364-12-5 Archives - Page 4 of 5 - Iodides-buliding-blocks

Bolton, Roger et al. published their research in Journal of the Chemical Society in 1982 |CAS: 364-12-5

The Article related to aryl iodide protiodeiodination kinetics, substituent effect protiodeiodination iodoarene, chlorobenzene methoxydechlorination kinetics, iodochlorobenzene substitution methanol kinetics and other aspects.Computed Properties of 364-12-5

On December 31, 1982, Bolton, Roger; Moore, Clive; Sandall, John P. B. published an article.Computed Properties of 364-12-5 The title of the article was Nucleophilic displacement in polyhaloaromatic compounds. Part 11. Kinetics of protiodeiodination of iodoarenes in dimethyl sulfoxide-methanol. And the article contained the following:

The kinetics were determined of the MeO–induced protiodeiodination of 15 polychloroiodobenzenes and 6 of their Br- or CF3-substituted analogs in 9:1 (volume) DMSO-MeOH at 323.2 K. The true reagent is the DMSO anion. The reaction rates in some cases approached the diffusion-controlled process. Cl and CF3 substituents promote the reaction in the order ortho > meta > para and ortho > para > meta, resp. Protiodeiodinaton is promoted by o-NO2 groups, but the p-NO2 group encourages methoxydeiodination. Unlike polychloroiodobenzenes, polychlorobenzenes underwent methoxydechlorination. A mechanism involving nucleophilic attack by a carbanion was proposed. The experimental process involved the reaction of 5-Bromo-2-iodobenzotrifluoride(cas: 364-12-5).Computed Properties of 364-12-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Janetka, James W. et al. published their patent in 2017 |CAS: 364-12-5

The Article related to antibacterial antagonist hemagglutination urinary tract infection glycoside preparation mannoside, alkyne azide cycloaddition suzuki coupling fimh inhibitor human antibiotic, triazole click preparation c glycoside urinary tract infection and other aspects.Quality Control of 5-Bromo-2-iodobenzotrifluoride

On September 14, 2017, Janetka, James W.; Mydock-McGrane, Laurel published a patent.Quality Control of 5-Bromo-2-iodobenzotrifluoride The title of the patent was Preparation of C-glycoside compounds useful for treating urinary tract infection. And the patent contained the following:

The present invention relates to mannosides I, wherein Ar is aryl, heteroaryl; Y1 and Y2 are independently H, hydroxyl, alkoxy, amino; were prepared and are useful as inhibitors of FimH and methods for the treatment or prevention of urinary tract infection, bacterial infection, Crohn’s disease, and inflammatory bowel disease. Thus, glycoside II was prepared and tested for its hemagglutination (EC>90 = 0.006 μM) inhibition and as FimH inhibitor. The experimental process involved the reaction of 5-Bromo-2-iodobenzotrifluoride(cas: 364-12-5).Quality Control of 5-Bromo-2-iodobenzotrifluoride

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yoshida, Suguru et al. published their research in Angewandte Chemie, International Edition in 2016 |CAS: 364-12-5

The Article related to silylbenzotrifluoride preparation defluorinative monoallylation allyltrimethylsilane trityl cation, fluorobutenyl fluorosilylarene preparation, c−f activation, allylation, fluorine, silanes, trityl cation and other aspects.Quality Control of 5-Bromo-2-iodobenzotrifluoride

Yoshida, Suguru; Shimomori, Ken; Kim, Youngchan; Hosoya, Takamitsu published an article in 2016, the title of the article was Single C-F Bond Cleavage of Trifluoromethylarenes with an ortho-Silyl Group.Quality Control of 5-Bromo-2-iodobenzotrifluoride And the article contains the following content:

The transformation of a single C-F bond of trifluoromethylarenes bearing a hydrosilyl group at the ortho position was achieved. The activation of the hydrosilyl group with a trityl cation in the presence of nucleophiles allowed for selective C-F bond functionalization, for example, by allylation, carboxylation, or chlorination. Further derivatization of the resulting fluorosilylarenes afforded various aromatic difluoromethylene compounds The experimental process involved the reaction of 5-Bromo-2-iodobenzotrifluoride(cas: 364-12-5).Quality Control of 5-Bromo-2-iodobenzotrifluoride

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yoshida, Suguru et al. published their research in Angewandte Chemie, International Edition in 2016 |CAS: 364-12-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Janetka, James W. et al. published their patent in 2017 |CAS: 364-12-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wacker, Dean A. et al. published their patent in 2009 |CAS: 364-12-5

The Article related to pyridone preparation gpr119 g protein coupled receptor agonist diabetes, pyrimidinylpiperidinyloxy pyridone preparation g protein coupled receptor agonist hyperglycemia, oxadiazolylcyclohexyloxy pyridone preparation g protein coupled receptor agonist obesity and other aspects.Formula: C7H3BrF3I

On January 22, 2009, Wacker, Dean A.; Rossi, Karen A.; Wang, Ying published a patent.Formula: C7H3BrF3I The title of the patent was Preparation of pyridones as GPR119 G protein-coupled receptor agonists. And the patent contained the following:

The invention is related to pyridones I and II [G = CH, N; Q = C, N; X = CH, N, provided that Q and X are not both N; Y = CH2, NH and derivatives, CO, O, OCH2 and derivatives, S(O)0-2; U = (CH2)n; V = (CH2)m; n, m = independently 0-2; Z = (CH2)q; q = 1-2; R1 = (un)substituted 6-membered monocyclic (hetero)/aryl, 5-membered monocyclic heteroaryl; R2 = (un)substituted cycloalkyl, (hetero)/aryl, heterocyclyl, etc.; R20, R21 = independently H, halo, CN, CO2H, OCF3, haloalkyl, etc.] which are GPR119 G protein-coupled receptor modulators, especially GPR119 G agonists, and are useful in treating, preventing, or slowing the progression of diseases requiring GPR119 G protein-coupled receptor modulator therapy. Thus, arylation of 4-benzyloxy-2(1H)-pyridone with 4-bromophenyl Me sulfone, debenzylation, alkylation of the hydroxypyridinone with tert-Bu 4-[(methylsulfonyl)oxy]piperidine-1-carboxylate (preparation given) gave III. The in vivo modulation of recombinant human GPR119 was determined in a HIT-T15 cAMP assay, human Tet-inducible CAMP assay and luciferase assay (some data given). I, alone, or in combination with another therapeutic agent, are useful for treating diabetes, hyperglycemia, impaired glucose tolerance, obesity, metabolic syndrome, etc. The experimental process involved the reaction of 5-Bromo-2-iodobenzotrifluoride(cas: 364-12-5).Formula: C7H3BrF3I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

New downstream synthetic route of 5-Bromo-2-iodobenzotrifluoride

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 364-12-5, name is 5-Bromo-2-iodobenzotrifluoride, A new synthetic method of this compound is introduced below., name: 5-Bromo-2-iodobenzotrifluoride

A vial containing 4-bromo-l-iodo-2-(trifluoromethyl)benzene was charged with potassium phosphate (0.130 g, 0.614 mmol), followed by a solution of N-(2,4- dimethoxybenzyl)-l-methyl-3-(4,4,5,5-tetramethyl- 1,3, 2-dioxaborolan-2-yl)-N-( 1 ,2,4- thiadiazol-5-yl)-lH-indole-6-sulfonamide (Intermediate H) (0.100 g, 0.175 mmol) and PdCl2(dppf)-CH2Cl2 (0.014 g, 0.018 mmol) in 1 mL of DMF. The vial was sealed and placed in a shaker block. The block was shaken for three hours at 85 C. The solution was filtered, washed with DMF and concentrated. The resulting solid was treated with a solution of TFA (0.270 mL, 3.51 mmol) in 1 mL of DCM. The vial was shaken at room temperature for two hours. The solution was concentrated and purified via reverse phase HPLC (8 min. gradient elution 15 to 75% ACN/H20, 0.1% TFA modifier) to afford 3-(4- bromo-2-(trifluoromethyl)phenyl)-l-methyl-N-(l,2,4-thiadiazol-5-yl)-lH-indole-6- sulfonamide as an off-white solid.

Reference:
Patent; DINEEN, Thomas; MARX, Isaac, E.; NGUYEN, Hanh, Nho; WEISS, Matthew; AMGEN INC.; WO2013/25883; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A new synthetic route of C7H3BrF3I

The synthetic route of 364-12-5 has been constantly updated, and we look forward to future research findings.

364-12-5, name is 5-Bromo-2-iodobenzotrifluoride, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 364-12-5

[0088] Step A: Preparation of 1 -(4-bromo-2-(trifluoromethyl)phenyl)-2,2-dimethylpropan- 1-one [0089] 4-Bromo-1-iodo-2-(trifluoromethyl)benzene(2.0 g, 5.70 mmol, 1.0 equiv) was placed in an oven-dried scintillation vial and dissolved in THF (11.4 mL). Isopropylmagenesium chloride lithium chloride complext (5.7 mL of a 1.3 M solution in ether, 7.41 mmol, 1.3 equiv) was added, and the resultant dark brown solution was stuffed at rt for 2 h. The Grignard solution was then added dropwise to a solution of trimethylacetyl chloride (0.893 g, 7.41 mmol, 1.3 equiv in 11 mL THF) and the reaction was stuffed overnight. The reaction was quenched carefully with sat. NH4C1, diluted with ethyl acetate and water, and the layers were separated. The aqueous layer was extracted with ethylacetate (xl) and the combined organics were washed with brine, dried over sodium sulfate, filtered and concentrated. Purification by silica gel chromatography eluting with a 5% ethyl acetate/hexane gradient afforded 1.05 g (3.40 mmol, 60% yield) of the title compound as a yellow oil. ?H NMR (400 MHz, CDC13) oe 7.83 (d, J= 1.9 Hz, 1H), 7.69 (ddd, J= 8.3, 1.9, 0.7 Hz, 1H), 7.17 (d, J= 8.2 Hz, 1H), 1.25 (s, 9H); ?3C NMR (126 MHz, CDC13) oe 211.1, 138.3, 134.3, 130.1 (q, J= 4.5 Hz), 126.9, 123.7, 122.8, 121.5, 44.7, 27.6; ESIIVIS m/z 310 [M+Hf?.

The synthetic route of 364-12-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DOW AGROSCIENCES LLC; LOSO, Michael R.; GUSTAFSON, Gary D.; KUBOTA, Asako; YAP, Maurice C.; BUCHAN, Zachary A.; STEWARD, Kimberly M.; SULLENBERGER, Michael T.; HOEKSTRA, William J.; YATES, Christopher M.; WO2015/160664; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Continuously updated synthesis method about 5-Bromo-2-iodobenzotrifluoride

The chemical industry reduces the impact on the environment during synthesis 5-Bromo-2-iodobenzotrifluoride. I believe this compound will play a more active role in future production and life.

Reference of 364-12-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 364-12-5, name is 5-Bromo-2-iodobenzotrifluoride, This compound has unique chemical properties. The synthetic route is as follows.

full text is not avalable from article

The chemical industry reduces the impact on the environment during synthesis 5-Bromo-2-iodobenzotrifluoride. I believe this compound will play a more active role in future production and life.

Reference:
Article; Nino, Patricia; Caba, Marta; Aguilar, Nuria; Terricabras, Emma; Albericio, Fernando; Fernandez, Joan-Carles; Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry; vol. 55B; 7; (2016); p. 854 – 881;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Simple exploration of 5-Bromo-2-iodobenzotrifluoride

According to the analysis of related databases, 364-12-5, the application of this compound in the production field has become more and more popular.

Related Products of 364-12-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 364-12-5 as follows.

Step 1: 1-(4-bromo-2-(trifluoromethyl)phenyl)ethanone MS: 266.9 [M++1]

According to the analysis of related databases, 364-12-5, the application of this compound in the production field has become more and more popular.