Category: 25245-27-6

Adding a certain compound to certain chemical reactions, such as: 25245-27-6, name is 1-Iodo-3,5-dimethoxybenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25245-27-6, Recommanded Product: 1-Iodo-3,5-dimethoxybenzene

1mmol of o-phenylenediamine, 1.2mmol of benzaldehyde, 1mmol3,5-dimethoxy iodobenzene as raw materials, into the 50mL pressure tube, using 10mol% CuSO4 as a catalyst, 2mmol KOH as a base,1,10-phenanthroline is used in an amount of 20 mol%N, N-dimethylformamide was used in an amount of 5 mL and the temperature was 120 C. The reaction was stirred for 24 h.The reaction solution was filtered through the residue and distilled under reduced pressure to give a white solid.The yield was 88% and 1- (3,5-dimethoxyphenyl) -2-phenyl-1H-benzimidazole was obtained as a white solid

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Reference:
Patent; Jiangsu Xian Ke Pharmaceutical Co., Ltd.; Liang Zhuowang; Huang Yuan; Xu Liangliang; (16 pag.)CN104557725; (2017); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25245-27-6, name is 1-Iodo-3,5-dimethoxybenzene, A new synthetic method of this compound is introduced below., name: 1-Iodo-3,5-dimethoxybenzene

1. Condensation reaction: in with a thermometer, condenser 250 ml four bottle is added between the 26.7g 5 – iodo – teredimethyl ether, 12.8g bromopropylene, 20.4g triethylamine, 2.2g dppp nickel chloride, 130 ml methyl tert-butyl ether, magnetic stirring, oil bath heating, when the temperature rises to 80 C and maintaining at 4 hours, after the reaction is cooled to ambient temperature, for 60 ml 10% hydrochloric acid aqueous solution washing the reaction liquid, water washed to neutral, the organic layer is distilled under reduced pressure to obtain between the 21.4g 5 – propenyl – teredimethyl ether, yield 96.1%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Weifang Xian Da Chemical Co., Ltd.; Li Kai; Wang Guangyue; Yang Qiwei; Zou Yabo; (7 pag.)CN106748673; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25245-27-6 as follows. COA of Formula: C8H9IO2

To a solution of 1-iodo-3,5-dimethoxybenzene (Compound No. 31, 2.01 g, 7.61 mmol) in CH2CI2 (20 mL) at 0C under argon was added a solution of BBr3 (1 M in CH2CI2, 11.4 mL, 11.4 mmol) and the mixture allowed to stir for 17 h. The reaction was quenched with MeOH (13 mL) and concentrated. The residue was diluted with EtOAc (25 mL) and the organic layer washed with water (3 x 20 mL) and brine (20 mL), dried (Mg504) and concentrated to a brown oil.

According to the analysis of related databases, 25245-27-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AQUINOX PHARMACEUTICALS INC.; MACKENZIE, Lyoyd, F.; MACRURY, Thomas, B.; HARWIG, Curtis; BOGUCKI, David; RAYMOND, Jeffery, R.; PETTIGREW, Jeremy, D.; KHLEBNIKOV, Vladimir; SHAN, Rudong; WO2014/110036; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 25245-27-6,Some common heterocyclic compound, 25245-27-6, name is 1-Iodo-3,5-dimethoxybenzene, molecular formula is C8H9IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of the styrene (3 mmol), the halogenated benzene (3 mmol), triethanolamine (3 mmol) and Pd(II) acetate (0.03 g) was stirred under argon at 100 C for 24 h. The reaction was cooled to 25 C, quenched by the addition of dil. aq. hydrochloric acid (2 N, 10 ml), and extracted with ether (3 × 100 ml). The organic phases were dried (Na2SO4), the solvents evaporated, and the crude product subjected to chromatography (silica gel, hexane/ethyl acetate mixtures).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Iodo-3,5-dimethoxybenzene, its application will become more common.

Reference:
Article; Albert, Sabrina; Horbach, Ralf; Deising, Holger B.; Siewert, Bianka; Csuk, Rene; Bioorganic and Medicinal Chemistry; vol. 19; 17; (2011); p. 5155 – 5166;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

25245-27-6, name is 1-Iodo-3,5-dimethoxybenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 1-Iodo-3,5-dimethoxybenzene

In a sealed tube purged with nitrogen, 1-iodo-3,5-dimethoxybenzene (36) (0.78 g, 3.0 mmol), (1S,2R,4aS,8aS)-1-(hydroxymethyl)-2,5,5,8a-tetramethyl-decahydronaphthalen-2-ol (3) (0.65 g, 2.68 mmol), Cs2CO3 (1.3 g, 4.0 mmol), 3,4,7,8-tetramethyl-[1,10]-phenylthroline (0.12 g, 0.50 mmol), CuI (0.05 g, 0.3 mmol), diglyme (2 mL) and toluene (10 mL) were added. The reaction mixture was stirred at 120 C. for 18 h. The reaction was cooled to room temperature, diluted with EtOAc (300 mL) and washed with water (100 mL). The organic layer was dried (Na2SO4) and concentrated. Purification by column chromatography on silica gel (Hexanes/EtOAc, 2:1) gave (1S,2R,4aS,8aS)-1-(3,5-dimethoxyphenoxymethyl)-2,5,5,8a-tetramethyl-decahydronaphthalen-2-ol (37) (0.71 g, 70%) as a colourless oil.

The synthetic route of 25245-27-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Aquinox Pharmaceuticals Inc.; US2011/136802; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

25245-27-6, name is 1-Iodo-3,5-dimethoxybenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 1-Iodo-3,5-dimethoxybenzene

General procedure: Under an argon atmosphere, a Schlenk tube was charged with bpy-MCM-41-CuI (78 mg, 0.05 mmol), diaryl diselenide (0.25 mmol), aryl iodide (0.5 mmol), Mg turnings (24 mg, 1.0 mmol) and DMF (1.5 mL). The mixture was stirred at 110 C under Ar for 20-40 h. After completion of the reaction, the reaction mixture was cooled to room temperature, diluted with ethyl acetate (15 mL), and filtered. The bpy-MCM-41-CuI catalyst residue was washed with 1.0 M dilute hydrochloric acid (2 × 5 mL), water (2 × 5 mL), and acetone (2 × 5 mL) when being reused in another catalytic cycle. The filtrate was concentrated under reduced pressure and the residue was purified by flash column chromatography on silica gel (petroleum ether (60-90 C)/ethyl acetate) to provide the desired product 3. CAUTION: All reactions using selenium containing compounds should be carried out in a well-ventilated fume cupboard.

The synthetic route of 25245-27-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhao, Ruonan; Yan, Chenyu; Jiang, Yuanyuan; Cai, Mingzhong; Journal of Chemical Research; vol. 42; 11; (2018); p. 584 – 588;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25245-27-6 as follows. Quality Control of 1-Iodo-3,5-dimethoxybenzene

Example 22B 3,5,3′-Trimethoxybiphenyl To a mixture of 600 mg (4.0 mmol) of 3-methoxyphenylboronic acid, 792 mg (3.0 mmol) of 3,5-dimethoxyiodobenzene, 34 mg (5 mol %) palladium(II)acetate, 182 mg (20 mol %) of tri-o-tolylphosphine, and 3.6 g (24 mmol) of cesium fluoride was added 10 mL of anhydrous dioxane. The reaction was stirred at reflux under N2 for 50 min, then poured into 30 mL of water and extracted with diethyl ether (3*10 mL). The combined ether layers were back extracted with saturated aqueous NaHCO3 solution (1*10 mL), then brine (1*10 mL), dried over MgSO4, filtered, and concentrated to an oil. This was purified via silica gel chromatography, eluding with 10% ethyl acetate:hexanes to provide the titled compound (650 mg, 89%).

According to the analysis of related databases, 25245-27-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Xin, Zhili; Liu, Gang; Pei, Zhonghua; Szczepankiewicz, Bruce G.; Serby, Michael D.; Zhao, Hongyu; US2004/167188; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25245-27-6, name is 1-Iodo-3,5-dimethoxybenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C8H9IO2

To a solution of 5-iodo-1,3-dimethoxybenzene (8, 20.98 g, 79.5 mmol) in dry DMF (75 mL), cooled to 0 C, was dropwise added POCl3 (42.64 g, 278.1 mmol). The reaction mixture was gradually warmed to room temperature and subsequently heated to 85 C. After stirring for 5 h at 75 C, the reaction mixture was poured into iced water (400 mL) and extracted with EtOAc (3*300 mL). The combined organic layer was washed with satd aq NaHCO3 (300 mL), dried over Na2SO4, and concentrated under reduced pressure. Recrystallization from hexanes/EtOAc (3/1) yielded benzaldehyde 9 (18.43 g, 79%) as a yellow solid; Rf 0.3 (hexanes/EtOAc=3/1); 1H NMR (200 MHz, CDCl3) delta 10.12 (s, 1H), 7.11 (d, J=2.3 Hz, 1H), 6.47 (d, J=2.2 Hz, 1H), 3.88 (s, 3H), 3.85 (s, 3H); 13C NMR (50 MHz, CDCl3) delta 190.6 (d, 1C), 164.6 (s, 1C), 163.3 (s, 1C), 119.2 (d, 1C), 118.3 (s, 1C), 99.1 (d, 1C), 98.6 (s, 1C), 56.0 (q, 1C), 55.9 (q, 1C); HRMS m/z calcd for [M+Na]+ 314.9489, found 314.9500; Anal. Calcd for C9H9IO3: C, 37.01; H, 3.11; found: C, 37.22; H, 3.14.

The synthetic route of 25245-27-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Mikula, Hannes; Skrinjar, Philipp; Sohr, Barbara; Ellmer, Doris; Hametner, Christian; Froehlich, Johannes; Tetrahedron; vol. 69; 48; (2013); p. 10322 – 10330;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25245-27-6 as follows. Computed Properties of C8H9IO2

In a dry two necked flask were introduced N-{2-[1-(3,5-dimethoxyphenyl)-cyclohexa-2,5-dienyl]-ethyl}-4-methyl-benzenesulfonamide 3b (66 mg, 0.168 mmol), silvercarbonate (93 mg, 0.336 mmol), triphenylphosphine (6.6 mg, 0.025 mmol), 3,5-dimethoxyiodobenzene4b (89 mg, 0.336), palladium acetate (1.9 mg, 0.008 mmol) and acetonitrile (8.5mL). The mixture was warmed to 85C and stirred for 20 hours. The mixture was filteredthrough celite, which was then washed with ethyl acetate. Evaporation of the solvents led to apaste, which was purified through silica gel chromatography (Petroleum ether/EtOAc 80:20),affording 5b as a viscous oil (48 mg, 52%). IR (film, KBr, numax, cm-1): 2937, 1594, 1458, 1425,1325, 1204, 1155, 1064, 839, 732. 1H NMR (300 MHz, CDCl3): deltaH 1.38-1.50 (1H, m,CHaHxCH2N), 1.72-1.84 (2H, m, CHaHxCH2N and CH cyclopropane), 2.21-2.26 (1H, m, CHcyclopropane), 2.41 (3H, s, CH3 tosyl), 2.91 (2H, qa, 3JHH 7.3 Hz, CH2N), 3.28 (1H, broad s, CHcyclopropane), 3.77 (12H, 2OCH3 x 2), 4.46 (1H, broad s, NH), 5.20 (1H, d, 3JHH 5.3 Hz, CHolefinic), 5.82-5.84 (1H, m, CH olefinic), 6.22 (2H, s, 2CH aromatic) 6.32 (4H, s, 2CH x 2aromatic), 7.25 (2H, d, 3JHH 8.3 Hz, CH x 2 tosyl), 7.63 (2H, d, 3JHH 8.3 Hz, CH x 2 tosyl). 13CNMR (75.5 MHz, CDCl3): deltaC 21.6 (CH3 tosyl), 37.1, 38.0 (2CH cyclopropane), 38.1 (C,aliphatic), 41.2, 41.3 (2CH2, CH2CH2N), 51.2 (CH allylic), 55.4, 55.5 (2OCH3 x 2), 98.2, 98.5(2CH aromatic), 105.9, 110.0 (2CH x 2 aromatic), 127.1, 129.8 (2CH x 2 tosyl), 131.6, 134.2(2CH olefinic), 137.0, 140.0, 143.4, 146.7 (4C aromatic), 160.5, 161.0 (2C x 2 aromatic).MS(ESI) m/z (%): 1121 (2M+Na, 22), 588 (M+K, 13), 572 (M+Na, 100). HRMS calcd for[M+Na]+ C31H35NNaO6S: 572.2083; found 572.2082 (0 ppm).

According to the analysis of related databases, 25245-27-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Lebeuf, Raphael; Robert, Frederic; Landais, Yannick; ARKIVOC; vol. 2014; 3; (2013); p. 6 – 17;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 25245-27-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25245-27-6, name is 1-Iodo-3,5-dimethoxybenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a dioxane (2 mL) solution of N-tosylhydrazone (0.24 mmol), tBuOLi (0.53 mmol), Pd2dba3 (0.02 mmol), and XPhos (0.04 mmol) was added the required aryl iodide (0.24 mmol). The mixture was stirred at 90 C for 5 h CH2Cl2 (5 mL) was then added to the cooled mixture which was filtered over a pad of Celite. After concentration, the residue was purified by silica gel chromatography to yield 1a-c, 1k.

The synthetic route of 1-Iodo-3,5-dimethoxybenzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Rasolofonjatovo, Evelia; Provot, Olivier; Hamze, Abdallah; Rodrigo, Jordi; Bignon, Jerome; Wdzieczak-Bakala, Joanna; Desravines, Deborah; Dubois, Joelle; Brion, Jean-Daniel; Alami, Mouad; European Journal of Medicinal Chemistry; vol. 52; (2012); p. 22 – 32;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com