Category: 25245-27-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25245-27-6, name is 1-Iodo-3,5-dimethoxybenzene, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H9IO2

An ice-cooled solution of 1-iodo-3,5-dimethoxybenzene (8.42 g,31.9 mmol) in DMF (60 mL) was treated under argon atmosphere with freshly distilled POCl3(14 mL, 150 mmol). The mixture was stirred for 30 min at 0 C, then 30 min at roomtemperature and finally heated at 100 C for 5h. The mixture was cooled at room temperatureand was poured with stirring into ice and water (1.5 L). After being stirred for 2h, theresulted suspension was filtered to give a light brown solid. This residue was purified by ashort plug of silica gel using diethyl ether as eluent afforded 1-iodo-3,5-dimethoxybenzaldehyde as a beige solid (5.2 g, 56% yield).1H NMR (300 MHz, CDCl3): delta = 10.1 (s, 1H), 7.13 (d, J = 2.2 Hz, 1H), 6.48 (d, J = 2.2 Hz,1H), 3.89 (s, 3H), 3.86 (s, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Petrignet, Julien; Inack Ngi, Samuel; Abarbri, Mohamed; Thibonnet, Jerome; Tetrahedron Letters; vol. 55; 5; (2014); p. 982 – 984;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 25245-27-6,Some common heterocyclic compound, 25245-27-6, name is 1-Iodo-3,5-dimethoxybenzene, molecular formula is C8H9IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a dry two necked flask were introduced N-[2-(1-Phenyl-cyclohexa-2,5-dienyl)-ethyl]-methanesulfonamide 3c (169 mg, 0.610 mmol), silver carbonate (336 mg, 1.22mmol), triphenylphosphine (24 mg, 0.092 mmol), 3,5-dimethoxy-iodobenzene 4b (322 mg, 1.22mmol), palladium acetate (6.8 mg, 0.030 mmol) and acetonitrile (24.5 mL). The mixture waswarmed to 85C and stirred for 16 hours. The mixture was filtered through celite, which wasthen washed with ethyl acetate. Evaporation of the solvents led to a paste, which was purifiedthrough silica gel chromatography (Petroleum ether/EtOAc 70:30), affording 5c as a white solid(98 mg, 39%). Mp = 123-125 C. IR (solid, KBr, numax, cm-1): 3295, 2936, 2255, 1606, 1454,1316, 1203, 1149, 1064, 973, 910, 777, 735, 710. 1H NMR (300 MHz, CDCl3): deltaH 1.53-1.63(1H, m, CHaHxCH2N), 1.90 (1H, d, 3JHH 6.0 Hz, CH cyclopropane), 1.93-2.00 (1H, m,CHaHxCH2N), 2.36 (1H, dta, JHH 6.0, 2.5 and 2.5 Hz, CH cyclopropane), 2.82 (3H, s,NSO2CH3), 3.00-3.10 (2H, m, CH2N), 3.19-3.23 (1H, m, CH cyclopropane), 3.78 (6H, s, OCH3 x2), 4.43 (1H, broad s, NH), 5.16 (1H, ddd, JHH 5.3, 2.2 and 1.5 Hz, CH olefinic), 5.91 (1H, dta, J= 5.3, 2.0 and 2.0 Hz, CH olefinic), 6.33 (1H, t, 4JHH 2.3 Hz, CH aromatic), 6.36 (1H, t, 4JHH 2.3Hz, CH x 2 aromatic), 7.17-7.35 (5H, m, 5CH aromatic). 13C NMR (75.5 MHz, CDCl3): 36.9(CH cyclopropane), 37.7 (C aliphatic), 37.9 (CH cyclopropane), 40.0 (NSO2CH3), (CH2N), 41.7(CH2CH2N), 51.3 (CH allylic), 55.4 (OCH3 x 2), 98.5 (CH aromatic), 105.8 (CH x 2 aromatic),126.6 (CH aromatic), 128.2 (CH x 2 aromatic), 131.6 (CH olefinic), 131.7 (CH x 2 aromatic),134.1 (CH olefinic), 137.5, 146.6 (2C aromatic), 160.9 (C x 2 aromatic). MS(SIMS) m/z (%):436 (M+Na, 35), 414 (M+H, 100), 305 (35). HRMS calcd for (M+H) C23H28NO4S 413.1661;found 413.1655 (1.5 ppm).

The synthetic route of 25245-27-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Lebeuf, Raphael; Robert, Frederic; Landais, Yannick; ARKIVOC; vol. 2014; 3; (2013); p. 6 – 17;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 25245-27-6, These common heterocyclic compound, 25245-27-6, name is 1-Iodo-3,5-dimethoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 20Synthesis of (1 S,2R,4a5,8a5)-1 -(3,5-dimethoxyphenoxymethyl)-2,5,5,8a-tetramethyl-decahydronaphthalen-2-ol (Compound No. 34) In a sealed tube purged with nitrogen, 1-iodo-3,5-dimethoxybenzene (Compound No. 31, 0.78 g, 2.95 mmol), (1S,2R,4a5,8a5)-1-(hydroxymethyl)-2,5,5,8a-tetramethyl-decahydronaphthalen-2-ol (Compound No. 26, 0.65 g, 2.68 mmol), Cs2CO3 (1.3 g, 3.99 mmol), 3,4,7,8-tetramethyl-[1,10]-phenylthroline (0.12 g, 0.50 mmol), Cul (0.05 g, 0.26 mmol), diglyme (2 mL) and toluene (10 mL) were added. The reaction mixture was stirred at 120C for 18 h. The reaction was cooled to room temperature, diluted with EtOAc (300 mL) and washed with water (100 mL). The organic layer was dried (Na2SO4) and concentrated. Purification by column chromatography on silica gel (Hexanes/EtOAc, 2:1) gave (1 S,2R,4aS,8aS)-1 -(3,5-dimethoxyphenoxymethyl)- 2,5,5,8a-tetramethyl-decahydronaphthalen-2-ol (Compound No. 34, 0.71 g, 70%) as a colorless oil. 1H NMR (CDCI3): 66.08 (s, 3H), 4.20 (m, 2H), 3.75 (s, 6H), 3.08 (s, 1H), 1.95-1.30 (m, 1OH), 1.30 (s, 3H), 1.25-1.00 (m, 2H), 0.90 (s, 6H), 0.88 (m, 2H), 0.80 (s, 3H).

The synthetic route of 25245-27-6 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25245-27-6, name is 1-Iodo-3,5-dimethoxybenzene, A new synthetic method of this compound is introduced below., category: iodides-buliding-blocks

To a mixture of 600 mg (4.0 mmol) of 3-methoxyphenylboronic acid, 792 mg (3.0 mmol) of 3,5-dimethoxyiodobenzene, 34 mg (5 mol %) palladium(II)acetate, 182 mg (20 mol %) of tri-o-tolylphosphine, and 3.6 g (24 mmol) of cesium fluoride was added 10 mL of anhydrous dioxane. The reaction was stirred at reflux under N 2 for 50 min, then poured into 30 mL of water and extracted with diethyl ether (3 10 mL). The combined ether layers were back extracted with saturated aqueous NaHCO 3 solution (1 10 mL), then brine (1 10 mL), dried over MgSO 4, filtered, and concentrated to an oil. This was purified via silica gel chromatography, eluting with 10%, ethyl acetate:hexanes to provide the titled compound (650 mg, 89%).

The synthetic route of 25245-27-6 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25245-27-6, name is 1-Iodo-3,5-dimethoxybenzene, A new synthetic method of this compound is introduced below., Computed Properties of C8H9IO2

General procedure: A mixture of the styrene (3 mmol), the halogenated benzene (3 mmol), triethanolamine (3 mmol) and Pd (II) acetate (0.03 g) was stirred under argon at 100 C for 24 h. The reaction was cooled to 25 C, quenched by the addition of dil. aq. hydrochloric acid (2 N, 10 ml), and extracted with ether (3 ¡Á 100 ml). The organic phases were dried (Na2SO4), the solvents evaporated, and the crude product was subjected to chromatography (silica gel, hexane/ethyl acetate mixtures).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Csuk, Rene; Albert, Sabrina; Siewert, Bianka; Schwarz, Stefan; European Journal of Medicinal Chemistry; vol. 54; (2012); p. 669 – 678;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 25245-27-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25245-27-6, name is 1-Iodo-3,5-dimethoxybenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a 25 mL single-necked flask was added 3,5-dimethoxyiodobenzene (5 mmol)And pd (oAc) 2 (1.0 mol%) / Eosin Y (1.5 mol%)Dissolved in 6 mL DMF (DMF: H2O = 5: 1) aqueous solution,Then, p-hydroxystyrene (5.3 mmol) was slowly added dropwise,The reaction was stirred at room temperature for about 15 h,TLC detection reaction ends. The reaction product was washed with water, separated, dried,Filtered, concentrated, recrystallized from ethyl acetate,To obtain a white crystal, i.e. derivative 6a. the yield of 83.4%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Iodo-3,5-dimethoxybenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhejiang University of Technology; Weng Jianquan; Dai Xiaoqiang; Zhu Yabo; Liu Xinghai; (7 pag.)CN106588582; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 25245-27-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 25245-27-6 name is 1-Iodo-3,5-dimethoxybenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of tetrabutylammonium bromide (1.100 g, 3.33mmol), potassium acetate (0.586 g, 3.57 mmol), and palladium acetate (0.025 g, 0.11mmol) in DMF (20 mL) were added substituted iodobenzene (2.21mmol) and substituted styrene (2.44 mmol). The reaction mixture was recharged with argon and stirred at 80C for 5 h in a sealed tube. The mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous NaCl and concentrated in vacuo. The residue was purified by column chromatography on silica gel (petroleum ether/ethyl acetate, 10:3) to afford pure product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Iodo-3,5-dimethoxybenzene, and friends who are interested can also refer to it.

Reference:
Article; Liang, Jian-Hua; Yang, Liang; Wu, Si; Liu, Si-Si; Cushman, Mark; Tian, Jing; Li, Nuo-Min; Yang, Qing-Hu; Zhang, He-Ao; Qiu, Yun-Jie; Xiang, Lin; Ma, Cong-Xuan; Li, Xue-Meng; Qing, Hong; European Journal of Medicinal Chemistry; vol. 136; (2017); p. 382 – 392;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 25245-27-6, name is 1-Iodo-3,5-dimethoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 1-Iodo-3,5-dimethoxybenzene

General procedure: A 10 mL flask was charged with a magnetic stir bar, CuI (19 mg,10 mol%), L2 (86 mg, 20 mol%), Cs2CO3 (651 mg, 2 mmol) and solid aryl iodides (1.0 mmol). The tube was evacuated and backfilled with argon (this procedure was repeated three times). Under a counter flow of Argon, DMSO (1.0 mL), 1.0 mmol aryl iodides (if liquid), 0.9 mL (12.0 mmol) aqueous ammonia (28%) were added by syringe slowly. The reaction mixture was allowed to stir under argon at room temperature for 24 h. Then the mixture was diluted with 30 ml dichloromethane and passed through a fritted glass filter, the filter cake being further washed with 15 ml dichloromethane, dried over Na2SO4, filtered and the most solvent was removed under vacuum. The residue was purified by column chromatography on silica gel with an eluent of petroleum ether and ethyl acetate.

The synthetic route of 1-Iodo-3,5-dimethoxybenzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chen, Dong; Dong, Xinrui; Jiang, Shang; Jiang, Sheng; Qiu, Yatao; Wu, Xiaoxing; Tetrahedron Letters; (2020);,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25245-27-6, name is 1-Iodo-3,5-dimethoxybenzene, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C8H9IO2

To a solution of aryl methoxy substituted aryl iodide (40 mmol) in isopropylamine (250 ml) were added Pd(PPh3)2Cl2 (0.4 mmol) and CuI (0.8 mmol), then trimethylsilylacetylene (44 mmol). The reaction mixture was stirred at ambient temperature for 2 to 4 hours under a slow stream of nitrogen. The reaction mixture was filtered and the residues were washed with ethyl acetate, and the solvent evaporated from the combined filtrates. The crude product was purified by column chromatography on silica gel using petroleum/ethyl acetate as an eluent to give the methoxy substituted arylethylyl trimethylsilanes.

According to the analysis of related databases, 25245-27-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; KENT STATE UNIVERSITY; SUMMA HEALTH SYSTEM; WO2008/157745; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25245-27-6, name is 1-Iodo-3,5-dimethoxybenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Iodo-3,5-dimethoxybenzene

1. Condensation reaction: in with a thermometer, condenser 250 ml four bottle is added between the 26.7g 5 – iodo – teredimethyl ether, 12.8g bromopropylene, 20.4g triethylamine, 2.2g dppp nickel chloride, 130 ml methyl tert-butyl ether, magnetic stirring, oil bath heating, when the temperature rises to 80 C and maintaining at 4 hours, after the reaction is cooled to ambient temperature, for 60 ml 10% hydrochloric acid aqueous solution washing the reaction liquid, water washed to neutral, the organic layer is distilled under reduced pressure to obtain between the 21.4g 5 – propenyl – teredimethyl ether, yield 96.1%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Weifang Xian Da Chemical Co., Ltd.; Li Kai; Wang Guangyue; Yang Qiwei; Zou Yabo; (7 pag.)CN106748673; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com