrile (75 mL) was added 1-fluoro-4-iodo-2-nitrobenzene (2.14 g, 8.02 mmol). The mixture was heated to reflux. After 16 h, the orange mixture was allowed to cool to room temperature and was diluted with water (150 mL). The mixture was extracted with dichloromethane (3*75 mL), and the combined organic phases were dried over magnesium sulfate, filtered, and concentrated to provide 3.82 g of an orange solid. Trituration of the crude material with hexanes afforded 3.17 g (89%) of 4-iodo-N-(1-(3-methoxy-4-((6-methoxypyridin-3-yl)methoxy)phenyl)ethyl)-2-nitroaniline as a bright orange solid.

Reference:
Patent; KANE, JR., John L.; MATTHEWS, Gloria; METZ, Markus; KOTHE, Michael; LIU, Jinyu; SCHOLTE, Andrew; US2015/158847; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

New downstream synthetic route of C6H3FINO2

Statistics shows that 1-Fluoro-4-iodo-2-nitrobenzene is playing an increasingly important role. we look forward to future research findings about 364-75-0.

Reference of 364-75-0, These common heterocyclic compound, 364-75-0, name is 1-Fluoro-4-iodo-2-nitrobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 3-3-1 Preparation of 4-iodo-N-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)-2-nitroaniline To a stirred solution of 3-methoxy-4-((4-methoxybenzyl)oxy)phenyl)methanamine (5.02 g, 18.37 mmol) in acetonitrile (75 mL) was added 1-fluoro-4-iodo-2-nitrobenzene (4.67 g, 17.49 mmol) and diisopropylethylamine (2.83 g, 21.86 mmol). The resulting bright yellow solution was heated to reflux. After 17 h, the orange mixture was allowed to cool to room temperature and was diluted with water. The mixture was extracted with dichloromethane (3*100 mL). The combined organic phases were dried over magnesium sulfate, filtered, and concentrated to provide 9.49 g (>100%) of 4-iodo-N-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)-2-nitroaniline as an orange semi-solid.

Statistics shows that 1-Fluoro-4-iodo-2-nitrobenzene is playing an increasingly important role. we look forward to future research findings about 364-75-0.

Application of 1-Fluoro-4-iodo-2-nitrobenzene

The synthetic route of 364-75-0 has been constantly updated, and we look forward to future research findings.

Reference of 364-75-0,Some common heterocyclic compound, 364-75-0, name is 1-Fluoro-4-iodo-2-nitrobenzene, molecular formula is C6H3FINO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-FLUORO-3-NITRO-1-CYCLOPROPYLBENZENE was prepared FROM 2-FLUORO-5-IODO-1- nitrobenzene and tricyclopropylindium according to the method described in J. Am. Chem. Soc. 2001,123, 4155-4160.

The synthetic route of 364-75-0 has been constantly updated, and we look forward to future research findings.

Share a compound : 364-75-0

According to the analysis of related databases, 364-75-0, the application of this compound in the production field has become more and more popular.

Related Products of 364-75-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 364-75-0 as follows.

A solution of the compound of Example 1(e) (4.6 g, 17.54 mmol), 1-fluoro-4-iodo-2-nitrobenzene of Intermediate Example 3 (4.683 g, 17.54 mmol, 1.0 eq.) and potassium fluoride (1.22 g, 21.05 mmol, 1.2 eq.) in DMF was heated at 130 C. for 5 h. The mixture was quenched and extracted as in Example 1(d). The solvent was distilled off and the crude residue was purified by column chromatography (60-120 silica gel, 50% ethyl acetate in hexane) to give the product in 76% yield (6.8 g). 1H NMR (300 MHz, DMSO-d6): delta 10.15 (br s, 1H), 9.41 (s, 1H), 8.35 (d, 1H), 7.78 (dd, 1H), 7.66-7.54 (m, 3H), 7.39 (m, 1H), 7.22 (m, 1H), 7.14-7.11 (m, 2H), 2.06 (s, 3H).

According to the analysis of related databases, 364-75-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Linnanen, Tero; Wohlfahrt, Gerd; Nanduri, Srinivas; Ujjinamatada, Ravi; Rajagopalan, Srinivasan; Mukherjee, Subhendu; US2015/11548; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some tips on 364-75-0

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 364-75-0, A common heterocyclic compound, 364-75-0, name is 1-Fluoro-4-iodo-2-nitrobenzene, molecular formula is C6H3FINO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The synthesis was carried out following a known procedure (Serizawa et al., ?Direct Synthesis of Pentafluoroethyl Copper from Pentafluoropropionate as an Economical C2F5 Source: Application to Pentafluoroethylation of Arylboronic Acids and Aryl Bromides,? Org. Lett. 16:3456-3459 (2014), which is hereby incorporated by reference in its entirety). A 25 mL Schlenk flask (equipped with a 10 mL solid addition funnel) was flame-dried under vacuum and cooled under Ar. The flask was charged with copper(I) chloride (516 mg, 5.21 mmol; transferred in an Ar-purged glove bag) and DMF (18 mL). Sodium tert-butoxide (1.01 g, 10.4 mmol; transferred in a glove bag) was added via the addition funnel in portions over 10 mm. After replacing the addition funnel with a septum, the mixture was stirred at room temperaturefor 2.5 hours, and then was heated at 50C while ethyl 2,2,3,3,3-pentafluoropropanoate (770 jiL,5.21 mmol) was added dropwise by syringe over 2-3 mm. The reaction was stirred at 50C for 3 hours and then was cooled to 0C. Triethylamine trihydrofluoride (325 jiL, 1.99 mmol) was added dropwise over 1-2 mm by syringe, which resulted in a nearly homogeneous solution. Stirring was continued at 0C for 5 mm, and then at room temperature for 15 mm. Solid 1-fluoro-4-iodo-2-nitrobenzene (662 mg, 2.48 mmol) was added in one-portion and the reaction was heated at 80C for 12 hours, under a balloon of Ar. After the reaction had cooled to room temperature, 1 M HC1 (15 mL) was added in portions over 1-2 mm by pipet. The mixture was diluted with water (50 mL) and Et20 (50 mL), and then was filtered through a pad (3 x 3 cm) of Celite under vacuum. The filter-cake was washed with Et20 (20 mL) and the combined filtrateswere transferred to a separatory funnel. The layers were separated and the aqueous phase was extracted with Et20 (2 x 30 mL). The organic extracts were pooled, washed with a 60:40 mixture of saturated NH4C1 solution/concentrated NH4OH solution (3 x 50 mL), half saturated NaC1 solution (2 x 50 mL) and brine (50 mL), dried (Mg504), and filtered. Concentration under vacuum gave 670 mg of an orange oil, which was used without further purification (seesynthesis of APS5-1 1).

Reference:
Patent; ICHAN SCHOOL OF MEDICINE AT MOUNT SINAL; DAR, Arvin, C.; CAGAN, Ross, L.; SCOPTON, Alex, P.; SONOSHITA, Masahiro; (175 pag.)WO2018/35346; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The important role of 364-75-0

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 364-75-0, name is 1-Fluoro-4-iodo-2-nitrobenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Fluoro-4-iodo-2-nitrobenzene

General procedure: A mixture of benzenesulfonamides (1, 1.0 mmol), halogenated nitrobenzene(2, 1.0 mmol) and K2CO3 (1.1 mmol) were dissolved in DMF in a microwave tube. Then, the reaction mixture was irradiated in a microwave apparatus at 140 C for 12 minutes. After the reaction mixture was cooled to ambient temperature, the product was concentrated, and the crude mixture was purified by column chromatography on silica gel to the desired products 3.

Reference:
Article; Huang, Zhi-You; Liu, Min; Mao, Yi-Jun; Chen, Yu-De; Wang, Yan-Ping; Liu, Chong; Tetrahedron Letters; vol. 60; 8; (2019); p. 626 – 629;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Extended knowledge of 364-75-0

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Fluoro-4-iodo-2-nitrobenzene, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 364-75-0, name is 1-Fluoro-4-iodo-2-nitrobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 364-75-0, Computed Properties of C6H3FINO2

Example 3-4-3 Preparation of 4-iodo-N-(3-methoxy-4-((6-methoxypyridin-3-yl)methoxy)benzyl)-2-nitroaniline To a stirred solution of (3-methoxy-4-((6-methoxypyridin-3-yl)methoxy)phenyl)methanamine (5.00 g, 18.23 mmol) in acetonitrile (75 mL) was added 1-fluoro-4-iodo-2-nitrobenzene (4.55 g, 17.04 mmol) and diisopropylethylamine (3.30 g, 25.56 mmol). The yellow solution was heated to reflux and stirred. After 4 h, the orange-brown mixture was allowed to cool to room temperature and was diluted with water (150 mL). The resulting bright orange precipitate was isolated by filtration and washed with water. The moist solids were dissolved in dichloromethane, and a small amount of water separated and was removed. The organic phase was dried over magnesium sulfate, filtered, and concentrated to provide 7.10 g (80%) of 4-iodo-N-(3-methoxy-4-((6-methoxypyridin-3-yl)methoxy)benzyl)-2-nitroaniline as a bright orange solid.