Category: 34683-73-3

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 34683-73-3 as follows. HPLC of Formula: C6H12ClI

(6) Synthesis of 15-chloro-3,6,9-trioxapentadecyl azide NaH (54.7 mg, 2.28 mmol), 2-(2-(2-azidoethoxy)ethoxy)ethanol (160.3 mg, 0.915 mmol), and THF (3 mL) were added to a 30-mL eggplant flask, followed by 2 hours of stirring at room temperature under an argon atmosphere. 1-chloro-6-iodohexane (152 muL, 1.01 mmol) was added to the solution, followed by 3.5 hours of stirring. Since the raw materials remained on TLC, 1-chloro-6-iodohexane (28 muL, 0.183 mmol) was added and then the solution was further stirred for 16 hours. Since the raw materials still remained, NaH (11.2 mg, 0.467 mmol) was added and then the solution was stirred for 5.5 hours. However, TLC remained unchanged. H2O was added to quench the reaction, and then the solvent was removed under reduced pressure. CHCl3 and 1M HCl were added to the flask and then the solution was stirred. The organic layer was collected and dried with MgSO4, and then the solvent was removed under reduced pressure. The thus obtained product was purified by flash column chromatography (elution solvent: hexane/EtOAc=6/1), and thus 42.6 mg (0.145 mmol, 15.8% yield) of a target product was obtained.

According to the analysis of related databases, 34683-73-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Toho University; FURUTA, Toshiaki; SONE, Masaki; SUZUKI, Akinobu; OKA, Eri; US2014/256015; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 34683-73-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 34683-73-3 name is 1-Chloro-6-iodohexane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 1-chloro-6-iodohexane (5.0 g, 20.24 mmol), 10 mL of acetone, and potassium thioacetate (2.31 g, 20.24 mmol) was stirred at room temperature for 20 h under nitrogen atmosphere. The excess of acetone was removed and the crude product was diluted with water and extracted three times with CH2Cl2. The combined organic layers were dried over Na2SO4 and concentrated to give 7a (3.74 g, 95% yield) as a white solid. 1H NMR (500 MHz, CDCl3): delta = 3.46 (t, J = 6.6 Hz, 2H), 2.80 (t, J = 7.4 Hz, 2H), 2.25 (s, 3H), 1.70 (m, 2H), 1,52 (m, 2H), 1.40-1.30 ppm (m, 4H); 13C NMR (125 MHz, CDCl3): delta = 195.8, 44.9, 32.4, 30.6, 29.3, 28.9, 28.0, 26.3 ppm.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Chloro-6-iodohexane, and friends who are interested can also refer to it.

Reference:
Article; Banerjee, Sumela; Voit, Brigitte; Heinrich, Gert; Boehme, Frank; Tetrahedron Letters; vol. 53; 17; (2012); p. 2236 – 2238;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 34683-73-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 34683-73-3, name is 1-Chloro-6-iodohexane, This compound has unique chemical properties. The synthetic route is as follows.

A 100 ml round bottom flask was charged with [2-(2-Hydroxy-ethoxy)-ethyl]-carbamic acid anthracen-9-ylmethyl ester (1.12 g, 3 mmol) and fresh sodium hydride, 60% dispersion in mineral oil (360 mg, 9 mmol) under inert atmosphere. 20 ml anhydrous THF was added and the reaction allowed to stir for 30 minutes. The flask is then cooled to between -10 and -20 C. by means of an ice/NaCl bath. When the temperature is reached 1-chloro-6-Iodohexane (1 ml, 6 mmol) is added via syringe. The reaction is maintained at ice/NaCl temperature for 2 hours, then slowly allowed to warm to room temperature overnight. At this point silica gel 60 is co-absorbed onto the reaction mixture with loss of solvent under reduced pressure. Silica gel chromatography takes place initially with heptane as eluent, followed by 10%, 20%, and 25% ethyl acetate. A total of 0.57 g (41% yield) of product is isolated from appropriate fractions: 1H NMR (CDCl3) delta 8.48 (s, H-10), 8.38 (d, H-1, 8), 8.01 (d, H-4, 5), 7.52 (dt, H-2, 3, 6, 7), 6.13 (s, CH2-anth), 5.29 (bs, exchangeable, NH), 3.74 (m, 4H), 3.55-3.15 (m, 8H), 1.84 (m, 4H), 1.61 (m, 1H), 1.43 (m, 1H), 1.25 (m, 2H). Mass spectrum, m/e Calcd for C26H32ClNO4H2O: 475.21 (100%), 476.22 (29.6%). Found: 475.21, 476.52.

The chemical industry reduces the impact on the environment during synthesis 1-Chloro-6-iodohexane. I believe this compound will play a more active role in future production and life.

Reference:
Patent; PROMEGA CORPORATION; Wood, Keith V.; Los, Georgyi V.; Bulleit, Robert F.; Klaubert, Dieter; McDougall, Mark; Zimprich, Chad; (78 pag.)US2016/31911; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 34683-73-3, name is 1-Chloro-6-iodohexane, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H12ClI

Example 6 Compound (6) is prepared as follows : Step 6. 1 : 5-(6-chlorohexyl)-2,2′-bithiophene; To a stirred solution of 2, 2′-bithiophene (10.0 g, 60.24 mmol) in anhydrous THF (150 mi) is added n-butyllithium (2.5 M in hexanes, 20.0 ml, 50.0 mmol) dropwise at-78 C under nitrogen. After complete addition, the mixture is allowed to warm to room temperature, with stirring, over 2 h, followed by the addition of 1- chloro-6-iodohexane (14.55 g, 50.0 mmol). The resultant mixture is stirred overnight at room temperature. The reaction is quenched with sat. aq. NH4Ci, and the reaction mixture is extracted with ethyl acetate (3 x 100 ml). The combined organic extracts are washed with water, brine, and dried over sodium sulphate. The solvent is removed under reduced pressure and the residue is purified by column chromatography on silica, eluting with petroleum ether, to give 5- (6- chlorohexyl)-2, 2′-bithiophene as a white solid (7.73 g, 54 %). H NMR (300 MHz, CDCl3) : 8 (ppm) 7.14 (d, J = 5.3 Hz, 1.3 Hz, 1 H, Ar-H), 7. 08 (dd, J = 3.5 Hz, 1.1 Hz, 1 H, Ar-H), 6.97 (m, 2H, Ar-H), 6.66 (d, J = 3.5 Hz, 1 H, Ar-H), 3.51 (d, J = 6.6 Hz, 2H, CICH2), 2.78 (t, J = 7.1 Hz 2H, ArCH2), 1.61-1. 81 (m, 4H, CH2), 1.35-1. 51 (m, 4H, CH2) ; MS (m/e) : 282 (M+, 2 %), 166 (8), 123 (39), 110 (22), 97 (100).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 34683-73-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 34683-73-3, name is 1-Chloro-6-iodohexane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of 2,2′-bithiophene (10.0 g, 60.24 mmol) in anhydrous THF (150 ml) was added n-butyllithium (2.5 M in hexanes, 20.0 ml, 50.0 mmol) dropwise at -78 C under nitrogen. After complete addition, the mixture was allowed to warm to room temperature, with stirring, over 2 h, followed by the addition of 1- chloro-6-iodohexane (14.55 g, 50.0 mmol). The resultant mixture was stirred overnight at room temperature. The reaction was quenched with sat. aq. NH4CI, and the reaction mixture was extracted with ethyl acetate (3 x 100 ml). The combined organic extracts were washed with water, brine, and dried over sodium sulphate. The solvent was removed under reduced pressure and the residue was purified by column chromatography on silica, eluting with petroleum ether, to give 5-(6-chlorohexyl)-2,2′-bithiophene as a white solid (7.73 g, 54 %). ?H NMR (300 MHz, CDC13): 8 (ppm) 7.14 (d, J = 5.3 Hz, 1.3 Hz, 1 H, Ar- H), 7.08 (dd, J = 3.5 Hz, 1.1 Hz, 1 H, Ar-H), 6.97 (m, 2H, Ar-H), 6.66 (d, J = 3.5 Hz, 1 H, Ar-H), 3.51 (d, J = 6.6 Hz, 2H, CICH2), 2.78 (t, J = 7.1 Hz 2H, ArCH2), 1.61-1.81 (m, 4H, CH2), 1.35-1.51 (m, 4H, CH2); MS (m/e): 282 (M+, 2 %), 166 (8), 123 (39), 110 (22), 97 (100)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Chloro-6-iodohexane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK PATENT GMBH; WO2005/121150; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

34683-73-3, name is 1-Chloro-6-iodohexane, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 34683-73-3

5-(7-Chloroheptyl)-3-methyl-isoxazole (VIII) 21.0 g (0.216 mol) of 3,5-dimethylisoxazole (VII) (prepared in accordance with the method of C. Kashima et al., Bull. Chem. Soc. Jap. 46, 310, 1973) are dissolved in 200 ml of absolute tetrahydrofuran, the solution is cooled to -80 C. and 160 ml of n-butyllithium (1.35M solution in n-hexane, 0.216 mol) are added dropwise at this temperature in the course of 40 minutes. The mixture is stirred at a temperature below -75 C. for a further 15 minutes. The reaction mixture is then added dropwise to a solution of 53.5 g (0.217 mol) of 1-iodo-6-chlorohexane (prepared in accordance with the method of W. F. Huber, J. Am. Chem. Soc. 73, 2730, 1951) in 150 ml of absolute tetrahydrofuran so that the temperature does not rise above -60 C. When the addition has ended, the mixture is stirred at -60 C. for a further 15 minutes and allowed to warm to room temperature. The reaction mixture is partitioned between methylene chloride and 0.2N HCl, the aqueous phase is extracted three more times with methylene chloride and the combined organic phases are dried over sodium sulfate and evaporated. The crude product (about 45 g) is distilled in portions in a bulb tube (air bath temperature 80 C./0.2 mbar). Yield: 26.9 g of a yellowish oil.

Statistics shows that 34683-73-3 is playing an increasingly important role. we look forward to future research findings about 1-Chloro-6-iodohexane.

Reference:
Patent; Chemie Linz Akteingesellschaft; US4812472; (1989); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 34683-73-3, name is 1-Chloro-6-iodohexane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 34683-73-3

6-(3’4′-dibenzyloxyflavon-3-yl)-hexyltrimethylammoniumchloride (6g) 4b was alkylated using 1-chloro-6-iodohexane, employing the same method as described for 5d. The crude product was purified by column chromatography (CH2Cl2) to give 1.6 g (94%) 3-(6-chlorohexyloxy)-3′,4′-dibenzyloxyflavone. 1H NMR (CDCl3): delta 1.36 (m, 4H, CH2), 1.68 (m, 4H, CH2), 3.47 (t, 2H, J=6 Hz, CH2Cl), 3.99 (t, 2H, J=6 Hz, OCH2), 5.23 (s, 2H, OCH2Ph), 5.27 (s, 2H, OCH2Ph), 7.03 (d, 1H, J=8 Hz, C5’H), 7.25-7.5 (m, 12H, 2* OCH2Ph+C6H, C8H), 7.66 (dt, 1H, J=7 Hz, 2 Hz, C7H), 7.71 (dd, 1H, J=8 Hz, 1 Hz, C6’H), 7.80 (d, 1H, J=1 Hz, C2’H), 8.23 (dd, 1H, J=7 Hz, 2 Hz, CSH).

The synthetic route of 34683-73-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Vereniging christelijk wetenschappelijk anderwijs; US2002/147353; (2002); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com