Category: 349404-93-9

Quinols As Novel Therapeutic Agents. 7.Synthesis of Antitumor 4-[1-(Arylsulfonyl-1H-indol-2-yl)]-4-hydroxycyclohexa-2,5-dien-1-ones by Sonogashira Reactions was written by McCarroll, Andrew J.;Bradshaw, Tracey D.;Westwell, Andrew D.;Matthews, Charles S.;Stevens, Malcolm F. G.. And the article was included in Journal of Medicinal Chemistry in 2007.Application In Synthesis of 4-Bromo-N-(2-iodophenyl)benzenesulfonamide The following contents are mentioned in the article:

Interaction of 2-iodoaniline or 5-fluoro-2-iodoaniline with a range of arylsulfonyl chlorides affords sulfonamides that undergo Sonogashira couplings under thermal or microwave conditions with the alkyne 4-ethynyl-4-hydroxycyclohexa-2,5-dien-1-one followed by cyclization to 4-[1-(arylsulfonyl-1H-indol-2-yl)]-4-hydroxycyclohexa-2,5-dien-1-ones. This method allows for incorporation of a range of substituents into the arylsulfonyl moiety, and compounds showed selective in vitro inhibition of cancer cell lines of colon and renal origin, a feature of compounds bearing the quinol pharmacophore. This study involved multiple reactions and reactants, such as 4-Bromo-N-(2-iodophenyl)benzenesulfonamide (cas: 349404-93-9Application In Synthesis of 4-Bromo-N-(2-iodophenyl)benzenesulfonamide).

4-Bromo-N-(2-iodophenyl)benzenesulfonamide (cas: 349404-93-9) belongs to iodide derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Application In Synthesis of 4-Bromo-N-(2-iodophenyl)benzenesulfonamide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Deacetylative Aryl Migration of Diaryliodonium Salts with C(sp²)-N Bond Formation toward ortho-Iodo N-Aryl Sulfonamides was written by Chen, Huangguan;Wang, Limin;Han, Jianwei. And the article was included in Organic Letters in 2020.Name: 4-Bromo-N-(2-iodophenyl)benzenesulfonamide The following contents are mentioned in the article:

An unprecedented approach of metal-free C(sp²)-N bond formation via deacetylation/intramol. aryl migration is demonstrated with novel N-sulfonamide substituted diaryliodonium salts. The reaction provides a variety of ortho-iodo N-aryl sulfonamides. The products were employed in several coupling reactions to afford useful diarylamine scaffolds. Furthermore, the key intermediates of zwitterionic iodoniums in the reaction were isolated and verified by the X-ray crystallog. anal., which showcased unambiguous mechanistic insight into the reactivity of the reaction cascade. This study involved multiple reactions and reactants, such as 4-Bromo-N-(2-iodophenyl)benzenesulfonamide (cas: 349404-93-9Name: 4-Bromo-N-(2-iodophenyl)benzenesulfonamide).

4-Bromo-N-(2-iodophenyl)benzenesulfonamide (cas: 349404-93-9) belongs to iodide derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Name: 4-Bromo-N-(2-iodophenyl)benzenesulfonamide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Efficient and Divergent Synthesis of Medium-Sized Lactams through Zinc-Catalyzed Oxidative Cyclization of Indolyl Ynamides was written by Li, Hang-Hao;Ye, Si-Han;Chen, Yang-Bo;Luo, Wen-Feng;Qian, Peng-Cheng;Ye, Long-Wu. And the article was included in Chinese Journal of Chemistry in 2020.HPLC of Formula: 349404-93-9 The following contents are mentioned in the article:

An efficient zinc-catalyzed oxidative cyclization of readily available indolyl ynamides has been developed, enabling rapid and practical access to a diverse array of valuable medium-sized lactams I (R¹ = H, 10-Me, 10-Cl, etc.; R² = Ph, 4-MeC₆H₄, 3-MeOC₆H₄, etc.; PG = Ms, Ts, Bs), II (R¹ = H, 8-Me, 9-Br, etc.; R² = Ph, 4-NCC₆H₄, 3-ClC₆H₄, etc.; PG = Ms, Ts, Bs) in mostly good to excellent yields with wide substrate scope. In addition, such an asym. synthesis has also been explored by employing the chiral substrate. This study involved multiple reactions and reactants, such as 4-Bromo-N-(2-iodophenyl)benzenesulfonamide (cas: 349404-93-9HPLC of Formula: 349404-93-9).

4-Bromo-N-(2-iodophenyl)benzenesulfonamide (cas: 349404-93-9) belongs to iodide derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.HPLC of Formula: 349404-93-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Copper-Catalyzed Cascade Cyclization of Indolyl Homopropargyl Amides: Stereospecific Construction of Bridged Aza-[n.2.1] Skeletons was written by Tan, Tong-De;Zhu, Xin-Qi;Bu, Hao-Zhen;Deng, Guocheng;Chen, Yang-Bo;Liu, Rai-Shung;Ye, Long-Wu. And the article was included in Angewandte Chemie, International Edition in 2019.SDS of cas: 349404-93-9 The following contents are mentioned in the article:

Catalytic cycloisomerization-initiated cascade cyclizations of terminal alkynes have received tremendous interest, and been widely used in the facile synthesis of a diverse array of valuable complex heterocycles. However, these tandem reactions have been mostly limited to noble-metal catalysis, and are initiated by an exo-cyclization pathway. Reported herein is an unprecedented copper-catalyzed endo-cyclization-initiated tandem reaction of indolyl homopropargyl amides, where copper catalyzes both the hydroamination and Friedel-Crafts alkylation process [e.g., I → II (85%)]. This method allows the practical and atom-economical synthesis of valuable bridged aza-[n.2.1] skeletons (n=3-6) with wide substrate scope, and excellent diastereoselectivity and enantioselectivity by a chirality-transfer strategy. Moreover, the mechanistic rationale for this novel cascade cyclization is also strongly supported by control experiments, and is distinctively different from the related gold catalysis. This study involved multiple reactions and reactants, such as 4-Bromo-N-(2-iodophenyl)benzenesulfonamide (cas: 349404-93-9SDS of cas: 349404-93-9).

4-Bromo-N-(2-iodophenyl)benzenesulfonamide (cas: 349404-93-9) belongs to iodide derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.SDS of cas: 349404-93-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com