Category: 276866-90-1

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 276866-90-1, name is 4-Chloro-3-iodobenzaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 4-Chloro-3-iodobenzaldehyde

General procedure: 2-Methoxyphenylboronic acid 6 (1.2mmol), Pd(PPh3)4 (0.1mmol) and Na2CO3 (1.5mmol) were added to a solution of benzaldehyde 5 (1.0mmol) in DMF (20ml). The mixture was stirred for overnight at 150 C. After cooling down to room temperature, the reaction mixture was quenched with saturated NaHCO3 and then extracted with EtOAc. The combined organic layers were dried over MgSO4, filtered, and evaporated. The residue was purified by column chromatography on silica gel (Hexane:Ether=10:1) to obtain desired product 7 in 64-98% yields.5.1.1.1 6-Chloro-2′-methoxy-[1,1′-biphenyl]-3-carbaldehyde (7b) 64% Yield (as a white solid): mp 82-83 C; 1H NMR (400 MHz, CDCl3) delta 9.99 (s, CHO), 7.81-7.78 (m, 2ArH), 7.61 (d, J = 8.8 Hz, ArH), 7.43-7.39 (m, ArH), 7.20 (dd, J = 7.6, 2.0 Hz, ArH), 7.04 (td, J = 7.6, 0.8 Hz, ArH), 7.00 (d, J = 8.4 Hz, ArH), 3.78 (s, OCH3); 13C NMR (CDCl3, 100 MHz) delta 191.09, 156.64, 140.80, 138.90, 134.75, 133.30, 130.79, 130.25, 130.01, 129.01, 127.21, 120.54, 111.04, 55.58; HRMS (ESI+) calcd for C14H11ClNaO2+ [M + Na]+ 269.0340, found 269.0343.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 276866-90-1.

Reference:
Article; Kim, Youngjae; Park, Hyeri; Lee, Jeongeun; Tae, Jinsung; Kim, Hak Joong; Min, Sun-Joon; Rhim, Hyewhon; Choo, Hyunah; European Journal of Medicinal Chemistry; vol. 123; (2016); p. 180 – 190;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com