Category: 355-43-1

Reference of 355-43-1, The chemical industry reduces the impact on the environment during synthesis 355-43-1, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, I believe this compound will play a more active role in future production and life.

General procedure: To a 25 mL of Schlenk tube equipped with a Teflon septum were added Ru(bpy)3Cl2 (1.5 mg, 0.5 mol%), Cs2CO3 (130 mg, 1.0 equiv) and 1 (0.4 mmol, 1.0 equiv) followed by DMSO 3.0 mL) with stirring. Perfluoroalkyl iodine (2.0 equiv.) was then added subsequently under Ar. The Schlenk tube was screw capped and the reaction was then under irradiated with a 12 W blue LEDs (460 nm-470 nm). After stirring for 24 h, the reaction mixture was diluted with ethyl acetate, washed with brine, the organic phases were collected and dried over anhydrous Na2SO4, filtered and concentrated. The residue was purified with silica gel chromatography to provide pure product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhang, Ben-Hou; Kong, Jing-Jing; Huang, Yang; Lou, Yue-Guang; Li, Xiao-Fei; He, Chun-Yang; Chinese Chemical Letters; vol. 28; 8; (2017); p. 1751 – 1754;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

355-43-1, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane

General procedure: In a three-necked round flask, 9-decene-1-ol (5.0mmol) and perfluoroalkyl iodide (6.0mmol) were dissolved in a mixture of CH3CN and H2O (1:1, 10mL total). Sodium dithionate (Na2S2O4) (5.8mmol) and sodium hydrogen carbonate (NaHCO3) (5.2mmol) were added to the reaction mixture and the solution was stirred at room temperature for 4h. The reaction mixture was extracted with ethyl acetate and washed three times with water. The organic layer was dried over sodium sulfate (Na2SO4), filtered, and evaporated to yield 3a (2.433g, 96.9%) or 3b (2.786g, 92.6%) as yellow liquid.

The synthetic route of 355-43-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Miyajima, Hiroki; Kasuya, Maria Carmelita Z.; Hatanaka, Kenichi; Journal of Fluorine Chemistry; vol. 222-223; (2019); p. 24 – 30;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 355-43-1, These common heterocyclic compound, 355-43-1, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A 25 mL of Schlenk tube equipped with a magnetic stir bar were charged with aniline (1.2 mmol, 3.0 equiv), K2CO3 (0.8 mmol, 2.0 equiv) and fac-Ir(ppy)3 (0.26 mg, 0.0004 mmol, 0.1 mol %) under air. The vessel was evacuated and backfilled with Ar (3 times), CnF2n+1I (n=6, 4, 2; 0.4 mmol, 1.0 equiv), anhydrous 1,2-dichloroethane (4 mL) were then added. The tube was screw capped and stirred at room temperature under irradiation of blue LEDs (12 W) for 24 hours. The reaction mixture was filtered through a pad of Celite and washed with ethyl acetate (3¡Á5 mL). The filtrate was concentrated. The residue was subjected to column chromatography on silica gel to afford the pure product.

The synthetic route of 355-43-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; He, Chun-Yang; Gu, Ji-Wei; Zhang, Xingang; Tetrahedron Letters; vol. 58; 41; (2017); p. 3939 – 3941;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 355-43-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 355-43-1 name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In a three-necked flask (200 mL) equipped with a condenser tube, 8.93 g (20.0 mmol) of perfluorohexyl iodide, 1.70 g (10.0 mmol) of 10-undecenol, 0.657 g of azobisisobutyronitrile (4.00 mmol), and the interior of the vessel was purged with argon and then heated at 80 C. for 8 hours with stirring. The reaction mixture was dissolved in 100 ml of ethanol and 5.00 g (76.5 mmol) of zinc powder was added and stirred for 15 minutes, then 3.00 g (50.0 mmol) of acetic acid was added and the mixture was heated under reflux for 5 hours. After cooling to room temperature, it was filtered through celite to remove residual zinc powder. After concentrating the filtrate under reduced pressure, diethyl ether was added and washed with water to remove excess acetic acid. After concentration under reduced pressure, recrystallization in hexane gave 4.04 g (yield 82%) of fluorinated alcohol (III-1) C 6 F 13 – (CH 2) 11 -OH.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, and friends who are interested can also refer to it.

Reference:
Patent; NEOS Corporation; Morioka, Kyoichi; Miyata, Koji; Terauchi, Shunji; Narimatsu, Shinsuke; Umeda, Takahiko; (14 pag.)JP6091963; (2017); B2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 355-43-1, These common heterocyclic compound, 355-43-1, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In a Pyrex glass tube were placed olefin (0.2 mmol), perfluoroalkyl iodide (1.0 mmol), and CH2Cl2 (5 mL). Then Na2S2O3 (0.5 mmol, 79 mg) and water (1 mL) were added to the mixture. After sealing the tube, the mixture was shaked and then irradiated with a Hg lamp at room temperature. After the reaction was completed, the mixture was extracted with CH2Cl2. The extract was washed with brine, dried over Na2SO4, filtered, and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography to afford pure product.

Statistics shows that 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane is playing an increasingly important role. we look forward to future research findings about 355-43-1.

Reference:
Article; Yajima, Tomoko; Jahan, Ishrat; Tonoi, Takayuki; Shinmen, Manami; Nishikawa, Aya; Yamaguchi, Kanako; Sekine, Izumi; Nagano, Hajime; Tetrahedron; vol. 68; 34; (2012); p. 6856 – 6861;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 355-43-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 355-43-1 as follows.

General procedure: To a 25 mL of Schlenk tube equipped with a Teflon septum were added Ru(bpy)3Cl2 (1.5 mg, 0.5 mol%), Cs2CO3 (130 mg, 1.0 equiv) and 1 (0.4 mmol, 1.0 equiv) followed by DMSO 3.0 mL) with stirring. Perfluoroalkyl iodine (2.0 equiv.) was then added subsequently under Ar. The Schlenk tube was screw capped and the reaction was then under irradiated with a 12 W blue LEDs (460 nm-470 nm). After stirring for 24 h, the reaction mixture was diluted with ethyl acetate, washed with brine, the organic phases were collected and dried over anhydrous Na2SO4, filtered and concentrated. The residue was purified with silica gel chromatography to provide pure product.

According to the analysis of related databases, 355-43-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhang, Ben-Hou; Kong, Jing-Jing; Huang, Yang; Lou, Yue-Guang; Li, Xiao-Fei; He, Chun-Yang; Chinese Chemical Letters; vol. 28; 8; (2017); p. 1751 – 1754;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 355-43-1, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, molecular formula is C6F13I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane

A Schlenk flask was charged with alkoxy ester 10b (3.48g, 10.0mmol), copper powder (1.40g, 22.0mmol), 2,2?-bipyridyl (20mg, 0.13mmol), DMSO (40mL) and hexafluorobenzene (80mL). The mixture was heated to 70C and perfluorohexyl iodide (4.47g, 22.0mmol), dissolved in hexafluorobenzene (20mL), was dropwise added. The mixture was then heated to 105C for 72h. After cooling to r.t., the mixture was partitioned between water (60mL) and dichloromethane (60mL) and the heterogeneous mixture formed was filtered over short silica gel column. The organic layer was separated and the aqueous layer was extracted with dichloromethane (3¡Á60mL). The combined organic layers were dried with anhydrous magnesium sulfate, the drying agent was filtered off and the solvent was removed on a rotary vacuum evaporator (40C, 1h, 25kPa) to give the target ester 11b (5.19g, 95.9%, colourless viscous oil).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 355-43-1, its application will become more common.

Reference:
Article; Kvi?ala, Jaroslav; Schindler, Martin; Kelbichova, Vendula; Babun?k, Mario; Ryba?kova, Marketa; Kvi?alova, Magdalena; Cva?ka, Josef; B?ezinova, Anna; Journal of Fluorine Chemistry; vol. 153; (2013); p. 12 – 25;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 355-43-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 355-43-1 as follows.

In a 25 mL round bottomed flask, was placed under N2 atmosphere a mixture of 2 (0.66 g, 2.0 mmol), perfluoro 1-iodohexane or perfluoro 1-iodooctane (2.5 mmol), AIBN (13 mg, 0.08 mmol) and 2 mL of 1,2-dichloroethane. The mixture was then stirred at 75C for 18 h. After cooling to room temperature, the solvent was removed under vacuum and the residue was subjected to a column chromatography on silica gel (ethyl acetate/hexane: 1/3) followed by a recrystallization in ethanol, to provide 3a and 3b as white solids. 4.3.1. 4′-{(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-2-iodononyl)oxy}-(1,1′-biphenyl)-4-yl benzoate (3a) Yield: 89%. 1H NMR (CDCl3) d 8.25 (d, 2H, J = 7.5 Hz), 7.5-7.7 (m,7H), 7.30 (d, 2H, J = 8.2 Hz), 7.0 (d, 2H, J = 8.5 Hz), 4.55 (quint., 1H, CHI), 4.21-4.38 (dd, 2H,2J = 10.5 Hz,3J = 4.8 Hz, CHICH2O), 2.85-3.23 (m, 2H, CF2CH2CHI). 13C NMR (CDCl3) d(ppm) 165.2(CO), 157.2 (ArO), 150.1 (ArO), 138.3, 134.2, 133.6, 130.2, 129.51, 128.5, 128.3, 127.8, 121.9, 115.2, 72.8 (CH2O), 37.8 (t,2JCF= 21 Hz, CF2CH2), 12.7 (CI). 19F NMR (CDCl3) d(ppm) 80.5 (t, CF3, 3JFF= 10.0 Hz), 113.1 & 113.3 (dm & dm, 21F, JA-B= 295 Hz, 2 diastereoisomers of CHICH2CF2), 121.5 (m, 2F), 122.6 (m,2F), 123.3 (m, 2F), 125.8 (m, 2F). HRMS (ESI) calculated for C28H18F13IO3Na+: 799.314 (found: 799.005).

According to the analysis of related databases, 355-43-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Marzouk, Samir; Khalfallah, Ali; Heinrich, Benoit; Khiari, Jamel Eddine; Kriaa, Abdelkader; Mery, Stephane; Journal of Fluorine Chemistry; vol. 197; (2017); p. 15 – 23;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

355-43-1, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C6F13I

Cooled to -78 C. zirconocene dichloride(Cp 2 ZrCl 2, 70.2 mg, 0.24 mmol)Of ether (2.4 mL)To the solution was added n-propylmagnesium chloride (2.0 M in ether solution, 0.12 mL, 0.24 mmol)1,4-Dioxane (23 [mu] L, 0.27 mmol)And n-tridecafluorohexyl iodide (C 6 F 13 I, 78 muL, 0.36 mmol) were added,And the mixture was stirred at the same temperature for 1 hour.Then,Methylaluminoxane(10% toluene solution, 0.16 mL, 0.24 mmol) was added thereto, the temperature was raised to 0 C., and the mixture was stirred for 2 minutes. After adding styrene oxide (23 muL, 0.20 mmol) to this, the temperature was raised to room temperature and stirred for 1 hour.After completion of the reaction, 1 N hydrochloric acid was added to quench the reaction and then extracted 3 times with ether, and the organic layers were combinedDried over sodium sulfate, filtered and the solvent was distilled off under reduced pressure to give a crude product. The crude product obtainedThe product was purified by silica gel column chromatography (hexane / ethyl acetate = 20/1 (v / v)) To obtain 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecaFluoro-1-phenyl-2-hydroxyoctane (77.5 mg, yield: 88%).

The synthetic route of 355-43-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TOKYO INSTITUTE OF TECHNOLOGY; TOSOH F-TECH INCORPORATED; MIKAMI, KOICHI; FUJIU, MOTOHIRO; (46 pag.)JP5894739; (2016); B2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 355-43-1, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane

General procedure: In a Pyrex glass tube were placed TTMSS (0.2 mmol), olefin (0.24 mmol), perfluoroalkyl iodide (0.24 mmol) and CH2Cl2 (5 mL). Then Na2S2O3 (0.5 mmol, 79 mg) and water (1 mL) were added to the mixture. After sealing the tube, the mixture was shaken and then irradiated with a Hg lamp at room temperature. After the reaction was completed, the mixture was extracted with CH2Cl2. The extract was washed with brine, dried over Na2SO4, filtered, and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography to afford pure product. 4.2.4 Ethyl 2-methyl-3-perfluorohexylpropanoate (6a) Colorless oil. 1H NMR (400 MHz, CDCl3) delta 4.20 (q, J = 7.2 Hz, 2H), 2.90 (m, 1H), 2.73 (m, 1H), 2.09 (m, 1H), 1.30 (d, J = 7.6 Hz, 3H), 1.25 (t, J = 7.2 Hz, 3H); 13C NMR (150 MHz, CDCl3) delta 174.6, 61.1, 34.9 (t, JC-F = 21.1 Hz, C6F13C), 32.8, 18.3, 14.0; IR (KBr) 2962, 1735, 1240, 1219, 1146, 806, 697 cm-1; HRMS (ESI+) m/z calcd for C12H11F13O2Na [M+Na]+ 457.0450, found 457.0444.

The synthetic route of 355-43-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yajima, Tomoko; Yamaguchi, Kanako; Hirokane, Rie; Nogami, Emiko; Journal of Fluorine Chemistry; vol. 150; (2013); p. 1 – 7;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com