Category: 2401-21-0

Synthetic Route of 2401-21-0,Some common heterocyclic compound, 2401-21-0, name is 1,2-Dichloro-3-iodobenzene, molecular formula is C6H3Cl2I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

PREPARATION 5 A mixture of p-aminopropiophenone (5 g), pyridine (2.7 g), and iodobenzene dichloride (7.5 g) in tetrahydrofuran (150 ml) was stirred for 3 hours at 0¡ã to 5¡ã C. The insoluble materials were filtered, and the filtrate was concentrated under reduced pressure. The residue was dissolved in chloroform, washed with an aqueous solution of sodium hydrogen sulfite, dried over magnesium sulfate, and concentrated to give an oil (8.8 g). The oil was subjected to column chromatography on silica gel eluding with chloroform. The fractions containing the desired compound were combined and concentrated under reduced pressure. The residual oil was triturated with a mixture of hexane and ethyl acetate to give pale yellow crystals of 4′-amino-3′-chloropropiophenone (1.1 g). mp: 79¡ã to 80¡ã C. IR (Nujol): 3500, 3380, 1670, 1620, 1595 cm-1. NMR (CDCl3, delta): 1.20 (3H, t, J=7 Hz), 2.88 (2H, q, J=7 Hz), 4.50 (2H, broad s), 6.72 (1H, d, J=8 Hz), 7.68 (1H, dd, J=8 Hz, 2 Hz), 7.88 (1H, d, J=2 Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,2-Dichloro-3-iodobenzene, its application will become more common.

Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US4866091; (1989); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

2401-21-0, name is 1,2-Dichloro-3-iodobenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 1,2-Dichloro-3-iodobenzene

G. 17alpha-Chloro-17beta-(3′,4′-Dichlorobenzylsulfinyl)-1,4-Androstadiene-3,11-Dione In a manner similar to that described in Example 2A, react 0.238 gms. of 17alpha-(3′,4′-dichlorobenzylthio)-1,4-androstadiene-3,11-dione, 8 ml. of pyridine, 2 ml. of water and 0.411 gm. of iodobenzene dichloride. Purify the residue utilizing thin layer silica gel chromatography, developing with ethyl acetate/chloroform (1:4) and eluding with ethyl acetate. Crystallize the major band from ether to obtain the title compound; m.p.=249¡ã-251¡ã C.

The synthetic route of 2401-21-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Schering Corporation; US4183924; (1980); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 2401-21-0, A common heterocyclic compound, 2401-21-0, name is 1,2-Dichloro-3-iodobenzene, molecular formula is C6H3Cl2I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

E. 17alpha-Chloro-17beta-(4′-Chlorobenzylsulfinyl)-1,4-Androstadiene-3,11-Dione In a manner similar to that described in Example 2A, react 0.4 gm. of 17alpha-(4′-chlorobenzylthio)-1,4-androstadiene-3,11-dione, 8 ml. of pyridine, 2 ml. of water and 0.85 gm. of iodobenzene dichloride. Isolate as in Example 2D, utilizing a 50 gm. silica gel column, and crystallizing from chloroform/ethyl acetate/hexane to obtain the title compound; nmr (dmso-d6) delta 0.83 (C13 –CH3, s), 1.38 (C10 –CH3, s), 4.02 (CH2 –phi, dd), 6.08 (C4 –H, d), 6.15 (C2 –H, dd), 7.65 (C1 –H, d), 7.43 (phi, q).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Schering Corporation; US4183924; (1980); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 2401-21-0, name is 1,2-Dichloro-3-iodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 1,2-Dichloro-3-iodobenzene

D. 17alpha-Chloro-17beta-Methylsulfinyl-1,4-Androstadiene-3,11-Dione In a manner similar to that described in Example 2A, react 2.4 gm. of 17alpha-methylthio-1,4-androstadiene-3,11-dione, 55.6 ml. of pyridine, 14.4 ml. of water and 5.76 gm. of iodobenzene dichloride. Pass the concentrated residue through a 250 gm. silica gel column, eluding first with chloroform and then with ethyl acetate. Evaporate the ethyl acetate eluates and crystallize from acetone/hexane to obtain the title compound; nmr (CDCl3) delta 1.21 (C13 –CH3, s), 1.45 (C10 –CH3, s), 2.55 (S–CH3, s), 6.10 (C4 –H, d), 6.20 (C2 –H, dd), 7.68 (C1 –H, d).

The synthetic route of 1,2-Dichloro-3-iodobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Schering Corporation; US4183924; (1980); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 2401-21-0,Some common heterocyclic compound, 2401-21-0, name is 1,2-Dichloro-3-iodobenzene, molecular formula is C6H3Cl2I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Method C 2,3-Dichloroiodobenzene (350 g, 1.282 mol) dissolved in dry ether (1250 ml) was added slowly, with stirring, to magnesium turnings (30.77 g, 1.282 mol) in dry diethyl ether (300 ml), in order to form 2,3-dichlorophenylmagnesium iodide under nitrogen.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,2-Dichloro-3-iodobenzene, its application will become more common.

Reference:
Patent; Glaxo Wellcome Inc.; US5925755; (1999); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 2401-21-0, name is 1,2-Dichloro-3-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2401-21-0, Recommanded Product: 2401-21-0

EXAMPLE 35 Benzyl 3-chloro-3-ethylsulphinyl-7-oxo-1-azabicyclo[3.2.0]heptane-2beta-carboxylate STR77 A solution of benzyl 3alpha-ethylthio-7-oxo-1azabicyclo[3.2.0]heptane-2beta-carboxylate (16) (0.050 g) in methylene chloride (5 ml) was stirred in an ice bath under argon and treated with water (1 drop), pyridine (0.040 g) and iodobenzene dichloride (0.091 g). The ice-bath was removed and the reaction mixture stirred at room temperature for 3 hours. The solution was then concentrated and chromatographed on silica gel 60 (<230 mesh) eluding with ethyl, acetate/60¡ã-80¡ã petroleum ether 7:3 to give benzyl 3-chloro-3-ethylsulphinyl-7-oxo-1-azabicyclo[3.2.0]heptane-2beta-carboxylate (56) (0.037 g) as a gum; tau(CDCl3) 2.61 (5H, s, phenyl), 4.75 (2H, s, benzyl CH2), 5.55 (1H, s, C2-H), 5.6-5.9 (1H, m, C5-H), 6.5-8.0 (6H, m, C4-H2, C6 -H2, SCH2) and 8.64 (3H, t J 7 Hz, CH3). This material was unstable and had to be progressed immediately as shown in example 17. If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it. Reference:
Patent; Beecham Group Limited; US4223038; (1980); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 2401-21-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2401-21-0 as follows.

(f) Synthesis of p-Nitrobenzyl (5R,6S)-6-[(R)-1-Hydroxyethyl]-2-Chloro-2-Ethanesulfinyl-1-Carbapenam-3-Carboxylate (Compound S15) STR39 Under a dry atmosphere, to a dichloromethane (4 ml) solution of Compound S14 (59 mg, 0.15 mmol) were added water (0.014 ml, 0.78 mmol) and pyridine (0.036 ml, 0.45 mmol), and further added dropwise a dichloromethane (2 ml) solution of iodobenzene dichloride (103 mg, 0.37 mmol) under ice-cooling, and the mixture was stirred at the same temperature for 30 minutes. Subsequently, triethylamine (0.042 ml, 0.30 mmol) was added and the mixture was stirred for 10 minutes. The reaction mixture was diluted with ethyl acetate, washed with an aqueous 5percent citric acid solution and water. The aqueous layer was reverse-extracted with ethyl acetate. The ethyl acetate solutions were combined, washed with an aqueous NaCl-saturated solution and dried. The solvent was removed by distillation under reduced pressure. The residue was purified by a medium pressure silica gel column chromatography (Lobar size A, ethyl acetate-hexane 3:2–>1:0) to obtain a mixture (pale yellowish viscous material, 51 mg, 77percent) of some isomers of Compound S15.

According to the analysis of related databases, 2401-21-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Ajinomoto Co., Inc.; US5342963; (1994); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

2401-21-0, These common heterocyclic compound, 2401-21-0, name is 1,2-Dichloro-3-iodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Method C 2,3-Dichloroiodobenzene (350 g, 1.282 mol) dissolved in dry ether (1250 ml) was added slowly, with stirring, to magnesium turnings (30.77 g, 1.282 mol) in dry diethyl ether (300 ml), in order to form 2,3-dichlorophenylmagnesium iodide under nitrogen.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2401-21-0.

Reference:
Patent; Glaxo Wellcome Inc.; US5912345; (1999); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

2401-21-0, The chemical industry reduces the impact on the environment during synthesis 2401-21-0, name is 1,2-Dichloro-3-iodobenzene, I believe this compound will play a more active role in future production and life.

Example 93 (S)-2-({1-[(E)-3-(2, 3-DICHLORO-PHENYL)-BUT-2-ENOYL]- PIPERIDINE-4-CARBONYL}-AMINO)-PROPIONIC acid Example 93A (E)-3- (2, 3-Dichloro-phenyl) -but-2-enoic acid ethyl ester A stirred solution of 2,3-dichloroiodoben- zene (3.00 g, 11.0 mmol) in dimethyl acetamide (10 ML) was heated to 100¡ãC for 16 h with tetrabutyl- ammonium chloride (2.78 g, 10.0 mmol), palladium acetate (90 mg, 0.40 mmol), dicyclohexyl methylamine (2.93, 15.0 mmol), and ethyl crotonate (1.41 g, 10.0 mmol) under N2 [procedure taken from Buchwald (1995) Chem. Eur. J 5: 3107-3112]. The reaction was diluted with methylene chloride (30 mL), and washed with 1N aqueous HC1 (3X20 mL) and water (3X20 mL). The organic phase was dried (NA2SO4), filtered, and concentrated to obtain an orange oil. The crude product was purified on a Biotage Flash 40 chroma- tography system eluting with the following gradient: 3percent methyl tert-butyl ether in petroleum ether (1 L) then 5percent methyl tert-butyl ether in petroleum ether (500 mL). Example 93A (500 mg, 19percent) was obtained as a white powder. 1H NMR (CDC13, 400 MHz) 5 7.42 (dd, J=8.20, 1.56 Hz, 1H), 7.19 (m, 1H), 7.08 (dd, J=7.81, 1.56 Hz, 1H), 5.81 (m, 1H), 4.22 (q, J=7.16 Hz, 2H), 2.47 (d, J=1.56 Hz, 3H), 1.32 (t, J=7.22 Hz, 3H). Based ON 1H NMR analysis, Example 93A had the”E”olefin geometry (see, Dyker (1999) Helv. Chim. Acta 82 : 588-596, for NMR data of an analogous o-bromo analogue).

The chemical industry reduces the impact on the environment during synthesis 1,2-Dichloro-3-iodobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ICOS CORPORATION; WO2005/16883; (2005); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 2401-21-0, name is 1,2-Dichloro-3-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2401-21-0, 2401-21-0

J. 17alpha-Chloro-17beta-Benzylsulfinyl-1,4-Androstadiene-3-One In a manner similar to that described in Example 2A, react 0.47 gm. of 17alpha-benzylthio-1,4-androstadiene-3-one, 19.2 ml. of pyridine, 4.8 ml. of water and 0.988 gm. of iodobenzene dichloride. Maintain the reaction at -40¡ã C. for 72 hours. Purify the residue by utilizing thin layer silica gel chromatography, developing with chloroform/ethyl acetate (2:1) and eluding with ethyl acetate to obtain the title compound; nmr (CDCl3) delta 1.23 (C10 and C13 –CH3, s), 4.03 (CH2 phi, dd), 6.08 (C4 –H, d), 6.23 (C2 –H, dd), 7.05 (C1 –H, d), 7.35 (phi, s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Dichloro-3-iodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Schering Corporation; US4183924; (1980); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com