Category: 229178-74-9

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 229178-74-9, name is 2,6-Difluoro-3-iodobenzoic acid, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C7H3F2IO2

To a mixture of 2,6-difluoro-3-iodobenzoic acid 3 (2.84 g, 10.0 mmol) in methanol (30 mL) was added SOCl2 (0.1 mL) dropwise at 0 C. After being stirred at reflux for 3 h, the mixture was concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, petroleum ether/ethyl acetate 15:1 to 10:1, v/v) to give the desired compound 4 as a white solid (2.75 g, 92%): mp 54-55 C (lit.6 mp 53-55 C); 1H NMR (CDCl3) delta 3.95 (s, 3H, CH3), 6.78-6.82 (t, 1H, J = 8.4 Hz, ArH), 7.78-7.83 (m, 1H, ArH); 13C NMR (CDCl3) delta 53.10, 75.42, 75.46, 75.69, 75.73 (dd, JC-F = 4.2, inlMMLBox = 26.8 Hz), 111.49, 111.69, 111.89 (t, JC-F = 19.8 Hz), 113.81, 113.84, 114.03, 114.07 (dd, JC-F = 3.9, inlMMLBox = 22.4 Hz), 141.42, 141.45, 141.51, 141.54 (dd, JC-F = 3.1, inlMMLBox = 9.4 Hz), 157.99, 158.05, 160.52, 160.58 (dd, JC-F = 6.2, inlMMLBox = 252.6 Hz), 159.48, 159.53, 162.04, 162.09 (dd, JC-F = 5.1, inlMMLBox = 256.2 Hz), 161.16; GC-MS: 298 M+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 229178-74-9.

Reference:
Article; He, Qiu-Qin; Gu, Shuang-Xi; Liu, Jia; Wu, Hai-Qiu; Zhang, Xuan; Yang, Liu-Meng; Zheng, Yong-Tang; Chen, Fen-Er; Bioorganic and Medicinal Chemistry; vol. 19; 16; (2011); p. 5039 – 5045;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 229178-74-9, name is 2,6-Difluoro-3-iodobenzoic acid, A new synthetic method of this compound is introduced below., SDS of cas: 229178-74-9

EXAMPLE 36A; Preparation of compound 2002; Step 1:; Sulfuric acid (3 mL) is added to a solution of 36a1 (15.0 g, 36.9 mmol) in MeOH (200 mL) and the resulting solution is stirred overnight at 800C. The mixture is cooled to RT, concentrated under reduced pressure, diluted with EtOAc (300 mL), washed with aqueous saturated sodium bicarbonate (3 x 100 mL), brine (100 mL), dried over Na2SO4, filtered and concentrated under reduced pressure to afford methyl ester 36a2.

The synthetic route of 229178-74-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; WO2009/76747; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com