Category: 20776-55-0

Adding a certain compound to certain chemical reactions, such as: 20776-55-0, name is 2-Amino-3-iodobenzoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20776-55-0, HPLC of Formula: C7H6INO2

S nthesis of 2-amino-N-cyclopropyl-3-iodo-benzamide (R82)Synthesis of R82 To 2-amino-3-iodo-benzoic acid (200 mg, 0.76 mmol) in DMF (1 mL) TBTU (244.15 mg, 0.76 mmol) and DIPEA (245.69 L, 1.52 mmol) are added and stirred at r.t. for 7 min. Cyclopropylamine (52.69 L, 0.76 mmol) is added and stirred at r.t. overnight. The reaction mixture is diluted with water and the precipitate is filtered off and dried. Yield 89%, m/z 303 [M+H]+, rt 0.49 min, LC-MS Method X012_S01.

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Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ANDERSKEWITZ, Ralf; GRAUERT, Matthias; GRUNDL, Marc; HAEBEL, Peter, Wilhelm; OOST, Thorsten; PAUTSCH, Alexander; PETERS, Stefan; BINDER, Florian; VINTONYAK, Viktor; WO2014/140075; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The chemical industry reduces the impact on the environment during synthesis 20776-55-0, name is 2-Amino-3-iodobenzoic acid, I believe this compound will play a more active role in future production and life. 20776-55-0

General procedure: A suspention of anthranilic acid A1-A17 (0.001mol), a catalytic amount of triethylamine and 4-isothiocyanato-benzenesulfonamide B17b (0.169g, 0.001mol) in absolute ethanol (25ml) was refluxed for 3. The reaction mixture was filtered while hot, left to cool and the solvent was removed under reduced pressure. The obtained residue was triturated from diethyl ether, filtered and dried under vacuo to obtain titled compound C: 1-17 as a whitish solid.

The chemical industry reduces the impact on the environment during synthesis 20776-55-0. I believe this compound will play a more active role in future production and life.

Reference:
Article; Alafeefy, Ahmed M.; Carta, Fabrizio; Ceruso, Mariangela; Supuran, Claudiu T.; Al-Tamimi, Abdul-Malek S.; Al-Kahtani, Abdulla A.; Bioorganic and medicinal chemistry; vol. 24; 6; (2016); p. 1402 – 1407;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com