Category: 3058-39-7

Synthetic Route of 3058-39-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3058-39-7 name is 4-Iodobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Polymer supported Cu(II) catalyst (0.05 g, 0.0098 mmol) in DMSO (5 mL) was taken in a 100 ml R.B flask and stirred at room temperature for 10 min. Then aryl halide (1 mmol), phenol(1 mmol), tetrabutylammonium bromide (tBu4NBr) (0.1 mmol),Cs2CO3 (1 mmol) and DMSO (5 mL) were added to it. The final reaction mixture was refluxed at 120 C under an open air condition.The reaction mixtures were collected at different time intervals and identified by GCMS and quantified by GC. After the completion of the reaction, the catalyst was filtered off and washed with water followed by acetone and dried in oven. The filtrate was extracted with ethyl acetate (3 x 20 ml) and the combined organic layers were dried with anhydrous Na2SO4 by vacuum. The filtrate was concentrated by vacuum and the resulting residue was purified by column chromatography on silica gel to provide the desired product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Iodobenzonitrile, and friends who are interested can also refer to it.

Reference:
Article; Islam, Sk.Manirul; Mondal, Sanchita; Mondal, Paramita; Roy, Anupam Singha; Tuhina; Salam, Noor; Mobarak, Manir; Journal of Organometallic Chemistry; vol. 696; 26; (2012); p. 4264 – 4274;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 3058-39-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3058-39-7, name is 4-Iodobenzonitrile belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Styrene (1.4mmol) was added to a stirring mixture of arylhalide (1.0 mmol), K2CO3(1.5 mmol), nano-pd catalyst(1.5mol%), TBAB (0.5mmol) in DMF (3.0mL) and thenthe reaction mixture was heated at 130 C for the appropriatetime. The mixture was cooled down to room temperatureand the catalyst was isolated using an externalmagnet. Then, the residue was diluted with H2O(10.0mL)and extracted with EtOAc (10 × 3). The combined organicphases were combined and dried over anhydrous Na2SO4.Concentration of the mixture and column chromatographyon silica gel afforded the desired cross-coupling productsin high yield.

The synthetic route of 4-Iodobenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Article; Khalili, Dariush; Banazadeh, Ali Reza; Etemadi-Davan, Elham; Catalysis Letters; vol. 147; 10; (2017); p. 2674 – 2687;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3058-39-7, name is 4-Iodobenzonitrile, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H4IN

The compound 4-cyanoiodobenzene 1a (0.023 g, 0.10 mmol, 1.0 eqv.) was added to the reactor in that order.DMSO (0.3 ml), Cs2CO3 (0.065 g, 0.20 mmol, 2.0 eq.).Phenol 2a (0.0113 g, 0.12 mmol, 1.2 eq.) was stirred at room temperature for 10 minutes.Then placed in an 80 C oil bath, reacted under light for 10 h,After the TLC detection reaction is completed, the reaction solution is subjected to filtration, extraction and column chromatography.The target product 3a was obtained in a yield of 83%.

The synthetic route of 3058-39-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; China Three Gorges University; Wang Long; Liu Na; Yang Qingqing; Hu Weimin; (6 pag.)CN109879779; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 3058-39-7, These common heterocyclic compound, 3058-39-7, name is 4-Iodobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A 50mL round-bottomed flask equipped with a gas inlet tube, a reflux condenser, and a magnetic stirring bar was charged with MCM-41-S-PdCl2 (173mg, 0.05 mmol Pd), aryl halide (5.0 mmol) and HCOONa (7.5 mmol). The flask was flushed with carbon monoxide. DMF (5 mL) was added by syringe and a slow stream of CO was passed into the suspension. The mixture was vigorously stirred at 100?110°C for 4?24h, cooled to room temperature, and diluted with diethyl ether (50 mL). The palladium catalyst was separated from the mixture by filtration, washed with distilled water (2×10 mL), ethanol (2×10 mL) and ether (2×10 mL) and reused in the next run. The ethereal solution was washed with water (3×20mL) and dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by flash column chromatography on silica gel (hexane?ethyl acetate=10:1). (0008) All formylation products were characterized by comparison of their spectra and physical data with authentic samples. IR spectra were determined on a Perkin-Elmer 683 instrument. 1H NMR (400MHz) and 13C NMR (100MHz) spectra were recorded on a Bruker Avance 400MHz spectrometer with TMS as an internal standard and CDCl3 as solvent.

The synthetic route of 3058-39-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Hao, Wenyan; Ding, Guodong; Cai, Mingzhong; Catalysis Communications; vol. 51; (2014); p. 53 – 57;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 3058-39-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3058-39-7, name is 4-Iodobenzonitrile belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Phenylpropiolic acid (43.8 mg, 0.3 mmol), iodobenzene (61.2 mg, 0.3 mmol), Na2CO3 (47.6 mg, 0.45 mmol), NaCuY (12 mg, 0.03 mmol) were added to a vial under DMSO (1.0 mL). The resulting mixture was heated to 100 °C for 12 h under vigorous stirring. After complete reaction, the reaction mixture was treated with water and extracted with EtOAc. The organic layer was dried under MgSO4 and concentrated by using vacuum evaporation. The crude mixture was purified by column chromatography.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Park, Jaerim; Jung, Dasom; Kim, Han-Sung; Na, Kyungsu; Lee, Sunwoo; Catalysis Communications; vol. 99; (2017); p. 83 – 88;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3058-39-7, name is 4-Iodobenzonitrile, A new synthetic method of this compound is introduced below., Formula: C7H4IN

The compound 4-cyanoiodobenzene 1a (1.0 mmol), DMSO (5 ml), Cs2CO3 (2.0 mmol), and phenol 2a (1.2 mmol) were added to the mixture, and the mixture was stirred at room temperature for 10 minutes. Then placed in an 80 C oil bath, reacted under lightAfter 10 h, after TLC detection reaction, the reaction solution was filtered, extracted and subjected to column chromatography to obtain the target product 4a, yield 79%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; China Three Gorges University; Wang Long; Liu Na; Yang Qingqing; Hu Weimin; (8 pag.)CN109824544; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 3058-39-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3058-39-7 as follows.

General procedure: A 10 mL round-bottom flask was charged with iodobenzene (4a, 1 mmol, 1 eq.), butyl acrylate (5, 1.5 mmol, 1.5 eq.), tributylamine (3 mmol, 3 eq.), H2O (2 mL), and Pd catalyst (0.01 mmol). The flask was stirred at 90 C in air. The reaction was monitored by thin layer chromatography (TLC) and gas chromatography (GC). After the reaction was complete, the reaction mixture was cooled to room temperature and then simply filtered to recover the catalyst. It was then washed with 10mL of H2O and ethyl acetate (EtOAc). The organic phase was separated from the aqueous phase, which was extracted three times with 30 mL EtOAc. The organic phases were collected together, dried over MgSO4, and filtered. The solvent was then evaporated under reduced pressure. Pure product was obtained via silica gel column chromatography with an eluent of EtOAc and hexane. The resulting product was analyzed by 1H NMR spectroscopy.

According to the analysis of related databases, 3058-39-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Lee, Yongwoo; Hong, Myeng Chan; Ahn, Hyunseok; Yu, Jeongmok; Rhee, Hakjune; Journal of Organometallic Chemistry; vol. 769; (2014); p. 80 – 93;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3058-39-7, name is 4-Iodobenzonitrile belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C7H4IN

General procedure: FMMWCNTs(at)CPA(at)SMTU(at)PdII NPs (IV) (0.35 mol-%,0.015 g) were added to a mixture of triethylamine (NEt3) (2 mmol, 0.202 g), methyl acrylate (1.2 mmol, 0.108 mL), and iodobenzene (1.0 mmol, 0.203 g) in solvent-free conditions at room temperature. After the completion of the reaction (15 min)which was monitored by TLC, the nanocatalyst was separated by a magnetic field, washed with ethyl acetate, and dried at room temperature for 24 h to be used in the next run. The reaction mixture was then extracted with ethyl acetate (55 mL) and the combined organic layer was dried over anhydrous Na2SO4. After evaporation of the solvent, the crude product was purifiedby TLC (or column chromatography using n-hexane/ethylacetate (50 : 1)) using n-hexane/ethyl acetate (8 : 2) to produce the pure methyl cinnamate (0.153 g, 98% yield).

The synthetic route of 3058-39-7 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3058-39-7, name is 4-Iodobenzonitrile, A new synthetic method of this compound is introduced below., category: iodides-buliding-blocks

To phenol (1.23 g, 13.10 mmol), copper(l) iodide (333 mg, 1.75 mmol), cesium carbonate (5.69 g, 17.47 mmol), 4-iodobenzonithle (2.00 g, 8.73 mmol) and N,N-dimethylglycine hydrochloride (366 mg, 2.62 mmol) under nitrogen was added degassed 1 ,4- dioxane (10.0 ml_). The whole mixture was heated at 90 0C for 88 hours. The cooled mixture was partitioned between ethyl acetate (100 ml_) and water (100 ml_). The organic layer was separated and the aqueous layer was extracted with ethyl acetate (2 x 100 ml_). The organic layers were combined and washed with brine (100 ml_) and dried with Na2SO4 and concentrated in vacuo. The crude material was purified by column chromatography EtOAc/ Hex (1 :12 ? 1 :8) to give the pure product as a white solid (quantative yield). 1H NMR (300 MHz, CDCL3) d(ppm): 7.00 (2H, d, J = 9.1 Hz), 7.06 (2H, d, J = 7.6 Hz), 7.23 (1 H, t, J = 7.2 Hz), 7.41 (2H, t, J = 8.1 Hz), 7.59 (2H, d, J = 9.1 Hz). 13C NMR (75 MHz, CDCL3) d(ppm): 105.9, 118.0 (CH), 119.0, 120.5 (CH), 125.3 (CH), 130.4 (CH), 134.2 (CH), 154.9, 161.8. MS (FAB+): 196 (MH+). HRMS for Ci3H9NO (MH+): calculated: 196.0762; found 196.0780.

The synthetic route of 3058-39-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERSITY OF NOTRE DAME DU LAC; WO2009/41972; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In an article, author is Qian, Qingli, once mentioned the application of 3058-39-7, COA of Formula: C7H4IN, Name is 4-Iodobenzonitrile, molecular formula is C7H4IN, molecular weight is 229.02, MDL number is MFCD00051310, category is iodides-buliding-blocks. Now introduce a scientific discovery about this category.

Direct removal of trace ionic iodide from acetic acid via porous carbon spheres

The main purpose of this paper is to report the direct removal Of trace ionic iodide (I(-)) from acetic acid through porous carbon spheres (PCS) derived from the carbonization of poly(vinylidene chloride). The surface morphology and pore size distribution of the PCS are distinct from activated carbon (AC); thus they possess the peculiar performance of removing ionic iodide from acetic acid. The easy reach of micropores in the PCS was different from that of AC, but similar to that of activated carbon fiber (ACF). The iodide removal process has a strong relation with temperature, which is a typical feature of physical adsorption. The ionic iodide content in acetic acid used in the adsorption experiment was at the parts Per billion level, and the factors influencing the adsorption are discussed in detail. (C) 2008 Elsevier Inc. All rights reserved.

If you are interested in 3058-39-7, you can contact me at any time and look forward to more communication. COA of Formula: C7H4IN.