Category: 31253-08-4

Jouanno, Laurie-Anne published the artcileExpeditious Microwave-Assisted Synthesis of 5-Alkoxyoxazoles from α-Triflyloxy Esters and Nitriles, Safety of Ethyl 2-Iodopropionate, the publication is Journal of Organic Chemistry (2012), 77(19), 8549-8555, database is CAplus and MEDLINE.

A rapid and general access to diversely substituted 5-alkoxyoxazoles from easily accessible α-triflyloxy/hydroxy esters and nitriles with good yields (41-76%) is reported. The versatility of the cyclization is shown for a range of substrates with high selectivity toward triflates over tosylates and proved to be compatible with sensitive functional groups. As an illustration of this transformation, the first synthesis of the recently isolated hydroxypyridine Me multijuguinate (I) was achieved in four steps through a hetero Diels-Alder reaction of the 5-alkoxyoxazole II and acrylic acid, followed by a protodecarboxylation reaction.

Journal of Organic Chemistry published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Safety of Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Landauer, S. R. published the artcileThe organic chemistry of phosphorus. I. Some new methods for the preparation of alkyl halides, Recommanded Product: Ethyl 2-Iodopropionate, the publication is Journal of the Chemical Society (1953), 2224-34, database is CAplus.

cf. C.A. 45, 9456e. (MeO)₃P (I) (0.1 mol) refluxed 30 min. at 100° with MeI and the product distilled, gave MePO(OMe)₂ (II); with molar ratios of I:MeI = 1:1, 2:1, 10:1, and 100:1, the yields of II were 90, 88, 93, and 80%, resp. I (6.2 g.) and 0.06 g. Me₂SO₄ refluxed 15 min. at 100° gave 8% recovered I and 81% II, b₁₂ 66°. (PhO)₃P (III) (31 g.) and 21 g. MeI refluxed 36 h. with exclusion of H₂O, the mixture treated with anhydrous ether, and the solid washed with anhydrous ether, dried, and weighed in vacuo, gave 42 g. (PhO)₃PMeI (IV), which was stored under ether, dried, and weighed in vacuo before use; IV taken up in Me₂CO and precipitated with anhydrous ether gave pure IV, m. 146°. IV (7.95 g.) in 30 mL. absolute EtOH and 150 mL. saturated alc. AgNO₃ gave after 3, 6, 10, 20, 80, 150, and 1440 min. 67, 73, 76, 79, 86, 92, and 100%, resp., total yield of AgI (204.5 mg. IV gave 09.6% AgI after 3 min.). IV (21 g.) shaken several min. with 35 mL. absolute EtOH and the solution distilled, gave 62% EtI, b. 72° (PhNEtMe₂I, m. 136-7°), PhOH, and 91% MePO(OPh)₂ (V), m. 35-6°. In a 2nd experiment in which the mixture was distilled at 0.5 mm., 66% EtI was collected in a trap at -80°; the residue, washed with 2N NaOH gave 86% V; the alk. washings gave with acid 96% PhOH. Iodides were similarly prepared from IV and the appropriate alc., cooling being necessary with reactive alcs., warming with less reactive alcs.; the iodide was isolated by distillation of the reaction mixture in vacuo, with the iodide collected at -80° in a trap (when the b.p. was much lower that of PhOH), by distillation with PhOH in vacuo and separation of the PhOH with cold dilute NaOH, or by removal of the PhOH from the reaction mixture with dilute NaOH and distillation The method is satisfactory with primary, secondary, tertiary (76% yield of Me₃CI), and unsaturated alcs. (83% yield of MeCH:CHCH₂I, b_40-5 55-6°), glycols (95% yield of CH₂(CH₂I)₂, b_0.5 50-1°, n²¹_D 1.6420), and Et lactate (92% yield of MeCHICO₂Et, b₈ 65-6°, n^20.5_D 1.5000), giving 60-95% yields. Cholesterol (9.5 g.) mixed with 12 g. IV, 10 mL. MeI added, the mixture refluxed 1 h. at 50-60°, kept overnight, extracted with 100 mL. petr. ether (b. 40-60°), the extract evaporated, the residue treated with 100 mL. H₂O, the insoluble part washed with Me₂CO, taken up in 200 mL. hot Me₂CO, cooled, and the solution decanted from the oil and cooled at 2° gave 30% cholesteryl iodide, m. 105° (from EtOAc), [α]^21.2_D -12.7° (CHCl₃). III (34 g.) and 13 g. PhCH₂Cl heated 60 h. at 170-5° and the mixture washed with petr. ether (b. 40-60°), gave 25 g. oily (PhO)₃P(CH₂ph)Cl (VI). VI (10 g.) kept overnight at room temperature with 2 g. (+)-2-octanol, α^21.4_D 7.72°, and the mixture distilled gave 79% (-)-2-chloroöctane, b₁₃ 60°, n²⁰_D 1.4275, [α]^22.4_D -24.72°. PCl₃ (23 g.) added (20 min.) to 54 g. stirred, cooled PhCH₂OH, 61 g. PhNMe₂, and 100 mL. absolute ether, the mixture filtered, and the filtrate distilled twice gave 8 g. (PhCH₂O)₂P(O)H, b_0.05 145-60°, 10 g. mixture, b_0.05 160-80°, and 18 g. (PhCH₂O)₃P (VII), b_0.05 180-95°, m. 52° (from petr. ether). VII and MeI heated 30 h. at 100° gave no addition product; heated 3 h. at 150°, VII and MeI gave PhCH₂I. Summaries are given for the preparation of 12 iodides, 4 bromides, and 5 chlorides directly from III, the halide (MeI, PhCH₂Br, or PhCH₂Cl), and the alc. III (68 g.), 40 g. BuI, and 6.4 g. absolute MeOH heated 24 h. at 165-85°, with the MeI fractionated off continuously, gave 16 g. MeI, b. 42-3°, n²⁰_D 1.5290. MeBr passed slowly (through a sintered glass plate) into a mixture of 50 g. III and 11 g. BuOH heated 12 h. (155-35°), the mixture distilled, and the product collected at -80°, gave 63% BuBr, b. 101.5°, n²⁰_D 1.4400. (EtO)₃P (16.6 g.), 14.2 g. MeI, and 22.2 g. BuOH refluxed 1 h. gave 64% impure EtI and 36% BuI, b. 110-30°, n²⁰_D 1.4935. Dry HCl passed (1.5 h.) into equimol. amounts of III and BuOH gave 76% BuCl, b. 77-9°, n¹⁷_D 1.4025; similarly (-)-2-octanol (kept overnight with III before HCl was added for 1 h.) gave 44% (+)-2-chloroöctane, b_8-10 53-6°, [α]^22.2_D 18.8°; 2 g. cholesterol, 5 g. III, and HCl (30 min. addition), treated with 20 mL. Me₂CO, gave 2.2 g. cholesteryl chloride, m. 95° (from EtOAc), [α]²⁰_D -33.3° (CHCl₃). III (34 g.), 7.4 g. BuOH, and 6 g. NH₄Cl refluxed 84 h. at 140° gave 63% BuCl, b. 77-8°, n²²_D 1.4015. Similarly III and BuOH with 6 g. NaCl (heated 120 h. at 170-80°) gave 16% BuCl; with 9.6 g. LiBr (heated 64 h. at 140°), 40% BuBr; with 16.5 g. NaI (heated 64 h. at 160-70°), 18.5% BuI. IV (7 g.), 1.5 g. absolute EtOH, and 3 g. PhNMe₂ warmed 15 min. on a steam bath and diluted with ether gave 3.8 g. PhNMe₂EtI, m. 131° (from EtOH). III (68 g.) and 14.8 g. BuOH heated 16 h. at 100° gave 18.5 g., b₁₀ 60-80° (mainly PhOH), 7.5 g., b₁₀ 80-120°, n²⁵_D 1.4580 [mainly (BuO)₃P], 7.8 g. mixture, b₁₀ 120-40°, n²⁵_D -1.4840, of (BuO)₃P and (BuO)₂P(O)Ph, 9 g., b₁₀ 140-70°, n²⁵_D 1.5302, [mainly BuOP(OPh)₂ (VIII)], 4.1 g., b₁₀ 170-80°, n²⁵_D 1.5819, (mixture of VIII and III), and 28 g. residue, n²⁵_D 1.5815. III (68 g.) and 14.8 g. BuOH kept 30 min. at room temperature and distilled gave 18 g. PhOH and a mixture of phosphites which, refluxed 3 h. with 13 g. MeI, gave 13 g. BuI, n²³_D 1.4990; the residue heated 24 h. with 28 g. MeI gave 15.1 g. addnl. BuI, b. 125-31°, n²²_D 1.4980. IV (23 g.) and 3 g. V refluxed 1 h. and distilled gave 5 g. MeI, b. 42-4°, n²⁰_D 1.5055. IV (5 g.) and 2.5 g. (BuO)₃P mixed to give a solution and distilled gave 1.8 g. BuI, b. 125-32°, n²³_D 1.4970. Et(O)PCl₂ (IX) (147 g., b. 117-18°) and 500 mL. absolute ether cooled in a freezing mixture and treated portion wise with NaOMe (from 46 g. powd. Na and 64 g. MeOH) in 500 mL. ether, the mixture kept 1 h. at room temperature, filtered, the filtrate distilled, and the product fractionated gave 56 g. EtOP(OMe)₂ (X), b. 124-7°, equivalent 138.0 (equivalents were determined by hydrolysis of about 150 mg. alkyl phosphite 1 h. at 100° with 5 mL. 70% alc. NaOH, dilution with 0.1N HCl, and titration of the excess alkali with bromophenol blue; the authors found that equivalents gave a better criterion of purity than elemental anal.). X (27.6 g.) refluxed 1 h. with 28.4 g. MeI and fractionated gave 27.5 g. MeI and 27 g. EtO(MeO)P(O)Me, b₁₅ 74-5°, equivalent 137.8. X (13.8 g.), 2 g. H₂O, and 10 mL. Me₂CO kept 1 h. and distilled gave P-containing fractions, 1.3 g., b_15-17 65-73°, 9 g. EtO(MeO)(HO)P, b_15-17 73-5°, equivalent 124.0, and 1.3 g., b_15-17 75-7°. Absolute MeOH (32 g.) and 121 g. PhNMe₂ added (1 h.) to 137 g. PCl₃ cooled, stirred in 1 l. absolute ether, 92 g. absolute EtOH, and 242 g. PhNMe₂ then added (2 h.), the mixture diluted with 500 mL. ether, filtered, the filtrate distilled, and the fraction, b_10-15 50-90°, fractionated gave 35 g. (EtO)₂POMe (XI), b. 136-9°, equivalent 152.6. XI (10 g.) and 8.5 g. MeI refluxed 30 min. and distilled gave 6.8 g. MeI and 6 g. (EtO)₂P(O)Me, b. 190-2°, n²³_D 1.4110, equivalent 152.0. XI (10 g.), 1.5 g. H₂O, and 10 mL. Me₂CO gave 5.3 g. (EtO)₂POH, b₈ 65-6°, n²¹_D 1.4070, equivalent 137.2. iso-PrOH (120 g.) and 242 g. PhNMe₂ added (80 min.) to cold 130 g. IX in 500 mL. absolute ether, the mixture stirred 30 min. and filtered, and the filtrate fractionated gave 97 g. (iso-PrO)₂POEt (XII), b₁₀ 69-71°, equivalent 192.1. XII (19.5 g.) and 14.2 g. MeI refluxed 30 min. at 100° and distilled gave 12 g. EtI, b. 71-3°, and 17 g. (iso-PrO)₂P(O)Me, b₅ 7-5-6°, n²⁰_D 1.4158. XII (19.5 g.), 2 g. H₂O, and 10 mL. Me₂CO refluxed 14 h. and distilled gave 12.5 g. (iso-PrO)₂P.OH, b₁₀ 89-90°, equivalent 159.3. The mechanism for the formation of alkyl halides is discussed. Halides included in tables: EtI, iso-PrI, n-BuI, sec-BuI, tert-BuI, (+)- and (-)-2-iodoöctane, cyclohexyl iodide, CH₂:CHCH₂I, MeCH:CHCH₂Cl, PhCH₂I, PhCH₂CH₂I, PhCHIMe, CH₂(CH₂I)₂, MeCHICO₂Et, Me₂C(CH₂I)₂, and Me₃CCH₂I; BuBr, CH₂:CHCH₂Br, CH₂(CH₂2Br)₂, MeCHBrCO₂Et; BuCl, CH₂:CHCH₂Cl, CH₂(CH₂Cl)₂, MeCHClCO₂Et, and n-C₆H₁₃Cl.

Journal of the Chemical Society published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Recommanded Product: Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Stoffelbach, Francois published the artcileHow the interplay of different control mechanisms affects the initiator efficiency factor in controlled radical polymerization: An investigation using organometallic Mo^III-based catalysts, Product Details of C5H9IO2, the publication is Journal of Organometallic Chemistry (2007), 692(15), 3133-3143, database is CAplus.

Compound CpMoI₂(iPr₂dad) (iPr₂dad = iPrN=CH-CH=NiPr), obtained by halide exchange from CpMoCl₂(iPr₂dad) and NaI, has been isolated and characterized by EPR spectroscopy, cyclic voltammetry, and X-ray crystallog. Its action as a catalyst in atom transfer radical polymerization (ATRP) and as a spin trap in organometallic radical polymerization (OMRP) of styrene and Me acrylate (MA) monomers has been investigated and compared with that of the dichloro analog. Compound CpMoCl₂(iPr₂dad) catalyzes the ATRP of styrene and MA with low efficiency factors f (as low as 0.37 for MA and Et 2-chloropropionate as initiator), while it irreversibly traps the corresponding growing radical chains under OMRP conditions. On the other hand, compound CpMoI₂(iPr₂dad) has a greater ATRP catalytic activity than the dichloro analog and yields f = 1 for MA and Et 2-iodopropionate as initiator. Under OMRP conditions, it does not irreversibly trap the growing radical chains. This comparison serves to illustrate the general principle that low initiator efficiency factors, sometimes observed in ATRP, may result from the interplay of the ATRP and OMRP mechanisms, when the latter ones involves an irreversible radical trapping process.

Journal of Organometallic Chemistry published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C13H18N2, Product Details of C5H9IO2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zsolnai, Tibor published the artcileAntimicrobial action of potential thiol reagents, Category: iodides-buliding-blocks, the publication is Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung 1: Medizinisch-Hygienische Bakteriologie, Virusforschung und Parasitologie, Originale (1970), 214(4), 507-17, database is CAplus.

The bacteriostatic, fungistatic, trichomonastatic, amebicidal and acaricidal activity of 58 compounds which react with SH groups, was studied. Some compounds were active in vitro, but none in vivo. In vitro cysteine (I), thioglycolate, serum, and peptone inhibited the bacteriostatic activity, suggesting a mechanism of action which involves SH-containing enzymes. XRCHCO2Et (R = H or alkyl, X = I or Br) showed a strong antimicrobial activity which diminished for R = alkyl. Of several α-bromocarbonyl compounds and α-bromonitriles, the highest activity was shown by ω-bromoacetophenone (II). Most β-nitrostyrene derivatives were very active, especially those with an electrophilic substituent in para position. Very strong bacteriostatic and fungistatic activity was shown by α-bromostyrene and α,β-dibromostyrene (III). An especially marked activity was shown by tetraiodoethylene. A broad spectrum of antibacterial activity was shown by 4-nitroquinoline 1-oxide. High activity was shown by RHgX (R = Et, 4-HO2CC6H4 and X = Cl, 2-NaO2CC6H4S) and by p-RC6H4As(SCH2CO2H)2 (R = Cl or NH2).

Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung 1: Medizinisch-Hygienische Bakteriologie, Virusforschung und Parasitologie, Originale published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C19H36BNO2Si, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hofmann, Thomas published the artcileIdentification of Novel Colored Compounds Containing Pyrrole and Pyrrolinone Structures Formed by Maillard Reactions of Pentoses and Primary Amino Acids, Recommanded Product: Ethyl 2-Iodopropionate, the publication is Journal of Agricultural and Food Chemistry (1998), 46(10), 3902-3911, database is CAplus.

Heating of pentoses with alanine in a ratio of 10:1 in aqueous solution at pH 7.0 generated the yellow 2-[(2-furyl)methylidene]-4-hydroxy-5-methyl-2H-furan-3-one, being well in line with data reported in the literature. Decreasing the relative concentrations of the pentose produced further colored nitrogen-containing compounds, among which (S)-4-hydroxy-5-methyl-2-[N-(1′-carboxyethyl)pyrrolyl-2-methylidene]-2H-furan-3-one could be identified by spectroscopic and synthetic experiments On the other hand, thermal treatment of an aqueous solution of pentose and L-alanine in the presence of furan-2-carboxaldehyde led to the formation of the novel red (2R)-4-oxo-3,5-bis[(2-furyl)methylidene]tetrahydropyrrolo[1,2-c]-5(S)-(2-furyl)oxazolidine and its 5(R)-(2-furyl)oxazolidine diastereomer, which were characterized by several 1D- and 2D-NMR techniques, LC/MS, and UV-vis spectroscopy as well as by synthesis of the chromophoric substructure. In addition, the red compounds (S)-4-[(E)-1-formyl-2-(2-furyl)ethenyl]-5-(2-furyl)-2-[(E)-(2-furyl)methylidene]-2,3-dihydro-α-amino-3-oxo-1H-pyrrole-1-acetic acid and the corresponding 2-[(Z)-(2-furyl)methylidene] isomer were identified in this Maillard mixture Quant. studies on the formation of these colorants clearly demonstrates the key role of 3-deoxypentos-2-ulose as an intermediate. Reaction pathways leading to the colorants from pentoses and alanine are discussed.

Journal of Agricultural and Food Chemistry published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Recommanded Product: Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Dai, Lei published the artcileVisible-Light-Driven N-Heterocyclic Carbene Catalyzed γ- and ε-Alkylation with Alkyl Radicals, COA of Formula: C5H9IO2, the publication is Angewandte Chemie, International Edition (2019), 58(50), 18124-18130, database is CAplus and MEDLINE.

The merging of photoredox catalysis and N-heterocyclic carbene (NHC) catalysis for γ- and ε-alkylation of enals with alkyl radicals was developed. The alkylation reaction of γ-oxidized enals with alkyl halides worked well for the synthesis γ-multisubstituted-α,β-unsaturated esters, including those with challenging vicinal all-carbon quaternary centers. The synthesis of ε-multisubstituted-α,β-γ,δ-diunsatd. esters by an unprecedented NHC-catalyzed ε-functionalization was also established.

Angewandte Chemie, International Edition published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, COA of Formula: C5H9IO2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Dowd, Paul published the artcileA general approach to substituted itaconate esters, Application In Synthesis of 31253-08-4, the publication is Synthetic Communications (1993), 23(16), 2307-22, database is CAplus.

General approaches to the synthesis of various itaconates, including 3-substituted esters, are presented. The complementary nature of the 3 methods is also shown. Thus, alkylation of Me₂NCH₂CH₂CO₂Et by treatment with LiN(CHMe₂)₂ (LDA), then RCHXCO₂R² (e.g., R = H, R² = Et, X = Br) affords Me₂NCH₂CH(CO₂R¹)CHRCO₂R² (42-82% yield) which are then quaternized with MeI and treated with DBU to give the elimination products, itaconate diesters RCH(CO₂R²)C(:CH₂)CO₂R¹ (86-93% yield). Deprotonation of Me₂NCH₂CH(CO₂R¹)CH₂CO₂R² (e.g., R¹ = R² = Et) with LDA and subsequent alkylation with RX (e.g., MeI) affords Me₂NCH₂CH(CO₂R¹)CHRCO₂R² in 17-46% yield. Subsequent quaternization and elimination reaction of the latter afford itaconate diesters RCH(CO₂R²)C(:CH₂)CO₂R¹ in good yield. A third alternative procedure consists of deprotonation of (EtO)₂P(O)CH₂CO₂R¹ with NaH, alkylation with RCHXCO₂R² to give (EtO)₂P(O)CH(CO₂R¹)CHRCO₂R² (51-74% yield), and subsequent methylenation with HCHO to give the itaconate diesters in 55-93% yield.

Synthetic Communications published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Application In Synthesis of 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chen, Chen published the artcilePhoto-selective chain end transformation of polyacrylate-iodide using cysteamine and its application to facile single-step preparation of patterned polymer brushes, Application In Synthesis of 31253-08-4, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(97), 13738-13741, database is CAplus and MEDLINE.

Cysteamine, which is an inexpensive and non-toxic aminothiol, was successfully employed as a photo-selective chain end transformation agent of iodo-terminated polymer chains (polymer-I). Polymer-I was selectively transformed to hydrogen-terminated (polymer-H) and thiol-terminated (polymer-SH) polymers with and without UV irradiation, resp. This method is applicable to acrylate polymers. This photo-selective reaction offered a single-step preparation of patterned polymer brushes with SH and H chain end functionalities as a unique application.

Chemical Communications (Cambridge, United Kingdom) published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Application In Synthesis of 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kashin, A. N. published the artcileReactivity of organotin compounds. XXVII. New method for the activation of organotin compounds in electrophilic substitution reactions. Study of the reaction kinetics of α-stannylated esters with iodine in the presence of triorganoiodostannanes, Synthetic Route of 31253-08-4, the publication is Zhurnal Organicheskoi Khimii (1984), 20(8), 1611-20, database is CAplus.

The kinetics of the reactions of R₃SnCHR¹CO₂R² (R = Me, Et, Bu; R¹ = H, Me, Ph; R² = Me, Et, Me₂CH, Me₃C) with iodine in DMF containing KI was studied. The reaction is autocatalytic with formation of R₃SnI, and the final product is ICHR¹CO₂R². In the presence of excess R₃SnI the reaction is 2nd order overall, 1st order in each reactant, and its rate is not dependent on the KI and R₃SnI concentrations

Zhurnal Organicheskoi Khimii published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Synthetic Route of 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Since, Marc published the artcileOriginal TDAE strategy using α-halocarbonyl derivatives, Name: Ethyl 2-Iodopropionate, the publication is Tetrahedron (2009), 65(31), 6128-6134, database is CAplus.

The selective C-C bond formation by the reaction of nitrobenzyl carbanions, formed via the TDAE strategy, with α-haloesters and α-haloamides is disclosed. This reaction, extended in benzodioxole and dimethoxybenzene series provides new potentially CNS active agents.

Tetrahedron published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C15H21BO2, Name: Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com