Category: 34883-46-0

Adding a certain compound to certain chemical reactions, such as: 34883-46-0, name is 1-Iodo-2-phenoxybenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 34883-46-0, Application In Synthesis of 1-Iodo-2-phenoxybenzene

In a 2L three-necked flask,Into 44.4g (150mmol, 1.0eq.) 2- iodo diphenyl ether,Dissolved with 1000 ml of chloroform,An additional 16.8 g (300 mmol, 2.0 eq.) of potassium hydroxide was added.95.85 g (600 mmol, 4.0 eq.) of liquid bromine was added dropwise at room temperature.After the completion of the dropwise addition, the reaction was stirred at room temperature for 12 hours.The reaction was quenched with a saturated Na 2 SO 3 solution, and a large amount of solid was precipitated, stirred, suction filtered, washed with water, washed with ethanol, and recrystallized from chloroform and ethanol.Finally, 50 g of Intermediate-1 was obtained in a yield of 73.3%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Iodo-2-phenoxybenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nanjing Gao Guang Semiconductor Materials Co., Ltd.; Jin Zhenyu; Qian Chao; Guo Shuai; Dai Peipei; (35 pag.)CN108101922; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

34883-46-0, name is 1-Iodo-2-phenoxybenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C12H9IO

Synthesis of 1-(2,6-diisopropylphenyl)-3-(2-methoxyphenyl)imidazolidin-2-one To a 200 mL Schlenk flask equipped with a magnetic stirbar was added copper (I) iodide (0.928 g, 4.87 mmol, 0.3 equiv.), K3PO4 (6.89 g, 32.5 mmol, 2 equiv.), 1-iodo-2-phenoxybenzene (2.11 mL, 16.2 mmol, 1 equiv.), and 1-(2,6-diisopropylphenyl)imidazolidin-2-one (4.0 g, 16.2 mmol, 1 equiv.). The vessel was sealed with a septum and purged with nitrogen. Subsequently, N,N’-dimethylethylenediamine (1.05 mL, 9.74 mmol, 0.6 equiv.) and N,N-dimethylacetamide (65 mL) were added via syringe. The reaction was placed into an aluminum heating block preheated to 130 C. and stirred for 24 h. After cooling to room temperature, the material was poured onto diethyl ether (250 mL) and washed with water (2*250 mL). The combined aqueous layers were back extracted with diethyl ether (1*250 mL), dried over MgSO4, and filtered. The solution was concentrated via rotary evaporation. Adsorption onto silica gel, purification via flash column chromatography (ISCO, 220 g silica, 20-30% EtOAc in hexanes gradient), and concentration via rotary evaporation yielded the product as a white solid (5.03 g, 92% yield). 1H NMR (400 MHz, Chloroform-d) delta 7.44-7.38 (m, 1H), 7.31 (dd, J=8.3, 7.1 Hz, 1H), 7.23-7.16 (m, 3H), 7.00-6.93 (m, 2H), 4.01-3.91 (m, 2H), 3.87 (s, 3H), 3.79-3.65 (m, 2H), 3.16 (hept, J=6.9 Hz, 2H), 1.28 (d, J=6.1 Hz, 6H), 1.26 (d, J=6.1 Hz, 6H). 13C NMR (101 MHz, Chloroform-d) delta 158.72, 155.22, 148.25, 133.74, 129.23, 128.62, 128.54, 127.53, 123.97, 120.93, 112.33, 55.72, 46.73, 45.58, 28.62, 24.61, 24.27. HRMS (ESI) Calculated for C22H28N2O2: [M+H]+: 353.2224. found 353.2229.

The synthetic route of 34883-46-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DOW GLOBAL TECHNOLOGIES LLC; Klosin, Jerzy; Fontaine, Philip P.; Figueroa, Ruth; Pearson, David M.; Senecal, Todd D.; (74 pag.)US2016/311837; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

34883-46-0, name is 1-Iodo-2-phenoxybenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 34883-46-0

(1)To 1-iodo-2-phenoxybenzene (2g, 6.8mmol)Triethylamine (20mL)Adding 4 methoxyphenylacetylene to the solution(0.98 g, 7.4 mmol), Pd(PPh3)2Cl2 (95 mg, 135 mumol), CuI (26 mg, 135 mumol).Under argon protection conditions,After the reaction was carried out for 10 h, triethylamine was removed under reduced pressure.The residue was extracted with ethyl acetate (20 mL×3) then water (10 mL)Wash twice with saturated brine (10 mL), dry over anhydrous sodium sulfate and filtered.The solvent was removed under pressure. The residue was purified by silica gel column chromatography eluting elut1-((4-Methoxyphenyl)ethynyl)-2-phenoxybenzene(1.7 g, 85% yield).

The synthetic route of 34883-46-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhongshan University Tumor Cure Center (Zhongshan University Affiliated Tumor Hospital ? Zhongshan University Tumor Institute); Wen Shijun; Huang Peng; Zhu Daqian; Tu Yalin; Luo Bingling; (28 pag.)CN108976248; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 34883-46-0, A common heterocyclic compound, 34883-46-0, name is 1-Iodo-2-phenoxybenzene, molecular formula is C12H9IO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 1.0 equivalent of intermediate Bn was dissolved in 120 ml of 0.4 M anhydrous tetrahydrofuran (THF).After cooling to -78 C, slowly add n-butyllithium (n-BuLi) (2.5 M,1.0 equivalent of the reaction solution was formed and stirred for 1 hour. then,The intermediate An (0.7 eq.) was added to the reaction solution and stirred at 25 C for an additional 3 hours.After the completion of the reaction, the reaction solution was cooled with a saturated aqueous solution of ammonium chloride, and then extracted with an organic solvent to separate the organic phase. After concentration, it was recrystallized from petroleum ether to obtain a white solid product. The white solid product was analyzed by FD-MS to determine the chemical structural formula, yield, and molecular formula and mass determined by FD-MS analysis of each of the intermediates C1 to C12 are listed in Table 3-1.

The synthetic route of 34883-46-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NICHEM FINE TECHNOLOGY CO., LTD.; LU, TAI-NI; WU, HUI-LING; SHIEH, SHWU-JU; CHEN, CHI-CHUNG; (84 pag.)TWI644912; (2018); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 34883-46-0, name is 1-Iodo-2-phenoxybenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C12H9IO

Intermediate Bn (1.0 eq) was dissolved in 120 mL of anhydrous THF (0.4M), and cooled to -78 C. n-Butyllithium (n-BuLi)(2.5 M, 1.0 eq) was slowly added to the above cooled solution, and the reaction mass was stirred for 1 h. After 1 h of stirring, Intermediate An (0.7 eq) was added to the reaction solution and stirred for additional 3 h at normal temperature. After the completion of the reaction, it was quenched by saturated solution of ammonium chloride, and extracted with organic solvent. The organic layer was separated, concentrated, and recrystallized with petroleum ether to obtain a white solid product. The white solid product was analyzed by FD-MS, and the result was listed in Table 3-1. The chemical structures of Intermediates Cn-1 were listed in Table 3-1

The synthetic route of 34883-46-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NICHEM FINE TECHNOLOGY CO., LTD.; WU, Hui-Ling; LIAO, Liang-Di; SHIEH, Shwu-Ju; CHEN, Chi-Chung; (145 pag.)US2018/155312; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 34883-46-0, name is 1-Iodo-2-phenoxybenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 34883-46-0

General procedure: Intermediate Bn (1.0 eq) was dissolved in 120 mL of anhydrous tetrahydrofuran (THF) (0.4M), and cooled to -78 C. n-Butyllithium (n-BuLi)(2.5 M, 1.0 eq) was slowly added to the above cooled solution, and the reaction mass was stirred for 1 h. After 1 h of stirring, Intermediate An (0.7 eq) was added to the reaction solution and stirred for additional 3 h at 25 C. After the completion of the reaction, it was quenched by saturated solution of ammonium chloride, and extracted with organic solvent. The organic layer was separated, concentrated, and recrystallized with petroleum ether to obtain a white solid product.

The synthetic route of 34883-46-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NICHEM FINE TECHNOLOGY CO., LTD.; LU, Tai-Ni; WU, Hui-Ling; SHIEH, Shwu-Ju; CHEN, Chi-Chung; (108 pag.)US2019/92745; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 34883-46-0, name is 1-Iodo-2-phenoxybenzene, A new synthetic method of this compound is introduced below., Product Details of 34883-46-0

[1030] To an ice- cooling mixture of 1-iodo-2-phenoxybenzene (0.404 g, 1.36 mmol) in THF (3 mL) was added isopropylmagnesium bromide (1.36 mL, 1.0 M solution in THF)drop-wise. After stirring at 0C for 1.5 h, a solution of compound 63 (100 mg, 0.27 mmol) in THF (2 mL) was quickly added drop-wise to the mixture above. The resulted mixture was stirred at 0C for 30mm, then slowly warmed up to room temperature and stirred for lh, the reaction mixture was once more cooled down to about 0C, and saturated ammonium chloride solution (5 mL) was added. Then the solvent was evaporated. The aqueous residue thatremained was diluted with water (10 mL), and the mixture was extracted with dichloromethane (10 mL x 3). The combined organic phase was washed with brine and dried over sodium sulfate, filtered and concentrated to afford compound 148.2 (80 mg, yield: 55%)as a yellow solid. [1031] m/z: [M+H]537

The synthetic route of 34883-46-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SHANGHAI DE NOVO PHARMATECH CO.,LTD.; LI, Qun; GAO, Daxin; (158 pag.)WO2016/131380; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 34883-46-0, name is 1-Iodo-2-phenoxybenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 34883-46-0, Quality Control of 1-Iodo-2-phenoxybenzene

In a 2L three-necked flask,Into 44.4g (150mmol, 1.0eq.) 2- iodo diphenyl ether,Dissolved with 1000 ml of chloroform,An additional 16.8 g (300 mmol, 2.0 eq.) of potassium hydroxide was added.95.85 g (600 mmol, 4.0 eq.) of liquid bromine was added dropwise at room temperature.After the completion of the dropwise addition, the reaction was stirred at room temperature for 12 hours.The reaction was quenched with a saturated Na 2 SO 3 solution, and a large amount of solid was precipitated, stirred, suction filtered, washed with water, washed with ethanol, and recrystallized from chloroform and ethanol.Finally, 50 g of Intermediate-1 was obtained in a yield of 73.3%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Iodo-2-phenoxybenzene, other downstream synthetic routes, hurry up and to see.

34883-46-0, name is 1-Iodo-2-phenoxybenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C12H9IO

(1): To 1-iodo-2-phenoxybenzene (2 g, 6.8 mmol)a solution of triethylamine (20 mL) added to phenylacetylene(0.83 g, 8.1 mmol), Pd(PPh3)2Cl2 (95 mg, 135 mumol), CuI (26 mg, 135 mumol).Under argon protection conditions, after 10 hours of reaction,Triethylamine was removed under reduced pressure.The residue was extracted with ethyl acetate (20 mL¡Á3).Then washed twice with water (10 mL) and saturated brine (10 mL).Dry over anhydrous sodium sulfate, filter, and remove the solvent under pressure.The residue was purified by silica gel column chromatography eluting elut1-phenoxy-2-(phenylethynyl)benzene(1.6 g, 88% yield).

The synthetic route of 34883-46-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhongshan University Tumor Cure Center (Zhongshan University Affiliated Tumor Hospital ? Zhongshan University Tumor Institute); Wen Shijun; Huang Peng; Zhu Daqian; Tu Yalin; Luo Bingling; (28 pag.)CN108976248; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com