Category: 3210-08-0

Related Products of 3210-08-0,Some common heterocyclic compound, 3210-08-0, name is 4-Iodobutan-1-ol, molecular formula is C4H9IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Method A: A solution of [PP(I)P] (215 mg, 0.292 mmol) in THF(10 mL) was added to a stirring suspension of CuI (55.6 mg,0.292 mmol) in THF (5 mL). The cloudy orange reaction mixturewas allowed to stir overnight at 50 C and then filtered throughCelite to obtain an orange filtrate. Removal of the volatiles fromthe filtrate in vacuo afforded analytically pure product as a paleorange solid (88.7 mg, 30% yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Iodobutan-1-ol, its application will become more common.

Reference:
Article; Knight, Sadie E.; Bezpalko, Mark W.; Foxman, Bruce M.; Thomas, Christine M.; Inorganica Chimica Acta; vol. 422; (2014); p. 181 – 187;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3210-08-0, name is 4-Iodobutan-1-ol, A new synthetic method of this compound is introduced below., Recommanded Product: 3210-08-0

To a solution of 5-iodobutan-1-ol (16.5 g, 82.5 mmol, 1 equiv) in dryDMSO (75 mL), solid NaCN (6.06 g, 124 mmol, 1.5 equiv) was added in small portions at0 C. The reaction progress was surveilled by NMR spectroscopy. It is instant and the titlecompound as well as THF (6 : 5) are formed. After complete conversion, the reaction mixturewas diluted with water (75 mL) and extracted with Et2O (5 ¡Á 100 mL). The combined organiclayers were washed with brine and dried over Na2SO4. Evaporation of the solvent yielded thetitle compound in pure form.

The synthetic route of 3210-08-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wuensch, Matthias; Schroeder, David; Froehr, Tanja; Teichmann, Lisa; Hedwig, Sebastian; Janson, Nils; Belu, Clara; Simon, Jasmin; Heidemeyer, Shari; Holtkamp, Philipp; Rudlof, Jens; Klemme, Lennard; Hinzmann, Alessa; Neumann, Beate; Stammler, Hans-Georg; Sewald, Norbert; Beilstein Journal of Organic Chemistry; vol. 13; (2017); p. 2428 – 2441;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 3210-08-0,Some common heterocyclic compound, 3210-08-0, name is 4-Iodobutan-1-ol, molecular formula is C4H9IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

N,N?-dibutylpiperazine (50.4 mmol, 10 g) and 4-iodobutanol (40.3 mmol, 8.1 g) were used in the same manner as Example 1, except that reaction was carried out at room temperature for 10 hours. In this manner, a compound represented by [Chemical Formula 5] was obtained (yield 85.6%). (0062) 1H NMR (300 MHz, DMSO) delta=0.89-0.91 (m, 6H), 1.29-1.52 (m, 8H), 1.71 (m, 4H), 2.80 (t, 6H), 3.01 (t, 2H), 3.22 (t, 4H), 3.34 (t, 4H), 3.46 (t, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Iodobutan-1-ol, its application will become more common.

Reference:
Patent; KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; LEE, Hyun Joo; LEE, Ung; KIM, Hong Gon; CHO, Shinhye; LEE, He Won; (16 pag.)US2020/155997; (2020); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 3210-08-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3210-08-0, name is 4-Iodobutan-1-ol belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Method B: Compound 3(68.9 mg, 0.074 mmol) was allowed to stir overnight in THF(10 mL) at 55 C. The solvent was removed from the product toafford pure 4 as a pale orange solid (65 mg, 87% yield). Yellow crystalssuitable for X-ray crystallography were grown from a concentratedCH2Cl2 solution of compound 4. 1H NMR (400 MHz, CD2Cl2):d 7.74 (m, 4H, Ar-H), 7.59 (m, 2H, Ar-H), 7.46 (m, 2H, Ar-H), 7.41(m, 8H, Ar-H), 7.27 (m, 2H, Ar-H), 7.18 (m, 2H, Ar-H), 7.07 (m,8H, Ar-H), 4.01 (m, 2H, O-CH2CH2CH2CH2-I), 3.88 (br, 2H, CH2),2.96 (m, 2H, O-CH2CH2CH2CH2-I), 2.54 (br, 2H, CH2), 1.67 (m, 2H,O-CH2CH2CH2CH2-I), 1.39 (m, 2H, O-CH2CH2CH2CH2-I). 31P NMR(161.8 MHz, CD2Cl2): d 93.1 (br, 1P), 10.7 (br, 2P). 13C NMR(100.5 MHz, C6D6): d 147.0, 135.6, 135.3, 134.1, 131.5, 130.0,129.6, 128.6, 124.3, 123.5, 66.8, 47.6, 33.2, 30.3, 7.0. Anal. Calc.for C42H40N2OP3CuI2: C, 50.49; H, 4.04; N, 2.80. Found: C, 50.22;H, 3.99; N, 2.77%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodobutan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Knight, Sadie E.; Bezpalko, Mark W.; Foxman, Bruce M.; Thomas, Christine M.; Inorganica Chimica Acta; vol. 422; (2014); p. 181 – 187;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com