Category: 2265-92-1

Wang, Zhi-Xian; Duan, Weili; Wiebe, Leonard I.; Balzarini, Jan; De Clercq, Erik; Knaus, Edward E. published the artcile< Synthesis of 1-(2-deoxy-β-D-ribofuranosyl)-2,4-difluoro-5-substituted-benzene thymidine mimics, some related α-anomers, and their evaluation as antiviral and anticancer agents>, Product Details of C6H3F2I, the main research area is nucleoside deoxyribofuranosyldifluorobenzene thymidine mimic synthesis antiviral cytotoxicity anticancer.

A group of unnatural 1-(2-deoxy-β-D-ribofuranosyl)-2,4-difluorobenzenes having a variety of C-5 substituents (H, Me, F, Cl, Br, I, CF3, CN, NO2, NH2), designed as thymidine mimics, were synthesized for evaluation as anticancer and antiviral agents. The coupling reaction of 3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride with an organocadmium reagent [(2,4-difluorophenyl)2Cd] afforded a mixture of the α- and β-anomeric products (α:β = 3:1 to 10:1 ratio). Treatment of the α-anomer with BF3·Et2O in nitroethane at 110-120°C for 30 min was developed as an efficient method for epimerization of the major α-anomer to the desired β-anomer. The 5-substituted (H, Me, Cl, I, NH2) β-anomers exhibited negligible cytotoxicity in a MTT assay (CC50 = 10-3-10-4 M range), relative to thymidine (CC50 = 10-3-10-5 M range), against a variety of cancer cell lines. In contrast, the 5-NO2 derivative was more cytotoxic (CC50 = 10-5-10-6 M range). A number of 5-substituted β-anomers, and some related α-anomers, that were evaluated using a wide variety of antiviral assay systems [HSV-1, HSV-2, varicella-zoster virus (VZV), vaccinia virus, vesicular stomatitis, cytomegalovirus (CMV) and human immunodeficiency (HIV-1, HIV-2) viruses], showed that this class of unnatural C-aryl nucleoside mimics are inactive antiviral agents.

Nucleosides, Nucleotides & Nucleic Acids published new progress about Antitumor agents. 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Product Details of C6H3F2I.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sviripa, Vitaliy M.; Zhang, Wen; Kril, Liliia M.; Liu, Alice X.; Yuan, Yaxia; Zhan, Chang-Guo; Liu, Chunming; Watt, David S. published the artcile< Halogenated diarylacetylenes repress c-myc expression in cancer cells>, Recommanded Product: 1,4-Difluoro-2-iodobenzene, the main research area is halogenated diarylacetylene preparation cmyc inhibitor cancer; Antineoplastic agents; Colon cancer; Diarylacetylenes; c-myc.

Halogenated diarylacetylenes that possess fluorine or chlorine substituents in one aryl ring and N-methylamino or N,N-dimethylamino in the other aryl ring inhibit the proliferation of LS174T colon cancer cells through the repression of c-myc expression and induction of the cyclin-dependent kinase inhibitor-1 (i.e., p21(Wif1/Cip1)) and represent potentially useful antineoplastic agents.

Bioorganic & Medicinal Chemistry Letters published new progress about Antiproliferative agents. 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Recommanded Product: 1,4-Difluoro-2-iodobenzene.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Namkung, Moses J.; Fletcher, T. Lloyd published the artcile< Derivatives of fluorene. XXV. Fluorofluorenes. 6>, Application In Synthesis of 2265-92-1, the main research area is FLUORINATION FLUORENES; FLUORENES FLUORO.

The synthesis of 5,6,7,8-tetrafluoro-2-acetamidofluorene, 1,4,7-trifluoro-2-acetamidofluorene (I), and 5,8-difluoro-2-acetamidofluorene, of a 1,2,3,4,7-penta-, a 1,2,3,4-tetra-, a 1,2,4,7-tetra-, a 1,4,7-tri-, and a 1,4-difluorofluorenone, and of related derivatives is reported together with their ir absorption data. Nitration of polyfluorofluorenones which have an unsubstituted 2 (or 7) position occurs at that position. An unexpected directive effect was observed in the nitration of 4,7-difluoro-2-acetamidofluorene.

Canadian Journal of Chemistry published new progress about 2265-92-1. 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Application In Synthesis of 2265-92-1.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Bing; Yang, Zhan; Gong, Wenqi; Chen, Xinhui; Bruce, Duncan W.; Wang, Shengyue; Ma, Huili; Liu, Yu; Zhu, Weiguo; Chi, Zhenguo; Wang, Yafei published the artcile< Intramolecular Through-Space Charge Transfer Based TADF-Active Multifunctional Emitters for High Efficiency Solution-Processed OLED>, Application In Synthesis of 2265-92-1, the main research area is thermally activated delayed fluorescence emitter organic light emitting diode.

Thermally activated delayed fluorescence (TADF) has been explored actively in luminescent organic materials. Yet, realizing such TADF-active, multifunctional emitters with high emission efficiency still remains hugely challenging. In this context, a series of twist-conjugated organic mols. bearing diphenylsulfone and 9,9-dimethylacridine moieties are designed and prepared, and are found to show, in one mol., TADF, room-temperature phosphorescence, triboluminescence, and aggregation-induced emission enhancement. In addition, remarkably high photoluminescence quantum efficiency, up to ≈100%, is achieved for these novel mols. Single-crystal anal. and theor. calculations reveal that the through-space charge transfer (TSCT) effect in these mols. is responsible for both the multifunctional emission and high emission efficiency. A maximum external quantum efficiency of 20.1% is achieved, which is among the highest recorded in a solution-processable device containing TSCT-based TADF materials. These results illustrate a new approach to achieving highly efficient TADF-active, multifunctional emitters.

Advanced Optical Materials published new progress about Absorption spectroscopy. 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Application In Synthesis of 2265-92-1.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhao, Lulu; Dong, Yanan; Xia, Qiangqiang; Bai, Jianfei; Li, Yuehui published the artcile< Zn-Catalyzed Cyanation of Aryl Iodides>, Application In Synthesis of 2265-92-1, the main research area is aryl cyanide preparation; formamide aryl iodide cyanation zinc catalyst.

An efficient method for the synthesis of cyanides such as ArCN [Ar = 4-ClC6H4, 4-MeC6H4, 1-naphthyl, etc.] via zinc-catalyzed cyanation of aryl iodides with formamide as cyanogen source was reported. The transformation was promoted by bisphosphine Nixantphos ligand. Under optimized conditions, a variety of electron-donating and electron-withdrawing aryl iodides were converted into the nitrile products ArCN in good to excellent yields. This approach was an exceedingly simple and benign method for the synthesis of aryl nitriles ArCN and was likely to proceed via a dinuclear-Zn concerted catalysis.

Journal of Organic Chemistry published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Application In Synthesis of 2265-92-1.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Waldvogel, S. R.; Wehming, K. M. published the artcile< Product subclass 2: iodoarenes>, HPLC of Formula: 2265-92-1, the main research area is review iodoarene preparation iodination organic synthesis.

A review of methods to prepare iodoarenes.

Science of Synthesis published new progress about Aryl halides Role: SPN (Synthetic Preparation), PREP (Preparation) (iodo). 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, HPLC of Formula: 2265-92-1.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Prakash, G. K. Surya; Mathew, Thomas; Hoole, Dushyanthi; Esteves, Pierre M.; Wang, Qi; Rasul, Golam; Olah, George A. published the artcile< N-Halosuccinimide/BF3-H2O, Efficient Electrophilic Halogenating Systems for Aromatics>, SDS of cas: 2265-92-1, the main research area is halosuccinimide trifluoroborane monohydrate electrophile halogenation aromatic.

N-Halosuccinimides (NXS, 1) are efficiently activated in trifluoromethanesulfonic acid and BF3-H2O, allowing the halogenations of deactivated aromatics Because BF3-H2O is more economic, easy to prepare, nonoxidizing, and offers sufficiently high acidity (-H0 ≈ 12, only slightly lower than that of trifluoromethanesulfonic acid), an efficient new electrophilic reagent combination of NXS/BF3-H2O has been developed. DFT calculations at the B3LYP/6-311++G**//B3LYP/6-31G* level suggest that protonated N-halosuccinimides undergo further protosolvation at higher acidities to reactive superelectrophilic species capable either in the transfer of X+ from the protonated forms of NXS to the aromatic substrate or in forming a highly reactive and solvated X+ which would readily react with the aromatic substrates. Structural aspects of the BF3-H2O complex have also been investigated.

Journal of the American Chemical Society published new progress about Acid catalysis. 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, SDS of cas: 2265-92-1.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Fyfe, Tim J.; Kellam, Barrie; Sykes, David A.; Capuano, Ben; Scammells, Peter J.; Lane, J. Robert; Charlton, Steven J.; Mistry, Shailesh N. published the artcile< Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor>, HPLC of Formula: 2265-92-1, the main research area is structure pharmacokinetics haloperidol dopamine D2 receptor.

Haloperidol is a typical antipsychotic drug (APD) associated with an increased risk of extrapyramidal side-effects (EPS) and hyperprolactinemia relative to atypical APDs such as clozapine. Both drugs are dopamine D2 receptor (D2R) antagonists, with contrasting kinetic profiles. Haloperidol displays fast association/slow dissociation at the D2R whereas clozapine exhibits relatively slow association/fast dissociation Recently, the authors have provided evidence that slow dissociation from the D2R predicts hyperprolactinemia, whereas fast association predicts EPS. Unfortunately, clozapine can cause severe side-effects independent of its D2R action. The results suggest an optimal kinetic profile for D2R antagonist APDs that avoids EPS. To begin exploring this hypothesis, the authors conducted a structure-kinetic relationship study of haloperidol and reveal that subtle structural modifications dramatically change binding kinetic rate constants, affording compounds with a clozapine-like kinetic profile. Thus, optimization of these kinetic parameters may allow development of novel APDs based on the haloperidol scaffold with improved side-effect profiles.

Journal of Medicinal Chemistry published new progress about Dopamine D2 receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, HPLC of Formula: 2265-92-1.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Gandeepan, Parthasarathy; Mo, Jiayu; Ackermann, Lutz published the artcile< Photo-induced copper-catalyzed C-H chalcogenation of azoles at room temperature>, Recommanded Product: 1,4-Difluoro-2-iodobenzene, the main research area is thiazole aryl halide sulfur copper catalyst photochem thioarylation; arylthio thiazole preparation green chem; aryl halide thiazole selenium copper catalyst photochem thioarylation; arylselanyl thiazole preparation green chem.

Inexpensive copper catalysts enabled direct C-H chalcogenations at ambient temperature by means of photo-induced catalysis. The expedient copper catalysis set the stage for C-S and C-Se bond formation from readily accessible non-volatile elemental chalcogens. The photo-assisted copper catalysis manifold proved suitable for a wide range of substrates with good functional group tolerance and exhibited high catalytic efficacy even at a reaction temperature of 25°.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Recommanded Product: 1,4-Difluoro-2-iodobenzene.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Rausis, Thierry; Schlosser, Manfred published the artcile< The basicity gradient-driven migration of iodine: conferring regioflexibility on the substitution of fluoroarenes>, Recommanded Product: 1,4-Difluoro-2-iodobenzene, the main research area is benzoic acid fluoro iodo preparation; naphthalenecarboxylic acid fluoro iodo preparation; benzene fluoro iodo preparation; naphthalene fluoro iodo preparation; fluorobenzene lithiation iodination carboxylation; migration basicity iodine fluoroarene; rearrangement lithiation iodine fluoroarene; fluorobenzoic acid iodo preparation; fluoronaphthalenecarboxylic iodo preparation; fluoroiodobenzene lithiation carboxylation rearrangement.

Six different fluoroarenes were submitted to the same transformations. Direct deprotonation with alkyllithium or lithium dialkylamide as reagents and subsequent carboxylation afforded acids. These included 2,6-difluorobenzoic acid, 3,6-difluoro-2-iodobenzoic acid, 2-fluoro-6-iodobenzoic acid, 2-fluoro-3-iodobenzoic acid, 2,3-difluoro-4-iodobenzoic acid and 1-fluoro-2-naphthalenecarboxylic acid. If the aryllithium intermediate was trapped with iodine rather than with dry ice, an iodofluoroarene (2, 7, 12, 17, 19, and 24) was formed. Iodoarenes included 1,3-difluoro-2-iodobenzene, 1,4-difluoro-2,3-diiodobenzene, 1-fluoro-2,3-diiodobenzene, 2-fluoro-1,3-diiodobenzene, 2,3-difluoro-1,4-diiodobenzene, and 1-fluoro-2-iodonaphthalene. These, upon treatment with lithium diisopropylamide, underwent deprotonation and iodine migration. The resulting new aryllithium species was intercepted either by carboxylation, to give 2,6-difluoro-3-iodobenzoic acid, 2,5-difluoro-3,6-diiodobenzoic acid, 2-fluoro-3,6-diiodobenzoic acid, 2,3-difluoro-4,6-diiodobenzoic acid, and 1-fluoro-3-iodo-2-naphthalenecarboxylic acid, or by neutralization to produce the iodofluoroarenes which included 2,4-difluoro-1-iodobenzene, 1,4-difluoro-2,5-diiodobenzene, 2-fluoro-1,4-diiodobenzene, 1-fluoro-3-iodonaphthalene. The latter family of compounds was converted into another set of acids, which included 2,4-difluorobenzoic acid, 2,5-difluoro-4-iodobenzoic acid, 1-fluoro-3-naphthalenecarboxylic acid, by subsequent treatment with butyllithium or isopropylmagnesium chloride and carbon dioxide.

European Journal of Organic Chemistry published new progress about Aromatic hydrocarbons Role: SPN (Synthetic Preparation), PREP (Preparation) (fluoroiodo). 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Recommanded Product: 1,4-Difluoro-2-iodobenzene.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com