Category: 34270-90-1

Related Products of 34270-90-1, A common heterocyclic compound, 34270-90-1, name is 1-Iodo-2-(2-iodoethoxy)ethane, molecular formula is C4H8I2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Spiro[4H-pyran-4,10′(4’H)-[6H]pyrimido[2,1-c][1,4]thiazepine]-2′-carboxylic acid, 2,3,5,6,7′,8′-hexahydro-3′-hydroxy-4′-oxo-, ethyl ester, 9′,9′-dioxide: To a stirred yellow mixture of intermediate 19/24 (0.1942 g, 0.50 mmol) intermediate 18 (0.208 g, 0.62 mmol) in DMF (5 mL) wad added Cs2CO3 (0.332 g, 1.02 mmol) at once at room temperature. After 24 h, the reaction mixture was diluted with Et2O (50 mL), washed with water (2×10 mL), brine (10 mL), dried (Na2SO4), filtered and concentrated to give colorless paste which was used in the subsequent step without purification.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 34270-90-1, name is 1-Iodo-2-(2-iodoethoxy)ethane, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1-Iodo-2-(2-iodoethoxy)ethane

Butyllithium (2.5 M in hexanes, 3.76 mL, 9.39 mmol) was added to a solution of oxindole (500 mg, 3.76 mmol) at -78 0C in TEtaF (40 mL). After complete addition, NJSfJSf1N- tetramethylethane-l,2-diamine (1.48 mL, 9.76 mmol) was added, maintaining the internal temperature < 70 0C. After 1 h at -78 0C, 2-iodoethyl ether (4.90 g, 15.0 mmol) was added and the reaction warmed to ambient temperature. After 48 h the reaction was quenched with H2O (5 mL) and the mixture was partitioned between EtOAc (100 mL) and H2O (100 mL). The aqueous solution was extracted with EtOAc (3 x 50 mL) and the combined organic layers were washed with brine (20 mL), dried over Na2SO4, filtered, and concentrated in vacuo. Purification by silica gel chromatography, eluting with a gradient of CH2Cl2MeOH- 100:0 to 97:3, gave the title compound. MS: m/z = 204 (M + 1). Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 34270-90-1. Reference:
Patent; MERCK & CO., INC.; WO2006/31610; (2006); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 34270-90-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 34270-90-1, name is 1-Iodo-2-(2-iodoethoxy)ethane, This compound has unique chemical properties. The synthetic route is as follows.

Step 2: To a 1 L flask filled with 2-chloroethylether (7 mL, 60 mmol) and acetone (280 mL) was added sodium iodide (45 g, 300 mmol). The reaction was heated at reflux under nitrogen for 7 d. The reaction was filtered and the filtrate was concentrated to yield crude 1-iodo-2-(2-iodoethoxy)ethane.To a mixture of 1-iodo-2-(2-iodoethoxy)ethane (848 mg, 2.6 mmol), LHMDS (5 mL, 1.0 M), and THF (5 mL) was added a solution of methyl 1-benzyl-4-(cyanomethyl)-1H-pyrrole-2-carboxylate (500 mg, 2.0 mmol) in THF (2.5 mL). The reaction was complete after stirring at room temperature for 15 min. An aqueous solution of saturated ammonium chloride was added followed by ethyl acetate and water. The mixture was extracted with ethyl acetate (1¡Á) and the combined organic extracts were washed with brine (1¡Á), dried over magnesium sulfate, and concentrated. The crude product was purified by chromatography on silica gel (0-50% ethyl acetate/hexane) to yield the pure methyl 1-benzyl-4-(4-cyanotetrahydro-2H-pyran-4-yl)-1H-pyrrole-2-carboxylate. MS: (M+H)+=324.8.

The chemical industry reduces the impact on the environment during synthesis 1-Iodo-2-(2-iodoethoxy)ethane. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Wyeth; US2009/137554; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 34270-90-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 34270-90-1, name is 1-Iodo-2-(2-iodoethoxy)ethane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of 800 mg (4.47 mmol) 4-methoxy-benzooxazole-2,7- diamine in 40 ml DMF at room temperature were added 2.47 g (17.9 mmol) potassium carbonate and 2.18 g (6.70 mmol) 1-IODO-2- (2-IODO-ETHOXY)-ETHANE and the mixture heated at 60 C for 48 h. After cooling to room temperature the mixture was poured onto water and extracted three times with ethyl acetate. The combined organic phases were washed with brine, then dried over sodium sulphate and concentrated in vacuo. Flash chromatography (2/98 methanol/dichloromethane, then 10/90 methanol/dichloromethane) afforded 585 mg (53 %) 4-methoxy-7-morpholin-4-yl- benzooxazol-2-ylamine as a light brown solid. ES-MS m/e (%) : 250 (M+H+, 100).

The synthetic route of 1-Iodo-2-(2-iodoethoxy)ethane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2004/63177; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 34270-90-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 34270-90-1 name is 1-Iodo-2-(2-iodoethoxy)ethane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: HCl (50 mg, 0.18 mmol) was added to 15 mL of an anhydrous DMF solution containing pre-washed NaH (60% oil mixture) (14 mg, 0.36 mmol) and 7-MEOTA at 0 C, and stirred for 30 min at room temperature. The bis-iodo compound dissolved in 2 mL of anhydrous DMF (29 mg, 0.09 mmol of 15, 33 mg, 0.09 mmol of 16, and 37 mg,0.09 mmol of 17) was added dropwise and the resulting solution was stirred for 10 h at 110 C. The resulting mixtures were extracted with EtOAc. The extract was dried with MgSO4, filtered,and concentrated in vacuo. The resulting residue was subjected to silica gel column chromatography (EtOAc) to afford tacrine dimers 3 (16 mg, 34%), 4 (17 mg, 33%), and 5 (21 mg, 38%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Iodo-2-(2-iodoethoxy)ethane, and friends who are interested can also refer to it.

Reference:
Article; Lee, Sang Kwang; Park, Min Kyun; Jhang, Ho Eun; Yi, Jinju; Nahm, Keepyong; Cho, Dae Won; Ra, Choon Sup; Musilek, Kamil; Horova, Anna; Korabecny, Jan; Dolezal, Rafael; Jun, Daniel; Kuca, Kamil Kuca; Bulletin of the Korean Chemical Society; vol. 36; 6; (2015); p. 1654 – 1660;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 34270-90-1, name is 1-Iodo-2-(2-iodoethoxy)ethane, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 34270-90-1

A stirred solution of Intermediate 71 (0.8 g, 2.42 mmol) and 1-iodo-2-(2-iodoethoxy)ethane (0.38 mL, 2.67 mmol) in anhydrous DMF (16 mL) was cooled to -l5C30 and purged with nitrogen for 5 minutes, then caesium carbonate (3.16 g, 9.69 mmol) wasadded. The reaction mixture was stirred for 2 h, with warming to 20C. Water (30 mL)was added and the aqueous layer was extracted with tert-buty1 methyl ether (3 x 30 mL).The combined organic layers were washed with water (2 x 30 mL) and brine (30 mL), then dried over sodium sulfate, filtered and concentrated. The resulting crude materialwas purified by flash column chromatography, using a gradient of tert-buty1 methyl etherin heptane (0-15%), to afford the title compound (927.9 mg, 86%) as a yellow solid. DH(500 MHz, CDCb) 7.90 (d, J 1.3 Hz, 1H), 7.06 (dd, J9.1, 1.6 Hz, 1H), 4.26 (t, J 11.8 Hz,5 2H), 3.89 (dd, J 11.9, 3.6 Hz, 2H), 2.45-2.33 (m, 2H), 1.75-1.69 (m, 2H), 1.65 (s, 9H).HPLC-MS (method 5): [M+H-BOC]+ m/z 300.0, 302.0, RT 2.11 minutes.

According to the analysis of related databases, 34270-90-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; UCB BIOPHARMA SPRL; BRACE, Gareth Neil; CHAPPELL, Rose Elizabeth; DEBOVES, Herve Jean Claude; FOLEY, Anne Marie; FOULKES, Gregory; JONES, Elizabeth Pearl; LECOMTE, Fabien Claude; QUINCEY, Joanna Rachel; SCHULZE, Monika-Sarah Elisabeth Dorothea; SELBY, Matthew Duncan; SMALLEY, Adam Peter; TAYLOR, Richard David; TOWNSEND, Robert James; ZHU, Zhaoning; (278 pag.)WO2018/229079; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 34270-90-1 as follows. Quality Control of 1-Iodo-2-(2-iodoethoxy)ethane

A mixture of compound 1 (1 mmol), 1-iodo-2-(2-iodoethoxy)ethane (1 mmol) and anhydrouspotassium carbonate (140 mg, 1 mmol) in anhydrous acetonitrile (10 mL) was heated under reflux for1 h and then quenched with water (5 mL). Product 47 was extracted with ethyl acetate and purified ona chromatotron eluting with dichloromethane/methanol (8:2).Yield 66%; m.p. >200 C (decomp.); 1H-NMR (DMSO-d6): delta 8.55 (m, 1H), 8.46 (d, J = 5.2 Hz, 1H), 7.83(m, 1H), 7.10 (m, 2H), 4.13 (m, 4H), 3.98 (m, 4H), 3.74 (m, 4H), 3.67 (m, 4H). HR-MS (ESI). Calcd forC16H21N4O2 (M+): m/z 301.1665. Found: m/z 301.1650. Anal. Calcd for C16H21N4IO2: C, 44.87; H, 4.94;N, 13.08. Found: C, 44.97; H, 5.09; N, 12.69.

According to the analysis of related databases, 34270-90-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Strekowski, Lucjan; Saczewski, Jaros?aw; Raux, Elizabeth A.; Fernando, Nilmi T.; Klenc, Jeff; Paranjpe, Shirish; Raszkiewicz, Aldona; Blake, Ava L.; Ehalt, Adam J.; Barnes, Samuel; Baranowski, Timothy C.; Sullivan, Shannon M.; Sata?a, Grzegorz; Bojarski, Andrzej J.; Molecules; vol. 21; 4; (2016);,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 34270-90-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 34270-90-1, name is 1-Iodo-2-(2-iodoethoxy)ethane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Disulfide 18 (82 mg, 0.105 mmol) was treated with NaBH4 (15 mg, 0.39 mmol) in dry DMF (1 mL) for 10 min before a solution of 35 (34 mg, 0.104 mmol) in dry DMF (1 mL) was added. The reaction mixture was stirred at room temperature for 1 h and then diluted with mildly acidic H2O. The aqueous phase was extracted four times with CH2Cl2 before the combined organic phases were concentrated in vacuo. The residue was dissolved in EtOAc and washed five times with H2O. The organic phase was dried over MgSO4, filtered and concentrated under reduced pressure. The crude product was purified by column chromatography (EtOAc/CH2Cl2 1:2) to afford 6 as white solid (24 mg, 27%): Rf: 0.24 (EtOAc/CH2Cl2 1:2); 1H NMR (400 MHz, CDCl3): deltaH 5.87 (s, 1H, H22), 4.98 (dd, 1H, J17,21a 1.6 Hz, Jgem 18.0 Hz, H21a), 4.80 (dd, 1H, J17,21b 1.6 Hz, Jgem 18.0 Hz, H21b), 3.60 (t, 2H, J24,25 7.0 Hz, H25), 3.25 (br s, 1H, H3), 2.77 (m, 1H, H17), 2.67 (t, 2H, J24,25 7.0 Hz, H24), 2.12 (m, 2H), 1.90-1.17 (m, 19H), 0.94 (s, 3H, CH3), 0.86 (s, 3H, CH3); 13C NMR (100 MHz, CDCl3): deltaC 174.7 (C20, C23), 117.8 (C22), 85.7 (C14), 73.6 (C21), 70.9 (C25), 51.0, 49.7 (C13, C17), 44.0, 42.0, 40.1, 37.2, 36.1, 35.7, 33.3, 31.8, 31.3, 30.9, 27.0, 26.9, 26.2, 23.8, 21.7, 21.2, 15.9; HRMS (ES): Calcd for C50H74O7S2Na 873.4773, found 873.4814.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Iodo-2-(2-iodoethoxy)ethane, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Jensen, Marie; Schmidt, Steffen; Fedosova, Natalya U.; Mollenhauer, Jan; Jensen, Henrik H.; Bioorganic and Medicinal Chemistry; vol. 19; 7; (2011); p. 2407 – 2417;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com