Electric Literature of 328-73-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 328-73-4 as follows.
To 60 mL of dry THF containing 3,5-dibromo-2-cyclohexyloxythiophene [S1] (1.2 g; 3.4 mmol) was added 1.6 M n-BuLi hexane solution (2.4 mL; 3.8 mmol) at -78 C under argon atmosphere, and the solution was stirred for 1 h at the low temperature. Tri-n-butyl borate (1.1 mL; 4.1 mmol) was slowly added to the reaction mixture at -78 C, and the mixture was stirred for 1 h at that temperature. After warming the solution up to room temperature, 20 wt% Na2CO3(aq) (6.0 mL), 3,5-bis(trifluoromethyl)-1-iodobenzene (1.2 g; 3.4 mmol), and tetrakis(triphenylphosphine)palladium(0) (0.080 g) were added to the reaction mixture. The mixture was refluxed overnight at 80 C. The product was extracted with ether. The organic layer was dried over MgSO4, filtered, and concentrated.The residue was purified by silica gel column chromatography using n-hexane as the eluent and by HPLC to give 1.1 g of 3-bromo-2-cyclohexyloxy-5-(3,5-bis(trifluoromethyl)phenyl)thiophene in 66% yield.
According to the analysis of related databases, 328-73-4, the application of this compound in the production field has become more and more popular.
Reference:
Article; Sato, Yuta; Kitagawa, Daichi; Kobatake; Tetrahedron; vol. 75; 35; (2019);,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com