Category: 2265-93-2

Related Products of 2265-93-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2265-93-2, name is 2,4-Difluoroiodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Synthesis of (2,4-difluorophenyl)propiolic Acid 4.95 ml (41.4 mmol) of 2,4-difluoroiodobenzene and 2.56 ml (41.4 mmol) of propiolic acid were dissolved in DMF (16 ml). Following cooling of the reaction medium to 0 C. (ice-water bath), 578 mg (0.83 mmol) of Pd(PPh3)2Cl2 and 308 mg (1.66 mmol) of Cul were added. The reaction solution was then cooled to -10 C. (ice methanol bath) and 14.5 ml (103.4 mmol) of diisopropylamine were added dropwise at this temperature. The cooling bath was then removed and the reaction mixture was stirred a further 16 h after RT had been re-established. The reaction solution was then diluted with EA and washed successively with a 2N HCl solution and a satd aq. NaCl solution. Following drying over MgSO4, filtration, and removal of solvent in vacuo, the residue was boiled with hexane and filtered after cooling to RT. The residue was dissolved in diethyl ether at 30 C. and filtered at this temperature. By removal of solvent in vacuo there were obtained from the filtrate 6.43 g (35.3 mmol, 85%) of (2,4-difluorophenyl)propiolic acid.

The synthetic route of 2,4-Difluoroiodobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Gruenenthal GmbH; US2007/112011; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 2265-93-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2265-93-2, name is 2,4-Difluoroiodobenzene, This compound has unique chemical properties. The synthetic route is as follows.

A mixture of (3S)-piperidin-3-ol hydrochloride (0.50 g, 0.0036 mol), l,3-difl’uoro-4- iodobenzene (0.522 mL, 0.00436 mol), copper(I) iodide (140 mg, 0.00073 mol), potassium phosphate (3.08 g, 0.0145 mol), and 1 ,2-ethanediol (0.810 mL, 0.0145 mol) in 1-butanol (7.28 mL, 0.0796 mol) was heated at 100 0C under nitrogen for 2 nights. The reaction mixture was treated with water, and then extracted with EtOAc. The organic layers were combined, washed with brine, dried and evaporated to dryness. The residue was used directly in next step without further purifications (529 mg, 69%). LCMS (M+H): 214.2.

The chemical industry reduces the impact on the environment during synthesis 2,4-Difluoroiodobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; INCYTE CORPORATION; WO2007/89683; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

2265-93-2, Name is 2,4-Difluoroiodobenzene, 2265-93-2, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

EXAMPLE 4; 2,4-Bis-(2,4-difluorophenyI)-3-l(3-pyridyl)hydroxymethyI]thiophene; To a suspension of 1.54gm (ll.lmmol) of potassium carbonate, 1.44gm (4.46mmol) of tetrabutylammonium bromide, and .05gm (0.22mmol) of palladium(II) diacetate in 1.ImL of acetonitrile/H2O (9:1) under a N2 atmosphere was added 1.83gm (6.69mmol) of 2,4-difluoro-l-iodobenzene and 0.50gm (4.46mmol) of thiorhohene-3-carboxaldehyde. The mixture was heated at 800C for 3days, and then diluted with ethyl acetate. The ethyl acetate solution was washed with water and dried over magnesium sulfate. The drying agent was filtered off, and the solvent was removed by rotoevaporation to give a red-brown solid which was purified by flash column chromatography on silica gel to give a mixture of 2-(2,4- difluorophenyl)thiophene-3-carboxaldehyde and 2,4-bis-(2,4- difluorophenyl)thiophene-3-carboxaldehyde which was used in the next reaction.

Statistics shows that 2,4-Difluoroiodobenzene is playing an increasingly important role. we look forward to future research findings about 2265-93-2.

Reference:
Patent; SYNGENTA LIMITED; WO2007/75487; (2007); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

2265-93-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2265-93-2, name is 2,4-Difluoroiodobenzene, A new synthetic method of this compound is introduced below.

To toluene 3.0mL solution of tert-butyl 2-amino-4-phenethyl benzoate 0.10g were added 2,4-difluoro-1-iodobenzene 0.10mL, cesium carbonate 0.22g, tris(dibenzylideneacetone)dipalladium(0) 3mg and 2-dicyclohexylphosphino-2′,4′,6′-triisopropyl biphenyl 8mg, and it was stirred at 110C for 24 hours. After the reaction mixture was cooled to room temperature, tris(dibenzylideneacetone)dipalladium(0) 3mg and 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl 8mg were added to it, and it was stirred at 110C for 24 hours. After the reaction mixture was cooled to room temperature, ethyl acetate and 10% citric acid aqueous solution were added to it. The organic layer was separated and collected, dried over anhydrous magnesium sulfate after washing with saturated sodium chloride aqueous solution, and the solvent was removed under reduced pressure. The obtained residue was refined by silica gel column chromatography [Trikonex company, Flash Tube 2008, eluent; hexane:ethyl acetate:acetic acid=20:1:1] to give tert-butyl 2-(2,4-difluoroanilino)-4-phenethylbenzoate. Trifluoroacetic acid 10mL was added to the obtained tert-butyl 2-(2,4-difluoroanilino)-4-phenethylbenzoate, and it was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure, methanol was added to the obtained residue, and solid matter was filtrated to give 2-(2,4-difluoroanilino)-4-phenethylbenzoic acid 59mg of white solid. 1H-NMR(DMSO-d6) delta value: 2.82(4H,s),6.65(1H,s),6.70(1H,dd,J=8.1,1.5Hz),7.05(1H,t dd,J=8.6,2.8,1.3Hz),7.14-7.21(3H,m),7.23-7.30(3H,m),7.37(1H,ddd,J=11.1,8.9,2.8Hz),7.81(1H,d,J=8. 1Hz),9.46(1H,s),12.85-13.20(1H,broad).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; TOYAMA CHEMICAL CO., LTD.; EP1860098; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A common heterocyclic compound, 2265-93-2, name is 2,4-Difluoroiodobenzene, molecular formula is C6H3F2I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 2265-93-2.

[0255] 2-Prop-2-ynyl-2,3-dihydro-isoindol-l-one (50.0mg, 0.29mmol) was dissolved in triethylamine (2mL). To this was added Pd(PPh3)4 (13mg, 0.012mmol), Cul (6.7mg, 0.035mmol) and 2,4-difluoro-l-iodo-benzene (52.0uL, 0.438mmol) and the reaction was allowed to stir overnight. The solvent was evaporated and the residue was purified by prep. TLC (30% EtOAc/Hexanes) to afford the title compound (20.0mg, 24%) as a brown oil. XH NMR (300 MHz, CDC13): 5 7.90 (d, 1H), 7.45 (m, 4H), 6.84 (t, 2H), 4.72 (s, 2H), 4.59 (s, 2H).

The synthetic route of 2,4-Difluoroiodobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com