Reference of 35944-64-0, These common heterocyclic compound, 35944-64-0, name is 3-Iodo-4-methylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 3-iodo-4-methylaniline (1 g, 4.29 mmol) in H2O (25 mL) was added H2SO4 (0.5 M, 25 mL). The solution was heated to 80 C. until all solid dissolved. Then the reaction was cooled to 0 C. and NaNO2 (444 mg, 6.39 mmol) was added in small portions. After 2 hr at this temperature, urea (126 mg, 2.1 mmol) was added at 0 C. The solution was allowed to warm up to room temperature and H2SO4 (0.5 M, 25 mL) was added. The reaction was refluxed for 30 min and cooled down to room temperature. The solution was extracted with EtOAc and Et2O and the combined organic phases were dried over Na2SO4, concentrated, and chromatographied to give the pure product v (800 mg, 80%).
Statistics shows that 3-Iodo-4-methylaniline is playing an increasingly important role. we look forward to future research findings about 35944-64-0.
Reference:
Patent; Synta Pharmaceuticals Corp.; US2006/173006; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com