Category: 2314-37-6

New stable backbone linker resins for solid-phase peptide synthesis was written by Gu, Wenxin;Silverman, Richard B.. And the article was included in Organic Letters in 2003.Recommanded Product: 2314-37-6 This article mentions the following:

Two new 4-methoxybenzaldehyde backbone linker resins were developed for the solid-phase synthesis of peptides. The linkers are very stable during the cleavage of common protecting groups for amines (Fmoc, Boc) and carboxylic acids (Me, All, t-Bu) in peptide synthesis. Cleavage from the resin with refluxing TFA is sufficiently mild for peptides containing polar and nonpolar amino acids. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Recommanded Product: 2314-37-6).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Recommanded Product: 2314-37-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Novel Copolymers of Styrene. 11. Some Ring-Substituted Methyl 2-Cyano-3-Phenyl-2-Propenoates was written by Kharas, Gregory B.;Chavez, Sonia E.;Luna, Alejandra N.;Lusk, Erin E.;Mendez, Daniel P.;O’Rourke, Daniel S.;Roat, Chad S.;Robinson, Sophia G.;Stamelos, George S.;Schoenburg, Joel D.;Vinanzaca, Daisy H.;Zermeno, Sergio J. R.;O’Mara, Myles P.. And the article was included in Journal of Macromolecular Science, Part A: Pure and Applied Chemistry in 2014.Quality Control of 3-Iodo-4-methoxybenzaldehyde This article mentions the following:

Electrophilic trisubstituted ethylenes, ring-substituted Me 2-cyano-3-phenyl-2-propenoates, RPhCH=C(CN)CO₂CH₃ (where R is 2-CH₃CO, 3-CH₃CO, 2-CN, 4-N(CH₃)₂, 4-N(C₂H₃)₂, 2-I, 4-I, 3-I-4-OCH₃, 5-I-2-OCH₃, 2,5-Br₂, 3,5-Br₂) were prepared and copolymerized with styrene. The monomers were synthesized by the piperidine catalyzed Knoevenagel condensation of ring-substituted benzaldehydes and Me cyanoacetate, and characterized by CHN anal., IR, ¹H and ¹³C-NMR. All the ethylenes were copolymerized with styrene (M₁) in solution with radical initiation (ABCN) at 70鎺矯. The compositions of the copolymers were calculated from nitrogen anal. and the structures were analyzed by IR, ¹H and ¹³C-NMR. The order of relative reactivity (1/r₁) for the monomers is 4-I (10.6) > 2-I (6.8) > 2-CN (4.8) > 3-I-4-OCH₃ (2.5) > 3-CH₃CO (2.3) > 5-I-2-OCH₃ (1.5) > 2-CH₃CO (0.8) > 3,5-Br₂ (0.6) > 2,5-Br₂ (0.5) > 4-N(C₂H₃)₂ (0.4) > 4-N(CH₃)₂ (0.3). Relatively high T_g of the copolymers in comparison with that of polystyrene indicates decrease in chain mobility of the copolymer due to the high dipolar character of the trisubstituted ethylene monomer unit. Decomposition of the copolymers in nitrogen occurred in two steps, first in the 200-500鎺矯 range with residue (2-21% weight), which then decomposed in the 500-800鎺矯 range. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Quality Control of 3-Iodo-4-methoxybenzaldehyde).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Quality Control of 3-Iodo-4-methoxybenzaldehyde

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

m-Iodosylbenzoic acid – a convenient recyclable reagent for highly efficient aromatic iodinations was written by Kirschning, Andreas;Yusubov, Mekhman S.;Yusubova, Roza Y.;Chi, Ki-Whan;Park, Joo Y.. And the article was included in Beilstein Journal of Organic Chemistry in 2007.Computed Properties of C8H7IO2 This article mentions the following:

M-Iodosylbenzoic acid is used to perform iodination of arenes in the presence of iodine at room temperature in acetonitrile. Separation of pure products is conveniently achieved by scavenging any aryl iodide by ion exchange with IRA-900 (hydroxide form). The reduced form of the reagent, m-iodobenzoic acid, can be easily recovered from the ion exchange resin or from the basic aqueous solution by simple acidification with HCl. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Computed Properties of C8H7IO2).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Computed Properties of C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pd-catalyzed cross-electrophile Coupling/C-H alkylation reaction enabled by a mediator generated via C(sp³)-H activation was written by Wu, Zhuo;Jiang, Hang;Zhang, Yanghui. And the article was included in Chemical Science in 2021.COA of Formula: C8H7IO2 This article mentions the following:

Pd-catalyzed cascade cross-electrophile coupling and C-H alkylation reaction of 2-iodo-alkoxylarenes with alkyl chlorides were reported. Methoxy and benzyloxy groups, which were ubiquitous functional groups and common protecting groups, were utilized as crucial mediators via primary or secondary C(sp³)-H activation. The reaction provided an innovative and convenient access for the synthesis of alkylated phenol derivatives, which were widely found in bioactive compounds and organic functional materials. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6COA of Formula: C8H7IO2).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.COA of Formula: C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A facile synthesis of 2-(2-hydroxyethyl)allylsilanes was written by Bardot, Valerie;Remuson, Roland;Gelas-Mialhe, Yvonne;Gramain, Jean-Claude. And the article was included in Synlett in 1996.Application In Synthesis of 3-Iodo-4-methoxybenzaldehyde This article mentions the following:

Indium-mediated allylsilylation of carbonyl compounds provides a facile and efficient route to 2-(2-hydroxyethyl)allylsilanes. For example, 3-iodo-2-(trimethylsilylmethyl)-1-propene reacts with 2,6-dichlorobenzaldehyde in the presence of In powder in DMF to give 90% 2,6-Cl₂C₆H₃CH(OH)CH₂C(:CH₂)CH₂SiMe₃. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Application In Synthesis of 3-Iodo-4-methoxybenzaldehyde).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Application In Synthesis of 3-Iodo-4-methoxybenzaldehyde

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A general synthetic route towards bastadins. Part 1: synthesis of the eastern part of bastadins 4-16 was written by Couladouros, Elias A.;Moutsos, Vassilios I.. And the article was included in Tetrahedron Letters in 1999.Formula: C8H7IO2 This article mentions the following:

A general synthetic route for the construction of the eastern part of the macrocyclic bastadins 4-16 is presented. The brominated biaryl ethers are synthesized using the iodonium salt method. The synthesis is accomplished within 18 steps in 15.5% overall yield. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Formula: C8H7IO2).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Formula: C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hard acid and soft nucleophile systems. 8. Reductive dehalogenation of o- and p-halophenols and their derivatives was written by Node, Manabu;Kawabata, Takeo;Ohta, Keiichiro;Fujimoto, Mayumi;Fujita, Eiichi;Fuji, Kaoru. And the article was included in Journal of Organic Chemistry in 1984.Reference of 2314-37-6 This article mentions the following:

Treatment of o– or p-halophenols and their derivatives with the AlCl₃-EtSH system provides a dehalogenated product in 85-98% yield. In an example, 2-BrC₆H₄OMe at room temperature in CH₂Cl₂ containing 2.5 mol equiv AlCl₃ and EtSH gave 95% PhOH in 1.5 h. Cl and F cannot be removed by this system. Electron-withdrawing groups retard the reaction rate. The method was used for dehalogenation of halonaphthols and polyhalophenols. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Reference of 2314-37-6).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Reference of 2314-37-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Effect of Water on the Functionalization of Substituted Anisoles with Iodine in the Presence of F-TEDA-BF₄ or Hydrogen Peroxide was written by Pavlinac, Jasminka;Zupan, Marko;Stavber, Stojan. And the article was included in Journal of Organic Chemistry in 2006.Computed Properties of C8H7IO2 This article mentions the following:

Water was found to be a convenient reaction medium for functionalization of substituted anisoles using iodine in the presence of Selectfluor (F-TEDA-BF₄) or hydrogen peroxide as mediators and oxidizers. Two types of functionalization were observed: iodination or oxidation In the iodination process, two reaction routes were established. In the case of the first route, a high iodine atom economy was achieved for selective and effective iodo functionalization with a stoichiometric ratio of substrate/iodine/(mediator/oxidizer) = 2:1:1.2. An electrophilic iodination reaction process was suggested for this route, with the oxidizer converting the liberated iodide anion to iodine. For the second reaction route, a stoichiometric ratio of substrate/iodine/(mediator/oxidizer) = 1:1:1 and a lower iodine atom economy were observed; in this case, ion radical formation in the first step of the reaction was suggested. Iodine was found to be an effective catalyst for the oxidation of a hydroxy benzyl functional group to benzaldehyde using F-TEDA-BF₄. Water is an effective medium for functionalization of anisole, p-methoxybenzyl alc., 1-(4-methoxyphenyl)ethanone, o-dimethoxybenzene, m-dimethoxybenzene, and p-dimethoxybenzene, whereas F-TEDA-BF₄ as a mediator/oxidizer could be replaced by hydrogen peroxide in the case of the functionalization of 1-(4-methoxyphenyl)ethanone, o-dimethoxybenzene, m-dimethoxybenzene, and p-dimethoxybenzene. Water changes the type of transformation of p-methoxybenzyl alc. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Computed Properties of C8H7IO2).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Computed Properties of C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Biological activity of various halogenated derivatives of Ioxynil was written by Cooke, A. R.;Hart, R. D.;Achuff, N. E.. And the article was included in Proceedings of the Northeastern Weed Control Conference in 1965.Application of 2314-37-6 This article mentions the following:

Ioxynil (I) is effective for the control of broadleaf weeds and grasses in small grains. The 3,5-dibromo- and 3-bromo- acetates of I and 3,5-dibromo-4-hydroxybenzonitrile acetate are almost as effective. Less active are the 3,5-dichloro, 3-iodo-, 3-bromo-, 3-chloro-, 3,5-dinitro-, and 3-nitro-derivatives of I, p-hydroxybenzonitrile, 3,5-diiodo-4-hydroxybenzamide, 3,5-diiodo-4-hydroxybenzoic acid, 3,5-diiodo-4-hydroxybenzene-sulfonamide, 3,5-diiodo-4-hydroxybenzamide, 3,5-diiodo-4-hydroxybenzaldehyde and its oxime, 3-iodo-p-anisaldehyde, 3,5-dichloro-4-hydroxybenzaldehyde, 3,5-diiodo-4-hydroxyhydrocinnamic acid, p-cyanophenoxyacetic acid, 2,6-dibromo-4-cyanophenoxyacetic acid, 2-chloro-4-cyanophenoxyacetic acid, and 3,-4-diiodosalicylonitrile. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Application of 2314-37-6).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Application of 2314-37-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Defining the Mechanism of Action and Enzymatic Selectivity of Psammaplin A against Its Epigenetic Targets was written by Baud, Matthias G. J.;Leiser, Thomas;Haus, Patricia;Samlal, Sharon;Wong, Ai Ching;Wood, Robert J.;Petrucci, Vanessa;Gunaratnam, Mekala;Hughes, Siobhan M.;Buluwela, Lakjaya;Turlais, Fabrice;Neidle, Stephen;Meyer-Almes, Franz-Josef;White, Andrew J. P.;Fuchter, Matthew J.. And the article was included in Journal of Medicinal Chemistry in 2012.COA of Formula: C8H7IO2 This article mentions the following:

Psammaplin A (11c) is a marine metabolite previously reported to be a potent inhibitor of two classes of epigenetic enzymes: histone deacetylases and DNA methyltransferases. The design and synthesis of a focused library based on the psammaplin A core has been carried out to probe the mol. features of this mol. responsible for its activity. By direct in vitro assay of the free thiol generated upon reduction of the dimeric psammaplin scaffold, we have unambiguously demonstrated that 11c functions as a natural prodrug, with the reduced form being highly potent against HDAC1 in vitro (IC₅₀ 0.9 nM). Furthermore, we have shown it to have high isoform selectivity, being 360-fold selective for HDAC1 over HDAC6 and more than 1000-fold less potent against HDAC7 and HDAC8. SAR around our focused library revealed a number of features, most notably the oxime functionality to be important to this selectivity. Many of the compounds show significant cytotoxicity in A549, MCF7, and W138 cells, with the SAR of cytotoxicity correlating to HDAC inhibition. Furthermore, compound treatment causes upregulation of histone acetylation but little effect on tubulin acetylation. Finally, we have found no evidence for 11c functioning as a DNMT inhibitor. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6COA of Formula: C8H7IO2).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.COA of Formula: C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com