Category: 29632-73-3

29632-73-3, name is 2-Bromo-4-iodoaniline, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C6H5BrIN

2-bromo-4-iodoaniline (500 mg, 1.68 mmol) was added to an eggplant-shaped flask, and 10 mL of dry N,N-dimethylformamide was added. Sodium hydride (110 mg, 2.52 mmol) was added, and 1-bromo-2-methoxyethane (350 mg, 2.52 mmol). Heat to 100 C and stir overnight. After completion of the reaction, asaturated sodium chloride solution was added, it was extracted with ethyl acetate three times, and the organic phases were combined, dried over anhydrous sodiumPurified on a silica gel column to obtain the target compound 576 mg.

The synthetic route of 29632-73-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhao Yujun; Li Zhiqiang; Yan Ziqin; Li Jia; Zhou Yubo; Su Mingbo; Chen Zheng; (138 pag.)CN109810110; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 29632-73-3, name is 2-Bromo-4-iodoaniline, A new synthetic method of this compound is introduced below., Computed Properties of C6H5BrIN

To a solution of (10) (570 mg, 1.9 mmol) in dry toluene (8 mL), was added PPh3 (65.5 mg, 0.2 mmol) and Pd(OAc)2 (47.5 %, 60 mg, 0.1 mmol). tert-Butyl Acrylate (370 mu., 2.5 mmol) and NEt3 (420 mu., 3.0 mmol) were added and the flask was stirred at reflux overnight. The reaction was allowed to cool and washed with saturated aqueous NH4C1, brine, extracted with DCM, dried (Na2S04), filtered and concentrated. Purification by column chromatography (Hexane:EtOAc = 12: 1, 9: 1, 4: 1) provided the title compound as a brown oil (238.5 mg, 0.8 mmol, 64 %) Rf : 0.23 (Hexane:EtOAc, 4: 1). 1H NMR (400 MHz; CDC13,): delta 1.51 (9H, s, C(CH3)3), 6.15 (1H, d, J = 15.8 Hz, CH), 6.69 (1H, d, J = 8.1Hz, ArCH), 7.23 (1H, d, J = 8.2 Hz, ArCH), 7.40 (1H, d, J = 15.8 Hz, CH), 7.55 (1H, s, ArCH). 13C NMR (100 MHz; CDC13,): delta 28.2, 80.2, 109.0, 115.3, 117.0, 126.0, 128.4, 132.4, 142.3, 145.7, 166.6.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; TEXAS TECH UNIVERSITY SYSTEM; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; TRIPPIER, Paul; VERMA, Kshitij; PENNING, Trevor, M.; ZHANG, Tianzhu; (204 pag.)WO2018/148721; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com