Category: 31970-26-0

Related Products of 31970-26-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 31970-26-0 name is 1-(4-Iodophenyl)propan-1-one, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Titanium tetrachloride (0.99 mL, 9 mmol) was added drop wise to a stirred suspension of Zn powder (1.18 g, 18 mmol) in dry THF (15 mL) under an argon atmosphere at -10 C, and this mixture was heated at reflux for 1.5 h to produce the titanium reagent. A cooled suspension of this titanium reagent was added to a solution of 4-(2-chloroethoxy)benzophenone (5a, 0.78 g, 3.0 mmol) and p-iodopropiophenone (6a, 0.78 g, 3.0 mmol) in THF (20 mL) at 0 C, and the reaction was allowed to proceed at reflux for 2 h. After cooling to 25 C, the reaction mixture was poured into a 10% aqueous K2CO3 solution (45 mL), this mixture was stirred vigorously for 5 min, and the dispersed insoluble material was removed by vacuum filtration. The organic fraction was separated, the aqueous layer was extracted with EtOAc (3 x 25 mL), and the combined organic fractions were dried (Na2SO4). Removal of the solvent in vacuo afforded a residue which was purified by silica gel column chromatography using EtOAc-hexane (1:4, v/v) as eluent followed by recrystallization of the product from ethanol to give (Z)-7a as a white solid (0.5 g, 35%);

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(4-Iodophenyl)propan-1-one, and friends who are interested can also refer to it.

Reference:
Article; Abdellatif, Khaled R.A.; Velazquez, Carlos A.; Huang, Zhangjian; Chowdhury, Morshed A.; Knaus, Edward E.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 4; (2011); p. 1195 – 1198;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 31970-26-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31970-26-0, name is 1-(4-Iodophenyl)propan-1-one belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Finely powdered cuprous bromide (20.21 g, 91 mmol) was suspended in ethyl acetate (30 mL) and heated to reflux. A solution of ketone (14 g, 54 mmol) in chloroform (30 mL) was added dropwise over 10 minutes. After refluxing for 7 hours, the reaction was left to cool overnight and filtered through Celite. The filtrate was washed with saturated aqueous sodium bicarbonate (2¡Á50 mL) and brine (50 mL), dried over magnesium sulfate and concentrated under reduced pressure. Recrystallization from hexane afforded a pale yellow solid. mp 76 C. Yield 12.2 g (66%). 1H NMR (CDCl3) delta7.83 (d, 2H), 7.72 (d, 2H), 5.21 (q, 2H), 1.87 (d, 3H). MI=338. IR (Liq film) cm-1 1677. Calculated for C9H8BrIO: C, 31.9%, H, 2.38%. Found: C, 32.2%, H, 2.5%.

The synthetic route of 1-(4-Iodophenyl)propan-1-one has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Tisdell, Francis Eugene; Bis, Scott Jerome; Hedge, Vidyadhar Babu; Martin, Timothy Patrick; Perreault, Denise Marie; Yap, Maurice Chee Hoong; Guenthenspberger, Katherine Anne; Dripps, James Edwin; Gifford, James Michael; Schoonover, Joe Raymond; Karr, Laura Lee; Dintenfass, Leonard Paul; Neese, Paul Allen; US2004/6108; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com