Category: 3268-21-1

Suzuki, Hitomi et al. published their research in Tetrahedron Letters in 1995 | CAS: 3268-21-1

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Reference of 3268-21-1

Copper-assisted displacement reaction of nonactivated iodoarenes with arenesulfinates. Convenient alternative synthesis of unsymmetrical diaryl sulfones was written by Suzuki, Hitomi;Abe, Hajime. And the article was included in Tetrahedron Letters in 1995.Reference of 3268-21-1 This article mentions the following:

In the presence of CuI in hot DMF, a variety of functionalized iodoarenes ArI (Ar = Ph, 4-MeC6H4, C6Me5, 4-PhSC6H4, etc.) undergo nucleophilic displacement reaction with sodium arenesulfinates Ar’SO2Na (Ar’ = Ph, 4-MeC6H4) to give the corresponding unsym. diaryl sulfones ArSO2Ar’ in moderate to good yields. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Reference of 3268-21-1).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Reference of 3268-21-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yamashita, Ken-ichi et al. published their research in New Journal of Chemistry in 2009 | CAS: 3268-21-1

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Electric Literature of C10H12I2

Photoinduced self-assembly of Pt(II)-linked rings and cages via the photolabilization of a Pt(II)-pyridine bond was written by Yamashita, Ken-ichi;Sato, Kei-ichi;Kawano, Masaki;Fujita, Makoto. And the article was included in New Journal of Chemistry in 2009.Electric Literature of C10H12I2 This article mentions the following:

An inert Pt(II)-pyridine bond is considerably labilized upon UV irradiation On the basis of this phenomenon, kinetically inert Pt(II)-linked coordination rings and cages are formed in high yields from their components by obtaining a kinetically distributed mixture and subsequently equilibrating the mixture into the thermodynamically stable structures upon temporary photolabilization. This method is applicable when the pyridine rings in the ligands are not conjugated with other aromatic rings, in good agreement with DFT calculations that indicate the dependency of the photolability on the π-conjugation of the ligand frameworks. Interruption of π-conjugation either by introducing an methylene linker or by twisting the aromatic rings are effective to accomplish the photoinduced self-assembly. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Electric Literature of C10H12I2).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Electric Literature of C10H12I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Richelle, Gaston J. J. et al. published their research in Angewandte Chemie, International Edition in 2018 | CAS: 3268-21-1

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Recommanded Product: 1,4-Diiodo-2,3,5,6-tetramethylbenzene

General and facile route to isomerically pure tricyclic peptides based on templated tandem CLIPS/CuAAC Cyclizations was written by Richelle, Gaston J. J.;Ori, Sumeet;Hiemstra, Henk;van Maarseveen, Jan H.;Timmerman, Peter. And the article was included in Angewandte Chemie, International Edition in 2018.Recommanded Product: 1,4-Diiodo-2,3,5,6-tetramethylbenzene This article mentions the following:

We report a one-pot ligation/cyclization technol. for the rapid and clean conversion of linear peptides into tricyclic peptides that is based on using tetravalent scaffolds containing two benzyl bromide and two alkyne moieties. These react via CLIPS/CuAAC reactions with cysteines and azides in the peptide. Flexibility in the scaffolds is key to the formation of isomerically pure products as the flexible scaffolds T41 and T42 mostly promote the formation of single isomeric tricycles while the rigid scaffolds T43 and T44 do not yield clean products. There seems to be no limitation to the number and types of amino acids present as 18 canonical amino acids were successfully implemented. We also observed that azides at the peptide termini and cysteine residues in the center gave better results than compounds with the functional groups placed the other way round. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Recommanded Product: 1,4-Diiodo-2,3,5,6-tetramethylbenzene).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Recommanded Product: 1,4-Diiodo-2,3,5,6-tetramethylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Martin, Rainer E. et al. published their research in Helvetica Chimica Acta in 1999 | CAS: 3268-21-1

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Synthetic Route of C10H12I2

Modulation of π-electron conjugation in oligo(triacetylene) chromophores by incorporation of a central spacer was written by Martin, Rainer E.;Wytko, Jennifer A.;Diederich, Francois;Boudon, Corinne;Gisselbrecht, Jean-Paul;Gross, Maurice. And the article was included in Helvetica Chimica Acta in 1999.Synthetic Route of C10H12I2 This article mentions the following:

A series of trimeric hybrid oligomers was prepared by insertion of different hetero-spacers between two (E)-hex-3-ene-1,5-diyne (E = 1,2-diethynylethene, DEE) moieties, and the optical and electrochem. properties of the resulting π-conjugated materials were compared to those of the DEE dimer and trimer, which formally contain a DEE moiety as homo-spacer. The hetero-spacers were: benzenoid (phenylene, naphthalene, biphenylene, anthracene), π-electron-deficient (pyrazine, pyridine) and π-electron-rich (thiophene, furan) aromatic rings, and trans-Pt(PEt3)2. The hybrid oligomers were synthesized using the method of K. Sonogashira et al. (1978), i.e., cross-coupling between mono-deprotected DEE and the appropriately bis-functionalized spacer. UV/VIS data revealed that the majority of the hetero-spacers were less effective than the homo-spacer DEE in facilitating π-electron delocalization along the linearly conjugated oligomeric backbone. With increasing degree of benzenoid aromaticity in the hetero-spacer, the electronic communication between the terminal DEE moieties in the hybrid oligomers was reduced. As a remarkable exception, a large bathochromic shift of the longest-wavelength absorption maximum, which is indicative of enhanced π-electron delocalization, was obtained upon introducing an anthracene-9,10-diyl moiety as hetero-spacer. Electrochem. studies by cyclic and steady-state voltammetry confirmed the limited extent of π-electron delocalization in the majority of the hybrid oligomers. The fluorescence properties of many of the DEE hybrid materials were dramatically enhanced upon incorporation of the heterospacers. The heterocyclic derivatives containing pyridine, pyrazine, or thiophene spacers, resp., displayed a strong fluorescence emission, demonstrating the value of combining repeat units to modulate oligomeric and polymeric properties. The pyridine derivative provided an interesting example of a mol. system, in which both the electronic absorption and emission characteristics can be reversibly switched as a function of pH. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Synthetic Route of C10H12I2).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Synthetic Route of C10H12I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sep-21 News Introduction of a new synthetic route about 3268-21-1

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 3268-21-1, name is 1,4-Diiodo-2,3,5,6-tetramethylbenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3268-21-1, HPLC of Formula: C10H12I2

To a solution of 1 (3.02 g, 7.82 mmol, 1 equiv), Pd(PPh3)2Cl2 (0.380 g, 0.541 mmol, 0.07 equiv) and CuI (0.101 g, 0.530 mmol, 0.07 equiv) in Et2NH was added ethynyltrimethylsilane (2.45 mL, 17.3 mmol, 2.2 equiv) and the reaction was stirred at RT overnight. The solvent was evaporated followed by extraction with CH2Cl2 (3 >< 100 mL) and washing of the organic layer with H20 (2 >< 200 mL) and brine (250 mL). The combined organic layers were dried over MgSO4 and concentrated in vacuo. The product was (0279) purified via column chromatography (PE) leading to 2 as off-white crystals (82%). 1H NMR (400 MHZ, CDClg) 6 2.38 (s, 12H), 0.27 (s, 18H). 13C NMR (400 MHZ, CDC13)8 136.0, 123.4, 104.2, 103.2, 18.5, 0.27. IRV 2957, 2138, 1270, 1073, 863 cm-1. HRMS (EI+) m/z caIcuIated for C20H30Si2 326.1886, found 326.1870. If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it. Reference:
Patent; STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN; UNIVERSITEIT VAN AMSTERDAM; RICHELLE, Gaston Julia Johannes; STREEFKERK, Dieuwertje Emma; VAN MAARSEVEEN, Jan Herman; TIMMERMAN, Peter; (162 pag.)WO2018/106112; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

September-21 News Some scientific research about 3268-21-1

According to the analysis of related databases, 3268-21-1, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3268-21-1, name is 1,4-Diiodo-2,3,5,6-tetramethylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1,4-Diiodo-2,3,5,6-tetramethylbenzene

1,4-Diiodo-2,3,5,6-tetramethylbenzene (1.16 g, 3 mmol),5-(tributyltin)-2,2′-bithiophene (5.6 g, 12 mmol) obtained in Example 1,Pd(PPh3)4 (24.3 mg, 0.021 mmol) was added sequentially under a nitrogen atmosphere.Add 25 ml of DMF (N,N-dimethylformamide),Rapidly warmed to 130 C, the system refluxed for 16 h,The reaction was shut down, cooled to room temperature, extracted with deionized water and dichloromethane respectively. The obtained organic phase was dried over anhydrous MgSO 4 and then purified by column chromatography. The stationary phase was 300 mesh silica gel and the mobile phase was dichloromethane. / petroleum ether (1:5), collecting the eluent containing the target product to evaporate the solvent,Obtaining 1.04 g of a yellow solid benzene-methyl-dithiophene derivative in a yield of 90%

According to the analysis of related databases, 3268-21-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Zhejiang University of Technology; Li Weijun; Luo Feifei; Zhang Cheng; Ouyang Mi; (9 pag.)CN109053675; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

September 2,2021 News Some tips on 3268-21-1

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3268-21-1, its application will become more common.

Some common heterocyclic compound, 3268-21-1, name is 1,4-Diiodo-2,3,5,6-tetramethylbenzene, molecular formula is C10H12I2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 1,4-Diiodo-2,3,5,6-tetramethylbenzene

General procedure: Compound 1a, 1b, 3a, 3b, 7a, or 7b, 0.57 mmol, was added with vigorous stirring at 20C to a solution of 0.2 mL (2.6 mmol) of trifluoroacetic acid in 3 mL of methylene chloride, 136 mg (0.57 mmol) of lead(IV) oxide was then added, and the mixture was stirred for 2-70 h. When the reaction was complete, the mixture was treated with water (50 mL) and extracted with chloroform (3 ×50 mL). The combined extracts were washed with water, a saturated aqueous solution of NaHCO3, and water again and dried over Na2SO4, and the solvent was distilled off. The residue was subjected to silica gel column chromatography using petroleum ether-ethyl acetate as eluent. Given below are the yields of the isolated compounds. (2,5-Diiodo-3,4,6-trimethylphenyl)methanol (2a). Yield 35%, colorless crystals, mp 152-154C. 1H NMR spectrum, delta, ppm: 1.94 s (1H, OH), 2.62 s (3H, CH3), 2.64 s (3H, CH3), 2.73 s (3H, CH3), 5.01 s (2H, CH2). 13C NMR spectrum, deltaC, ppm: 28.6 (CH3), 29.4 (CH3), 29.9 (CH3), 70.3 (CH2), 111.4, 113.1, 138.3, 139.2, 139.8, 140.8. Mass spectrum: m/z 402[M]+. HRMS: found: 402.9059; calculated for C10H13I2O: [M + H]+ 402.9050.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3268-21-1, its application will become more common.

Reference:
Article; Sandzhieva; Aryamova; Sukharzhevskii; Grinenko; Vasilyev; Russian Journal of Organic Chemistry; vol. 54; 3; (2018); p. 397 – 402; Zh. Org. Khim.; vol. 54; 3; (2018); p. 393 – 398,6;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some scientific research about 1,4-Diiodo-2,3,5,6-tetramethylbenzene

According to the analysis of related databases, 3268-21-1, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3268-21-1, name is 1,4-Diiodo-2,3,5,6-tetramethylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1,4-Diiodo-2,3,5,6-tetramethylbenzene

1,4-Diiodo-2,3,5,6-tetramethylbenzene (1.16 g, 3 mmol),5-(tributyltin)-2,2′-bithiophene (5.6 g, 12 mmol) obtained in Example 1,Pd(PPh3)4 (24.3 mg, 0.021 mmol) was added sequentially under a nitrogen atmosphere.Add 25 ml of DMF (N,N-dimethylformamide),Rapidly warmed to 130 C, the system refluxed for 16 h,The reaction was shut down, cooled to room temperature, extracted with deionized water and dichloromethane respectively. The obtained organic phase was dried over anhydrous MgSO 4 and then purified by column chromatography. The stationary phase was 300 mesh silica gel and the mobile phase was dichloromethane. / petroleum ether (1:5), collecting the eluent containing the target product to evaporate the solvent,Obtaining 1.04 g of a yellow solid benzene-methyl-dithiophene derivative in a yield of 90%

According to the analysis of related databases, 3268-21-1, the application of this compound in the production field has become more and more popular.

Introduction of a new synthetic route about 1,4-Diiodo-2,3,5,6-tetramethylbenzene

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 3268-21-1, name is 1,4-Diiodo-2,3,5,6-tetramethylbenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3268-21-1, Safety of 1,4-Diiodo-2,3,5,6-tetramethylbenzene

To a solution of 1 (3.02 g, 7.82 mmol, 1 equiv), Pd(PPh3)2Cl2 (0.380 g, 0.541 mmol, 0.07 equiv) and CuI (0.101 g, 0.530 mmol, 0.07 equiv) in Et2NH was added ethynyltrimethylsilane (2.45 mL, 17.3 mmol, 2.2 equiv) and the reaction was stirred at RT overnight. The solvent was evaporated followed by extraction with CH2Cl2 (3 >< 100 mL) and washing of the organic layer with H20 (2 >< 200 mL) and brine (250 mL). The combined organic layers were dried over MgSO4 and concentrated in vacuo. The product was (0279) purified via column chromatography (PE) leading to 2 as off-white crystals (82%). 1H NMR (400 MHZ, CDClg) 6 2.38 (s, 12H), 0.27 (s, 18H). 13C NMR (400 MHZ, CDC13)8 136.0, 123.4, 104.2, 103.2, 18.5, 0.27. IRV 2957, 2138, 1270, 1073, 863 cm-1. HRMS (EI+) m/z caIcuIated for C20H30Si2 326.1886, found 326.1870. If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Introduction of a new synthetic route about 3268-21-1

According to the analysis of related databases, 3268-21-1, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3268-21-1 as follows. Product Details of 3268-21-1

(Step 3) Synthesis of Compound 169; [0096] After 250 mg of 1,4-diiodo-2,3,5,6-tetramethylbenzene (d) (0.648 mmol) was dissolved in 3 ml of 1,2-dimethoxyethane, 0.5 ml of ethanol and 0.5 ml of water were added to the solution. To the solution, 537 mg of potassium carbonate (3.89 mmol) and 350 mg of Boric acid compound (c) (1.943 mmol) were added and 37.4 mg of tetrakis(triphenylphosphine)palladium (0) (0.324 mmol) was added under argon atmosphere. The suspension was refluxed overnight under argon atmosphere. After cooling, water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The extract was washed with water and saturated brine, successively, dried and concentrated. The residue was recrystallized from methanol to obtain Compound 169 (213 mg; 82% yield).

According to the analysis of related databases, 3268-21-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SHIONOGI & CO., LTD.; EP1354877; (2003); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com