Category: 3032-81-3

Electric Literature of 3032-81-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3032-81-3, name is 1,3-Dichloro-5-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of N-picolinoylcyclododecylamine (3) (0.2 mmol, 57.6 mg), aryl iodide4 (0.4 mmol), Ag2CO3 (0.3 mmol, 82.7 mg), and Pd(OAc)2 (0.04 mmol, 9.0 mg)in t-AmOH (1 mL) was stirred for 48 h at 110 C in the dark. After dilution withEtOAc, the mixture was filtered and the filtrate was concentrated in vacuo. Theresidue was purified by preparative TLC (EtOAc/CHCl3/hexane = 1:1:8) to givethe corresponding product. Trans-3-(4-nitrophenyl)-N-picolinoylcyclododecylamine[5a(trans)]

The synthetic route of 1,3-Dichloro-5-iodobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Seki, Atsushi; Tetrahedron Letters; vol. 58; 45; (2017); p. 4232 – 4235;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 3032-81-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3032-81-3, name is 1,3-Dichloro-5-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 1,3-dichloro-5-iodo-benzene in 1,4-dioxane (160 mL) was added Copper(I) iodide (0.661g), pyridine-2-carboxylic acid (0.812g), and cesium carbonate (32g) under Argon. Then dimethyl propanedioate (15g) was added at room temperature via dropping funnel.The mixture was heated to 90C for 5h. After completion of the reaction mixture was diluted with water and extracted with ethyl acetate (2x). the combinated organic layers were washed with brine, dried over sodium sulphate and concentrated. The crude was purified by silica gel column chromatography (3RF 200) using a gradient of ethyl acetate (0 to 10%) in cyclohexane to give the title compound (11.75 g, 77.1% Yield). LC-MS (method A): 277 (M+1)+, 275 (M-1)+retention time 1.02 min.

The synthetic route of 1,3-Dichloro-5-iodobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; JUNG, Pierre, Joseph, Marcel; DUMEUNIER, Raphael; GAGNEPAIN, Julien, Daniel, Henri; STOLLER, Andre; RENDINE, Stefano; (165 pag.)WO2019/115404; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3032-81-3, name is 1,3-Dichloro-5-iodobenzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 3032-81-3

General procedure: [(Cinnamyl)PdCl]2 (5 mol percent) and AsPh3 (10 mol percent) were transferred into a vial (4 mL reaction volume) equipped with a septum, a small cannula and a stirring bar. After the vials were purged with argon, 1,4-dioxane distilled from sodium ketyl, 2 ml, iodobenzene (1 mmol), and HMDS (2 mmol) were injected into the vial by syringe. Then, the vial was placed in an alloy plate, which was transferred into a 300 mL autoclave of the 4560 series from Parr Instruments.(R). under argon atmosphere. After flushing the autoclave three times with CO, a pressure of 10 bar was adjusted and the reaction was performed for 16 h at 110 ¡ãC. Due to the sensitivity of the products no isolation was performed and characterization was done by GC-MS. Determination of the yield was done using the calibration factor of benzoyltrimethyl silane.

According to the analysis of related databases, 3032-81-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Wu, Xiao-Feng; Neumann, Helfried; Beller, Matthias; Tetrahedron Letters; vol. 53; 5; (2012); p. 582 – 584;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3032-81-3, name is 1,3-Dichloro-5-iodobenzene, A new synthetic method of this compound is introduced below., Computed Properties of C6H3Cl2I

General procedure: Amide derivatives (0.2 mmol), 4-methoxy iodobenzene (3 equiv.), Pd(OAc)2 (10 mmolpercent), C6H13COOAg (2 equiv.) were combined in o-xylene (1 mL) in a 10mL vial. The vial was sealed with a Teflon lined cap, and the reaction was stirred in 120 ¡ãC oil bath for 24 hours without an inert gas atmosphere. After cooled to room temperature, the mixture was extracted with ethyl acetate (3 x 10mL). The residue was purified by silica-gel column chromatography to afford the corresponding product.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Yan, Xufei; Long, Rongrong; Luo, Feihua; Yang, Li; Zhou, Xiangge; Tetrahedron Letters; vol. 58; 1; (2017); p. 54 – 58;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3032-81-3, name is 1,3-Dichloro-5-iodobenzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 3032-81-3

General procedure: A Schlenk tube with a magnetic stir bar was charged with Pd(OAc)2 (10 molpercent, 0.0056 g), AgOTf (1.1 equiv., 0.0707 g), TBAB (20 molpercent, 0.0161g), 2-phenylpyridine N-oxides 1 (0.25 mmol), iodobenzene and its derivatives 2 (0.375 mmol) and H2O (1 mL). The resulting solution was stirred at 100¡ãC for 12 h. The resulting organic layer was extracted with trichloromethane, treated with Na2SO4 and concentrated in vacuo. The product was isolated by short column chromatography using ethyl acetate and methanol as eluent.

According to the analysis of related databases, 3032-81-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhang, Wei; Li, Zhengkai; Zhang, Yihan; Yang, Li; Zhou, Xiangge; Synthetic Communications; vol. 47; 8; (2017); p. 793 – 802;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 3032-81-3, name is 1,3-Dichloro-5-iodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C6H3Cl2I

General procedure: To a solution of phenol 3 (0.45 mmol), aryl iodide 2 (0.45 mmol), ferrocenyl allene 1 (0.3 mmol) and Cs2CO3 (0.9 mmol) in MeCN (2.0 mL)was added Pd(PPh3)4 (0.015 mmol) under a N2 atmosphere. The resulting mixture was heated at 80 ¡ãC for 2 h. After completion of thereaction, the mixture was cooled to room temperature. The solvent was removed under vacuum, and the resulting residue was purified on a silica gel column (PE/EtOAc, 10:1) to provide the corresponding ferrocene-containing allylic ester product

The synthetic route of 1,3-Dichloro-5-iodobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wu, Xin-Xing; Wang, Chenjun; Zhao, Wanrong; Zhao, Haiying; Chen, Shufeng; Synthesis; vol. 50; 20; (2018); p. 4097 – 4103;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 3032-81-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3032-81-3 as follows.

EXAMPLE 4; Step A. tert-Butyl 3-{[4-((2RS)-2-{[5-chloro-1-(3,5-dichlorophenyl)-1H-indol-2-yl]carbonyl}pentyl)benzoyl]amino}propanoate; To a vial containing the title compound of Example 3 Step D (100 mg, 0.26 mmol), were added 3,5-dichloro iodobenzene (0.045 mL, 0.31 mmol), copper iodide (2.5 mg, 0.012 mmol), potassium phosphate (116 mg, 0.55 mmol), and 1,2-trans-N,N-dimethylcyclohexane diamine (0.0082 mL, 0.05 mmol). The reaction mixture was placed under a nitrogen atmosphere, and anhydrous toluene (0.300 mL, deoxygenated via nitrogen sparge), was added. The vial was then capped and placed in a pre-heated oil bath (110¡ã C.) and stirred rapidly for 20 h. The mixture was allowed to cool to room temperature, then was filtered through a silica gel plug, eluting with EtOAc. The filtrate was concentrated in vacuo: LCMS B, tr=3.10 min, m/z 528.1 [M+H]+. The crude adduct was dissolved in 1,4-dioxane (1.5 mL). 2 N aq. LiOH (1.3 mL, 2.6 mmol) was added, and the resultant mixture was stirred at 50¡ã C. for 1 h. The mixture was allowed to cool to room temperature whereupon it was quenched by the addition of 2 N aq. HCl. The aqueous phase was extracted with EtOAc, and the organic phase was dried over Na2SO4 and concentrated in vacuo. To the crude carboxylic acid obtained above were added EDC (150 mg, 0.78 mmol), HOBt (105 mg, 0.78 mmol), and beta-alanine tert-butyl ester hydrochloride (141 mg, 0.78 mmol). The resultant mixture was dissolved in DMF (2 mL), DIEA (0.275 mL, 1.56 mmol) was added, and the reaction mixture was stirred at 50¡ã C. for 18 h. The reaction mixture was quenched by addition of sat. aq. NH4Cl, and the aqueous phase was extracted with EtOAc. The organic phase was concentrated in vacuo. Purification by flash chromatography on silica gel (0 to 70percent, then 70 to 100percent EtOAc in hexanes) provided the title compound: LCMS B, tr=3.01 min, m/z 663.1 [M+H]+; 1H NMR (500 MHz, CDCl3) delta 7.67 (d, J=2.0 Hz, 1H), 7.66 (s, 1H), 7.65 (d, J=8.0 Hz, 2H), 7.46 (t, J=7.0 Hz, 1H), 7.27-7.21 (m, 4H), 6.96 (d, J=8.0 Hz, 2H), 8.87 (t, J=5.5 Hz, 1H), 3.65 (q, J=6.0 Hz, 2H), 3.64-3.59 (m, 1 H), 3.04 (dd, J=14.0, 9.0 Hz, 1H), 2.83 (dd, J=14.0, 5.5 Hz, 1H), 2.52 (t, J=6.0 Hz, 1H), 1.80-1.73 (m, 1H), 1.59-1.52 (m, 1H), 1.44 (s, 9H), 1.41-1.33 (m, 2H), 0.92 (t, J=7.0 Hz, 3H).

According to the analysis of related databases, 3032-81-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Kim, Ronald M.; Bittner, Amy R.; Sinz, Christopher Joseph; Parmee, Emma R.; US2007/88071; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 3032-81-3, A common heterocyclic compound, 3032-81-3, name is 1,3-Dichloro-5-iodobenzene, molecular formula is C6H3Cl2I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A suspension of DL-5-methoxypyrrolidin-2-one (3a) or arylaminopyrrolidinones 3b,c (1 equiv), CuI (0.5 equiv), cesium carbonate (2 equiv), and corresponding aryl iodide (1 equiv) in dioxane was placed under a nitrogen atmosphere. The coupling ligand DMEDA (1 equiv) was added dropwise by using a syringe and the mixture was then stirred at 60 ¡ãC for various periods of time (14?88 h). At the end ofthe reaction, the insoluble salts deposited after cooling at r.t. were collected by filtration then washed with dichloromethane. The resulting filtrate was concentrated in vacuo and the residue was partitioned between water and dichloromethane. The organic layer was dried on MgSO4 and evaporated to dryness. The residue was finally purified by chromatography on silica gel column (EtOAc/n-heptane) to afford pure N-arylated compound 40?44.

The synthetic route of 3032-81-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Baudelet, Davy; Daich, Adam; Rigo, Benoit; Lipka, Emmanuelle; Gautret, Philippe; Homerin, Germain; Claverie, Christelle; Rousseau, Jolanta; Abuhaie, Cristina-Maria; Ghinet, Alina; Synthesis; vol. 48; 14; (2016); p. 2226 – 2244;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 3032-81-3, These common heterocyclic compound, 3032-81-3, name is 1,3-Dichloro-5-iodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 26 3-(3,5-Dichloro-phenylamino)-N-phenyl-benzamide A mixture of 3-amino-N-phenyl-benzamide (2.0 g, 9.4 mmol), 3,5-dichloroiodobenzene (2.65 g, 9.7 mmol), N-ethylmorpholine (1.1 g, 9.5 mmol), and copper(II) acetate (0.1 g, 0.6 mmol) in N,N-dimethylformamide (6 mL) was stirred under an inert atmosphere and heated to reflux. After 120 hours, the mixture was allowed to cool and was stirred into water (300 mL) and acidified with concentrated hydrochloric acid. The mixture was extracted with dichloromethane (300 mL) and the extract separated and washed successively with 2N hydrochloric acid, water, 0.5 M aqueous potassium carbonate, water, and saturated aqueous sodium chloride, then dried over MgSO4. The solution was filtered and stripped of solvent under reduced pressure to leave a solid residue which was subjected to chromatography on a column of silica gel in chloroform to afford the product (0.1 g); m.p. 164-165¡ã C. after recrystallization from ethyl alcohol. Calculated for C19H14Cl2N2O: C, 63.88; H, 3.95; N, 7.84. Found: C, 63.64; H, 4.04; N, 7.61.

Statistics shows that 1,3-Dichloro-5-iodobenzene is playing an increasingly important role. we look forward to future research findings about 3032-81-3.

Reference:
Patent; Warner-Lambert Company; US6268387; (2001); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding some certain compound to certain chemical reactions, such as: 3032-81-3, name is 1,3-Dichloro-5-iodobenzene, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3032-81-3. 3032-81-3

General procedure: A mixture of N-picolinoylcyclododecylamine (3) (0.2 mmol, 57.6 mg), aryl iodide4 (0.4 mmol), Ag2CO3 (0.3 mmol, 82.7 mg), and Pd(OAc)2 (0.04 mmol, 9.0 mg)in t-AmOH (1 mL) was stirred for 48 h at 110 C in the dark. After dilution withEtOAc, the mixture was filtered and the filtrate was concentrated in vacuo. Theresidue was purified by preparative TLC (EtOAc/CHCl3/hexane = 1:1:8) to givethe corresponding product. Trans-3-(4-nitrophenyl)-N-picolinoylcyclododecylamine[5a(trans)]

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1,3-Dichloro-5-iodobenzene.

Reference:
Article; Seki, Atsushi; Tetrahedron Letters; vol. 58; 45; (2017); p. 4232 – 4235;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com