Category: 31599-61-8

These common heterocyclic compound, 31599-61-8, name is 4-Iodo-1,2-dimethylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: iodides-buliding-blocks

Step 1: (3,4-Dimethyl-phenyl)-phenethyl-amine A dried flask was charged with 21 mg (0.11 mmol) CuI and 1.4 g (4.3 mmol) cesium carbonate under argon. 0.40 ml (3.2 mmol) phenethylamine, 0.5 g (2.1 mmol) 4-iodo-0-xylene in solution in 1 ml dried DMF and finally 0.058 ml (0.43 mmol) 2-acetylcyclohexanone were successively added. The mixture was stirred at room temperature for 24 hours. The mixture was diluted with water. The aqueous layer was extracted twice with ethyl acetate. The combined extracts were dried over Na2SO4, filtered and concentrated in vacuo. The crude oil was purified with flash column chromatography on silica eluding with a gradient formed from heptane and ethylacetate to provide 0.10 g (22%) of the title compound as a yellow oil. MS (m/e): 226.2 (MH+).

The synthetic route of 4-Iodo-1,2-dimethylbenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Knust, Henner; Nettekoven, Matthias; Pinard, Emmanuel; Roche, Olivier; Rogers-Evans, Mark; US2009/36422; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 31599-61-8, name is 4-Iodo-1,2-dimethylbenzene, molecular formula is C8H9I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C8H9I

General procedure: A Schlenk tube with a magnetic stir bar was charged with Pd(OAc)2 (10 mol%, 0.0056 g), AgOTf (1.1 equiv., 0.0707 g), TBAB (20 mol%, 0.0161g), 2-phenylpyridine N-oxides 1 (0.25 mmol), iodobenzene and its derivatives 2 (0.375 mmol) and H2O (1 mL). The resulting solution was stirred at 100C for 12 h. The resulting organic layer was extracted with trichloromethane, treated with Na2SO4 and concentrated in vacuo. The product was isolated by short column chromatography using ethyl acetate and methanol as eluent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 31599-61-8, its application will become more common.

Reference:
Article; Zhang, Wei; Li, Zhengkai; Zhang, Yihan; Yang, Li; Zhou, Xiangge; Synthetic Communications; vol. 47; 8; (2017); p. 793 – 802;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31599-61-8, name is 4-Iodo-1,2-dimethylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 31599-61-8

General procedure: Aryl thiourea (1, 0.5 mmol), aryl iodide (2, 0.6 mmol), CuSO4*5H2O (0.05 mmol), Cs2CO3 (2.0 equiv), 2,2?-bypyridine (0.05 mmol) were added in sealed tube equipped with a septum and magnetic stirring bar, H2O (2.0 mL) was then added. The mixture was stirred at 100 C and checked by TLC until the starting material was finished (about 3h). The reaction was terminated with sat. NH4Cl solution (3 mL) and then extracted with ethyl acetate. The crude solution was dried over anhydrous Na2SO4 and evaporated under vacuum. The residue was purified by flash column chromatography to afford the desired product 3a.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 31599-61-8.

Reference:
Article; Liu, Xing; Zhu, Hui; Zhang, Shi-Bo; Cheng, Yu; Peng, Han-Ying; Dong, Zhi-Bing; Tetrahedron Letters; vol. 59; 33; (2018); p. 3165 – 3170;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 31599-61-8, name is 4-Iodo-1,2-dimethylbenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 31599-61-8, Application In Synthesis of 4-Iodo-1,2-dimethylbenzene

General procedure: CAUTION: Azides are potentially explosive and so appropriateprecautions against blast must be taken when preparing, handlingand heating them. Reactions must be carried out on a small scale. A mixture of the aryl iodide (1.0 mmol), sodium azide (1.2 mmol),DBU (0.15 mmol) and Cu(OAc)2·H2O (0.1 mmol) in DMSO (3.0 mL)in a 10 mL flask was heated to 95 C (the temperature in the reaction flask was monitored) for 1.5-5.0 h. After the reaction was completed asjudged by TLC, the cooled mixture was poured into water (30 mL)containing several drops of ammonia. The resulting aqueous phase was extracted with ethyl acetate (3 × 30 mL). The combined organic phases were washed with brine (50 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was loaded on asilica gel column and eluted with petroleum ether (boiling range 60-90 C)/ethyl acetate to afford the product.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Jiang, Yuqin; Suo, Huajun; Zhao, Yaru; Li, Xiyong; Sun, Yamin; Li, Xingfeng; Dong, Wenpei; Li, Wei; Zhang, Weiwei; Xu, Guiqing; Journal of Chemical Research; vol. 42; 5; (2018); p. 247 – 250;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 31599-61-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31599-61-8, name is 4-Iodo-1,2-dimethylbenzene, This compound has unique chemical properties. The synthetic route is as follows.

Charged 1-iodo-2,4-dimethylbenzene (10 grams, 43.09 mmol, MW: 232.06), 2-hexyldecan-1-ol (12.54 grams, 51.71 mmol, MW: 242.44), cesium carbonate, (21.23 grams, 64.62 mmol, MW: 328.5), 1,10-phenathroline (1.55 grams, 8.601 mmol, MW: 180.21), copper (1) iodide (0.840 grams, 4.307 mmol, MW: 195.01) and 100 ml dry xylene in 350 milliliter three necked round bottom flask. The reaction mixture was heated with stirring at 140 C. for 24 hours under nitrogen. The resulting suspension was cooled to room temperature and filtered through celite and alumina. The low boiling (xylene) component removed by rotary evaporator and high boiling component by air bath oven at 200 C. under high vacuum for 1 hour. The residue was purified by flask chromatography on silica gel with hexane. The final colorless product yielded 7.0 grams (47%). The product 13C NMR analysis suggests the formation of alkylarylther product. 13C NMR (CDCl3): 158.01, 137.65, 130.27, 128.24, 116.28, 111.19, 70.99, 37.91, 32.12, 31.61, 30.18, 29.85, 29.47, 26.97, 22.90, 20.10, 18.83, 14.19.

The chemical industry reduces the impact on the environment during synthesis 4-Iodo-1,2-dimethylbenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ExxonMobil Research and Engineering Company; Patil, Abhimanyu O.; Bodige, Satish; Luo, Shuji; Deighton, Shane; Oumar-Mahamat, Halou; (24 pag.)US2017/137734; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 31599-61-8,Some common heterocyclic compound, 31599-61-8, name is 4-Iodo-1,2-dimethylbenzene, molecular formula is C8H9I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

0.288 mol of 3,4-dimethyl iodobenzene, 0.24 mol of carbazole, 0.02 mol of phenanthroline, 0.02 mol of cuprous iodide,Cesium carbonate 0.384 mol was charged into a 1000 ml three-necked flask, dissolved in 300 ml of DMF,Vacuum – nitrogen three times, the temperature to 152 C, the reaction overnight. The reaction solution was passed through a silica funnel,Rinse with methylene chloride to no product dissolution;Spin to about 400ml with 500ml water, liquid, take dichloromethane phase, washed with water three times; spin dry,Add 100ml dissolved,Add 500ml of ethanol to a large amount of solid precipitation, filtration, vacuum drying at 55 .To give 0.2136 mol of 9- (3,4-dimethylbenzene) -9H-carbazole in 89% yield

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Iodo-1,2-dimethylbenzene, its application will become more common.

Reference:
Patent; Jilin Optical and Electronic Materials Co., Ltd.; Gao, Chunji; Wang, Yongguang; Li, Wenjun; Bi, Yan; (17 pag.)CN104650044; (2017); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31599-61-8, name is 4-Iodo-1,2-dimethylbenzene, A new synthetic method of this compound is introduced below., name: 4-Iodo-1,2-dimethylbenzene

(37-1) Synthesis of 3-(3,4-dimethylphenyl)-2-propyne-1-ol (compound 37-1) [Show Image] A mixture of 1-iodo-3,4-dimethylbenzene (5.00 g), copper(I) iodide (82.1 mg), triphenylphosphine (283 mg), tris(dibenzylideneacetone)dipalladium(0) chloroform adduct (446 mg), propargyl alcohol (1.40 ml), diisopropylethylamine (15.0 ml) and tetrahydrofuran (100 ml) was stirred at room temperature for 5 hr. The reaction mixture was added to brine, and the mixture was extracted with ethyl acetate, washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=98:2 – 80:20) to give the object product (2.12 g) as a brown oil. 1H-NMR(CDCl3) delta (ppm): 1.64(1H, t, J=6.2Hz), 2.23(3H, s), 2.26(3H, s), 4.48(2H, d, J=6.0Hz), 7.07(1H, d, J=7.7Hz), 7.18(1H, d, J=7.7Hz), 7.22(1H, s).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; EP2168944; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 31599-61-8, A common heterocyclic compound, 31599-61-8, name is 4-Iodo-1,2-dimethylbenzene, molecular formula is C8H9I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A two-necked flask equipped with a magnetic stirring bar was charged with Cs2CO3 (2 or 3 mmol), MCM-41-L-proline-CuI (0.1 mmol), aryl iodide (1.0 mmol), acetamidine hydrochloride (1.2 or 2 mmol) and DMF (3.0 mL) under Ar. The reaction mixture was stirred at 130 or 140 C for 20 h. After being cooled to room temperature, the mixture was diluted with CH2Cl2 (10 mL) and filtered. The catalyst was washed with distilled water (2 × 5 mL) and EtOH (2 × 5 mL) and air dried when reused in the next run. The filtrate was concentrated with the aid of a rotary evaporator and the residue was purified by column chromatography on silica gel using petroleum ether (30-60 C)/ethylacetate (10:1 to 1:1) as eluent to give the desired product 2. All the products 2a-z are known compounds.

The synthetic route of 31599-61-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Huang, Xue; Xiao, Ruian; You, Chongren; Yan, Tao; Cai, Mingzhong; Journal of Chemical Research; vol. 41; 6; (2017); p. 315 – 320;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 31599-61-8, name is 4-Iodo-1,2-dimethylbenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 31599-61-8, Application In Synthesis of 4-Iodo-1,2-dimethylbenzene

General procedure: To a stirred solution of aryl halide (1 mmol) in 2.5 mL heptane were added the alkene (1.5 mmol) and the internal standard (unde-cane, 0.3 mmol). An aqueous solution (2.5 mL) containing ligand 1or 2 (0.1 mmol), Na2PdCl4(0.005 mmol) and NaHCO3(1.5 mmol)was then added. The reaction mixture was heated at 100C for 18 h.The reaction mixture was cooled to room temperature. Once the organic phase has been recovered, the aqueous phase was washed twice with diethyl ether (2 × 2 mL). The combined organic phases were dried over anhydrous MgSO4 and heptane was removed under vacuum. The residue was purified by chromatography over a silica gel column. Elution with 10% ethyl acetate – heptane gave the expected bisaryl products as colorless oils.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Potier, Jonathan; Menuel, Stephane; Rousseau, Jolanta; Tumkevicius, Sigitas; Hapiot, Frederic; Monflier, Eric; Applied Catalysis A: General; vol. 479; (2014); p. 1 – 8;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31599-61-8, name is 4-Iodo-1,2-dimethylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 31599-61-8

General procedure: Aryl thiourea (1, 0.5 mmol), aryl iodide (2, 0.6 mmol), CuSO4*5H2O (0.05 mmol), Cs2CO3 (2.0 equiv), 2,2?-bypyridine (0.05 mmol) were added in sealed tube equipped with a septum and magnetic stirring bar, H2O (2.0 mL) was then added. The mixture was stirred at 100 C and checked by TLC until the starting material was finished (about 3h). The reaction was terminated with sat. NH4Cl solution (3 mL) and then extracted with ethyl acetate. The crude solution was dried over anhydrous Na2SO4 and evaporated under vacuum. The residue was purified by flash column chromatography to afford the desired product 3a.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 31599-61-8.

Reference:
Article; Liu, Xing; Zhu, Hui; Zhang, Shi-Bo; Cheng, Yu; Peng, Han-Ying; Dong, Zhi-Bing; Tetrahedron Letters; vol. 59; 33; (2018); p. 3165 – 3170;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com