Category: 26059-40-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 26059-40-5, name is 2-(2-Iodophenyl)ethan-1-ol, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-(2-Iodophenyl)ethan-1-ol

Example 10: Synthesis of Compound IIA; 2-(2-Iodo-phenyl)-ethanol (0.75g, 3.03 mmol) wasdissolved in toluene (20cm3) , and added dropwise to astirred suspension oftetrakis(triphenylphosphine)palladium(O) (3.50g, 3.03mmol) in toluene (150cm3) . The suspension was degassedand purged with N2. The mixture was stirred at room temperature for 12 hours. The mixture was refrigeratedto aid crystallisation. The resultant precipitate wasfiltered under nitrogen and washed with diethyl ether (3x 20cm3) and dried in vacuo to give compound IIA as awhite solid (1.135g, 43%), this was then recrystallisedfrom dichloromethane and petroleum ether to givecolourless needles. (Found: C, 55.52; H, 4.27%.C44H39lOP2Pd.dichloromethane requires C, 56.07; H, 4.29%);NMR assignments made by DEPT, 8H [CDC13] 0.04 (t, 2JH-9,H-s =6.03 Hz’lH, H-9), 2.58 (t, 2JH-7,H-8 = 6.76 Hz, 2H, H-7),3.27 (pseudo q, 2JH-8,H-9, = 6-03 Hz’ 2^H-8,H-7 = 6.76 Hz, 2H,H-8), 6.23-6.30 (bd, J = 7.5 Hz, 1H, H-2 or 3 or 4 or 5),6.35-6.40 (t, J = 7.06 Hz, 1H, H-2 or 3 or 4 or 5), 6.55-6.61 (t, J = 7.06 Hz, 1H, H-2 or 3 or 4 or 5), 6.88-7.05(m, 1H, H-2 or 3 or 4 or 5), 7.20-7.27 (m, 12H, PPh3) ,7.30-7.35 (m, 6H, PPh3) , 7.39-7.47 (m, 12H, PPh3) ; 5C[CDC13] 42.22 (C-7), 61.42, (C-8), 123.23 (C-2 or 3 or 4or 5), 124.78 (C-2 or 3 or 4 or 5), 127.81 (C-ll or 12),129.41 (C-2 or 3 or 4 or 5), 129.89 (C-13), 131.92 (t, J= 0.23 Hz C-10-P), 134.92 (C-ll or 12), 135.97 (C-2 or 3oor 4 or 5), 141.39 (C-l or 6), 159.65 (C-l or 6); 8P[CDC13] 5 = 23.16, (s); m/z Electrospray 751.3 (M-I =127) C44H39IOP2Pd requires 879.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; HERIOT-WATT UNIVERSITY; WO2006/10885; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 26059-40-5, The chemical industry reduces the impact on the environment during synthesis 26059-40-5, name is 2-(2-Iodophenyl)ethan-1-ol, I believe this compound will play a more active role in future production and life.

Aryl iodide 9 (1.15 g, 4.63 mmol) and stannane 183 (2.08 g, 6.98 mmol) were dissolved in toluene (15 mL) under argon. The solution was degassed for 10 minutes. Pd2(dba)3 (430 mg, 0.47 mmol) was added at room temperature, followed by P(t-Bu)3 (112 mg, 0.55 mmol, 10% in hexane). The reaction was heated at 80 C and stirred for 12 hours at that temperature. After cooling at room temperature, the solution was filtered through a silica plug and concentrated under reduced pressure. Silica gel flash chromatography provided alcohol 19 as oil (963 mg, 68%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-Iodophenyl)ethan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Fischer, Derek; Nguyen, Thong X.; Trzoss, Lynnie; Dakanali, Marianna; Theodorakis, Emmanuel A.; Tetrahedron Letters; vol. 52; 38; (2011); p. 4920 – 4923;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

26059-40-5, name is 2-(2-Iodophenyl)ethan-1-ol, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 26059-40-5

2-(2-iodophenyl)ethanol 91 (4.85 g, 19.60 mmol) was dissolved in acetonitrile (60 mL) and IBX (16.0 g, 57.10 mmol) was added at room temperature. The mixture was stirred under reflux for 1 hour and then cooled to room temperature. The mixture was then filtered through a large cotton plug, and the filtrate was concentrated and purified through a silica plug. The crude aldehyde was obtained as oil and used without further purification. A THF (10 mL) solution of the aldehyde obtained above was added to a solution of 2-methyl-1-propenylmagnesium bromide (64 mL, 32 mmol, 0.5 M in THF) in THF (65 mL) at 0 C via cannula, over 40 minutes. The reaction was allowed to warm to room temperature and stirred overnight. The reaction was then diluted with hexanes, quenched with saturated NH4Cl and extracted with diethyl ether (3 x 50 mL). The combined extracts were dried over MgSO4 and purified via silica gel flash chromatography (EtOAc/hexanes) to give iodide 11 as oil (3.37 g, 57%, 2 steps).

The synthetic route of 26059-40-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Fischer, Derek; Nguyen, Thong X.; Trzoss, Lynnie; Dakanali, Marianna; Theodorakis, Emmanuel A.; Tetrahedron Letters; vol. 52; 38; (2011); p. 4920 – 4923;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 26059-40-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 26059-40-5 as follows.

General procedure: A magnetic stirring bar, 2-iodobenzyl alcohol (1a, 116.0 mg, 0.5 mmol), NEt3 (251.6 mg, 2.5 mmol), and MeCN (10 mL) were placed in a stainless steel autoclave equipped with an inserted Pyrex glass liner. The autoclave was closed, purged three times with carbon monoxide, pressurized with 65 atm of CO and then heated at 250 C by salt bath with stirring for 16 h. After the reaction, excess CO was discharged at room temperature. The solvent was removed under reduced pressure, and the residue was purified by flash chromatography on silica gel (hexane/EtOAc = 3/1) to give 2a (60.4 mg, 91%) as a white solid.

According to the analysis of related databases, 26059-40-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Fukuyama, Takahide; Bando, Takanobu; Ryu, Ilhyong; Synthesis; vol. 50; 15; (2018); p. 3015 – 3021;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 26059-40-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 26059-40-5, name is 2-(2-Iodophenyl)ethan-1-ol belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(1) weighing 2-iodo-phenethyl alcohol 1.0g in 100mL single-necked flask,Join 20mL THF room temperature stirring to dissolve,2.8 g of di-tert-butyl azodicarboxylate and 3.2 g of triphenylphosphine solid were sequentially added,The reaction was stirred at room temperature for 1.5h,The reaction solution was washed once with 20 mL of 1 mol / L diluted hydrochloric acid,20mL saturated sodium bicarbonate once, 20mL saturated brine once,The organic phase is dried over anhydrous magnesium sulphate, filtered and the filtrate is removed by rotary evaporation to give 5.8 g of crude product. The crude product was purified by column chromatography on silica gel eluting with PE: EA = 20: 1 to give 1.6 g of a white solid,Namely N, N’-di-tert-butoxycarbonyl-2-iodophenethylhydrazine,Yield86%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-Iodophenyl)ethan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Wuxi Jiehua Pharmaceutical Technology Co., Ltd.; Gou Yuancheng; (7 pag.)CN107033090; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com