Category: 301673-14-3

Liu, Xian-Guan; Dong, Ci-Shuang; Li, Fei; Zhang, Bo published an article in 2021. The article was titled 《Manganese-Mediated Direct Functionalization of Hantzsch Esters with Alkyl Iodides via an Aromatization-Dearomatization Strategy》, and you may find the article in Organic Letters.Computed Properties of C10H18INO2 The information in the text is summarized as follows:

Manganese-mediated direct functionalization of the Hantzsch esters with readily accessible alkyl iodides through an aromatization-dearomatization strategy was reported for the first time. Applying this protocol, a library of valuable 4-alkyl-1,4-dihydropyridines were facilely afforded in good yields. This simple and practical reaction proceeded under visible-light irradiation at room temperature and displays high functional-group compatibility. Addnl., the method was applicable for gram-scale synthesis and late-stage functionalization of complex mols. The experimental process involved the reaction of tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Computed Properties of C10H18INO2)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Computed Properties of C10H18INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Mingjun; Yu, Mo; Wang, Ziwen; Liu, Yuxiu; Wang, Qingmin published an article in 2022. The article was titled 《Rapid Access to Aliphatic Sulfonamides》, and you may find the article in Organic Letters.Formula: C10H18INO2 The information in the text is summarized as follows:

Herein, a mild, rapid, straightforward method for visible-light-mediated sulfonamide ethylation to afford a diverse array of compounds with C(sp3)-sulfonamide skeletons RS(O)2N(R1)R2 (R = 4-phenylbutyl, 3,3-dimethylbutyl, 2-cyclobutylethyl, 4-(pyridin-2-yl)butyl, etc.; R1 = H, Ph, 2-oxooxolan-3-yl, benzyl, etc.; R2 = H, Me, phenyl) was reported. The method relies on inexpensive, abundant, com. available primary, secondary, and tertiary alkyl carboxylic acids I (R3 = 2-phenylethyl, 2,2-diphenylethyl, 2-(pyridin-3-yl)ethyl, pentyl, etc.) and alkyl iodides R4I (R4 = 2-cyclohexylethyl, pentyl, 4-(trimethylsilyl)butyl, hept-6-yn-1-yl, etc.) as substrates. The method has a broad substrate scope and potential utility for late-stage functionalization of natural products and synthetic medicines and can be expected to facilitate rapid structural diversification of bioactive mols. In addition to this study using tert-Butyl 4-iodopiperidine-1-carboxylate, there are many other studies that have used tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Formula: C10H18INO2) was used in this study.

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Formula: C10H18INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Ren, Xiaoxiao; Gao, Xing; Min, Qiao-Qiao; Zhang, Shu; Zhang, Xingang published an article in Chemical Science. The title of the article was 《(Fluoro)alkylation of alkenes promoted by photolysis of alkylzirconocenes》.SDS of cas: 301673-14-3 The author mentioned the following in the article:

An unprecedented example of alkylzirconocenes Cp2ZrCl(CH2)2R (R = Bn, dimethyl(phenyl)silyl, trimethylsilyl, etc.) promoted difluoroalkylation of alkyl- and silyl-alkenes RCH=CH2 with a variety of unactivated difluoroalkyl iodides and bromides R1C(F2)X (R1 = [(ethanesulfonyl)oxy]methyl, (morpholin-4-yl)carbonyl, 3-[(4-chlorophenyl)carbonyloxy]propyl, etc.; X = I, Br) under the irradiation of visible light without a catalyst. The resulting difluoroalkylated compounds RC(F2)R1 can serve as versatile synthons in organic synthesis. The reaction can also be applied to activated difluoroalkyl, trifluoromethyl, perfluoroalkyl, monofluoroalkyl, and nonfluorinated alkyl halides, providing a general method to controllably access fluorinated compounds Preliminary mechanistic studies reveal that a single electron transfer (SET) pathway induced by a Zr(III) species is involved in the reaction, in which the Zr(III) species is generated by the photolysis of alkylzirconocene with blue light. In the experiment, the researchers used tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3SDS of cas: 301673-14-3)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.SDS of cas: 301673-14-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Category: iodides-buliding-blocksIn 2016 ,《Reaction of Alkyl Halides with Rongalite: One-Pot and Telescoped Syntheses of Aliphatic Sulfonamides, Sulfonyl Fluorides, and Unsymmetrical Sulfones》 was published in Organic Letters. The article was written by Shavnya, Andre; Coffey, Steven B.; Hesp, Kevin D.; Ross, Stuart C.; Tsai, Andy S.. The article contains the following contents:

An efficient methodol. has been developed for the one-pot or telescoped synthesis of aliphatic sulfonamides, sulfonyl fluorides, and unsym. sulfones on the basis of interrupted alkylation of sodium hydroxymethylsulfinate (rongalite) with alkyl halides. The protocols are conducted under mild conditions, use inexpensive and shelf-stable reagents, and are not sensitive to air/moisture. These conditions can be applied in rapid parallel chem. synthesis, which was demonstrated by the preparation of a small sulfonamide library based on the core structure of the anticoagulant drug Tirofiban. The experimental process involved the reaction of tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Category: iodides-buliding-blocks)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2018,Hofmayer, Maximilian S.; Hammann, Jeffrey M.; Cahiez, Gerard; Knochel, Paul published 《Iron-Catalyzed C(sp2)-C(sp3) Cross-Coupling Reactions of Di(hetero)arylmanganese Reagents and Primary and Secondary Alkyl Halides》.Synlett published the findings.SDS of cas: 301673-14-3 The information in the text is summarized as follows:

An iron-catalyzed cross-coupling between di(hetero)arylmanganese reagents and primary and secondary alkyl halides is reported. No rearrangement of secondary alkyl halides to unbranched products was observed in these C-C bond-forming reactions. In addition to this study using tert-Butyl 4-iodopiperidine-1-carboxylate, there are many other studies that have used tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3SDS of cas: 301673-14-3) was used in this study.

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.SDS of cas: 301673-14-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chen, Kun-Quan; Shen, Jie; Wang, Zhi-Xiang; Chen, Xiang-Yu published their research in Chemical Science in 2021. The article was titled 《A donor-acceptor complex enables the synthesis of E-olefins from alcohols, amines and carboxylic acids》.Computed Properties of C10H18INO2 The article contains the following contents:

Herein, a fundamentally distinct strategy enabled by electron donor-acceptor (EDA) complexes was presented for the selective synthesis of olefins from simple and easily available starting materials such as alcs., amines and carboxylic acids. The conversions took place via photoactivation of the EDA complexes of the activated substrates with alkali salts, followed by hydrogen atom elimination from in-situ generated alkyl radicals. This method was operationally simple and straightforward and free of photocatalysts and transition-metals, and showed high regio- and stereoselectivities. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Computed Properties of C10H18INO2)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Computed Properties of C10H18INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Palladium-catalyzed reductive Heck reaction of α,β-unsaturated alkenes and cycloalkyl iodides》 were Liu, Zhenwei; Wei, Shanshan; Liang, Apeng; Li, Jingya; Zou, Dapeng; Wu, Yusheng; Wu, Yangjie. And the article was published in Tetrahedron Letters in 2019. Electric Literature of C10H18INO2 The author mentioned the following in the article:

The palladium catalyzed reductive Heck reactions of unactivated cycloalkyl iodides RI [R = cyclopentyl, Ph, 1-[(tert-butoxy)(oxo)methane]azetidin-3-yl, oxolan-3-yl, etc.] with α,β-unsaturated alkenes R1CH=CH2 [R1 = COOMe, CN, COOPh, C(O)Me, etc.] have been developed. A number of hydrocycloalkylated compounds RCH2CH2R1 were obtained in reasonable yields under the optimized conditions. The obvious advantage of this approach is that the hydride source was provided by Et3N and no other reductant or base was required in the reaction. In the experimental materials used by the author, we found tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Electric Literature of C10H18INO2)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Electric Literature of C10H18INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Shan; Zhang, Jian-Xin; Zhang, Tian-Yi; Meng, Huan; Chen, Bi-Hong; Shu, Wei published their research in Nature Communications in 2021. The article was titled 《Enantioselective access to chiral aliphatic amines and alcohols via Ni-catalyzed hydroalkylations》.Category: iodides-buliding-blocks The article contains the following contents:

A nickel-catalyzed enantioselective hydroalkylation of acyl enamines R1C(O)N(R2)CH=CH2 (R1 = C6H5, 1-naphthyl, 2-furyl, etc.; R2 = H, Me) and enol esters R3C(O)OCH=CH2R4 (R3 = C6H5, 4-CH3OC6H4, 2-naphthyl; R4 = H, C4H9, C6H13, (CH2)4Cl) with alkyl halides R5I [R5 = 2-phenylethyl, 3-(thiophen-2-yl)propyl, 3-(9H-carbazol-9-yl)propyl, etc.] to afford enantioenriched α-branched aliphatic acyl amines (R)-R1C(O)N(R2)CH(R5)Me and esters R3C(O)OCH(R5)CH2R4 in good yields with excellent levels of enantioselectivity has been described. The operationally simple protocol provides a straightforward access to chiral secondary alkyl-substituted amine and secondary alkyl-substituted alc. derivatives from simple starting materials with great functional group tolerance. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Category: iodides-buliding-blocks)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Cobalt-Catalyzed Csp3-Csp3 Cross-Coupling of Functionalized Alkylzinc Reagents with Alkyl Iodides》 was published in Organic Letters in 2020. These research results belong to Lutter, Ferdinand H.; Grokenberger, Lucie; Benz, Maximilian; Knochel, Paul. Related Products of 301673-14-3 The article mentions the following:

A mild cobalt-catalyzed Negishi-type cross-coupling of various functionalized dialkylzinc reagents with primary and secondary alkyl iodides in acetonitrile is reported using a combination of 20% CoCl2 and chelating nitrogen ligands. The method allows the construction of mols. with alkyl chains bearing sensitive functional groups at room temperature The experimental part of the paper was very detailed, including the reaction process of tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Related Products of 301673-14-3)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Related Products of 301673-14-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2016,Cheung, Chi Wai; Hu, Xile published 《Amine synthesis via iron-catalysed reductive coupling of nitroarenes with alkyl halides》.Nature Communications published the findings.Name: tert-Butyl 4-iodopiperidine-1-carboxylate The information in the text is summarized as follows:

The reductive coupling of nitroarenes RNO2 (R = 4-OHC6H4, OHCH2CH2C6H4, 1-naphthyl, etc.) with alkyl halides R1X (R1 = butan-2-yl, oxolan-3-yl, cyclooctyl, etc.) to yield (hetero)aryl amines, e.g., I has been reported. A simple iron catalyst enables the coupling with numerous primary, secondary and tertiary alkyl halides. Broad scope and high functional group tolerance are demonstrated. Mechanistic study suggests that nitrosoarenes and alkyl radicals are involved as intermediates. This new C-N coupling method provides general and step-economical access to aryl amines. In the experiment, the researchers used tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Name: tert-Butyl 4-iodopiperidine-1-carboxylate)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Name: tert-Butyl 4-iodopiperidine-1-carboxylate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com