Category: 2786-00-7

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2786-00-7, name is 5-Iodo-2-methoxybenzoic acid, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 5-Iodo-2-methoxybenzoic acid

5-iodo-2-methoxybenzoic acid (2.0 g, 7.2 mmol) was suspended in anhydrous dichloromethane (40 ml). To this suspension was added, with stirring under nitrogen, oxalyl chloride (0.754 ml, 8.62 mmol). N,N-dimethylformamide (0.035 ml) was then added dropwise to the reaction mixture, and the mixture stirred for 1 hour at room temperature. When the intermediate acid chloride was fully formed as demonstrated by LC/MS, isopropanol (20 ml) was slowly added, then after 15 minutes solid sodium bicarbonate (2 g) was slowly added. The reaction was diluted with 40 ml of 1:1 saturated sodium bicarbonate and water, and the aqueous phase extracted with dichloromethane (3*40 ml). The organic extracts were combined, dried over magnesium sulfate, and solvent removed under reduced pressure. The residue was purified by column chromatography (0 to 50% ethyl acetate in hexanes) to afford isopropyl 5-iodo-2-methoxybenzoate as an oil (1.6 g, 5.0 mmol). 69% yield. 321 (M+1).

According to the analysis of related databases, 2786-00-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Gilead Sciences, Inc.; US2012/4267; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2786-00-7, name is 5-Iodo-2-methoxybenzoic acid, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 5-Iodo-2-methoxybenzoic acid

General procedure: A solution of 3-iodobenzoic acid (4.6 g, 18.5 mmol, 1.0 equiv) and triethylamine (3.78 g,37.1 mmol, 2 equiv) in anhydrous dichloromethane (150 mL) was allowed to stir at room temperature for 10 min under a nitrogen atmosphere. The mixture was cooled to 0 C, and after 30 min, thionyl chloride (20.4 mmol, 1.1 equiv) was added dropwise and allowed to stir for 1.5 h. The reaction mixture was brought to room temperature, with continued stirring for 30 min followed by concentration by rotary evaporation.

According to the analysis of related databases, 2786-00-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Brummel, Beau R.; Giambalvo, Lauren N.; Gross, Kristopher G.; Kobra, Khadijatul; Lex, Timothy R.; McMillen, Colin D.; Panda, Soham; Pennington, William T.; Swasy, Maria I.; Whitehead, Daniel C.; Tetrahedron Letters; (2020);,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

2786-00-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2786-00-7, name is 5-Iodo-2-methoxybenzoic acid, This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 5-iodo-2-methoxybenzoic acid (13.4 g, 48 mmol), acetyl chloride (1 mL) and ethanol (50 mL) was heated 4 hours with stirring at reflux. The mixture was concentrated and the residue was dissolved in diethyl ether. The solution was poured into ice-cold saturated sodium bicarbonate and the organic phase was washed with brine, dried (K2 CO3), filtered and concentrated to give ethyl 5-iodo-2-methoxybenzoate (13.5 g, 44 mmol) as an oil.

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Reference:
Patent; Syntex (U.S.A.) Inc.; US5739336; (1998); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com