Category: 23307-72-4

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 23307-72-4, is researched, SMILESS is ClC1=CN=CC([N-]S(=O)(C2=CC=C(N)C=C2)=O)=N1.[Na+], Molecular C10H8ClN4NaO2SJournal, Article, Research Support, Non-U.S. Gov’t, Journal of Molecular Modeling called Non-stochastic and stochastic linear indices of the molecular pseudograph’s atom-adjacency matrix: a novel approach for computational in silico screening and “”rational”” selection of new lead antibacterial agents, Author is Marrero-Ponce, Yovani; Marrero, Ricardo Medina; Torrens, Francisco; Martinez, Yamile; Bernal, Milagros Garcia; Zaldivar, Vicente Romero; Castro, Eduardo A.; Abalo, Ricardo Grau, the main research direction is antibacterial mol pseudograph atom adjacency matrix drug design QSAR.HPLC of Formula: 23307-72-4.

A novel approach (TOMOCOMD-CARDD) to computer-aided rational drug design is illustrated. This approach is based on the calculation of the non-stochastic and stochastic linear indexes of the mol. pseudograph’s atom-adjacency matrix representing mol. structures. These TOMOCOMD-CARDD descriptors are introduced for the computational (virtual) screening and rational selection of new lead antibacterial agents using linear discrimination anal. The two structure-based antibacterial-activity classification models, including non-stochastic and stochastic indexes, classify correctly 91.61% and 90.75%, resp., of 1525 chems. in training sets. These models show high Matthews correlation coefficients (MCC = 0.84 and 0.82). An external validation process was carried out to assess the robustness and predictive power of the model obtained. These QSAR models permit the correct classification of 91.49% and 89.31% of 505 compounds in an external test set, yielding MCCs of 0.84 and 0.79, resp. The TOMOCOMD-CARDD approach compares satisfactorily with respect to nine of the most useful models for antimicrobial selection reported to date. Finally, an in silico screening of 87 new chems. reported in the antiinfective field with antibacterial activities is developed showing the ability of the TOMOCOMD-CARDD models to identify new lead antibacterial compounds

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 23307-72-4, is researched, Molecular C10H8ClN4NaO2S, about High-throughput screening of pesticide and veterinary drug residues in baby food by liquid chromatography coupled to quadrupole Orbitrap mass spectrometry, the main research direction is pesticide veterinary drug baby food quadrupole Orbitrap mass spectrometry; Baby food; Multi-residue methods; Q-Orbitrap; Targeted-screening; Validation.Quality Control of Sodium ((4-aminophenyl)sulfonyl)(6-chloropyrazin-2-yl)amide.

A new anal. method was developed and validated for simultaneous anal. of 333 pesticide and veterinary drug residues in baby food. Response surface methodol. was employed to optimize a generic extraction method. Ultrahigh-performance liquid chromatog. and electrospray ionization quadrupole Orbitrap high-resolution mass spectrometry (UHPLC-ESI Q-Orbitrap) was used for the separation and detection of all the analytes. The method was validated by taking into consideration the guidelines specified in Commission Decision 2002/657/EC and SANCO/12571/2013. The extraction recoveries were in a range of 79.8-110.7%, with coefficient of variation <8.3%. The 333 compounds behave dynamic in the range 0.1-1000 μg kg-1 concentration, with correlation coefficient >0.99. The limits of detection for the analytes are in the range 0.01-5.35 μg kg-1. The limits of quantification for the analytes are in the range 0.01-9.27 μg kg-1. This method has been successfully applied on screening of pesticide and veterinary drugs in ninety-three com. baby food samples, and tilmicosin, fenbendazole, tylosin tartrate and thiabendazole were detected in some samples tested in this study. The present study is very useful for fast screening of different food contaminants.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Sodium ((4-aminophenyl)sulfonyl)(6-chloropyrazin-2-yl)amide(SMILESS: ClC1=CN=CC([N-]S(=O)(C2=CC=C(N)C=C2)=O)=N1.[Na+],cas:23307-72-4) is researched.Quality Control of (2S)-(+)-3-Chloropropane-1,2-diol. The article 《Non-stochastic and stochastic linear indices of the molecular pseudograph’s atom-adjacency matrix: a novel approach for computational in silico screening and “”rational”” selection of new lead antibacterial agents》 in relation to this compound, is published in Journal of Molecular Modeling. Let’s take a look at the latest research on this compound (cas:23307-72-4).

A novel approach (TOMOCOMD-CARDD) to computer-aided rational drug design is illustrated. This approach is based on the calculation of the non-stochastic and stochastic linear indexes of the mol. pseudograph’s atom-adjacency matrix representing mol. structures. These TOMOCOMD-CARDD descriptors are introduced for the computational (virtual) screening and rational selection of new lead antibacterial agents using linear discrimination anal. The two structure-based antibacterial-activity classification models, including non-stochastic and stochastic indexes, classify correctly 91.61% and 90.75%, resp., of 1525 chems. in training sets. These models show high Matthews correlation coefficients (MCC = 0.84 and 0.82). An external validation process was carried out to assess the robustness and predictive power of the model obtained. These QSAR models permit the correct classification of 91.49% and 89.31% of 505 compounds in an external test set, yielding MCCs of 0.84 and 0.79, resp. The TOMOCOMD-CARDD approach compares satisfactorily with respect to nine of the most useful models for antimicrobial selection reported to date. Finally, an in silico screening of 87 new chems. reported in the antiinfective field with antibacterial activities is developed showing the ability of the TOMOCOMD-CARDD models to identify new lead antibacterial compounds

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Marrero-Ponce, Yovani; Medina-Marrero, Ricardo; Torrens, Francisco; Martinez, Yamile; Romero-Zaldivar, Vicente; Castro, Eduardo A. published the article 《Atom, atom-type, and total nonstochastic and stochastic quadratic fingerprints: a promising approach for modeling of antibacterial activity》. Keywords: antibacterial screening QSAR model.They researched the compound: Sodium ((4-aminophenyl)sulfonyl)(6-chloropyrazin-2-yl)amide( cas:23307-72-4 ).Electric Literature of C10H8ClN4NaO2S. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:23307-72-4) here.

The Topol. Mol. Computer Design (TOMOCOMD-CARDD) approach has been introduced for the classification and design of antimicrobial agents using computer-aided mol. design. For this propose, atom, atom-type, and total quadratic indexes have been generalized to codify chem. structure information. In this sense, stochastic quadratic indexes have been introduced for the description of the mol. structure. These stochastic fingerprints are based on a simple model for the intramol. movement of all valence-bond electrons. In this work, a complete data set containing 1006 antimicrobial agents is collected and presented. Two structure-based antibacterial activity classification models have been generated. The models (including nonstochastic and stochastic indexes) classify correctly more than 90% of 1525 compounds in training sets. These models permit the correct classification of 92.28% and 89.31% of 505 compounds in an external test sets. The approach, also, satisfactorily compares with respect to nine of the most useful models for antimicrobial selection reported to date. Finally, a virtual screening of 87 new compounds reported in the anti-infective field with antibacterial activities is developed showing the ability of the models to identify new leads as antibacterial.

In addition to the literature in the link below, there is a lot of literature about this compound(Sodium ((4-aminophenyl)sulfonyl)(6-chloropyrazin-2-yl)amide)Electric Literature of C10H8ClN4NaO2S, illustrating the importance and wide applicability of this compound(23307-72-4).

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: Sodium ((4-aminophenyl)sulfonyl)(6-chloropyrazin-2-yl)amide. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Sodium ((4-aminophenyl)sulfonyl)(6-chloropyrazin-2-yl)amide, is researched, Molecular C10H8ClN4NaO2S, CAS is 23307-72-4, about Non-stochastic and stochastic linear indices of the molecular pseudograph’s atom-adjacency matrix: a novel approach for computational in silico screening and “”rational”” selection of new lead antibacterial agents.

A novel approach (TOMOCOMD-CARDD) to computer-aided rational drug design is illustrated. This approach is based on the calculation of the non-stochastic and stochastic linear indexes of the mol. pseudograph’s atom-adjacency matrix representing mol. structures. These TOMOCOMD-CARDD descriptors are introduced for the computational (virtual) screening and rational selection of new lead antibacterial agents using linear discrimination anal. The two structure-based antibacterial-activity classification models, including non-stochastic and stochastic indexes, classify correctly 91.61% and 90.75%, resp., of 1525 chems. in training sets. These models show high Matthews correlation coefficients (MCC = 0.84 and 0.82). An external validation process was carried out to assess the robustness and predictive power of the model obtained. These QSAR models permit the correct classification of 91.49% and 89.31% of 505 compounds in an external test set, yielding MCCs of 0.84 and 0.79, resp. The TOMOCOMD-CARDD approach compares satisfactorily with respect to nine of the most useful models for antimicrobial selection reported to date. Finally, an in silico screening of 87 new chems. reported in the antiinfective field with antibacterial activities is developed showing the ability of the TOMOCOMD-CARDD models to identify new lead antibacterial compounds

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Sodium ((4-aminophenyl)sulfonyl)(6-chloropyrazin-2-yl)amide, is researched, Molecular C10H8ClN4NaO2S, CAS is 23307-72-4, about Voltammetric determination of sulfaclozine sodium at sephadex-modified carbon paste electrode, the main research direction is sulfaclozine sodium sephadex modified carbon paste electrode.COA of Formula: C10H8ClN4NaO2S.

The electrochem. behavior of Sulfaclozine Sodium (SLC) was studied at a bare and sephadex-modified carbon paste electrodes by cyclic voltammetry and square wave voltammetry. The cyclic voltammetry (CV) showed a well-defined irreversible oxidation peak at 0.94 V in Britton-Robinson buffer pH 7.0. The strong affinity of SLC to sephadex allowed accumulation of SLC at the surface of electrode and thus higher electrochem. sensitivity to SLC. The influence of sephadex loading, the pH of the solution and the scan rate on the peak current was studied. A linear calibration curve covering the concentration range from 0.005 to 1 mM was obtained using SWV. The method was successfully applied for the determination of SLC in the veterinary pharmaceutical formulations with satisfactory accuracy and precision.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

COA of Formula: C10H8ClN4NaO2S. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Sodium ((4-aminophenyl)sulfonyl)(6-chloropyrazin-2-yl)amide, is researched, Molecular C10H8ClN4NaO2S, CAS is 23307-72-4, about Voltammetric determination of sulfaclozine sodium at sephadex-modified carbon paste electrode. Author is Hussien, Emad Mohamed; Saleh, Hanaa; El Henawee, Magda; Abou El Khair, Afaf; Ahmed, Neven.

The electrochem. behavior of Sulfaclozine Sodium (SLC) was studied at a bare and sephadex-modified carbon paste electrodes by cyclic voltammetry and square wave voltammetry. The cyclic voltammetry (CV) showed a well-defined irreversible oxidation peak at 0.94 V in Britton-Robinson buffer pH 7.0. The strong affinity of SLC to sephadex allowed accumulation of SLC at the surface of electrode and thus higher electrochem. sensitivity to SLC. The influence of sephadex loading, the pH of the solution and the scan rate on the peak current was studied. A linear calibration curve covering the concentration range from 0.005 to 1 mM was obtained using SWV. The method was successfully applied for the determination of SLC in the veterinary pharmaceutical formulations with satisfactory accuracy and precision.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Study of the interaction between sodium salts of (2E)-3-(4′-halophenyl)prop-2-enoyl sulfachloropyrazine and bovine serum albumin by fluorescence spectroscopy, published in 2013-04-30, which mentions a compound: 23307-72-4, Name is Sodium ((4-aminophenyl)sulfonyl)(6-chloropyrazin-2-yl)amide, Molecular C10H8ClN4NaO2S, Safety of Sodium ((4-aminophenyl)sulfonyl)(6-chloropyrazin-2-yl)amide.

Three sodium salts of (2E)-3-(4′-halophenyl)prop-2-enoyl sulfachloropyrazine (CCSCP) were synthesized and their structures were determined by 1H and 13C NMR, LC-MS and IR. The binding properties between CCSCPs and bovine serum albumin (BSA) were studied using fluorescence spectroscopy in combination with UV-vis absorbance spectroscopy. The results indicate that the fluorescence quenching mechanisms between BSA and CCSCPs were static quenching at low concentrations of CCSCPs or combined quenching (static and dynamic) at higher CCSCP concentrations of 298, 303 and 308 K. The binding constants, binding sites and corresponding thermodn. parameters (ΔH, ΔS, ΔG) were calculated at different temperatures All ΔG values were neg., which revealed that the binding processes were spontaneous. Although all CCSCPs had neg. ΔH and pos. ΔS, the contributions of ΔH and ΔS to ΔG values were different. When the 4′-substituent was fluorine or chlorine, van der Waals interactions and hydrogen bonds were the main interaction forces. However, when the halogen was bromine, ionic interaction and proton transfer controlled the overall energetics. The binding distances between CCSCPs and BSA were determined using the Foerster non-radiation energy transfer theory and the effects of CCSCPs on the conformation of BSA were analyzed by synchronous fluorescence spectroscopy. Copyright © 2012 John Wiley & Sons, Ltd.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 23307-72-4, is researched, SMILESS is ClC1=CN=CC([N-]S(=O)(C2=CC=C(N)C=C2)=O)=N1.[Na+], Molecular C10H8ClN4NaO2SJournal, Article, Research Support, Non-U.S. Gov’t, Analytica Chimica Acta called A self-assembly pipette tip graphene solid-phase extraction coupled with liquid chromatography for the determination of three sulfonamides in environmental water, Author is Sun, Ning; Han, Yehong; Yan, Hongyuan; Song, Yanxue, the main research direction is sulfonamide antibiotic determination water graphene solid extraction LC; Environmental water; Liquid chromatography-fluorescence detection; Pipette tip graphene solid-phase extraction; Sulfonamide antibiotics.Safety of Sodium ((4-aminophenyl)sulfonyl)(6-chloropyrazin-2-yl)amide.

A sensitive, economical, and miniaturized self-assembly pipet tip graphene solid-phase extraction (PT-G-SPE) coupled with liquid chromatog. fluorescence detection (LC-FD) was developed for rapid extraction and determination of three sulfonamide antibiotics (SAs) in environmental water samples. The PT-G-SPE cartridge, assembled by packing 1.0 mg of graphene as sorbent into a 100 μL pipet tip, showed high adsorption capacity for the SAs owing to the large surface area and unique structure of graphene. The factors that affected the extraction efficiency of PT-G-SPE, including sample volume, pH, sorbent amount, washing solvent and eluent solvent were optimized. Good linearity for SAs was obtained in a range of 2-4000 pg mL-1 with correlation coefficients (r2) ≥0.9993. The recoveries of the SAs at three spiked levels ranged from 90.4 to 108.2% with RSD ≤6.3%. In comparison with other sorbents such as C18, HLB, SCX, PCX, and multiwalled carbon nanotubes, one advantage of using graphene as sorbent of pipet tip solid-phase extraction (PT-SPE) was that PT-G-SPE could adsorb larger sample volume (10 mL) at a small amount of sorbent (1 mg) and low solvent consumption with good extraction efficiency, which not only increased the fraction of analytes to LC and the sensitivity of SAs determination, but also reduced the cost and pollution.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 23307-72-4, is researched, SMILESS is ClC1=CN=CC([N-]S(=O)(C2=CC=C(N)C=C2)=O)=N1.[Na+], Molecular C10H8ClN4NaO2SJournal, Article, Research Support, Non-U.S. Gov’t, Luminescence called Study of the interaction between sodium salts of (2E)-3-(4′-halophenyl)prop-2-enoyl sulfachloropyrazine and bovine serum albumin by fluorescence spectroscopy, Author is Luo, Xuan; Du, Chuanrong; Wei, Jinrui; Deng, Jiang; Lin, Yijie; Lin, Cuiwu, the main research direction is fluorescence spectroscopy bovine serum albumin CCSCP sodium salt.Computed Properties of C10H8ClN4NaO2S.

Three sodium salts of (2E)-3-(4′-halophenyl)prop-2-enoyl sulfachloropyrazine (CCSCP) were synthesized and their structures were determined by 1H and 13C NMR, LC-MS and IR. The binding properties between CCSCPs and bovine serum albumin (BSA) were studied using fluorescence spectroscopy in combination with UV-vis absorbance spectroscopy. The results indicate that the fluorescence quenching mechanisms between BSA and CCSCPs were static quenching at low concentrations of CCSCPs or combined quenching (static and dynamic) at higher CCSCP concentrations of 298, 303 and 308 K. The binding constants, binding sites and corresponding thermodn. parameters (ΔH, ΔS, ΔG) were calculated at different temperatures All ΔG values were neg., which revealed that the binding processes were spontaneous. Although all CCSCPs had neg. ΔH and pos. ΔS, the contributions of ΔH and ΔS to ΔG values were different. When the 4′-substituent was fluorine or chlorine, van der Waals interactions and hydrogen bonds were the main interaction forces. However, when the halogen was bromine, ionic interaction and proton transfer controlled the overall energetics. The binding distances between CCSCPs and BSA were determined using the Foerster non-radiation energy transfer theory and the effects of CCSCPs on the conformation of BSA were analyzed by synchronous fluorescence spectroscopy. Copyright © 2012 John Wiley & Sons, Ltd.

If you want to learn more about this compound(Sodium ((4-aminophenyl)sulfonyl)(6-chloropyrazin-2-yl)amide)Computed Properties of C10H8ClN4NaO2S, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(23307-72-4).

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com