Category: 27913-58-2

Related Products of 27913-58-2,Some common heterocyclic compound, 27913-58-2, name is 4-(4-Iodophenyl)butanoic acid, molecular formula is C10H11IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(g) 74-p-iodophenyl-butric acid (502 mg, 1.7 mmol, 1.07 eq. ) was dissolved in DMF (1.5 ml) and NEt3 (2 eq.). HBTU (751 mg, 1.98 mmol, 1.23 eq.) was added. The solution was stirred at 0 C for 1 h. The solution was added drop wise to Boc-Lys-OMe (428 mg, 1.6 ramol) in DMF (1.5 ml) and Et3 (2 eq.). The solution was stirred at 0 C for 4 h. The product was extracted with citric acid (1 M) and ethyl acetate/n-Hexane (9:1). The organic phase was rinsed with brine, dried over a2S04 and concentrated under reduced pressure. Purification was achieved by CC (SiC>2,MeOH/CH2Cl2 1:50) to give a clear oil. 653.5 mg (1.23 mmol, 75%). LC-MS [M+H]+ = 532.77 (calc. for C22H33IN2O5, 532.14). 1H-NMR (MeOH-d4) delta 7.59, 6.98, 4.09, 3.69, 3.15, 2.59, 2.29, 2.18, 1.88, 1.78/1.64, 1.51, 1.42 ppm

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(4-Iodophenyl)butanoic acid, its application will become more common.

Reference:
Patent; MERCK & CIE; SCHIBLI, Roger; MOSER, Rudolf; MUeLLER, Cristina Magdalena; STRUTHERS, Harriet; GROEHN, Viola; AMETAMEY, Simon Mensah; FISCHER, Cindy Ramona; WO2013/24035; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 27913-58-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 27913-58-2, name is 4-(4-Iodophenyl)butanoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step A: Preparation of methyl 4-(4-iodophenyl)-butyrate To a solution of 4-(p-iodophenyl)-butyric acid (45.0 g, 0.155 mol) in methanol (1.3 L), was added sulfuric acid (concentrated, 8.4 mL) dropwise and it was stirred at room temperature under nitrogen for 3 hours. The reaction mixture was concentrated on a rota-vapor, the residue was then partitioned between ethyl acetate (700 mL) and saturated sodium bicarbonate aqueous solution (500 mL). The organic phase was separated, washed with brine (2*200 mL), then dried over Na2SO4 and filtered. Evaporation of solvent gave the titled compound as an oil that was used in step B without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(4-Iodophenyl)butanoic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Cano, Ivan Collado; Dominianni, Samuel James; Etgen, Garret Jay; Garcia-Paredes, Cristina; Johnston, Richard Duane; Letourneau, Michael Edward; Mantlo, Nathan Bryan; Martinelli, Michael John; Mayhugh, Daniel Ray; Saeed, Ashraf; Thompson, Richard Craig; Wang, Xiaodong; Coffey, David Scott; Schmid, Christopher Randall; Vicenzi, Jeffrey Thomas; Xu, Yanping; US2004/102500; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 27913-58-2, name is 4-(4-Iodophenyl)butanoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C10H11IO2

[0240] A flask was charged with 4-(p-iodophenyl)butyric acid (600 mg, 2.07 mmol), DCC (427 mg, 2.07 mmol), and N-hydroxysuccinimide (238 mg, 2.07 mmol). Diehl or omethane (6 mL) was added, and the reaction stirred at room temperature for 4 h. Filtering the reaction mixture through a short celite pad, rinsing the pad with dichl or omethane (5 mL), and removing the solvent under vacuum provided crude 4- (p-iodophenyl)butyric acid NHS ester. To this was added DMF (8 mL), 4- aminobutyric acid (525 mg, 5.19 mmol), and diisopropylethylamine (2 mL). The reaction was stirred at room temperature for 24 h, then loaded onto a 100 g Cl 8 Isco gold column. Eluting with 15% to 85% acetonitrile in water with 0.1% TFA provided 70 (560 mg, 1.49 mmol, 72% yield).

The synthetic route of 27913-58-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TARVEDA THERAPEUTICS, INC.; BILODEAU, Mark T.; MOREAU, Benoit; KADIYALA, Sudhakar; WOOSTER, Richard; WHITE, Brian H.; (102 pag.)WO2019/195384; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 27913-58-2, A common heterocyclic compound, 27913-58-2, name is 4-(4-Iodophenyl)butanoic acid, molecular formula is C10H11IO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In one preparation, 428-aminoheptanoic acid: 10 mumol of 428 were stirred with 8 mumol of N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide (EDC) and 10 mumol of N- hydroxysuccinimide (NHS) in 50 mul of DMSO for 3 hours at 30 0C followed by addition of 20 mumol of 7-aminoheptanoic acid (Bachem) in 100 mul of 1 M NaHCO3, pH 9. The reaction was allowed to stir overnight at 30 0C. After quenching of remaining reagents with excess of Trizma base the reaction was purified by HPLC and characterized by mass spectrometry.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; PHILOCHEM AG; WO2008/53360; (2008); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 27913-58-2 as follows. HPLC of Formula: C10H11IO2

4-(p-Iodophenyl)butyric acid (580 mg, 2.0 mmol) and N-hydroxysuccinimide (345 mg, 3.0 mmol) were dissolved in CH2Cl2 (10 mL) and cooled to 0 C. under Ar. A solution of DCC (620 mg, 3.0 mmol) in CH2Cl2 (4 mL) was added dropwise over 10 min, and the reaction was warmed to rt and stirred overnight at rt. The reaction was filtered to remove the insoluble urea by-product, and the filter cake was washed with CH2Cl2. The organic fractions were combined and concentrated under reduced pressure, and the crude product was purified by silica chromatography (EtOAC:hexane=1:1) to give N-succinimidyl 4-(p-iodophenyl)butanoate as a white solid (400 mg, 52%). 1H NMR (500 MHz, CDCl3) delta 7.61 (d, 2H, J=8.2 Hz), 6.96 (d, 2H, J=8.2 Hz), 2.85 (br s, 4H), 2.68 (t, 2H, J=7.6 Hz), 2.60 (t, 2H, J=7.3 Hz), 2.04 (quint, 2H, J=7.4 Hz).

According to the analysis of related databases, 27913-58-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Cornell University; Babich, John W.; Kelly, James M.; Amor-Coarasa, Alejandro; Ponnala, Shashikanth; (36 pag.)US2017/368005; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 27913-58-2, The chemical industry reduces the impact on the environment during synthesis 27913-58-2, name is 4-(4-Iodophenyl)butanoic acid, I believe this compound will play a more active role in future production and life.

Figure 1 shows possible building-block reagents, starting from which the compounds of the inventions may be synthesised. The carboxylic acid of compound 428 (obtainable from SIGMA, catalogue number 15634) was activated with one equivalent of EDC and 1.2 equivalents of NHS in DMSO for 4h at 30 0C prior to addition of ten equivalents of 7-aminoheptanoic acid and triethylamine. The reaction was stirred overnight at 30 C, to EPO yield 428-aminoheptanoic acid. The product was purified by HPLC (see Example 21, General Methods) and analysed by mass-spectrometry.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(4-Iodophenyl)butanoic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PHILOCHEM AG; WO2008/53360; (2008); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 27913-58-2, name is 4-(4-Iodophenyl)butanoic acid, A new synthetic method of this compound is introduced below., Product Details of 27913-58-2

To an ice-cooled THF (20 mL) mixture of 4- (4-iodophenyl) butanoic acid (1) (2.90 g, 10.0 mmol) was added borane-tetrahydrofuran complex (20 mL, 1.0 M, 20 mmol) dropwise over 30 min. The resulting mixture was stirred for 1.5 hr at room temperature, and then quenched with a 1: 1 HOAc/MeOH (1 mL). The solvent was stripped, and the residue was then partitioned between EtOAc and water. The organic layer was separated, washed with saturated [NAHCO3] and brine, dried over [MGS04,] and evaporated to produce a quantitative yield of the crude alcohol as an oil. To a [CH2CL2] (12 mL) mixture of the crude alcohol (1.75 g, 6.3 mmol) was added [4-METHYLMORPHOLINE] N-oxide (1.11 g, 9.5), 4 [A] powdered molecular sieves (3 g), and tetrapropylammonium [PERRUTHENATE] (“TRAP”, [0.] [11 G,] 0.3 mmol). The resulting slurry was stirred for 1 hr at room temperature. The crude material was purified on silica gel (eluting with 5-50% ethyl acetate in hexane) to afford 1.11 g (64% yield) of the desired aldehyde product (2) as an oil. LCMS : m/z = 257.0 (M+H- H20).

The synthetic route of 27913-58-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHARMACIA CORPORATION; WO2004/811; (2003); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27913-58-2, name is 4-(4-Iodophenyl)butanoic acid, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 4-(4-Iodophenyl)butanoic acid

A solution of BORANE-TETRAHYDROFURAN (200M .) was added dropwise to a stirred solution of 4- (4-IODOPHENYL) butanoic acid (25g) at 0C under nitrogen. After 2h methanol (200MI) was added dropwise. And then the solvent was removed in vacuo. The residue was partitioned between ether and water and the organic phase was separated. The combined organic layers were dried (NA2SO4) and evaporated to give the title compound (23 g). LCMS RT = 3.34 min.

According to the analysis of related databases, 27913-58-2, the application of this compound in the production field has become more and more popular.