Category: 260558-15-4

Reference of 260558-15-4,Some common heterocyclic compound, 260558-15-4, name is 4-Bromo-2-iodo-1-methylbenzene, molecular formula is C7H6BrI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-(5-Bromo-2-methyl-phenyl)-6-chloro-pyrimidin-2-ylamine) was synthesised in 2 steps from 5-bromo-2-methyl-1-iodo-benzene as described in Example 81.

The synthetic route of 260558-15-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Cell Therapeutics, Inc.; US2004/204386; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 260558-15-4, The chemical industry reduces the impact on the environment during synthesis 260558-15-4, name is 4-Bromo-2-iodo-1-methylbenzene, I believe this compound will play a more active role in future production and life.

To a solution of 2-methyl-5-bromo-iodobenzene (12 g, 40.4 mmol) in tetrahydrofuran (75 ml), cooled to -78 C., was added a solution of isopropylmagnesium chloride (4.6 g, 44.5 mmol) in tetrahydrofuran (22.2 ml) dropwise over 20 minutes. After stirring at -78 C. for 30 minutes, the mixture was warmed slowly to -20 C. and stirred for 1 hour. After cooling again to -78 C., trimethylborate (8.4 g, 80.8 mmol) was added dropwise. After warming to 0 C., the mixture was stirred for 2 hours, treated with 1 M hydrochloric acid (35 ml), and extracted with ethyl acetate (2*50 ml). The combined extracts were washed with water (50 ml), dried over sodium sulfate, and concentrated under reduced pressure. The residual solid was suspended in hexane (50 ml), filtered, washed with hexane (30 ml) and dried under reduced pressure to provide 2-methyl-5-bromo-phenylboronic acid (7.32 g, 84% yield) as a white solid. 1H NMR (DMSO-d6) delta 7.92 (s, 1H), 7.46 (d, J=8.1 Hz, 1H), 7.13 (d, J=8.1 Hz, 1H), 2.59 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-2-iodo-1-methylbenzene, other downstream synthetic routes, hurry up and to see.

These common heterocyclic compound, 260558-15-4, name is 4-Bromo-2-iodo-1-methylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 4-Bromo-2-iodo-1-methylbenzene

A dry flask was charged with 4-BROMO-2-IODO-1-METHYL-BENZENE (6.85 G, 23.1 MMOL) and the flask was evaporated and then filled with argon and this process repeated twice. Dry THF (20 mL) was added, and the solution cooled to-35 C ; then isopropylmagnesium chloride (11.5 mL, 2.0 M in diethyl ether, 23 MMOL) was added slowly over 40 min keeping the temperature below-35 C. On completion of the addition the reaction mixture was stirred at-35 C for 30 min. A THF solution of ZNCI2 (3.93 G, 28. 9 mmol, 0.7 M) was added dropwise over 20 min. The reaction mixture was stirred at 0 C for 20 min; then 2-chloro-4-nitro-benzoyl chloride (5.33 g, 24.2 MMOL) and Cu (OAC) Z (92 mg, 0.46 MMOL) were added and the reaction mixture was allowed to warm to room temperature. After 16 h the reaction mixture was poured into a mixture of ETOAC/WATER, then shaken and separated. The aqueous phase was extracted with more EtOAc. The organic phases were combined, dried (MGS04), filtered, and concentrated in vacuo to afford the crude product. The crude product was purified by flash chromatography using EtOAc/petroleum ether 1: 14 as the eluent to give the title compound as almost white solid.

The synthetic route of 4-Bromo-2-iodo-1-methylbenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LEO PHARMA A/S; WO2005/9940; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com