Category: 2265-92-1

Wu, Chenggui; Yang, Xinjun; Shang, Yong; Cheng, Hong-Gang; Yan, Wei; Zhou, Qianghui published the artcile< Synthesis of Benzofused Dioxabicycle Scaffolds via a Catellani Strategy>, Synthetic Route of 2265-92-1, the main research area is benzofused dioxabicycle preparation chemoselective regioselective; aryl iodide epoxide terminal alkyne Catellani reaction oxacyclization.

Reported is a modular strategy for the preparation of the unique benzofused dioxabicycle scaffolds involving a Catellani reaction of aryl iodides, epoxides, and terminal alkynes and an oxa-cyclization. This is a mild, scalable, chemoselective, and atom-economical protocol, compatible with various functionalized aryl iodides, epoxides, and terminal alkynes. With the ability to build up the mol. complexity rapidly and efficiently from feedstock chems., this method will have wide applications in organic synthesis.

Organic Letters published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Synthetic Route of 2265-92-1.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Naghani, Farhad Fereydooni; Emamian, Saeedreza; Zare, Karim published the artcile< Exploring influence of fluorine substitution on the strength and nature of halogen bond between iodobenzene and hydrogen cyanide>, HPLC of Formula: 2265-92-1, the main research area is fluorine substituted iodobenzene hydrogencyanide strength halogen bond.

In the present study, the intermol. I … N halogen bond (XB) interaction between iodobenzene (IBZ) and its fluorinated derivatives (as Lewis acids LA 1 through LA 20) with HCN (as Lewis base LB) is theor. explored to shed light on the electronic nature and strength of the mentioned non-covalent interaction (NCI). The hydrogen atoms of Ph ring in IBZ were substituted by fluorine atom to probe different impacts of this atom. Such a substitution is paid attention from the number as well as the position of fluorine atoms points of view. Our analyses reveal that this XB interaction whose interaction energy spans a narrow range between 1.0 and 3.0 kcal·mol-1 should be classified as a weak NCI. The symmetry-adapted perturbation theory (SAPT) anal. evidences that the I … N XB in the investigated binary complexes (BCs) is mainly dominated by electrostatic and dispersion interactions, and, in the meantime, induction interactions can safely be ignored. Among the many I … N XB descriptors, Vs,max, which corresponds to the most pos. value of electrostatic potential computed for the iodine atom in LAs, plays a key role. Indeed, such an easily and rapidly computable quantity (Vs,max) allows a sufficiently accurate prediction of interaction energy together with SAPT-derived components anal. to become feasible by a simple inclusion of Vs,max value within the numerous explored estimators. Although the strength of I … N XB interaction in the studied BCs is increased by an increase in the number of fluorine substituent, the position of fluorine atom cannot significantly alter the strength of the mentioned interaction.

Journal of Physical Organic Chemistry published new progress about Bader electron density. 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, HPLC of Formula: 2265-92-1.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Smith, Garry R.; Brenneman, Douglas E.; Zhang, Yan; Du, Yanming; Reitz, Allen B. published the artcile< Small-Molecule Anticonvulsant Agents with Potent In Vitro Neuroprotection and Favorable Drug-Like Properties>, Synthetic Route of 2265-92-1, the main research area is difluoroethylsulfamide anticonvulsant neuroprotectant central nervous system pharmacokinetics pharmacodynamics.

Severe seizure activity is associated with reoccurring cycles of excitotoxicity and oxidative stress that result in progressive neuronal damage and death. Intervention with these pathol. processes is a compelling disease-modifying strategy for the treatment of seizure disorders. We have optimized a series of small mols. for neuroprotective and anticonvulsant activity as well as altered their phys. properties to address potential metabolic liabilities, to improve CNS penetration, and to prolong the duration of action in vivo. Utilizing phenotypic screening of hippocampal cultures with nutrient medium depleted of antioxidants as a disease model, cell death and decreased neuronal viability produced by acute treatment with glutamate or hydrogen peroxide were prevented. Modifications to our previously reported proof of concept compounds have resulted in a lead which has full neuroprotective action at <1 nM and antiseizure activity across six animal models including the kindled rat and displays excellent pharmacokinetics including high exposure to the brain. These modifications have also eliminated the requirement for a chiral mol., removing the possibility of racemization and making large-scale synthesis more easily accessible. These studies strengthen our earlier findings which indicate that potent, multifunctional neuroprotective anticonvulsants are feasible within a single mol. entity which also possesses favorable CNS-active drug properties in vitro and in vivo. Journal of Molecular Neuroscience published new progress about Anticonvulsants. 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Synthetic Route of 2265-92-1.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pan, Cheng; Wang, Limin; Han, Jianwei published the artcile< Palladium-Catalyzed Site-Selective Benzocylization of Aromatic Acids with o-Fluoro-Substituted Diaryliodonium Salts toward 3,4-Benzocoumarins>, Formula: C6H3F2I, the main research area is benzocoumarin preparation palladium catalyzed site selective benzocyclization; benzocyclization aromatic acid fluoro substituted diaryliodonium salt.

By using 2-fluoro-substituted diaryliodonium salts, a novel benzocylization has been accomplished for the synthesis of 3,4-benzocoumarin derivatives via a cascade of ortho-arylation and defluorination in the presence of palladium catalysts. The reaction exhibits a broad compatibility of readily available aromatic acids with an excellent level of site-selectivity. Mechanistic investigations revealed a unique reactivity of carboxylic acid directed arylation by followed nucleophilic substitution of aromatic fluoride in the present system.

Organic Letters published new progress about Aromatic carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Formula: C6H3F2I.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Miller, Eric M.; Walczak, Maciej A. published the artcile< Light-Mediated Cross-Coupling of Anomeric Trifluoroborates>, Product Details of C6H3F2I, the main research area is BMIDA ester deoxy sugar disaccharide fluoroborate glycosylation; light mediated cross coupling anomeric fluoroborate stereoselective arylation etherification.

Stereoselective reactions at the anomeric carbon constitute the cornerstone of preparative carbohydrate chem. Here, we report stereoselective C-arylation and etherification reactions of anomeric trifluoroborates derived from BMIDA esters. These reactions are characterized by high anomeric selectivities for 2-deoxysugars and broad substrate scope (24 examples), including disaccharides and trifluoroborates with free hydroxyl groups. Taken together, this new class of carbohydrate reagents adds the palette of anomeric nucleophile reagents suitable for efficient installation of C-C bonds.

Organic Letters published new progress about Arylation catalysts, stereoselective. 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Product Details of C6H3F2I.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Frei, Reto; Blackwell, Helen E. published the artcile< Small Molecule Macroarray Construction via Palladium-Mediated Carbon-Carbon Bond-Forming Reactions: Highly Efficient Synthesis and Screening of Stilbene Arrays>, Safety of 1,4-Difluoro-2-iodobenzene, the main research area is amine cellulose supported preparation coupling benzoic acid vinyl; benzamide vinyl cellulose supported preparation Heck iodoarene palladium mediated; stilbenecarboxamide macroarray preparation Vibrio fischeri quorum sensing receptor inhibition.

The application of palladium-mediated Heck reactions to the efficient construction of a 100-member stilbene macroarray on planar cellulose support was discussed. The stilbene library was evaluated in a bacterial quorum sensing (QS) assay and indicated several new inhibitors of a QS receptor in the Gram-neg. bacterium Vibrio fischeri.

Chemistry – A European Journal published new progress about Aliivibrio fischeri. 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Safety of 1,4-Difluoro-2-iodobenzene.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shen, Chaoren; Spannenberg, Anke; Wu, Xiao-Feng published the artcile< Palladium-Catalyzed Carbonylative Four-Component Synthesis of Thiochromenones: The Advantages of a Reagent Capsule>, Related Products of 2265-92-1, the main research area is four component reaction fluoroiodobenzene phenylacetylene carbonylative palladium catalyst; thiochromenone preparation; carbonylation; multicomponent reactions; palladium catalysis; thiochromenones.

Multicomponent reactions, especially those involving four or even more reagents, have been a long-standing challenge because of the issues associated with balancing reactivity, selectivity, and compatibility. Herein, we demonstrate how the use of a reagent capsule provides straightforward access to synthetically valuable thiochromenone derivatives by a palladium-catalyzed carbonylative four-component reaction. To the best of our knowledge, this is the first example of applying a capsule to prevent catalyst poisoning and undesired side reactions of the multicomponent reaction.

Angewandte Chemie, International Edition published new progress about Alkynes, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Related Products of 2265-92-1.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Burt, Michael; Amini, Kasra; Lee, Jason W. L.; Christiansen, Lars; Johansen, Rasmus R.; Kobayashi, Yuki; Pickering, James D.; Vallance, Claire; Brouard, Mark; Stapelfeldt, Henrik published the artcile< Communication: Gas-phase structural isomer identification by Coulomb explosion of aligned molecules>, Category: iodides-buliding-blocks, the main research area is gas phase structure difluoroiodobenzene dihydroxybromobenzene; femtosecond laser induced coulomb explosion.

The gas-phase structures of four difluoroiodobenzene and two dihydroxybromobenzene isomers were identified by correlating the emission angles of at. fragment ions created, following femtosecond laser-induced Coulomb explosion. The structural determinations were facilitated by confining the most polarizable axis of each mol. to the detection plane prior to the Coulomb explosion event using one-dimensional laser-induced adiabatic alignment. For a mol. target consisting of two difluoroiodobenzene isomers, each constituent structure could addnl. be singled out and distinguished. (c) 2018 American Institute of Physics.

Journal of Chemical Physics published new progress about Dissociative photoionization, coulomb explosion. 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Category: iodides-buliding-blocks.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Polivkova, Jana; Piotrowski, David W. published the artcile< Stereodefined Cyclopentanes by Hydroarylation-Ring Opening>, Category: iodides-buliding-blocks, the main research area is stereodefined cyclopentane preparation; hydroarylation azabicycloheptenone nucleophilic ring opening.

The hydroarylation of 2-azabicyclo[2.2.1]hept-5-en-3-one followed by nucleophilic ring opening was employed as an operationally simple route to stereodefined trisubstituted cyclopentane analogs. This synthetic sequence was successfully executed using a variety of nucleophiles including hydroxide, alkoxide, hydride, Grignard reagents, and amines. E.g., hydroarylation of rac-2-azabicyclo[2.2.1]hept-5-en-3-one with PhI, followed by reaction with di-tert-Bu dicarbonate, gave 15% I and 25% II. Ring opening of II with LiOH in water gave 71% cyclopentane derivative (III). This methodol. facilitated the preparation of a constrained version of dipeptidylpeptidase 4 inhibitor sitagliptin.

Synthetic Communications published new progress about Diastereoselective synthesis. 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Category: iodides-buliding-blocks.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Abraham, Raymond J.; Cooper, M. Ashley published the artcile< A re-investigation of 4JFF and 5JFF nuclear spin-spin couplings in substituted benzenes, a novel conformational tool>, COA of Formula: C6H3F2I, the main research area is benzene nuclear spin coupling B3LYP.

A theor. anal. of the 4JFF and 5JFF couplings in fluorobenzenes separates the σ and π components of the substituent coefficients The π bond mechanism is dominant but the σ bond mechanism must be included to give accurate values of the couplings. For monosubstituted difluorobenzenes the 4JFF and 5JFF couplings can be predicted from the calculated π densities by linear equations. The use of additive substituent effects allows the prediction of the meta4JFF couplings for multisubstituted compounds The π dependence of the 4JFF coupling in 2,6-difluorobenzenes provides a novel and simple method of determining the torsional angle of the C1 substituent and the benzene ring for non-sym. functional groups (acetyl, carboxymethyl, dimethylamino, amide, nitro etc.). This could be used to determine the geometries of such mols. in biol. systems. The π dependence of the 4JFF coupling is also of importance in the charged species of 2,6-difluoroanilinium (4JFF 2.1 Hz) and 2,6-difluoro-N,N,N-trimethylanilinium (4JFF 0.0 Hz) due to the very different π electron densities.

Physical Chemistry Chemical Physics published new progress about Bond angle, torsional. 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, COA of Formula: C6H3F2I.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com