Category: 220185-63-7

Ghosh, Munmun et al. published their research in Tetrahedron Letters in 2015 | CAS: 220185-63-7

4,5-Dichloro-2-iodoaniline (cas: 220185-63-7) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Application of 220185-63-7

Domino Suzuki coupling and condensation reaction: an efficient strategy towards synthesis of phenanthridines was written by Ghosh, Munmun;Ahmed, Atiur;Singha, Raju;Ray, Jayanta K.. And the article was included in Tetrahedron Letters in 2015.Application of 220185-63-7 This article mentions the following:

A short and convenient hetero-annulation protocol was developed for the synthesis of substituted phenanthridines via domino Suzuki coupling and condensation between N-(2-iodo-aryl)-formamide derivatives and 2-formylphenylboronic acid in the presence of Pd(OAc)2, Cs2CO3 and PPh3 as catalytic system in dry DMF at 85-90° for 6-7 h. The intermediate after Suzuki coupling and deprotection of nitrogen under the same catalytic system, furnishes the corresponding phenanthridines in good yields after immediate condensation and dehydration. In the experiment, the researchers used many compounds, for example, 4,5-Dichloro-2-iodoaniline (cas: 220185-63-7Application of 220185-63-7).

4,5-Dichloro-2-iodoaniline (cas: 220185-63-7) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Application of 220185-63-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Xiaoyan et al. published their research in Tetrahedron Letters in 2004 | CAS: 220185-63-7

4,5-Dichloro-2-iodoaniline (cas: 220185-63-7) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.SDS of cas: 220185-63-7

Synthesis of optically active ring-A substituted tryptophans as IDO inhibitors was written by Li, Xiaoyan;Yin, Wenyuan;Sarma, P. V. V. Srirama;Zhou, Hao;Ma, Jun;Cook, James M.. And the article was included in Tetrahedron Letters in 2004.SDS of cas: 220185-63-7 This article mentions the following:

The first stereoselective synthesis of optically active 6-chloro-L-tryptophan, 5-nitro-D-tryptophan, 6-nitro-D-tryptophan, 5,6-dichloro-L-tryptophan, 6-aza-D-tryptophan, as well as the first synthesis of the optically active 7-methoxy-D-tryptophan with potential activity at IDO (IDO = indoleamine 2,3-dioxygenase) via the Schollkopf chiral auxiliary is described. In the experiment, the researchers used many compounds, for example, 4,5-Dichloro-2-iodoaniline (cas: 220185-63-7SDS of cas: 220185-63-7).

4,5-Dichloro-2-iodoaniline (cas: 220185-63-7) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.SDS of cas: 220185-63-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com